Paolo REMONDELLI | ELEMENTI DI BIOLOGIA E GENOMICA

cod. 0622700046

ELEMENTI DI BIOLOGIA E GENOMICA

	0622700046
	DIPARTIMENTO DI INGEGNERIA DELL'INFORMAZIONE ED ELETTRICA E MATEMATICA APPLICATA
	EQF7
	COMPUTER ENGINEERING
	2017/2018

CURRICULUM BIOINFORMATICA E SALUTE DIGITALE

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2017
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	ELEMENTI DI BIOLOGIA E GENOMICA
	BIO/10	3	24	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS
	BIO/10	2	16	EXERCISES	SUPPLEMENTARY COMPULSORY SUBJECTS
2	ELEMENTI DI BIOLOGIA E GENOMICA
	BIO/13	2	16	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS
	BIO/13	2	16	EXERCISES	SUPPLEMENTARY COMPULSORY SUBJECTS

PROFESSORS

	MARIA CATERINA TURCO1 Curriculum
	PAOLO REMONDELLI2 Curriculum

	Objectives
	To provide the knowledge of the structure (cellular and molecular basis) and functioning of the eukaryotic, prokaryotic and viral cells. Learning the fundamentals of molecular biology: DNA and RNA structure, the DNA duplication mechanisms, transcription and its settings in prokaryotes and eukaryotes; RNA splicing and editing mechanisms; cell cycle control and oncogenesis. Provide the knowledge to understand the transmission mechanisms of heredity and the main inheritance models; provide the basic concepts to understand the behavior of genes in populations; introduce elements of human genetics, approach the student to the analysis and interpretation of genetic data. Knowledge and understanding Elements of biology and biochemistry. Proteins and their structures. Structure-function relationship. Nucleic acids (DNA, RNA) and genetic information transfer. Applied Knowledge and understanding Abililty to relate the basic biology and genetics issues presented in the course to data processing and analysis operations.

To provide the knowledge of the structure (cellular and molecular basis) and functioning of the eukaryotic, prokaryotic and viral cells. Learning the fundamentals of molecular biology: DNA and RNA structure, the DNA duplication mechanisms, transcription and its settings in prokaryotes and eukaryotes; RNA splicing and editing mechanisms; cell cycle control and oncogenesis. Provide the knowledge to understand the transmission mechanisms of heredity and the main inheritance models; provide the basic concepts to understand the behavior of genes in populations; introduce elements of human genetics, approach the student to the analysis and interpretation of genetic data.

Knowledge and understanding
Elements of biology and biochemistry. Proteins and their structures. Structure-function relationship. Nucleic acids (DNA, RNA) and genetic information transfer.

Applied Knowledge and understanding
Abililty to relate the basic biology and genetics issues presented in the course to data processing and analysis operations.

	Prerequisites
	None.

	Contents
	•Organizing levels of living matter: Procariots, eukaryotes, viruses. •Macromolecules: glucides; lipids; Proteins: primary, secondary, tertiary and quaternary structure; Nucleic acids: RNA and DNA •The cell: prokaryotic and eukaryotic cells, cytoplasmic organelles, nucleus and plasma membrane. •Duplication of DNA •The mitosis: various phases and the behavior of chromosomes •Meiosis: various phases and the behavior of chromosomes. •Basic differences between mitosis and meiosis •Mendelian genetics and heredity: from genotype to phenotype; Homozygous and heterozygous concept; Principles of inheritance: dominant, recessive, linked to sexual chromosomes. •Genes and gene expression: RNA transcription; Structure and function of ribosomal RNA, transfer RNA and messenger RNA, translation genetic code and post-translational modifications; •DNA: structure and function of genes, chromosomes and human genomes; •Gene mutations: substitutions, deletions, insertions; Spontaneous and induced mutations; DNA repair mechanisms. •Chromosomal mutations: Number abnormalities (polyploidy and aneuploidy, monosomy and trisomy in humans); Structural abnormalities (deletion, duplication, inversion and translocation); Chromosome Analysis Techniques. •Non-Mendelian inheritance: mitochondrial legacy; Genomic Imprinting. •Recombinant DNA Techniques as a tool for molecular genetics: concepts of genetic manipulation, gene therapy, cell therapy. •New Genome and Transcriptome Analysis Techniques: Microarray, Next Generation Sequencing (NGS), Whole Exome Sequencing (WES), RNAseq •Cancer genetics: proto-oncogenes, onco-suppressors, tumor progression.

Contents

•Organizing levels of living matter: Procariots, eukaryotes, viruses.
•Macromolecules: glucides; lipids; Proteins: primary, secondary, tertiary and quaternary structure; Nucleic acids: RNA and DNA
•The cell: prokaryotic and eukaryotic cells, cytoplasmic organelles, nucleus and plasma membrane.
•Duplication of DNA
•The mitosis: various phases and the behavior of chromosomes
•Meiosis: various phases and the behavior of chromosomes.
•Basic differences between mitosis and meiosis
•Mendelian genetics and heredity: from genotype to phenotype; Homozygous and heterozygous concept; Principles of inheritance: dominant, recessive, linked to sexual chromosomes.
•Genes and gene expression: RNA transcription; Structure and function of ribosomal RNA, transfer RNA and messenger RNA, translation genetic code and post-translational modifications;
•DNA: structure and function of genes, chromosomes and human genomes;
•Gene mutations: substitutions, deletions, insertions; Spontaneous and induced mutations; DNA repair mechanisms.
•Chromosomal mutations: Number abnormalities (polyploidy and aneuploidy, monosomy and trisomy in humans); Structural abnormalities (deletion, duplication, inversion and translocation); Chromosome Analysis Techniques.
•Non-Mendelian inheritance: mitochondrial legacy; Genomic Imprinting.
•Recombinant DNA Techniques as a tool for molecular genetics: concepts of genetic manipulation, gene therapy, cell therapy.
•New Genome and Transcriptome Analysis Techniques: Microarray, Next Generation Sequencing (NGS), Whole Exome Sequencing (WES), RNAseq
•Cancer genetics: proto-oncogenes, onco-suppressors, tumor progression.

	Teaching Methods
	The course will consist in frontal theoretical lectures.

	Verification of learning
	THE FINAL EXAM IS DESIGNED TO EVALUATE AS A WHOLE THE KNOWLEDGE AND UNDERSTANDING OF THE CONCEPTS PRESENTED IN THE COURSE, AND THE ABILITY TO APPLY SUCH KNOWLEDGE TO RELATE BIOLOGY/GENETICS PROBLEMS TO DATA ANALYSIS TECHNIQUES. THE EXAM CONSISTS OF AN ORAL INTERVIEW, OF ABOUT 30 MINUTES, IN WHICH THE CANDIDATE IS ASKED TO ILLUSTRATE SOME OF THE CONCEPTS PRESENTED DURING THE LECTURES, AND TO ANSWER SOME QUESTIONS BY THE COMMITTEE AIMED AT VERIFYING IF THE CANDIDATE HAS CLEARLY UNDERSTOOD THE IMPLICATIONS OF THE CONCEPT AND ITS CONNECTIONS TO OTHER CONTENTS OF THE COURSE.

Verification of learning

THE FINAL EXAM IS DESIGNED TO EVALUATE AS A WHOLE THE KNOWLEDGE AND UNDERSTANDING OF THE CONCEPTS PRESENTED IN THE COURSE, AND THE ABILITY TO APPLY SUCH KNOWLEDGE TO RELATE BIOLOGY/GENETICS PROBLEMS TO DATA ANALYSIS TECHNIQUES.

THE EXAM CONSISTS OF AN ORAL INTERVIEW, OF ABOUT 30 MINUTES, IN WHICH THE CANDIDATE IS ASKED TO ILLUSTRATE SOME OF THE CONCEPTS PRESENTED DURING THE LECTURES, AND TO ANSWER SOME QUESTIONS BY THE COMMITTEE AIMED AT VERIFYING IF THE CANDIDATE HAS CLEARLY UNDERSTOOD THE IMPLICATIONS OF THE CONCEPT AND ITS CONNECTIONS TO OTHER CONTENTS OF THE COURSE.

	Texts
	Sadava, Hillis, Heller, Berenbaum. Life: The Science of Biology, (10th Edition), Sinauer Associates, 2011 Solomon, Berg, Martin. Biology (9th Edition), Brokes-Cole, 2010 Russell, Hertz, McMillan. Biology: The Dynamic Science (3th Edition), CENGAGE Learning, 2014

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BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2019-05-14]

Paolo REMONDELLI | ELEMENTI DI BIOLOGIA E GENOMICA