Antonello PETRELLA | TOXICOLOGY AND CHEMOTHERAPY
Antonello PETRELLA TOXICOLOGY AND CHEMOTHERAPY
cod. 0760200028
TOXICOLOGY AND CHEMOTHERAPY
| 0760200028 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2016/2017 |
| OBBLIGATORIO | |
| YEAR OF COURSE 5 | |
| YEAR OF DIDACTIC SYSTEM 2010 | |
| PRIMO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | ||
|---|---|---|---|---|---|
| TOSSICOLOGIA MODULO DI TOSSICOLOGIA E CHEMIOTERAPIA | |||||
| BIO/14 | 5 | 40 | LESSONS | ||
| CHEMIOTERAPIA MODULO DI TOSSICOLOGIA E CHEMIOTERAPIA | |||||
| BIO/14 | 5 | 40 | LESSONS | ||
| Objectives | |
|---|---|
| KNOWLEDGE AND UNDERSTANDING THE AIM OF THIS CLASS IS TO PROVIDE STUDENTS WITH THE KNOWLEDGE AND UNDERSTANDING IN THE FIELD OF PHARMACOKINETICS, PHARMACODYNAMICS, DRUG RESISTANCE AND TOXICOKINETICS, OF DRUGS AND BIOACTIVE MOLECULES WITH CHEMOTHERAPEUTIC ACTIVITY AND THE RATIONAL USE OF COMBINATORIAL CHEMOTHERAPY DRUGS; TOXIC INTERACTIONS BETWEEN BIOMOLECULES FROM FOOD AND ENVIRONMENTAL; NATURAL AND SYNTHETIC MOLECULES WITH SPECIFIC BIOLOGICAL ACTIVITIES IN THE CNS AND PERIPHERAL NERVOUS SYSTEM; PSYCHOACTIVE DRUGS AND DRUGS DEPENDENCE. APPLYING KNOLEDGE AND UNDERSTANDING TO BE ABLE TO APPLY THE ACQUIRED KNOWLEDGE ABOUT DRUGS AND XENOBIOTIC FOR THE MANAGEMENT OF HUMAN PATHOLOGIES AS WELL AS FOR THE EVALUATION OF DRUG INTERACTIONS AND TOXICITY REACTIONS MAKING JUDGMENTS MAKING JUDGEMENTS AND INTEGRATING KNOWLEDGE TO MANAGE THE COMPLEXITY OF SIDE OR TOXIC EFFECTS THARAPY. WITH REGARD TO THE PHARMACIST ROLE AS INTERFACE BETWEEN THE PHYSICIAN AND THE PATIENT, TO MAKE JUDGMENTS ON THE BASIS OF INCOMPLETE OR LIMITED INFORMATIONS, BUT THAT INCLUDE REFLECTING ON SOCIAL AND ETHICAL RESPONSABILITIES LINKED TO THE APPLICATION OF THEI KNOWLEDGE AND JUDGEMENTS. COMMUNICATION SKILLS THE ABUILITY TO COMUNICATE INA A CLEAR AND UNAMBIGUOUS CONCLUSIONS OF THEIR KNOWLEDGE AND JUDEGEMENTS TO A SPECIALIST (HEALTH WORKERS) AND NOT SPECIALISTS (PATIENTS) OF ANY GRADE AND LEVEL OF EDUCATION. LEARNING SKILLS LEARNING SKILLS IN A SELF-DIRECTED OR AUTONOMY THAT MAY HELP FOR CONTINOUS UPDATING, A NECESSARY CONDITION FOR THE PERFORMANCE OF THE FUNCTIONS OF A PHARMACIST, THROUGH THE USE OF TESTE, SCIENTIFIC PUBLICATIONS IN THE FIELD, THE MAIN DATA BASES OF REGULATORY AGENCIES (EMA, FDA, AIFA ETC.) |
| Prerequisites | |
|---|---|
| CHEMOTHERAPY TECHNICAL KNOWLEDGE PROVIDED BY GENERAL CHEMISTRY, ORGANIC CHEMISTRY, BIOCHEMISTRY AND PHARMACOLOGY IS REQUIRED FARMACOLOGIA GENERALE: FOR UNDERSTANDING OF THIS COURSE, IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY AND PATHOLOGY TOXICOLOGY PREREQUISITES FOR UNDERSTANDING OF THIS COURSE , IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY, BIOCHEMISTRY, PATHOLOGY AND PHARMACOLOGY. TOXICOLOGY |
| Contents | |
|---|---|
| CHEMOTHERAPY STRUCTURE, PROPERTIES, MECHANISM OF ACTION, MECHANISMS OF RESISTANCE, ASPECTS OF PHARMACOKINETICS, THERAPEUTIC USES AND SIDE EFFECTS. ANTIBACTERIAL DRUGS: -LACTAMS, SULFONAMIDES, TETRACYCLINES, AMINOGLYCOSIDES AND MACROLIDES. ANTI-TUBERCULOSIS DRUGS: ISONIAZID, RIFAMPICIN, ETHAMBUTOL, STREPTOMYCIN, PYRAZINAMIDE, AMINOSALICYLIC ACID, CYCLOSERINE AND ETHIONAMIDE ANTI-MALARIALS: CHLOROQUINE, QUININE, MEFLOQUINE, PRIMAQUINE, PROGUANIL AND ARTEMISININ. ANTINEOPLASTIC AGENTS: ALKYLATING DRUGS, ANTIMETABOLITES, ANTI-MITOTIC DRUGS, CYTOTOXIC ANTIBIOTICS, HORMONE ANTAGONISTS, MONOCLONAL ANTIBODIES AND SMALL MOLECULES. ANTIVIRAL DRUGS: ANTIHERPETIC AGENTS, PHARMACOLOGY OF ANTIVIRAL DRUGS FOR INFLUENZA, ANTIRETROVIRAL DRUGS. TOXICOLOGY DOSE TOXIC RESPONSE. SIDE EFFECTS AND TOXIC EFFECTS. PHARMACOKINETIC INTERACTIONS AND PHARMACODINAMIC INTERACTIONS. DRUG ALLERGY AND DRUG IDIOSYNCRASY. PSYCOACTIVE DRUGS: ETHYL ALCOHOL, OPIATES, COCAINE, ECSTAYAND OTHER AMPHETAMINES, LYSERGIC ACID DIETHYLAMIDE, MESCALINE, PASILOCYBIN, CANNABINNOIDS. DRUGS DEPENDENCE, TOLERANCE, PHARMACOKINETIC AND PHARMACODINAMICS RELATINS TO USE AND ABUSE. WITHDRAWAL SYNDROMES, CESSATION THERAPIES. TOXIC OF FOOD ORIGIN ( TITANIC AND BOTULINIC TOXINS, GLUTE, MILK, MYCOTOXINS AND OTHER DIFFERENT CONTAMINANTS PRESENT IN FOOD OR WHAT COULD BE ORIGINATED IN ANY FOOD PREPARATION. TOXICS PRESENT IN YHE ENVIRONMENT (PCBS, DIOXINS, BENZENE AND OTHER ORGANIC SOLVENTS, OZONE AND CO) POISONINGS FROM HEAVY METALS AND ANTIDOTIC THAERAPY. ENDOCRINE INTERFERING COMPOUNDS OF DIFFERENT ORIGIN. RADON AND TOXIC SUBSTANCES FOR THEIR RADIOACTIVITY. PHYTOESTROGENIC MOLECULES. TREATMENTS OF POISONINGS. MICROBIAL CONTAMINATION OF FOODS. EXOTOXINS AND ENDOTOXINS OF BACTERIAL ORIGIN. MUTAGENESIS TESTS AND GENOTOXICITY. |
| Teaching Methods | |
|---|---|
| LECTURES |
| Verification of learning | |
|---|---|
| ORAL INTERVIEW |
| Texts | |
|---|---|
| CHEMOTHERAPY BG KATZUNG, FARMACOLOGIA GENERALE E CLINICA, III ED. ITALIANA, PICCIN EDITORE. 2) GOODMAN & GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, IX ED. ITALIANA, ZANICHELLI EDITORE. TOXICOLOGY KLAASSEN CD, WATKINS III JB, CASARETT & DOULL, ELEMENTI DI TOSSICOLOGIA, EDIZIONE ITALIANA A CURA DI PATRIZIA HRELIA E GIORGIO CANTELLI FORTI, CASA EDITRICE AMBROSIANA PAOLETTI R, NICOSIA S, CLEMENTI F, FUMAGALLI G, FARMACOLOGIA GENERALE E MOLECOLARE, UTET. GOODMAN &GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, X EDIZIONE ITALIAN, ZANICHELLI. DOLARA, TOSSICOLOGIA GENERALE ED AMBIENTALE, EDITORE PICCIN. KATZUNG, FARMACOLOGIA, EDITORE PICCIN |
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