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ANALYTICAL CHEMISTRY AND PHYSICAL CHEMISTRY

Carlo CRESCENZI ANALYTICAL CHEMISTRY AND PHYSICAL CHEMISTRY

0760400010
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
2024/2025

OBBLIGATORIO
YEAR OF COURSE 2
YEAR OF DIDACTIC SYSTEM 2023
AUTUMN SEMESTER
CFUHOURSACTIVITY
972LESSONS
CARLO CRESCENZI T Curriculum
ANNA MARIA D'URSI Curriculum
Objectives
THE COURSE AIMS TO PROVIDE A COMPLETE OVERVIEW OF THE ANALYTICAL PROCESS, STARTING FROM THE CHEMICAL-PHYSICAL FUNDAMENT OF THE EQUILIBRIUM AND THE QUANTITIES BEING MEASURED UP TO THE CHOICE OF METHODS OF ANALYSIS, THE PROCESSING AND INTERPRETATION OF THE RESULTS OBTAINED.
ON THE APPLICATION
CONCERNING THE PHYSICAL CHEMISTRY PART, THE COURSE AIM TO PROVIDE STUUDENTS WITH THE PHYSICAL CHEMICAL PRINCIPLES IN PHARMACY AND THE
PHARMACEUTICAL SCIENCES. PHYSICAL PHARMACY

REGARDING THE PHYSICAL CHEMISTRY MODULE, THE CHEMICAL PHYSICAL PRINCIPLES USEFUL FOR UNDERSTANDING THE PROCESSES OF THE WORLD OF PHARMACY AND PHARMACEUTICAL SCIENCES WILL BE PROVIDED. IN PARTICULAR, KNOWLEDGE ON THE STATES OF MATTER. THERMODYNAMICS, DETERMINATION OF PHYSICAL PROPERTIES, MOLECULES, COMPLEXITY AND BINDING WITH PROTEINS, DIFFUSION, RELEASE AND DISSOLUTION OF DRUGS, INTERFACTIOUS PHENOMENES, COLLOIDAL DISPERSIONS GROSSOLANE DISPERSIONS, REOLOGY.


HE WILL ALSO POSSESS A GENERAL KNOWLEDGE OF QUALITATIVE AND QUANTITATIVE ANALYSIS METHODS; IN PARTICULAR, HE WILL KNOW THE THEORETICAL BASIS OF THE CLASSIC GRAVIMETRIC, VOLUMETRIC AND INSTRUMENTAL METHODS WITH PARTICULAR REGARD TO SPECTROPHOTOMETRIC TECHNIQUES, THE USE OF EXTRACTION, SEPARATION AND PURIFICATION TECHNIQUES WITH CHROMATOGRAPHIC METHODS. FURTHERMORE, HE WILL KNOW THE METHODS OF STATISTICAL ANALYSIS NECESSARY FOR THE CORRECT EVALUATION AND CORRELATION OF THE RESULTS.

APPLYING KNOWLEDGE AND UNDERSTANDING
AT THE END OF THE COURSE THE STUDENT WILL BE ABLE TO:
- APPLY AND PROPERLY MANAGE THE CALCULATION OF THERMODYNAMICS AND KINETICS PROBLEMS
- APPLY THE STOICHIOMETRIC CALCULATION NECESSARY FOR THE USE OF GRAVIMETRIC AND VOLUMETRIC METHODS
- TO INTERPRET THE EMISSION AND INTERACTION PHENOMENA OF MATTER WITH ELECTROMAGNETIC RADIATION FROM A CHEMICAL-PHYSICAL POINT OF VIEW;
- PLAN THE USE OF SPECTROPHOTOMETRIC, EXTRACTION, CHROMATOGRAPHIC SEPARATION AND PURIFICATION TECHNIQUES IN ORDER TO OBTAIN QUALITATIVE AND QUANTITATIVE INFORMATION;
- INTERPRET A CHROMATOGRAM ALSO IN TERMS OF EVALUATING EFFICIENCY AND RESOLUTION;
- APPLY STATISTICAL METHODS AND TESTS FOR THE INTERPRETATION OF DATA AND THE EVALUATION OF THEIR RELIABILITY.

MAKING JUDGMENTS
THE STUDENT WILL BE ABLE TO:
- PUT IN THE RIGHT CONTEXT THE QUESTIONS SHE/HE WILL BE ASKED DURING THE EXAMINATION (BOTH WRITTEN AND ORAL) AND SELECT THE MOST APPROPRIATE AND SPECIFIC ANSWER, AVOIDING UNNECESSARY AND NOT REQUESTED GENERAL DISSERTATIONS;
- PROPERLY LINK TOGETHER THE KNOWLEDGE DERIVING FROM DIFFERENT DISCIPLINES ON A CERTAIN TOPIC AND INTEGRATE THEM TO HAVE A BETTER UNDERSTANDING:
- INTERACT WITH THE THEMES SUGGESTED BY THE TEACHER AND, EVEN WITH THE HELP OF THE RECOMMENDED TEXTS AND TEACHING MATERIALS, BE ABLE TO MAKE INDEPENDENT JUDGMENTS

COMMUNICATION SKILLS
THE STUDENT WILL BE ABLE TO EXPLAIN AND DEVELOP CONCEPTS WITH CLARITY, SYNTHESIS AND LANGUAGE SKILLS.
Prerequisites
TO GAIN ACCESS TO THE EXAM, THE STUDENT MUST HAVE PASSED THE EXAMINATION OF GENERAL AND INORGANIC CHEMISTRY. APPROPRIATE PROFICIENCY IN BASIC MATHEMATICS, PHYSICS AND STOICHIOMETRY AS WELL AS SOME KNOWLEDGE OF ORGANIC CHEMISTRY ARE ALSO REQUIRED.
Contents
BASIC CONCEPTS OF ANALYTICAL CHEMISTRY
FIGURE OF MERITS AND RELIABILITY: SENSITIVITY, SELECTIVITY, DYNAMIC RANGE, ROBUSTNESS, ACCURACY, PRECISION, TRUENESS. RECOVERY AND DILUTION TESTS.
STATISTICAL ASSESSMENT AND TREATMENT OF EXPERIMENTAL DATA.
ERRORS; UNIVARIATE ANALYSIS; TESTS OF SIGNIFICANCE, T-TEST, F TEST, DIXON TEST (OR Q-TEST); CALIBRATION METHODS: EXTERNAL STANDARDS, INTERNAL STANDARDS, STANDARD ADDITION; VARIABLE CORRELATION AND REGRESSION; INTRODUCTION TO MULTIVARIATE ANALYSIS.
CHEMICAL EQUILIBRIA IN ANALYTICAL CHEMISTRY
ACTIVITY AND CONCENTRATION, IONIC STRENGTH. EQUILIBRIA IN SOLUTION.
ACID-BASE TITRATIONS; COMPLEXOMETRIC TITRATIONS; PRECIPITATION TITRATIONS; REDOX TITRATIONS.
GRAVIMETRIC TECHNIQUES OF ANALYSIS.
BASIC CONCEPTS ON INSTRUMENTAL ANALYTICAL TECHNIQUES
THE ANALYTICAL SIGNAL, QUALITATIVE AND QUANTITATIVE ASPECTS.
SPECTROSCOPIC TECHNIQUES:
DEFINITION OF ELECTROMAGNETIC RADIATION. INTERACTION BETWEEN ELECTROMAGNETIC RADIATIONS AND MATTER: ABSORPTION AND EMISSION, ENERGY LEVELS AND TRANSITIONS. QUALITATIVE AND QUANTITATIVE ASPECTS: ABSORPTION AND EMISSION SPECTRA; LAMBERT-BEER'S LAW.
UV-VIS AND IR SPECTROSCOPY. ATOMIC ABSORPTION SPECTROSCOPY. REFLECTANCE SPECTROSCOPY.
SEPARATIONS TECHNIQUES:
LIQUID-LIQUID EXTRACTION. SOLID PHASE EXTRACTION. SUPERCRITICAL FLUID EXTRACTION.
CHROMATOGRAPHY
THE PRINCIPLES OF CHROMATOGRAPHY. LIQUID CHROMATOGRAPHY. GAS CHROMATOGRAPHY. HYPHENATION OF CHROMATOGRAPHY AND MASS SPECTROMETRY. PLANAR CHROMATOGRAPHY.
SHORT INTRODUCTION TO ELECTROANALYTICAL METHODS
ELECTROCHEMICAL CELLS. POTENTIOMETRY. VOLTAMMETRY. CONDUCTIMETRY.

REGARDING THE PHYSICAL CHEMISTRY MODULE, THE CHEMICAL PHYSICAL PRINCIPLES USEFUL FOR UNDERSTANDING THE PROCESSES OF THE WORLD OF PHARMACY AND PHARMACEUTICAL SCIENCES WILL BE PROVIDED. IN PARTICULAR, KNOWLEDGE ON THE STATES OF MATTER. THERMODYNAMICS, DETERMINATION OF PHYSICAL PROPERTIES(8 HOURS, 1CFU), MOLECULES, COMPLEXITY AND BINDING WITH PROTEINS (8 HOURS,1CFU), DIFFUSION, RELEASE AND DISSOLUTION OF DRUGS,(8 HOURS, 1CFU) INTERFACTIOUS PHENOMENES, COLLOIDAL DISPERSIONS GROSSOLANE DISPERSIONS, REOLOGY. (8 HOURS,1CFU)



Teaching Methods
"ANALYTICAL CHEMISTRY:
THE COURSE CONSISTS OF LECTURES AND GROUP/INDIVIDUAL NUMERICAL AND PRATCTICAL EXERCISES

THE EXERCISES WILL BE DISCUSSED IN THE CLASSROOM AND/OR INDIVIDUALLY DURING OFFICE HOURS.
PHYSICAL CHEMISTRY:
THE COURSE CONSISTS OF LECTURES AND NUMERICAL EXERCISES USING CALCULATORS AND TABLES.
THE PURPOSE OF THE NUMERICAL EXERCISES IS TO VERIFY THE CANDIDATE'S ACTUAL MASTERY OF KNOWLEDGE AND ABILITY TO APPLY IT IN DIFFERENT TYPES OF PROBLEMS.
THE EXERCISES WILL BE DISCUSSED IN THE CLASSROOM AND/OR INDIVIDUALLY DURING OFFICE HOURS. THE EXERCISES COLLECTED WILL BE USED IN THE EXAMINATION EVALUATION.

COURSE ATTENDANCE IS MANDATORY IN ACCORDANCE WITH THE DEPARTMENT REGULATIONS."
Verification of learning
THE EXAM INVOLVES THE PASSAGE OF A WRITTEN AND AN ORAL TEST. FOR PHYSICAL CHEMISTRY IN THE WRITTEN TEST THE STUDENT WILL BE ASKED TO SOLVE NUMERICAL EXERCISES AND ANSWER OPEN QUESTIONS OR COMMENT ON GRAPHS. THE ORAL TEST WILL BE OPTIONAL FOR PASSING THE EXAM.



THE WRITTEN TEST PROPOSES NUMERICAL EXERCISES OF ANALYTICAL CHEMISTRY . THE ORAL EXAM IS DESIGNED TO EVALUATE THE THEORETICAL KNOWLEDGE ACQUIRED AND THE EXHIBITION SKILLS.
THE MINIMUM LEVEL OF EVALUATION (18) IS ASSIGNED WHEN THE STUDENT HAS A PIECEMEAL KNOWLEDGE OF THE THEORETICAL CONTENTS AND SHOWS A LIMITED ABILITY TO USE THEM IN THE CONTEXT OF STUDY.
THE MAXIMUM LEVEL (30) IS ASSIGNED WHEN THE STUDENT DEMONSTRATES A COMPLETE AND ACCURATE KNOWLEDGE.
30 CUM LAUDE IS GIVEN WHEN THE CANDIDATE SHOWS SIGNIFICANT MASTERY OF THE THEORETICAL CONTENT AND HIGH ABILITY TO LINK THE CONCEPTS OF THE DIFFERENT BRANCHES OF PHYSICAL CHEMISTRY AND ANALYTICAL CHEMISTRY.
Texts
ANALYTICAL CHEMISTY:
DANIEL C. HARRIS; CHARLES A. LUCY, QUANTITATIVE CHEMICAL ANALYSIS, TENTH EDITION| 2020
DOUGLAS A. SKOOG, DONALD M. WEST, F. JAMES HOLLER, STANLEY R. CROUCH, FUNDAMENTALS OF ANALYTICAL CHEMISTRY, CENGAGE LEARNING
DAVID HARVEY, ANALYTICAL CHEMISTRY 2.1 , HTTPS://CHEM.LIBRETEXTS.ORG/BOOKSHELVES/ANALYTICAL_CHEMISTRY

PHYSICAL CHEMISTRY

MARTIN’S PHYSICAL PHARMACY
AND PHARMACEUTICAL SCIENCES
PHYSICAL CHEMICAL AND BIOPHARMACEUTICAL PRINCIPLES
IN THE PHARMACEUTICAL SCIENCES
B. PISPISA, CHIMICA FISICA BIOLOGICA, ARACNE, ROMA.
G. M. BARROW, PHYSICAL CHEMISTRY FOR THE LIFE SCIENCE,
More Information
THE COURSE IS TAUGHT IN ITALIAN
THE ATTENDANCE IS MANDATORY
LOCATION: DEPARTMENT OF PHARMACY
Lessons Timetable

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