CHEMIOTERAPIA E TOSSICOLOGIA

Giuseppina AUTORE CHEMIOTERAPIA E TOSSICOLOGIA

0760100027
DIPARTIMENTO DI FARMACIA
CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI
PHARMACY
2015/2016

OBBLIGATORIO
YEAR OF COURSE 5
YEAR OF DIDACTIC SYSTEM 2010
PRIMO SEMESTRE
CFUHOURSACTIVITY
1CHEMIOTERAPIA MODULO DI CHEMIOTERAPIA E TOSSICOLOGIA
540LESSONS
2TOSSICOLOGIA MODULO DI CHEMIOTERAPIA E TOSSICOLOGIA
540LESSONS
Objectives
THE COURSE AIMD TO PROVIDE STUDENTS WITH:
KNOWLEDGE AND UNDERSTANDING
BASIC KNOWLEDGE IN THE FIELD OF PHARMACOKINETICS AND TOXICOKINETICS OF BIOACTIVE MOLECULES OF NATURAL AND SYNTHETIC ORIGIN WITH ANTIBACTERIAL, ANTIVIRAL, ANTIPROTOZOAL, ANTHELMINTIC AND ANTITUMOR ACTIVITY; TOXIC INTERACTIONS BETWEEN ALL THESE DRUGS AND BIOMOLECULES FROM FOOD AND ENVIRONMENTAL TOXICITY TO DETERMINE; UNDERSTANDING MECHANISMS OF DRUG RESISTANCE AND ON THE RATIONALE OF SYNERGISTIC DRUGS USED IN CHEMOTHERAPY; NOTIONS ON THE MOLECULES OF NATURAL AND SYNTHETIC ORIGIN CNS-ACTIVE; PSYCHOACTIVE DRUGS AND DRUG DEPENDENCE; CRAVIN; PHARMACODYNAMIC TOLERANCE AND WITHDRAWAL SYNDROMES; CESSATION THERAPIES. THE COURSE ALSO INCLUDES SOME SPECIFIC ISSUES CONCERNING: 1. RECENT DISCOVERY OF DRUGS THAT NOW MAKE IT POSSIBLE TO DEAL WITH MORE RADICAL TREATMENT OF SEVERE DISEASES SUCH AS CANCER AND AIDS, PARTICULARLY AGGRESSIVE; 2. TOXIC ENVIRONMENTAL AND FOOD SOURCE THAT ALLOW A SYSTEMATIC UNDERSTANDING AND CRITICAL AWARENESS OF TOXIC PRODUCTS IN THE ENVIRONMENT.
APPLYING KNOLEDGE AND UNDERSTANDING
THA ABILITY TO APPLY THE KNOWLEDGE ACQUIRED IN CHEMOTHERAPY AND TOXICOLOGICAL PROBLEMS THAT MAY OCCUR AS A RESULT OF EXPOSURE TO: ANTIBIOTICS AND OTHER CHEMOTHERAPIES, PSYCHOACTIVE DRUGS AND TOXIC SUBSTANCES FROM VARIOUS SOURCES SUCH AS THE ASSESSMENT OF ADVERSE EVENTS FOR THE SUSTAINABILITY OF THERAPY; IDENTIFICATION OF PROBLEMS RELATED TO DRUG ABUSE AND DRUG USE BOTH FOR EXPOSURE TO TOXIC SUBSTANCES FROM THE ENVIRONMENT BOTH FOR RESTORING THE NORMAL BACTERIAL FLORA.
MAKING JUDGMENTS
MAKING JUDGEMENTS AND INTEGRATING KNOWLEDGE TO MANAGE THE COMPLEXITY OF SIDE OR TOXIC EFFECTS THERAPY. WITH REGARD TO THE PHARMACIST ROLE AS INTERFACE BETWEEN THE PHYSICIAN AND THE PATIENT, TO MAKE JUDGMENTS ON THE BASIS OF INCOMPLETE OR LIMITED INFORMATIONS, BUT THAT INCLUDE REFLECTING ON SOCIAL AND ETHICAL RESPONSABILITIES LINKED TO THE APPLICATION OF THEI KNOWLEDGE AND JUDGEMENTS.
COMMUNICATION SKILLS
THE ABILITY TO COMUNICATE IN A CLEAR AND UNAMBIGUOUS CONCLUSIONS OF THEIR KNOWLEDGE AND JUDEGEMENTS TO A SPECIALIST (HEALTH WORKERS) AND NOT SPECIALISTS (PATIENTS) OF ANY GRADE AND LEVEL OF EDUCATION.
LEARNING SKILLS
LEARNING SKILLS IN A SELF-DIRECTED OR AUTONOMY THAT MAY HELP FOR CONTINOUS UPDATING, A NECESSARY CONDITION FOR THE PERFORMANCE OF THE FUNCTIONS OF A PHARMACIST, THROUGH THE USE OF TEXTES, SCIENTIFIC PUBLICATIONS IN THE FIELD, THE MAIN DATA BASES OF REGULATORY AGENCIES (EMA, FDA, AIFA ETC.)
Prerequisites
PREREQUISITES
FOR UNDERSTANDING OF THIS COURSE , IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY, BIOCHEMISTRY, PATHOLOGY, PHARMACOLOGY AND MICROBIOLOGY.
Contents
PROGRAM OF CHEMOTHERAPY
CONCEPTS OF ANTIBIOTIC THAERAPY AND CHEMOTHERAPY AND THEIR SELECTIVE TOXICITY. DRUG RESISTANCE TO CHEMOTHERAPICS. TREATMENT OF DISEASES OF VIRAL ORIGIN AND DRUGS USED FOR: INFLUENZA, INFECTIONS CAUSED BY HERPES VIRUSES, HEPATITIS VIRUSES, ACQUIRED IMMUNODEFICIENCY VRUS HIV. RATIONAL COMBINATION THERAPIES AND CRITERIA FOR CHOICE OF DRUGS TO BIND TO. SEXUALLY TRANSMITTED DISEASES AND THEIR TREATMENTS. ANTIMALARIAL AND ANTHELMINTIC DRUGS; DRUGS FOR THE TREATMENT OF TOXOPLASMOSIS; ANTI FOLIC DRUGS WITH ANTIBACTERIAL, ANTIPROTOZOAL AND ANTITUMOR ACTIVITY; AMMIGLUCOSIDES, MACROLIDES; QUINOLONES; BETALACTAM ANTIBIOTICS AND INHIBITORS OF BETA-LACTAMASES; ANTICANCER DRUGS OF OLD AND NEW GENERATION FOR THE MOST RATIONALE AND SPECIFIC COMBINED CANCER THERAPY
PROGRAM OF TOXICOLOGY
DOSE TOXIC RESPONSE. SIDE EFFECTS AND TOXIC EFFECTS. PHARMACOKINETIC INTERACTIONS AND PHARMACODINAMIC INTERACTIONS. DRUG ALLERGY AND DRUG IDIOSYNCRASY. PSYCOACTIVE DRUGS: ETHYL ALCOHOL, OPIATES, COCAINE, ECSTAYAND OTHER AMPHETAMINES, LYSERGIC ACID DIETHYLAMIDE, MESCALINE, PASILOCYBIN, CANNABINNOIDS. DRUGS DEPENDENCE, TOLERANCE, PHARMACOKINETIC AND PHARMACODINAMICS RELATINS TO USE AND ABUSE. WITHDRAWAL SYNDROMES, CESSATION THERAPIES. TOXIC OF FOOD ORIGIN ( TITANIC AND BOTULINIC TOXINS, GLUTE, MILK, MYCOTOXINS AND OTHER DIFFERENT CONTAMINANTS PRESENT IN FOOD OR WHAT COULD BE ORIGINATED IN ANY FOOD PREPARATION. TOXICS PRESENT IN YHE ENVIRONMENT (PCBS, DIOXINS, BENZENE AND OTHER ORGANIC SOLVENTS, OZONE AND CO) POISONINGS FROM HEAVY METALS AND ANTIDOTIC THAERAPY. ENDOCRINE INTERFERING COMPOUNDS OF DIFFERENT ORIGIN. RADON AND TOXIC SUBSTANCES FOR THEIR RADIOACTIVITY. PHYTOESTROGENIC MOLECULES. TREATMENTS OF POISONINGS. MICROBIAL CONTAMINATION OF FOODS. EXOTOXINS AND ENDOTOXINS OF BACTERIAL ORIGIN. MUTAGENESIS TESTS AND GENOTOXICITY.
Teaching Methods
FRONTAL LESSONS AND INTERACTIVA DISCUSSIONS ON THE MAIN FIELDS OF THE COURSES
Verification of learning
METHODS EVALUATION
TEST IN ITINERE FOR SELF-ASSESSMENT
ORAL INTERVIEW
Texts
REFERENCE BOOKS
KLAASSEN CD, WATKINS III JB, CASARETT & DOULL, ELEMENTI DI TOSSICOLOGIA, EDIZIONE ITALIANA A CURA DI PATRIZIA HRELIA E GIORGIO CANTELLI FORTI, CASA EDITRICE AMBROSIANA
PAOLETTI R, NICOSIA S, CLEMENTI F, FUMAGALLI G, FARMACOLOGIA GENERALE E MOLECOLARE, UTET.
GOODMAN & GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, X EDIZIONE ITALIANA, ZANICHELLI.
DOLARA, TOSSICOLOGIA GENERALE ED AMBIENTALE, EDITORE PICCIN.
KATZUNG, FARMACOLOGIA, EDITORE PICCIN
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