ENVIRONMENTAL TOXICOLOGY

Giuseppina AUTORE ENVIRONMENTAL TOXICOLOGY

0760100029
DIPARTIMENTO DI FARMACIA
CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI
PHARMACY
2015/2016

YEAR OF COURSE 4
YEAR OF DIDACTIC SYSTEM 2010
PRIMO SEMESTRE
CFUHOURSACTIVITY
540LESSONS
Objectives
THE COURSE AIM TO PROVIDE STUDENTS WITH:
KNOWLEDGE AND UNDERSTANDING
BASIC KNOWLEDGE IN THE FIELD OF PHARMACOLOGY AND TOXICOLOGY, TOXICOCINETIOC OF BIOACTIVE MOLECULES NOT ONLY USED IN THERAPIES TO THREAT DISEASES BUT ALSO PRESENT IN FOOD, ENVIRONMENT AND FOOD PREPARATIONS OR CONSERVATION; TOXIC INTERACTIONS BETWEEN BIOMOLECULES FROM FOOD AND ENVIRONMENTAL TOXICITY TO DETERMINE; THE COURSE ALSO INCLUDES SOME SPECIFIC ISSUES CONCERNING TOXIC ENVIRONMENTAL AND FOOD SOURCE THAT ALLOW A SYSTEMATIC UNDERSTANDING AND CRITICAL AWARENESS OF TOXIC PRODUCTS IN THE ENVIRONMENT.
APPLYING KNOLEDGE AND UNDERSTANDING
THA ABILITY TO APPLY THE KNOLEDGE ACQUIRED IN ENVIRONMENTAL TOXICOLOGY IN PROBLEMS THAT MAY OCCUR AS A RESULT OF EXPOSURE TO TOXIC SUBSTANCES FROM VARIOUS SOURCES SUCH AS THE ASSESSMENT OF ADVERSE SIDE EFFECTS, TO IDENTIFY PROBLEMS AND SOLVING THEM TAKING INTO ACCOUNT THE INTERDISCIPLINARITY THAT CHARACTERIZES TH ENVIRONMENTAL TOXICOLOGY.
MAKING JUDGMENTS
MAKING JUDGEMENTS AND INTEGRATING KNOWLEDGE TO MANAGE THE COMPLEXITY OF SIDE OR TOXIC EFFECTS THERAPIES. WITH REGARD TO THE PHARMACIST ROLE AS INTERFACE BETWEEN THE PHYSICIAN AND THE PATIENT, TO MAKE JUDGMENTS ON THE BASIS OF INCOMPLETE OR LIMITED INFORMATIONS, BUT THAT INCLUDE REFLECTING ON SOCIAL AND ETHICAL RESPONSABILITIES LINKED TO THE APPLICATION OF THEI KNOWLEDGE AND JUDGEMENTS.
COMMUNICATION SKILLS
THE ABILITY TO COMMUNICATE IN A CLEAR AND UNAMBIGUOUS CONCLUSIONS OF THEIR KNOWLEDGE AND JUDGMENTS TO A SPECIALIST (HEALTH WORKERS) AND NOT SPECIALISTS (PATIENTS) OF ANY GRADE AND LEVEL OF EDUCATION.
LEARNING SKILLS
LEARNING SKILLS IN A SELF-DIRECTED OR AUTONOMY THAT MAY HELP FOR CONTINOUS UPDATING, A NECESSARY CONDITION FOR THE PERFORMANCE OF THE FUNCTIONS OF A PHARMACIST, THROUGH THE USE OF TESTE, SCIENTIFIC PUBLICATIONS IN THE FIELD, THE MAIN DATA BASES OF REGULATORY AGENCIES (EMA, FDA, AIFA ETC.)
Prerequisites
FOR UNDERSTANDING OF THIS COURSE, IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY, BIOCHEMISTRY, PATHOLOGY AND PHARMACOLOGY.
Contents
DOSE RELATED SIDE EFFECTS OF DRUGS AND ENVIRONMENTALE MOLECULES. ADVERSE SIDE EFFECTS AND TOXIC EFFECTS. PHARMACOKINETIC INTERACTIONS AND PHARMACODINAMIC INTERACTIONS. DRUG ALLERGY AND DRUG IDIOSYNCRASY. TOXIC OF FOOD ORIGIN (TETANIC AND BOTULINIC TOXINS, GLUTEN, MILK, MYCOTOXINS AND OTHER DIFFERENT CONTAMINANTS PRESENT IN FOOD OR WHAT COULD BE ORIGINATED IN ANY FOOD PREPARATION). TOXICS PRESENT IN THE ENVIRONMENT (PCBS, DIOXINS, BENZENE AND OTHER ORGANIC SOLVENTS, THIN DUSTS, OZONE AND CO). POISONINGS FROM HEAVY METALS AND ANTIDOTIC THERAPY. ENDOCRINE INTERFERING COMPOUNDS OF DIFFERENT ORIGIN. RADON AND TOXIC SUBSTANCES FOR THEIR RADIOACTIVITY. PHYTOESTROGENIC MOLECULES. TREATMENTS OF POISONINGS. MICROBIAL CONTAMINATION OF FOODS. EXOTOXINS AND ENDOTOXINS OF BACTERIAL ORIGIN. MUTAGENESIS AND GENOTOXICITY TESTS.
Teaching Methods
FRONTAL LESSONS
Verification of learning
IN ITINERE TESTS FOR SELF-ASSESSMENT
ORAL INTERVIEW
Texts
KLAASSEN CD, WATKINS III JB, CASARETT & DOULL, ELEMENTI DI TOSSICOLOGIA, EDIZIONE ITALIANA A CURA DI PATRIZIA HRELIA E GIORGIO CANTELLI FORTI, CASA EDITRICE AMBROSIANA
PAOLETTI R, NICOSIA S, CLEMENTI F, FUMAGALLI G, FARMACOLOGIA GENERALE E MOLECOLARE, UTET.
GOODMAN & GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, X EDIZIONE ITALIAN, ZANICHELLI.
DOLARA, TOSSICOLOGIA GENERALE ED AMBIENTALE, EDITORE PICCIN.
KATZUNG, FARMACOLOGIA, EDITORE PICCIN
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