Pietro CAMPIGLIA | CHIMICA FARMACEUTICA II
Pietro CAMPIGLIA CHIMICA FARMACEUTICA II
cod. 0760100023
CHIMICA FARMACEUTICA II
| 0760100023 | |
| DIPARTIMENTO DI FARMACIA | |
| CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI | |
| PHARMACY | |
| 2015/2016 |
| OBBLIGATORIO | |
| YEAR OF COURSE 4 | |
| YEAR OF DIDACTIC SYSTEM 2010 | |
| SECONDO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 10 | 80 | LESSONS |
| Objectives | |
|---|---|
| THE COURSE AIMS TO PROVIDE STUDENTS BASIC KNOWLEDGE ABOUT GENERAL STRATEGIES OF DESIGN, SYNTHESIS, THE STUDY OF THE MECHANISMS AND CHEMICAL-TOXICOLOGICAL ASPECTS AND THE RELATIONSHIPS BETWEEN CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY OF DRUGS. FOR THIS PURPOSE, THE CHEMICAL-PHYSICAL PROPERTIES AND STEREO-ELECTRONIC PROPERTIES OF THE DRUGS WILL BE ANALYZED IN A CRITICAL AND PLACED IN RELATION TO THE THERAPEUTIC USE OF THE DRUG. ALSO, IT WILL BE DISCUSSED POTENTIAL STRUCTURAL CHANGES, DICTATED BY METABOLIC PROCESSES THAT ALLOW TO MODULATE THE PROFILE OF A DRUG TO ITS THERAPEUTIC USE. IT IS EXPECTED THAT THE STUDENT ACQUIRES KNOWLEDGE OF THE BASIC CONCEPTS RELATED TO THE STUDY OF THE CHEMICAL AND MOLECULAR DRUGS AND IS ABLE TO DISCUSS THE MECHANISMS OF ACTION AND STRUCTURE-ACTIVITY RELATIONSHIPS BASED ON THE CHEMICAL PROPERTIES OF THE MOLECULES INVOLVED. IT IS ALSO EXPECTED THAT THE STUDENTS ACQUIRE THE NECESSARY ELEMENTS TO DESIGN DRUGS ON A RATIONAL BASIS. |
| Prerequisites | |
|---|---|
| STUDENTS HAVE TO KNOW ORGANIC AND INORGANIC CHEMISTRY, BIOLOGY, BIOCHEMISTRY, ELEMENTS OF ANATOMY AND PHYSIOLOGY. |
| Contents | |
|---|---|
| PART I: PRINCIPLES OF DRUG DISCOVERY DRUGDISCOVERY FROM NATURAL PRODUCTSDRUG DESIGN AND RELATIONSHIP OF FUNCTIONAL GROUPS TO PHARMACOLOGIC ACTIVITY .MOLECULARMODELING .RECEPTORS AND DRUG ACTION PART II: DRUG RECEPTORS AFFECTING NEUROTRANSMISSION AND ENZYMES AS CATALYTIC RECEPTORS DRUGSAFFECTINGCHOLINERGICNEUROTRANSMISSION. ADRENERGIC RECEPTORS AND DRUGS AFFECTING ADRENERGIC NEUROTRANSMISSION .SEROTONIN RECEPTORS AND DRUGS AFFECTING SEROTONERGIC NEUROTRANSMISSION . AMINO ACID NEUROTRANSMITTERS IN THE CENTRAL NERVOUS SYSTEM . INHIBITORS OF NERVE CONDUCTION: LOCAL ANESTHETICS .PHOSPHODIESTERASEINHIBITORS PART III: PHARMACODYNAMIC AGENTS SECTION 1: DRUGS AFFECTING CENTRAL NERVOUS SYSTEM GENERAL ANESTHETICS. SEDATIVE-HYPNOTICS. ANTISEIZURE AGENTS . ANTIDEPRESSANTS. PSYCHOTHERAPEUTIC DRUGS: ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS .HALLUCINOGENS, STIMULANTS AND RELATED DRUGS OF ABUSE OPIOIDANALGESICS. DRUGS USED TO TREAT NEUROMUSCULAR DISORDERS: ANTIPARKINSONIAN AND SPASMOLYTIC AGENTS SECTION 2: DRUGS AFFECTING THE CARDIOVASCULAR SYSTEM CARDIAC AGENTS: CARDIAC GLYCOSIDES, ANTIANGINAL, AND ANTIARRHYTHMIC DRUGS . DIURETICS. ANGIOTENSIN CONVERTING ENZYME INHIBITORS, ANTAGONISTS AND CALCIUM BLOCKERS .CENTRAL AND PERIPHERAL SYMPATHOLYTICS AND VASODILATORS .ANTIHYPERLIPOPROTEINEMICS AND INHIBITORS OF CHOLESTEROL BIOSYNTHESIS |
| Teaching Methods | |
|---|---|
| LECTURES |
| Verification of learning | |
|---|---|
| WRITTEN EXAMINATION INTRODUCTION TO THE ORAL INTERVIEW |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. • MONOGRAFIE DELLA COLLANA "CHIMICA DEI RECETTORI", EDITORE C. MELCHIORRE, CLUEB (BOLOGNA). • C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS • KLEEMANN, ENGEL, KUTSCHER, REICHERT, PHARMACEUTICAL SUBSTANCES, 5TH ED., THIEME VERLAG. • BURGER’S MEDICINAL CHEMISTRY, DRUG DISCOVERY AND DEVELOPMENT. 7TH EDITION. WILEY. JOURNAL OF MEDICINAL CHEMISTRY, ACS. |
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