Matteo D'AMORE | PHARMACEUTICAL TECHNOLOGY AND PLANTS

cod. 0760200021

PHARMACEUTICAL TECHNOLOGY AND PLANTS

	0760200021
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
	2017/2018

PERCORSO COMUNE Cohort 2014/2015

	OBBLIGATORIO
	YEAR OF COURSE 4
	YEAR OF DIDACTIC SYSTEM 2010
	PRIMO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	TECNICA FARMACEUTICA MODULO DI TECNICA E IMPIANTI
	CHIM/09	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	IMPIANTI DELL'INDUSTRIA FARMACEUTICA MODULO DI TECNICA E IMPIANTI
	CHIM/09	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	MATTEO D'AMORE2 T Curriculum
	PASQUALE DEL GAUDIO1 Curriculum

	Objectives
	PHARMACEUTICAL TECHNOLOGY TO KNOW AND UNDERSTAND THE CONCEPTS OF BIOPHARMACEUTICS AND PHARMACOKINETICS APPLIED TO PHARMACEUTICAL DOSAGE FORMS; TO UNDERSTAND THE MECHANISMS OF DRUG DIFFUSION AND DISSOLUTION OF THE DRUGS AND TECHNOLOGICAL, CHEMICAL AND PHISICAL METHODS TO CONTROL LADME PLANTS STUDENTS MUST HAVE ACQUIRED BASICS IN UNIT OPERATIONS, MAIN APPARATUSES AND PLANTS EXERCISE. STUDENTS MUST HAVE ACQUIRED SKILL TO APPLY THE BASICS OF UNIT OPERATIONS TO THE MOST COMMON PROBLEMS OF CHEMICAL AND PHARMACEUTICAL PLANTS. STUDENTS MUST HAVE ACQUIRED A CRITICAL APPROACH TO INDIVIDUATE AND TO EVALUATE THE MAIN PHENOMENA AND THE MAIN UNIT OPERATIONS INVOLVED IN A PRODUCTION ACTIVITY. STUDENTS MUST KNOW HOW TO DISCUSS A TOPIC IN FIELD OF THE UNIT OPERATIONS. STUDENTS MUST KNOW HOW TO APPLY THE ACQUIRED KNOWLEDGE IN CONTEXTS EVEN DIFFERENT THAN THE ONES PRESENTED DURING THE COURSE AND TO BE ABLE TO DEEPEN THE TOPICS DEALT WITH WITHIN THE COURSE.

PHARMACEUTICAL TECHNOLOGY
TO KNOW AND UNDERSTAND THE CONCEPTS OF BIOPHARMACEUTICS AND PHARMACOKINETICS APPLIED TO PHARMACEUTICAL DOSAGE FORMS; TO UNDERSTAND THE MECHANISMS OF DRUG DIFFUSION AND DISSOLUTION OF THE DRUGS AND TECHNOLOGICAL, CHEMICAL AND PHISICAL METHODS TO CONTROL LADME

PLANTS
STUDENTS MUST HAVE ACQUIRED BASICS IN UNIT OPERATIONS, MAIN APPARATUSES AND PLANTS EXERCISE.
STUDENTS MUST HAVE ACQUIRED SKILL TO APPLY THE BASICS OF UNIT OPERATIONS TO THE MOST COMMON PROBLEMS OF CHEMICAL AND PHARMACEUTICAL PLANTS.
STUDENTS MUST HAVE ACQUIRED A CRITICAL APPROACH TO INDIVIDUATE AND TO EVALUATE THE MAIN PHENOMENA AND THE MAIN UNIT OPERATIONS INVOLVED IN A PRODUCTION ACTIVITY.
STUDENTS MUST KNOW HOW TO DISCUSS A TOPIC IN FIELD OF THE UNIT OPERATIONS.
STUDENTS MUST KNOW HOW TO APPLY THE ACQUIRED KNOWLEDGE IN CONTEXTS EVEN DIFFERENT THAN THE ONES PRESENTED DURING THE COURSE AND TO BE ABLE TO DEEPEN THE TOPICS DEALT WITH WITHIN THE COURSE.

	Prerequisites
	BASIC KNOWLEDGE OF MATHEMATICS, PHYSICS,INORGANIC AND ORGANIC CHEMISTRY, ANALITICAL CHEMISTRY AND PHYSICAL CHEMISTRY.

	Contents
	•BASIC KNOWLEDGE OF BIOPHARMACEUTICS AND PHARMACOKINETICS. •PHARMACEUTICAL DOSAGE FORMS, DRUG ADMINISTRATION ROUTE AND DRUG ABSORPTION. •COMPARTMENT MODEL. KINETIC OF ABSORPTION OF DRUGS. PHARMACEKINETIC PARAMETERS. BIOAVAILABILITY AND BIOEQUIVALENCE. •DRUG DIFFUSION THROUGH BIOLOGICAL MEMBRANE: FICK LAW. STEADY-STATE AND FREE DIFFUSION. DRUG DIFFUSION THEORETICAL MODEL. •DRUG SOLUBILITY. EFFFECTIVE SURFACE AREA. DRUG WETTING PROPERTIES. DISSOLUTION THEORETICAL MODEL. DRUG RATE DISSULUTION APPARATUS. DOSAGE FORMS DISSOLUTION PROCESS VARIABLES. •DRUG SOLID STATE PROPERTIES. CRYSTALLINE, AMORPHOUS, LIQUID-CRYSTALLINE DRUG SOLIDE STATE. DRUG POLYMORPHISM. •BASIC KNOWLED ON DRUG INCLUSION COMPLEXES. •SOLID STATE ANALYSES BY OPTIC AND ELCTRONIC MICRISCOPY. THERMAL ANALYSES. •PYLYMERIC METERIALS IN PHARMACEUTICS. •OPTIMIZATION PROCESSES IN THE DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS. DEFINITIONS. SI BASE AND SUPPLEMENTARY QUANTITIES AND UNITS. CLOSED AND OPEN SYSTEMS; CONTINUOUS AND BATCH PROCESSES. CHEMICAL REACTION. EQUIPMENT AND PROCESS LAYOUT. MASS AND ENERGY BALANCES. UNIT OPERATIONS MODELS. UNIT OPERATIONS THAT INVOLVE ONLY THE EXCHANGE OF ENERGY. UNIT OPERATIONS THAT INVOLVE ENERGY AND MASS EXCHANGE. MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS. HEAT EXCHANGE: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS. CONCENTRATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS. DRYING: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS. DISTILLATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS. EXTRACTION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS. MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS BASICS OF CHEMICAL REACTORS. CLASSIFICATION AND STUDY OF CHEMICAL REACTORS

Contents

•BASIC KNOWLEDGE OF BIOPHARMACEUTICS AND PHARMACOKINETICS.
•PHARMACEUTICAL DOSAGE FORMS, DRUG ADMINISTRATION ROUTE AND DRUG ABSORPTION.
•COMPARTMENT MODEL. KINETIC OF ABSORPTION OF DRUGS. PHARMACEKINETIC PARAMETERS. BIOAVAILABILITY AND BIOEQUIVALENCE.
•DRUG DIFFUSION THROUGH BIOLOGICAL MEMBRANE: FICK LAW. STEADY-STATE AND FREE DIFFUSION. DRUG DIFFUSION THEORETICAL MODEL.
•DRUG SOLUBILITY. EFFFECTIVE SURFACE AREA. DRUG WETTING PROPERTIES. DISSOLUTION THEORETICAL MODEL. DRUG RATE DISSULUTION APPARATUS. DOSAGE FORMS DISSOLUTION PROCESS VARIABLES.
•DRUG SOLID STATE PROPERTIES. CRYSTALLINE, AMORPHOUS, LIQUID-CRYSTALLINE DRUG SOLIDE STATE. DRUG POLYMORPHISM.
•BASIC KNOWLED ON DRUG INCLUSION COMPLEXES.
•SOLID STATE ANALYSES BY OPTIC AND ELCTRONIC MICRISCOPY. THERMAL ANALYSES.
•PYLYMERIC METERIALS IN PHARMACEUTICS.
•OPTIMIZATION PROCESSES IN THE DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS.

DEFINITIONS. SI BASE AND SUPPLEMENTARY QUANTITIES AND UNITS. CLOSED AND OPEN SYSTEMS; CONTINUOUS AND BATCH PROCESSES. CHEMICAL REACTION. EQUIPMENT AND PROCESS LAYOUT. MASS AND ENERGY BALANCES. UNIT OPERATIONS MODELS. UNIT OPERATIONS THAT INVOLVE ONLY THE EXCHANGE OF ENERGY. UNIT OPERATIONS THAT INVOLVE ENERGY AND MASS EXCHANGE. MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS.
HEAT EXCHANGE: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS.
CONCENTRATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS.
DRYING: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS.
DISTILLATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS.
EXTRACTION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS.
MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS
BASICS OF CHEMICAL REACTORS. CLASSIFICATION AND STUDY OF CHEMICAL REACTORS

	Teaching Methods
	FRONTAL LESSONS AND INTERACTIVE LEARNING LECTURES.

	Verification of learning
	ORAL EXAMINATION. ORAL INTERVIEW.

	Texts
	A. T. FLORENCE, D. ATWOOD, LE BASI CHIMICO-FISICHE DELLA TECNOLOGIA FARMACEUTICA, EDISES 2002. A. MARTIN, PHYSICAL PHARMACY, ED. LEA AND FABIGER, PHILADELPHIA, 1994. CHASIN, LANGER, BIODEGRADABLE POLYMERS AS DRUG DELIVERY SYSTEM, M. DEKKER, 1990. D. FRISO, M. NIERO, OPERAZIONI UNITARIE DELL’INGEGNERIA ALIMENTARE, CLEUP, PADOVA, 2010 P. CAPPELLI V. VANNUCCHI, CHIMICA DEGLI ALIMENTI. CONSERVAZIONE E TRASFORMAZIONE, ZANICHELLI ED., BOLOGNA, 2005 A.S. FOUST ET AL., I PRINCIPI DELLE OPERAZIONI UNITARIE, CASA ED. AMBROSIANA, MILANO 1980 L. FABRIS, S. RIGAMONTI, LA FABBRICAZIONE INDUSTRIALE DEI MEDICINALI, SOC. EDITRICE ESCULAPIO-BOLOGNA 2008 O. LEVELSPIEL, INGEGNERIA DELLE REAZIONI CHIMICHE, CASA EDITRICE AMBROSIANA, MILANO, 1978

Texts

A. T. FLORENCE, D. ATWOOD, LE BASI CHIMICO-FISICHE DELLA TECNOLOGIA FARMACEUTICA, EDISES 2002.
A. MARTIN, PHYSICAL PHARMACY, ED. LEA AND FABIGER, PHILADELPHIA, 1994.
CHASIN, LANGER, BIODEGRADABLE POLYMERS AS DRUG DELIVERY SYSTEM, M. DEKKER, 1990.
D. FRISO, M. NIERO, OPERAZIONI UNITARIE DELL’INGEGNERIA ALIMENTARE, CLEUP, PADOVA, 2010
P. CAPPELLI V. VANNUCCHI, CHIMICA DEGLI ALIMENTI. CONSERVAZIONE E TRASFORMAZIONE, ZANICHELLI ED., BOLOGNA, 2005
A.S. FOUST ET AL., I PRINCIPI DELLE OPERAZIONI UNITARIE, CASA ED. AMBROSIANA, MILANO 1980
L. FABRIS, S. RIGAMONTI, LA FABBRICAZIONE INDUSTRIALE DEI MEDICINALI, SOC. EDITRICE ESCULAPIO-BOLOGNA 2008
O. LEVELSPIEL, INGEGNERIA DELLE REAZIONI CHIMICHE, CASA EDITRICE AMBROSIANA, MILANO, 1978

	More Information
	PLACE AND TIME OF DELIVERY. THE COURSE IS DELIVERED AT THE DEPARTMENT OF PHARMACY; TIMETABLE AND CLASSROOM: HTTP://WWW.FARMACIA.UNISA.IT/DIDATTICA/INDEX.

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Matteo D'AMORE | PHARMACEUTICAL TECHNOLOGY AND PLANTS