Antonello PETRELLA | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

cod. 0712100017

PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES

	0712100017
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2017/2018

PERCORSO COMUNE Cohort 2015/2016

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2010
	ANNUALE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	FARMACOLOGIA GENERALE MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	BIO/14	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	CHIMICA FARMACEUTICA E TOSSICOLOGICA MODULO DI PRINCIPI DI FARMACOLOGIA E CHIMICA FARMACEUTICA
	CHIM/08	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	ANTONELLO PETRELLA1 T Curriculum
	MANUELA RODRIQUEZ2 Curriculum

	Objectives
	To know and understand the mechanism of action and pharmacokinetics of drugs used in human pathologies. To be able to apply the acquired Knowledge about the mechanism of drug action for the management of human pathologies as well as the evaluation of interactions and adverse reactions. To provide the knowledge of the chemical bases that effect the activities of the drugs both as regards the pharmacokinetic and the pharmacodynamic properties. To provide the basis for understanding chemical properties of selected classes of drugs either of synthetic or natural origin. The student should apply the acquired knowledge about the mechanism of drug action for the evaluation of interactions between drugs and herbal products and related adverse reactions.

To know and understand the mechanism of action and pharmacokinetics of drugs used in human pathologies.
To be able to apply the acquired Knowledge about the mechanism of drug action for the management of human pathologies as well as the evaluation of interactions and adverse reactions.
To provide the knowledge of the chemical bases that effect the activities of the drugs both as regards the pharmacokinetic and the pharmacodynamic properties. To provide the basis for understanding chemical properties of selected classes of drugs either of synthetic or natural origin. The student should apply the acquired knowledge about the mechanism of drug action for the evaluation of interactions between drugs and herbal products and related adverse reactions.

	Prerequisites
	MEDICINAL CHEMISTRY: INORGANIC CHEMISTRY, ORGANIC CHEMISTRY, BIOCHEMISTRY AND PHARMACOLOGY ARE CONSIDERED BRIDGING COURSES THAT PROVIDE STUDENTS WITH THE BASIC KNOWLEDGE REQUIRED FOR THIS COURSE. PHARMACOLOGY: ANATOMY, PHYSIOLOGY AND PATHOLOGY

	Contents
	PHARMACOLOGY: PHARMACOKINETICS: ROUTES OF ADMINISTRATION. ABSORPTION. DISTRIBUTION. METABOLISM. EXCRETION. PHARMACOKINETIC INTERACTIONS. PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR. AGONIST. PD2. ANTAGONIST. PA2. PARTIAL AGONIST/ANTAGONIST. TRANSDUCTION OF DRUG/RECEPTOR INTERACTION. IONOTROPIC RECEPTORS. METABOTROPIC RECEPTORS. VOLTAGE-GATED ION CHANNELS. NTRACELLULAR RECEPTORS. RECEPTORS FOR GROWTH FACTORS. INTRACELLULAR TRANSDUCTION MECHANISMS. CALCIUM HOMEOSTASIS. PHARMACODYNAMIC INTERACTIONS. MEDICINAL CHEMISTRY: DRUGS, PHITODRUG, ENZYMES AND DRUG TARGETS: DEFINITIONS ENZYMES AND RECEPTORS AS PHARMACEUTICAL TARGETS: DESIGN AND THERAPEUTIC USES OF ENZYMATIC INHIBITORS AND ACTIVATORS. PHARMACOKINETICS: LIBERATION, ABSORPTION, DISTRIBUTION, BIOTRANSFORMATION, EXCRETION AND THEIR INTERRELATIONSHIP. DRUG CONCENTRATION AND ITS SITES OF ACTION. TOXICITY OF DRUGS. ROUTES OF ADMINISTRATION. CHEMICAL STRUCTURE, MECHANISM OF ACTION, STRUCTURE-ACTIVITY RELATIONSHIP. PHARMACOKINETICS AND PHARMACODYNAMICS INFORMATION FROM THE SCIENTIFIC BASIS OF MODERN PHARMACOTHERAPY OF THE MOST IMPORTANT CLASSES OF ACTIVE INGREDIENTS IN HERBAL MEDICINE: PHITODRUGS OF CNS, METABOLIC DISEASES (SUCH AS DIABETES, THYROID DISORDERS, OBESITY), INFLAMMATORY DISEASES, DIURETICS AND CONSTIPATION DRUGS. CONVENTIONAL DRUGS AND PHITODRUGS INTERACTIONS, NUTRITIONAL SUPPLEMENT, VITAMINS AND FUNCTIONAL FOODS.

Contents

PHARMACOLOGY:
PHARMACOKINETICS: ROUTES OF ADMINISTRATION. ABSORPTION. DISTRIBUTION. METABOLISM. EXCRETION.
PHARMACOKINETIC INTERACTIONS.
PHARMACODYNAMICS: INTERACTION DRUG/RECEPTOR.
AGONIST. PD2.
ANTAGONIST. PA2.
PARTIAL AGONIST/ANTAGONIST.
TRANSDUCTION OF DRUG/RECEPTOR INTERACTION.
IONOTROPIC RECEPTORS.
METABOTROPIC RECEPTORS.
VOLTAGE-GATED ION CHANNELS.
NTRACELLULAR RECEPTORS.
RECEPTORS FOR GROWTH FACTORS.
INTRACELLULAR TRANSDUCTION MECHANISMS.
CALCIUM HOMEOSTASIS.
PHARMACODYNAMIC INTERACTIONS.

MEDICINAL CHEMISTRY:
DRUGS, PHITODRUG, ENZYMES AND DRUG TARGETS: DEFINITIONS
ENZYMES AND RECEPTORS AS PHARMACEUTICAL TARGETS: DESIGN AND THERAPEUTIC USES OF ENZYMATIC INHIBITORS AND ACTIVATORS.
PHARMACOKINETICS: LIBERATION, ABSORPTION, DISTRIBUTION, BIOTRANSFORMATION, EXCRETION AND THEIR INTERRELATIONSHIP. DRUG CONCENTRATION AND ITS SITES OF ACTION. TOXICITY OF DRUGS. ROUTES OF ADMINISTRATION.
CHEMICAL STRUCTURE, MECHANISM OF ACTION, STRUCTURE-ACTIVITY RELATIONSHIP.
PHARMACOKINETICS AND PHARMACODYNAMICS INFORMATION FROM THE SCIENTIFIC BASIS OF MODERN PHARMACOTHERAPY OF THE MOST IMPORTANT CLASSES OF ACTIVE INGREDIENTS IN HERBAL MEDICINE:
PHITODRUGS OF CNS, METABOLIC DISEASES (SUCH AS DIABETES, THYROID DISORDERS, OBESITY), INFLAMMATORY DISEASES, DIURETICS AND CONSTIPATION DRUGS.
CONVENTIONAL DRUGS AND PHITODRUGS INTERACTIONS, NUTRITIONAL SUPPLEMENT, VITAMINS AND FUNCTIONAL FOODS.

	Teaching Methods
	THE COURSE IS TAUGHT IN 80 HOURS AND IT IS DIVIDED IN TWO MODULES (MODULE A AND MODULE B) PROVIDING (10 CREDITS). MODULE A, 40 HOURS (5 CREDITS), IS ON GENERAL PHARMACOLOGY. MODULE B, 40 HOURS (5 CREDITS), IS ON MEDICINAL CHEMISTRY. THE FREQUENCY OF LECTURES IN THE CLASSROOM IS OBLIGATORY. IN ORDER TO SUBMIT THE FINAL EVALUATION, THE STUDENT SHOULD BE ATTENDED AT LEAST 70% OF THE HOURS REQUIRED. THE PRESENCE CHECKING MODE IS GENERALLY ELECTRONIC TYPE OR STATED BY THE PROFESSOR AT THE BEGINNING OF THE COURSE

Teaching Methods

THE COURSE IS TAUGHT IN 80 HOURS AND IT IS DIVIDED IN TWO MODULES (MODULE A AND MODULE B) PROVIDING (10 CREDITS). MODULE A, 40 HOURS (5 CREDITS), IS ON GENERAL PHARMACOLOGY. MODULE B, 40 HOURS (5 CREDITS), IS ON MEDICINAL CHEMISTRY.
THE FREQUENCY OF LECTURES IN THE CLASSROOM IS OBLIGATORY. IN ORDER TO SUBMIT THE FINAL EVALUATION, THE STUDENT SHOULD BE ATTENDED AT LEAST 70% OF THE HOURS REQUIRED. THE PRESENCE CHECKING MODE IS GENERALLY ELECTRONIC TYPE OR STATED BY THE PROFESSOR AT THE BEGINNING OF THE COURSE

	Verification of learning
	THE LEARNING OBJECTIVES ARE VERIFIED BY AN EXAMINATION, WHICH PROVIDES A WRITTEN TEST (MODULE B OF MEDICINAL CHEMISTRY) AND AN ORAL TEST (FOR BOTH MODULES) IN DIFFERENT SCHEDULED DAYS. THE WRITTEN TEST (120 MINUTES) IS FINALIZED TO CHECK THE CAPACITY TO CORRECTLY DRAW CHEMICAL STRUCTURES, STRUCTURAL MODIFICATIONS AND GRAPHICS. THE ORAL TEST (30 MINUTES) CONSISTS IN QUESTIONS AND DISCUSSION OF THE WRITTEN ELABORATION. IT IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE OF THE APPROPRIATE TERMINOLOGY OF BOTH MODULES AS WELL AS THE STUDENT CAPACITY OF EXPOSITION. THE MAXIMUM SCORE IS 30/30 AND IS INTENDED TO BE PASSED WITH THE MINIMUM VOTE OF 18/30. THE FINAL VOTE IS PROVIDED BY THE MEDIUM OF THE VOTES REPORTED IN ANY TEST.

Verification of learning

THE LEARNING OBJECTIVES ARE VERIFIED BY AN EXAMINATION, WHICH PROVIDES A WRITTEN TEST (MODULE B OF MEDICINAL CHEMISTRY) AND AN ORAL TEST (FOR BOTH MODULES) IN DIFFERENT SCHEDULED DAYS. THE WRITTEN TEST (120 MINUTES) IS FINALIZED TO CHECK THE CAPACITY TO CORRECTLY DRAW CHEMICAL STRUCTURES, STRUCTURAL MODIFICATIONS AND GRAPHICS. THE ORAL TEST (30 MINUTES) CONSISTS IN QUESTIONS AND DISCUSSION OF THE WRITTEN ELABORATION.
IT IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE OF THE APPROPRIATE TERMINOLOGY OF BOTH MODULES AS WELL AS THE STUDENT CAPACITY OF EXPOSITION.
THE MAXIMUM SCORE IS 30/30 AND IS INTENDED TO BE PASSED WITH THE MINIMUM VOTE OF 18/30. THE FINAL VOTE IS PROVIDED BY THE MEDIUM OF THE VOTES REPORTED IN ANY TEST.

	Texts
	B.G. KATZUNG, BASIC AND CLINICAL PHARMACOLOGY- PICCIN THOMAS L. LEMKE, DAVID A. WILLIAMS FOYE - FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY- PICCIN

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Antonello PETRELLA | PHARMACOLOGY AND PHARMACEUTICS PRINCIPLES