Placido NERI | CHEMISTRY OF BIOMIMETIC COMPOUNDS
Placido NERI CHEMISTRY OF BIOMIMETIC COMPOUNDS
cod. 0522300047
CHEMISTRY OF BIOMIMETIC COMPOUNDS
| 0522300047 | |
| DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI" | |
| EQF7 | |
| CHEMISTRY | |
| 2024/2025 |
| YEAR OF COURSE 2 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/06 | 5 | 40 | LESSONS | |
| CHIM/06 | 1 | 12 | EXERCISES |
| Exam | Date | Session | |
|---|---|---|---|
| CHIMICA DEI COMPOSTI BIOMIMETICI | 16/01/2025 - 15:00 | SESSIONE ORDINARIA | |
| CHIMICA DEI COMPOSTI BIOMIMETICI | 16/01/2025 - 15:00 | SESSIONE DI RECUPERO | |
| CHIMICA DEI COMPOSTI BIOMIMETICI | 14/02/2025 - 15:00 | SESSIONE ORDINARIA | |
| CHIMICA DEI COMPOSTI BIOMIMETICI | 14/02/2025 - 15:00 | SESSIONE DI RECUPERO |
| Objectives | |
|---|---|
| GENERAL OBJECTIVE: THE COURSE AIMS TO PROVIDE KNOWLEDGE REGARDING THE UNDERSTANDING OF THE SECONDARY CHEMICAL INTERACTIONS THAT ARE AT THE BASIS OF BIOLOGICAL SYSTEMS, SUCH AS THE DNA DOUBLE HELIX, PROTEIN-SUBSTRATE RECOGNITION AND ENZYMES. TAKING INSPIRATION FROM NATURE, THE BASIC RULES FOR THE DESIGN OF ARTIFICIAL BIOMIMETIC SYSTEMS WITH SPECIFIC PROPERTIES AND FUNCTIONS WILL BE LEARNT. KNOWLEDGE AND UNDERSTANDING: THE STUDENT: - WILL KNOW THE CHEMICAL-PHYSICAL FOUNDATIONS OF SUPRAMOLECULAR INTERACTIONS; - WILL KNOW THE MOST COMMON BIOMIMETIC SYSTEMS ABLE TO EXPLAIN FUNCTIONS SUCH AS MOLECULAR RECOGNITION AND SENSING, SUPRAMOLECULAR CATALYSIS IN ARTIFICIAL ENZYMES AND CONTROLLED MOVEMENTS IN MOLECULAR MACHINES; - WILL UNDERSTAND THE STRUCTURAL RELATIONSHIPS OF STERIC-INTERACTIONAL COMPLEMENTARITY UNDERLYING MOLECULAR RECOGNITION AND SELF-ASSEMBLY. ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING: THE STUDENT WILL BE ABLE TO: - DESIGN ARTIFICIAL BIOMIMETIC SYSTEMS WITH SPECIFIC PROPERTIES AND FUNCTIONS; - EXAMINE THE SUPRAMOLECULAR PROPERTIES OF MOLECULES OF SYNTHETIC OR BIOLOGICAL ORIGIN; - DEVELOP SYNTHETIC PROCEDURES TO OBTAIN TYPICAL BIOMIMETIC COMPOUNDS; - SOLVE PROBLEMS RELATING TO THE STOICHIOMETRY AND THE FORMATION CONSTANT OF SUPRAMOLECULAR COMPLEXES. INDEPENDENT JUDGMENT: THE STUDENT WILL BE ABLE TO: - ASSESS THE SUPRAMOLECULAR INTERACTIONAL POTENTIALITY OF MOLECULES OF MEDIUM COMPLEXITY; - DISCERN BETWEEN KINETIC AND THERMODYNAMIC ASPECTS IN SUPRAMOLECULAR PHENOMENA; - SELECT THE MOST SUITABLE MOLECULAR RECEPTORS FOR A SPECIFIC RECOGNITION OR CATALYSIS. COMMUNICATION SKILLS: THE STUDENT WILL BE ABLE TO: - COMMUNICATE IN THE LANGUAGE AND TERMS USED BY THE SUPRAMOLECULAR CHEMISTRY COMMUNITY; - REPRESENT AND COMMUNICATE, THROUGH TEXTS, CHEMICAL STRUCTURES, REACTION SCHEMES AND INTERNATIONAL CONVENTIONS THE RESULTS OF OWN RESEARCH OR PROCESSING. LEARNING ABILITY: THE STUDENT WILL BE ABLE TO: - USE TRADITIONAL BIBLIOGRAPHICAL TOOLS AND PUBLICATIONS IN THE SECTOR OF BIOMIMETIC AND SUPRAMOLECULAR CHEMISTRY; - UNDERSTAND AND INTERPRET TEXTS OF LITERATURE ON BIOMIMETIC AND SUPRAMOLECULAR CHEMISTRY; - PROCEED TO CONTINUOUSLY UPDATE YOUR KNOWLEDGE OF BIOMIMETIC CHEMISTRY, USING TECHNICAL-SCIENTIFIC LITERATURE. |
| Prerequisites | |
|---|---|
| THE MAIN PREREQUISITES CONCERN THE CONCEPTS OF GENERAL, INORGANIC AND ORGANIC CHEMISTRY, AS WELL AS THE ACQUAINTANCE WITH THE USE OF THE SYMBOLOGY OF ORGANIC CHEMISTRY AND BASIC STEREOCHEMISTRY. FURTHERMORE, IT IS REQUIRED THE KNOWLEDGE OF BASIC ORGANIC SYNTHESIS AND SPECTROMETRIC ORGANIC TECHNIQUES. |
| Contents | |
|---|---|
| CHEMICAL SECONDARY INTERACTIONS IN BIOLOGICAL SYSTEMS, EXAMPLES DERIVED FROM DNA, RNA, PROTEINS, ENZYMES (2 HOURS). INTERMOLECULAR INTERACTIONS, STRUCTURAL AND ENERGETICAL ASPECTS (8 HOURS). MOLECULAR RECOGNITION THERMODYNAMIC AND KINETIC ASPECTS (4 HOURS). CLASSES OF COMMON HOSTS (2 HOURS). CATIONIC (4 HOURS), ANIONIC (2 HOURS), MOLECULAR RECOGNITION AND ITS APPLICATIONS (4 HOURS). SUPRAMOLECULAR CATALYSIS (4 HOURS). SELF-ASSEMBLY (4 HOURS). CRYSTAL ENGINEERING (2 HOURS). SUPRAMOLECULAR DEVICES AND MOLECULAR MACHINES (4 HOURS). PRACTICES AND PROBLEMS (12 HOURS): DISCUSSION OF PRACTICAL EXAMPLES AND GUIDED RESOLUTION OF EXERCISES AND PROBLEMS RELATED TO THE COURSE TOPICS. |
| Teaching Methods | |
|---|---|
| The lessons of the course are of frontal type with the aid of multimedia material. An exercise part is foreseen with the discussion of practical examples and works taken from the most recent literature. All teaching material will be made available to students at the end of each block of lessons |
| Verification of learning | |
|---|---|
| THE ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY PASSING AN EXAM. THE EXAM INCLUDES AN ORAL INTERVIEW WITH QUESTIONS AND DISCUSSIONS ON THE CONTENTS OF THE PROGRAM AND ON RELATED PUBLICATIONS IN ORDER TO ASCERTAIN KNOWLEDGE AND EXPOSURE SKILLS. THE STUDENT WILL BE EVALUATED WITH A MARK EXPRESSED OUT OF THIRTY (MINIMUM VOTE 18/30). THE STUDENT ACHIEVES THE EXCELLENCE LEVEL IF HE/SHE IS ABLE TO SOLVE UNUSUAL PROBLEMS (OR TYPE OF PROBLEMS NOT EXPLAINED DURING THE LESSONS) PROPOSED AT THE ORAL TEST. |
| Texts | |
|---|---|
| J. W. STEED AND J. L. ATWOOD, SUPRAMOLECULAR CHEMISTRY, WILEY 2000. J.-M. LEHN , SUPRAMOLECULAR CHEMISTRY: CONCEPTS AND PERSPECTIVES, VCH 1995. P. D. BEER, P. A. GALE, D. K. SMITH SUPRAMOLECULAR CHEMISTRY. J. W. STEED AND J. L. ATWOOD, ENCYCLOPEDIA OF SUPRAMOLECULAR CHEMISTRY, MARCEL DEKKER 2004. COMPREHENSIVE SUPRAMOLECULAR CHEMISTRY II, 2ND ED., ELSEVIER, 2017, ED. JERRY ATWOOD, APPUNTI DALLE LEZIONI. LESSON “POWER-POINT” PRESENTATIONS. |
| More Information | |
|---|---|
| LECTURER EMAIL ADDRESS: NERI@UNISA.IT |
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