Antonello PETRELLA | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

cod. 0712100017

PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

	0712100017
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2016/2017

PERCORSO COMUNE Cohort 2014/2015

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2010
	SECONDO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	FARMACOLOGIA GENERALE MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	BIO/14	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	CHIMICA FARMACEUTICA E TOSSICOLOGICA MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	CHIM/08	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	ANTONELLO PETRELLA1 T Curriculum
	MANUELA RODRIQUEZ2 Curriculum

	Objectives
	To know and understand the mechanism of action and pharmacokinetics of drugs used in human pathologies. To be able to apply the acquired Knowledge about the mechanism of drug action for the management of human pathologies as well as the evaluation of interactions and adverse reactions. To provide the knowledge of the chemical bases that effect the activities of the drugs both as regards the pharmacokinetic and the pharmacodynamic properties. To provide the basis for understanding chemical properties of selected classes of drugs either of synthetic or natural origin. The student should apply the acquired knowledge about the mechanism of drug action for the evaluation of interactions between drugs and herbal products and related adverse reactions.

To know and understand the mechanism of action and pharmacokinetics of drugs used in human pathologies.
To be able to apply the acquired Knowledge about the mechanism of drug action for the management of human pathologies as well as the evaluation of interactions and adverse reactions.
To provide the knowledge of the chemical bases that effect the activities of the drugs both as regards the pharmacokinetic and the pharmacodynamic properties. To provide the basis for understanding chemical properties of selected classes of drugs either of synthetic or natural origin. The student should apply the acquired knowledge about the mechanism of drug action for the evaluation of interactions between drugs and herbal products and related adverse reactions.

	Prerequisites
	MEDICINAL CHEMISTRY: TECHNICAL KNOWLEDGE PROVIDED BY INORGANIC CHEMISTRY, ORGANIC CHEMISTRY, BIOCHEMISTRY AND PHARMACOLOGY. PHARMACOLOGY: ANATOMY, PHYSIOLOGY AND PATHOLOGY

	Contents
	PHARMACOLOGY: PHARMACOKINETICS: ROUTES OF ADMINISTRATION. ABSORPTION. DISTRIBUTION. METABOLISM. EXCRETION. PHARMACOKINETIC INTERACTIONS. PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR. AGONIST. PD2. ANTAGONIST. PA2. PARTIAL AGONIST/ANTAGONIST. TRANSDUCTION OF DRUG/RECEPTOR INTERACTION. IONOTROPIC RECEPTORS. METABOTROPIC RECEPTORS. VOLTAGE-GATED ION CHANNELS. NTRACELLULAR RECEPTORS. RECEPTORS FOR GROWTH FACTORS. INTRACELLULAR TRANSDUCTION MECHANISMS. CALCIUM HOMEOSTASIS. PHARMACODYNAMIC INTERACTIONS. MEDICINAL CHEMISTRY: DRUGS, ENZYMES AND DRUG TARGETS: DEFINITIONS DRUG DESIGN OF AGONISTS, ANTAGONISTS, PARTIAL AGONISTS AND INVERSE AGONISTS. NUCLEIC ACIDS AS DRUG TARGETS PHARMACOKINETICS: LIBERATION, ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION AND TOXICITY OF DRUGS. ADMINISTRATION OF DRUGS. DISPENSING MEDICATION. ANTIHYPERTENSIVE AGENTS AND VASODILATORS; ANTIDIABETIC AGENTS; LAXATIVES: DEFINITIONS AND GENERAL INFORMATION. CLASSIFICATION OF SYNTHETIC TOPICAL AND SYSTEMIC DRUGS. STRUCTURES, MECHANISM OF ACTION, STRUCTURE ACTIVITY RELATIONSHIP, PHARMACOKINETICS AND PHARMACODYNAMICS.

Contents

PHARMACOLOGY:
PHARMACOKINETICS: ROUTES OF ADMINISTRATION. ABSORPTION. DISTRIBUTION. METABOLISM. EXCRETION.
PHARMACOKINETIC INTERACTIONS.
PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR.
AGONIST. PD2.
ANTAGONIST. PA2.
PARTIAL AGONIST/ANTAGONIST.
TRANSDUCTION OF DRUG/RECEPTOR INTERACTION.
IONOTROPIC RECEPTORS.
METABOTROPIC RECEPTORS.
VOLTAGE-GATED ION CHANNELS.
NTRACELLULAR RECEPTORS.
RECEPTORS FOR GROWTH FACTORS.
INTRACELLULAR TRANSDUCTION MECHANISMS.
CALCIUM HOMEOSTASIS.
PHARMACODYNAMIC INTERACTIONS.

MEDICINAL CHEMISTRY:
DRUGS, ENZYMES AND DRUG TARGETS: DEFINITIONS
DRUG DESIGN OF AGONISTS, ANTAGONISTS, PARTIAL AGONISTS AND INVERSE AGONISTS.
NUCLEIC ACIDS AS DRUG TARGETS
PHARMACOKINETICS: LIBERATION, ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION AND TOXICITY OF DRUGS.
ADMINISTRATION OF DRUGS. DISPENSING MEDICATION.
ANTIHYPERTENSIVE AGENTS AND VASODILATORS; ANTIDIABETIC AGENTS; LAXATIVES: DEFINITIONS AND GENERAL INFORMATION. CLASSIFICATION OF SYNTHETIC TOPICAL AND SYSTEMIC DRUGS. STRUCTURES, MECHANISM OF ACTION, STRUCTURE ACTIVITY RELATIONSHIP, PHARMACOKINETICS AND PHARMACODYNAMICS.

	Teaching Methods
	LECTURES.

	Verification of learning
	- WRITTEN TEST - ORAL INTERVIEW - IN ITINERE TESTS

	Texts
	B.G. KATZUNG, BASIC AND CLINICAL PHARMACOLOGY- PICCIN THOMAS L. LEMKE, DAVID A. WILLIAMS FOYE - FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY- PICCIN

BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2019-03-11]

Antonello PETRELLA | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES