Matteo D'AMORE | PHARMACEUTICAL TECHNOLOGY AND PLANTS

cod. 0760200021

PHARMACEUTICAL TECHNOLOGY AND PLANTS

	0760200021
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
	2022/2023

PERCORSO COMUNE Cohort 2019/2020

	OBBLIGATORIO
	YEAR OF COURSE 4
	YEAR OF DIDACTIC SYSTEM 2016
	AUTUMN SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	TECNICA FARMACEUTICA MODULO DI TECNICA E IMPIANTI
	CHIM/09	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	IMPIANTI DELL'INDUSTRIA FARMACEUTICA MODULO DI TECNICA E IMPIANTI
	CHIM/09	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	PASQUALE DEL GAUDIO1 T Curriculum
	MATTEO D'AMORE2 Curriculum

	Objectives
	PHARMACEUTICAL TECHNOLOGY TO KNOW AND UNDERSTAND THE CONCEPTS OF BIOPHARMACEUTICS AND PHARMACOKINETICS APPLIED TO PHARMACEUTICAL DOSAGE FORMS; TO UNDERSTAND THE MECHANISMS OF DRUG DIFFUSION AND DISSOLUTION OF THE DRUGS AND TECHNOLOGICAL, CHEMICAL AND PHISICAL METHODS TO CONTROL LADME PLANTS STUDENTS MUST HAVE ACQUIRED BASICS IN UNIT OPERATIONS, MAIN APPARATUSES AND PLANTS EXERCISE. STUDENTS MUST HAVE ACQUIRED SKILL TO APPLY THE BASICS OF UNIT OPERATIONS TO THE MOST COMMON PROBLEMS OF CHEMICAL AND PHARMACEUTICAL PLANTS. STUDENTS MUST HAVE ACQUIRED A CRITICAL APPROACH TO INDIVIDUATE AND TO EVALUATE THE MAIN PHENOMENA AND THE MAIN UNIT OPERATIONS INVOLVED IN A PRODUCTION ACTIVITY. STUDENTS MUST KNOW HOW TO DISCUSS A TOPIC IN FIELD OF THE UNIT OPERATIONS. STUDENTS MUST KNOW HOW TO APPLY THE ACQUIRED KNOWLEDGE IN CONTEXTS EVEN DIFFERENT THAN THE ONES PRESENTED DURING THE COURSE AND TO BE ABLE TO DEEPEN THE TOPICS DEALT WITH WITHIN THE COURSE.

PHARMACEUTICAL TECHNOLOGY
TO KNOW AND UNDERSTAND THE CONCEPTS OF BIOPHARMACEUTICS AND PHARMACOKINETICS APPLIED TO PHARMACEUTICAL DOSAGE FORMS; TO UNDERSTAND THE MECHANISMS OF DRUG DIFFUSION AND DISSOLUTION OF THE DRUGS AND TECHNOLOGICAL, CHEMICAL AND PHISICAL METHODS TO CONTROL LADME

PLANTS
STUDENTS MUST HAVE ACQUIRED BASICS IN UNIT OPERATIONS, MAIN APPARATUSES AND PLANTS EXERCISE.
STUDENTS MUST HAVE ACQUIRED SKILL TO APPLY THE BASICS OF UNIT OPERATIONS TO THE MOST COMMON PROBLEMS OF CHEMICAL AND PHARMACEUTICAL PLANTS.
STUDENTS MUST HAVE ACQUIRED A CRITICAL APPROACH TO INDIVIDUATE AND TO EVALUATE THE MAIN PHENOMENA AND THE MAIN UNIT OPERATIONS INVOLVED IN A PRODUCTION ACTIVITY.
STUDENTS MUST KNOW HOW TO DISCUSS A TOPIC IN FIELD OF THE UNIT OPERATIONS.
STUDENTS MUST KNOW HOW TO APPLY THE ACQUIRED KNOWLEDGE IN CONTEXTS EVEN DIFFERENT THAN THE ONES PRESENTED DURING THE COURSE AND TO BE ABLE TO DEEPEN THE TOPICS DEALT WITH WITHIN THE COURSE.

	Prerequisites
	BASIC KNOWLEDGE OF MATHEMATICS, PHYSICS,INORGANIC AND ORGANIC CHEMISTRY, ANALITICAL CHEMISTRY AND PHYSICAL CHEMISTRY.

	Contents
	PHARMACEUTICAL TECHNOLOGY •BASIC KNOWLEDGE OF BIOPHARMACEUTICS AND PHARMACOKINETICS – (4 H) •PHARMACEUTICAL DOSAGE FORMS, DRUG ADMINISTRATION ROUTE AND DRUG ABSORPTION – (4 H) •COMPARTMENT MODEL. KINETIC OF ABSORPTION OF DRUGS. PHARMACEKINETIC PARAMETERS. BIOAVAILABILITY AND BIOEQUIVALENCE – (4 H) •DRUG DIFFUSION THROUGH BIOLOGICAL MEMBRANE: FICK LAW. STEADY-STATE AND FREE DIFFUSION. DRUG DIFFUSION THEORETICAL MODEL – (4 H) •DRUG SOLUBILITY. EFFFECTIVE SURFACE AREA. DRUG WETTING PROPERTIES. DISSOLUTION THEORETICAL MODEL. DRUG RATE DISSULUTION APPARATUS. DOSAGE FORMS DISSOLUTION PROCESS VARIABLES – (4 H) •DRUG SOLID STATE PROPERTIES. CRYSTALLINE, AMORPHOUS, LIQUID-CRYSTALLINE DRUG SOLIDE STATE. DRUG POLYMORPHISM – (4 H) •BASIC KNOWLED ON DRUG INCLUSION COMPLEXES – (4 H) •SOLID STATE ANALYSES BY OPTIC AND ELCTRONIC MICRISCOPY. THERMAL ANALYSES – (4 H) •PYLYMERIC METERIALS IN PHARMACEUTICS – (4 H) •OPTIMIZATION PROCESSES IN THE DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS – (4 H) PHARMACEUTICAL INDUSTRY IMPLANTS DEFINITIONS. SI BASE AND SUPPLEMENTARY QUANTITIES AND UNITS. CLOSED AND OPEN SYSTEMS; CONTINUOUS AND BATCH PROCESSES. CHEMICAL REACTION. EQUIPMENT AND PROCESS LAYOUT. MASS AND ENERGY BALANCES – (6 H) UNIT OPERATIONS MODELS. UNIT OPERATIONS THAT INVOLVE ONLY THE EXCHANGE OF ENERGY. UNIT OPERATIONS THAT INVOLVE ENERGY AND MASS EXCHANGE. MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS – (6 H) HEAT EXCHANGE: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H) CONCENTRATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H) DRYING: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H) DISTILLATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H) EXTRACTION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H) MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS – (4 H) BASICS OF CHEMICAL REACTORS. CLASSIFICATION AND STUDY OF CHEMICAL REACTORS – (4 H)

Contents

PHARMACEUTICAL TECHNOLOGY
•BASIC KNOWLEDGE OF BIOPHARMACEUTICS AND PHARMACOKINETICS – (4 H)
•PHARMACEUTICAL DOSAGE FORMS, DRUG ADMINISTRATION ROUTE AND DRUG ABSORPTION – (4 H)
•COMPARTMENT MODEL. KINETIC OF ABSORPTION OF DRUGS. PHARMACEKINETIC PARAMETERS. BIOAVAILABILITY AND BIOEQUIVALENCE – (4 H)
•DRUG DIFFUSION THROUGH BIOLOGICAL MEMBRANE: FICK LAW. STEADY-STATE AND FREE DIFFUSION. DRUG DIFFUSION THEORETICAL MODEL – (4 H)
•DRUG SOLUBILITY. EFFFECTIVE SURFACE AREA. DRUG WETTING PROPERTIES. DISSOLUTION THEORETICAL MODEL. DRUG RATE DISSULUTION APPARATUS. DOSAGE FORMS DISSOLUTION PROCESS VARIABLES – (4 H)
•DRUG SOLID STATE PROPERTIES. CRYSTALLINE, AMORPHOUS, LIQUID-CRYSTALLINE DRUG SOLIDE STATE. DRUG POLYMORPHISM – (4 H)
•BASIC KNOWLED ON DRUG INCLUSION COMPLEXES – (4 H)
•SOLID STATE ANALYSES BY OPTIC AND ELCTRONIC MICRISCOPY. THERMAL ANALYSES – (4 H)
•PYLYMERIC METERIALS IN PHARMACEUTICS – (4 H)
•OPTIMIZATION PROCESSES IN THE DEVELOPMENT OF PHARMACEUTICAL DOSAGE FORMS – (4 H)

PHARMACEUTICAL INDUSTRY IMPLANTS
DEFINITIONS. SI BASE AND SUPPLEMENTARY QUANTITIES AND UNITS. CLOSED AND OPEN SYSTEMS; CONTINUOUS AND BATCH PROCESSES. CHEMICAL REACTION. EQUIPMENT AND PROCESS LAYOUT. MASS AND ENERGY BALANCES – (6 H)
UNIT OPERATIONS MODELS. UNIT OPERATIONS THAT INVOLVE ONLY THE EXCHANGE OF ENERGY. UNIT OPERATIONS THAT INVOLVE ENERGY AND MASS EXCHANGE. MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS – (6 H)
HEAT EXCHANGE: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H)
CONCENTRATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H)
DRYING: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H)
DISTILLATION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H)
EXTRACTION: PHYSICAL PRINCIPLES, EQUIPMENT, AND PROCESS DIAGRAMS – (4 H)
MAIN INNOVATIONS IN SEVERAL UNIT OPERATIONS – (4 H)
BASICS OF CHEMICAL REACTORS. CLASSIFICATION AND STUDY OF CHEMICAL REACTORS – (4 H)

	Teaching Methods
	FRONTAL LECTURES AND INTERACTIVE LEARNING. FRONTAL LECTURES ARE CONDUCTED BY MULTIMEDIA PRESENTATIONS. LECTURES.

	Verification of learning
	ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY THE PASSING OF AN EXAM, CONSISTENT FOR THE FIRST MODULE IN AN ORAL TEST NOT EXCEEDING 30 MINUTES ON SUBJECTS RELATED TO THE DRUG RELEASE MECHANISMS FROM DIFFERENT FORMULATIONS, THE INFLUENCE OF THE DRUG PHYSICO-CHEMICAL PROPERTIES ON ITS ABSORPTION, MODIFICATION OF THE DRUG PHARMACOLOGICAL EFFECT BY MODIFYING FORMULATION PROPERTIES, AND FOR THE SECOND MODULE IN AN ORAL TEST NOT EXCEEDING 30 MINUTES ON THE SUBJECTS OF TRANPORT PHENOMENA, UNIT OPERATIONS, MAIN APPARATUSES IN THE PHARMACEUTICAL INDUSTRY. THE TESTS ENABLE TO CHECK THE LEVEL OF ACQUISITION OF SKILL, OF CORRECT TERMINOLOGY, OF ABILITY OF ANALYSIS, WHICH SHOULD CONSTITUTE THE ACQUIRED KNOWLEDGE. THE EVALUATION TAKES INTO ACCOUNT SYNTHESIS AND EXPOSURE ABILITY, LANGUAGE APPROPRIATENESS; CAPACITY OF ANALYSIS.

Verification of learning

ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY THE PASSING OF AN EXAM, CONSISTENT FOR THE FIRST MODULE IN AN ORAL TEST NOT EXCEEDING 30 MINUTES ON SUBJECTS RELATED TO THE DRUG RELEASE MECHANISMS FROM DIFFERENT FORMULATIONS, THE INFLUENCE OF THE DRUG PHYSICO-CHEMICAL PROPERTIES ON ITS ABSORPTION, MODIFICATION OF THE DRUG PHARMACOLOGICAL EFFECT BY MODIFYING FORMULATION PROPERTIES, AND FOR THE SECOND MODULE IN AN ORAL TEST NOT EXCEEDING 30 MINUTES ON THE SUBJECTS OF TRANPORT PHENOMENA, UNIT OPERATIONS, MAIN APPARATUSES IN THE PHARMACEUTICAL INDUSTRY. THE TESTS ENABLE TO CHECK THE LEVEL OF ACQUISITION OF SKILL, OF CORRECT TERMINOLOGY, OF ABILITY OF ANALYSIS, WHICH SHOULD CONSTITUTE THE ACQUIRED KNOWLEDGE. THE EVALUATION TAKES INTO ACCOUNT SYNTHESIS AND EXPOSURE ABILITY, LANGUAGE APPROPRIATENESS; CAPACITY OF ANALYSIS.

	Texts
	A. T. FLORENCE, D. ATWOOD, LE BASI CHIMICO-FISICHE DELLA TECNOLOGIA FARMACEUTICA, EDISES 2002. A. MARTIN, PHYSICAL PHARMACY, ED. LEA AND FABIGER, PHILADELPHIA, 1994. CHASIN, LANGER, BIODEGRADABLE POLYMERS AS DRUG DELIVERY SYSTEM, M. DEKKER, 1990. D. FRISO, M. NIERO, OPERAZIONI UNITARIE DELL’INGEGNERIA ALIMENTARE, CLEUP, PADOVA, 2010 P. CAPPELLI V. VANNUCCHI, CHIMICA DEGLI ALIMENTI. CONSERVAZIONE E TRASFORMAZIONE, ZANICHELLI ED., BOLOGNA, 2005 A.S. FOUST ET AL., I PRINCIPI DELLE OPERAZIONI UNITARIE, CASA ED. AMBROSIANA, MILANO 1980 L. FABRIS, S. RIGAMONTI, LA FABBRICAZIONE INDUSTRIALE DEI MEDICINALI, SOC. EDITRICE ESCULAPIO-BOLOGNA 2008 O. LEVELSPIEL, INGEGNERIA DELLE REAZIONI CHIMICHE, CASA EDITRICE AMBROSIANA, MILANO, 1978 MCCABE W.L., SMITH J.C., HARRIOT P.- UNIT OPERATIONS IN CHEMICAL ENGINEERING, MCGRAW-HILL INTERNATIONAL EDITIONS

Texts

A. T. FLORENCE, D. ATWOOD, LE BASI CHIMICO-FISICHE DELLA TECNOLOGIA FARMACEUTICA, EDISES 2002.
A. MARTIN, PHYSICAL PHARMACY, ED. LEA AND FABIGER, PHILADELPHIA, 1994.
CHASIN, LANGER, BIODEGRADABLE POLYMERS AS DRUG DELIVERY SYSTEM, M. DEKKER, 1990.
D. FRISO, M. NIERO, OPERAZIONI UNITARIE DELL’INGEGNERIA ALIMENTARE, CLEUP, PADOVA, 2010
P. CAPPELLI V. VANNUCCHI, CHIMICA DEGLI ALIMENTI. CONSERVAZIONE E TRASFORMAZIONE, ZANICHELLI ED., BOLOGNA, 2005
A.S. FOUST ET AL., I PRINCIPI DELLE OPERAZIONI UNITARIE, CASA ED. AMBROSIANA, MILANO 1980
L. FABRIS, S. RIGAMONTI, LA FABBRICAZIONE INDUSTRIALE DEI MEDICINALI, SOC. EDITRICE ESCULAPIO-BOLOGNA 2008
O. LEVELSPIEL, INGEGNERIA DELLE REAZIONI CHIMICHE, CASA EDITRICE AMBROSIANA, MILANO, 1978
MCCABE W.L., SMITH J.C., HARRIOT P.- UNIT OPERATIONS IN CHEMICAL ENGINEERING, MCGRAW-HILL INTERNATIONAL EDITIONS

	More Information
	PLACE AND TIME OF DELIVERY. THE COURSE IS DELIVERED AT THE DEPARTMENT OF PHARMACY; TIMETABLE AND CLASSROOM: HTTP://WWW.FARMACIA.UNISA.IT/DIDATTICA/INDEX.

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Matteo D'AMORE | PHARMACEUTICAL TECHNOLOGY AND PLANTS