PHARMACOGNOSY

Sonia PIACENTE PHARMACOGNOSY

0760100020
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACY
2017/2018

OBBLIGATORIO
YEAR OF COURSE 4
YEAR OF DIDACTIC SYSTEM 2010
PRIMO SEMESTRE
CFUHOURSACTIVITY
540LESSONS
Objectives
The course is aimed at the acquisition of knowledge and understanding of the plant origin, the chemical features, the biological activity and the use of the main herbal drugs in pharmaceutics, pharmaceutical technology, cosmetics and in food supplements. The student, on the basis of the acquired skills, will be able to recognize the herbal drugs and to evaluate and address problems related to their use.
Prerequisites
PLANT BIOLOGY, PHARMACEUTICAL BOTANY,ORGANIC CHEMISTRY, AND BIOCHEMISTRY
Contents
DEFINITION OF PHARMACOGNOSY, HERBAL DRUG AND ACTIVE PRINCIPLE; PLANT NOMENCLATURE AND TAXONOMY. PLANTS AND THEIR STRUCTURES. ORGANIZED AND NOT ORGANIZED HERBAL DRUGS. EXTRACTIVE METHODS. CONSERVATION, STABILITY AND VARIABILITY OF HERBAL DRUGS AND DERIVED PREPARATIONS. ELEMENTS OF QUALITY CONTROL. FOR EACH HERBAL DRUG: BOTANICAL SOURCE, MACROSCOPIC AND MICROSCOPIC CHARACTERS, QUALI-QUANTITATIVE CHEMICAL PROFILE, BIOACTIVE CONSTITUENTS, BIOLOGICAL ACTIVITY, THERAPEUTIC USES. HERBAL DRUGS EMPLOYED FOR THEIR CONTENT IN CARBOHYDRATES, TERPENOIDS AND STEROIDS; ESSENTIAL OILS; RESINS AND GUMS, SAPONINS, CARDIAC GLYCOSIDES; AROMATIC COMPOUNDS, PHENOLS, TANNINS, FLAVONOIDS, COUMARINS, LIGNANS. ANTRAQUINONES. DRUGS EMPLOYED FOR THEIR CONTENT IN ALKALOIDS.
MAIN METABOLIC PATHWAYS OF PRIMARY METABOLISM, THE INTERCONNECTION OF METABOLISMS, THE ACTIVATION OF SECONDARY METABOLISM. DEFINITION AND SYSTEMATIC OF SECONDARY METABOLITES (MS). METHODOLOGIES APPLIED TO STUDY THE SECONDARY METABOLITES PATHWAY. BIOSYNTHETIC PATHWAY OF CARBOHYDRATES: MONOSACCARIDES, DISACCHARIDES, POLISACCHARIDES, STARCH. BIOSYNTHETIC PATHWAY OF SHIKIMATE. (PHENOLS, POLYPHENOLS, COUMARINS, PHENYLPROPANOIDS. BIOSYNTHETIC PATHWAY OF ACETATE. POLYKETIDES AND FLAVONOIDS. THE SYNTHESIS OF IPP (ISOPENTENYL PYROPHOSPHATE) IN THE CYTOSOL AND PLASTID. THE ROLE OF TERPENOIDS IN PLANT DEFENSE. TERPENOIDS: LOCALIZATION, BIOLOGICAL ACTIVITY. STRUCTURAL FEATURES OF STEROLS, STEROIDAL AND TERPENOID SAPONINS THE ALKALOIDS BIOSYNTHESIS, FUNCTIONAL CLUSTERS AND BIOLOGICAL ACTIVITY. ALKALOIDS DERIVING FROM ORNITINE, LISINE, PHENYLALANINE, TYROXINE, AND TRYPTOFANE.
Teaching Methods
LECTURES, SEMINARS, TUTORIALS
Verification of learning
THE EXAMINATION CONSISTS OF A WRITTEN AND ORAL TEST, TO BE SUSTEINED IN THE SAME EXAM SESSION. THE RATING IS X/30. PASS THE WRITTEN TEST WITH A SCORE OF 18/30, IT IS MANDATORY TO BE ABLE TO TAKE THE ORAL TEST, AND REACH THE FINAL GRADE. THE WRITTEN TEST TAKES TWO HOURS AND CONSISTS OF OPEN QUESTIONS ON THE MAIN LEARNING OUTCOMES.
THE STUDENT WILL BE ASKED TO DISCUSS THE MAIN TOPICS OF THE COURSE, TRYING TO DEMONSTRATE CRITICAL THOUGHT AND AWARENESS OF THE STRUCTURE OF THE FIELD OF STUDY.
Texts
DEWICK PAUL M., CHIMICA, BIOSINTESI E BIOATTIVITÀ DELLE SOSTANZE NATURALI 2/ED.- EDIZIONE ITALIANA A CURA DI ERNESTO FATTORUSSO [DEWICK - PICCIN EDITORE]
MANN J. CHEMICAL ASPECTS OF BIOSYNTHESIS, CHEMISTRY PRIMERS, OXFORD.
G. SAMUELSSON FARMACOGNOSIA - FARMACI DI ORIGINE NATURALE. SECONDA EDIZIONE ITALIANA A CURA DI: F. CAPASSO, R. DE PASQUALE, I. MORELLI, CASA EDITRICE EMSI, ROMA.
F. CAPASSO, R. DE PASQUALE, G. GRANDOLINI, N. MASCOLO.
FARMACOGNOSIA: FARMACI NATURALI, LORO PREPARAZIONI ED IMPIEGO TERAPEUTICO, CASA EDITRICE: SPRINGER-VERLAG
More Information
SONIA PIACENTE
HTTP://WWW.UNISA.IT/DOCENTI/SONIAPIACENTE/INDEX
  BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2019-05-14]