Antonello PETRELLA | TOXICOLOGY AND CHEMOTHERAPY
Antonello PETRELLA TOXICOLOGY AND CHEMOTHERAPY
cod. 0760200028
TOXICOLOGY AND CHEMOTHERAPY
| 0760200028 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2021/2022 |
| OBBLIGATORIO | |
| YEAR OF COURSE 5 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| AUTUMN SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | ||
|---|---|---|---|---|---|
| TOSSICOLOGIA MODULO DI TOSSICOLOGIA E CHEMIOTERAPIA | |||||
| BIO/14 | 5 | 40 | LESSONS | ||
| CHEMIOTERAPIA MODULO DI TOSSICOLOGIA E CHEMIOTERAPIA | |||||
| BIO/14 | 5 | 40 | LESSONS | ||
| Objectives | |
|---|---|
| KNOWLEDGE AND UNDERSTANDING THE AIM OF THIS CLASS IS TO PROVIDE STUDENTS WITH THE KNOWLEDGE AND UNDERSTANDING IN THE FIELD OF PHARMACOKINETICS, PHARMACODYNAMICS, DRUG RESISTANCE AND TOXICOKINETICS, OF DRUGS AND BIOACTIVE MOLECULES WITH CHEMOTHERAPEUTIC ACTIVITY AND THE RATIONAL USE OF COMBINATORIAL CHEMOTHERAPY DRUGS; TOXIC INTERACTIONS BETWEEN BIOMOLECULES FROM FOOD AND ENVIRONMENTAL; NATURAL AND SYNTHETIC MOLECULES WITH SPECIFIC BIOLOGICAL ACTIVITIES IN THE CNS AND PERIPHERAL NERVOUS SYSTEM; PSYCHOACTIVE DRUGS AND DRUGS DEPENDENCE. APPLYING KNOLEDGE AND UNDERSTANDING TO BE ABLE TO APPLY THE ACQUIRED KNOWLEDGE ABOUT DRUGS AND XENOBIOTIC FOR THE MANAGEMENT OF HUMAN PATHOLOGIES AS WELL AS FOR THE EVALUATION OF DRUG INTERACTIONS AND TOXICITY REACTIONS |
| Prerequisites | |
|---|---|
| CHEMOTHERAPY TECHNICAL KNOWLEDGE PROVIDED BY GENERAL CHEMISTRY, ORGANIC CHEMISTRY, BIOCHEMISTRY AND PHARMACOLOGY IS REQUIRED FARMACOLOGIA GENERALE: FOR UNDERSTANDING OF THIS COURSE, IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY AND PATHOLOGY TOXICOLOGY PREREQUISITES FOR UNDERSTANDING OF THIS COURSE , IT IS IMPORTANT THE ACQUISITION OF THE FOLLOWING DISCIPLINES: ANATOMY, PHYSIOLOGY, BIOCHEMISTRY, PATHOLOGY AND PHARMACOLOGY. TOXICOLOGY |
| Contents | |
|---|---|
| CHEMOTHERAPY STRUCTURE, PROPERTIES, MECHANISM OF ACTION, MECHANISMS OF RESISTANCE, ASPECTS OF PHARMACOKINETICS, THERAPEUTIC USES AND SIDE EFFECTS. ANTIBACTERIAL DRUGS: -LACTAMS, SULFONAMIDES, TETRACYCLINES, AMINOGLYCOSIDES AND MACROLIDES. ANTI-TUBERCULOSIS DRUGS: ISONIAZID, RIFAMPICIN, ETHAMBUTOL, STREPTOMYCIN, PYRAZINAMIDE, AMINOSALICYLIC ACID, CYCLOSERINE AND ETHIONAMIDE ANTI-MALARIALS: CHLOROQUINE, QUININE, MEFLOQUINE, PRIMAQUINE, PROGUANIL AND ARTEMISININ. ANTINEOPLASTIC AGENTS: ALKYLATING DRUGS, ANTIMETABOLITES, ANTI-MITOTIC DRUGS, CYTOTOXIC ANTIBIOTICS, HORMONE ANTAGONISTS, MONOCLONAL ANTIBODIES AND SMALL MOLECULES. ANTIVIRAL DRUGS: ANTIHERPETIC AGENTS, PHARMACOLOGY OF ANTIVIRAL DRUGS FOR INFLUENZA, ANTIRETROVIRAL DRUGS. TOXICOLOGY DOSE TOXIC RESPONSE. SIDE EFFECTS AND TOXIC EFFECTS. PHARMACOKINETIC INTERACTIONS AND PHARMACODINAMIC INTERACTIONS. DRUG ALLERGY AND DRUG IDIOSYNCRASY. PSYCOACTIVE DRUGS: ETHYL ALCOHOL, OPIATES, COCAINE, ECSTAYAND OTHER AMPHETAMINES, LYSERGIC ACID DIETHYLAMIDE, MESCALINE, PASILOCYBIN, CANNABINNOIDS. DRUGS DEPENDENCE, TOLERANCE, PHARMACOKINETIC AND PHARMACODINAMICS RELATINS TO USE AND ABUSE. WITHDRAWAL SYNDROMES, CESSATION THERAPIES. TOXIC OF FOOD ORIGIN ( TITANIC AND BOTULINIC TOXINS, GLUTE, MILK, MYCOTOXINS AND OTHER DIFFERENT CONTAMINANTS PRESENT IN FOOD OR WHAT COULD BE ORIGINATED IN ANY FOOD PREPARATION. TOXICS PRESENT IN YHE ENVIRONMENT (PCBS, DIOXINS, BENZENE AND OTHER ORGANIC SOLVENTS, OZONE AND CO) POISONINGS FROM HEAVY METALS AND ANTIDOTIC THAERAPY. ENDOCRINE INTERFERING COMPOUNDS OF DIFFERENT ORIGIN. RADON AND TOXIC SUBSTANCES FOR THEIR RADIOACTIVITY. PHYTOESTROGENIC MOLECULES. TREATMENTS OF POISONINGS. MICROBIAL CONTAMINATION OF FOODS. EXOTOXINS AND ENDOTOXINS OF BACTERIAL ORIGIN. MUTAGENESIS TESTS AND GENOTOXICITY. |
| Teaching Methods | |
|---|---|
| LECTURES |
| Verification of learning | |
|---|---|
| ORAL INTERVIEW IT IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE OF THE APPROPRIATE TERMINOLOGY OF BOTH MODULES AS WELL AS THE STUDENT CAPACITY OF EXPOSITION. THE MAXIMUM SCORE IS 30/30 AND IS INTENDED TO BE PASSED WITH THE MINIMUM VOTE OF 18/30. |
| Texts | |
|---|---|
| CHEMOTHERAPY BG KATZUNG, FARMACOLOGIA GENERALE E CLINICA, III ED. ITALIANA, PICCIN EDITORE. 2) GOODMAN & GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, IX ED. ITALIANA, ZANICHELLI EDITORE. TOXICOLOGY KLAASSEN CD, WATKINS III JB, CASARETT & DOULL, ELEMENTI DI TOSSICOLOGIA, EDIZIONE ITALIANA A CURA DI PATRIZIA HRELIA E GIORGIO CANTELLI FORTI, CASA EDITRICE AMBROSIANA PAOLETTI R, NICOSIA S, CLEMENTI F, FUMAGALLI G, FARMACOLOGIA GENERALE E MOLECOLARE, UTET. GOODMAN &GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, X EDIZIONE ITALIAN, ZANICHELLI. DOLARA, TOSSICOLOGIA GENERALE ED AMBIENTALE, EDITORE PICCIN. KATZUNG, FARMACOLOGIA, EDITORE PICCIN |
| More Information | |
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