Patrizia GAZZERRO | GENERAL PATHOLOGY

cod. 0760100017

GENERAL PATHOLOGY

	0760100017
	DIPARTIMENTO DI FARMACIA
	EQF7
	PHARMACY
	2016/2017

PERCORSO COMUNE Cohort 2014/2015

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2010
	PRIMO SEMESTRE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
	MED/04	10	80	LESSONS	BASIC COMPULSORY SUBJECTS

	Objectives
	THE COURSE OF GENERAL PATHOLOGY HAS THE OBJECTIVE TO PROVIDE THE STUDENT WITH THE MASTERY OF MEDICAL TERMINOLOGY AND START TO UNDERSTAND THE FUNDAMENTAL PATHOLOGICAL PROCESSES THAT UNDERLIE DISEASES. IN PARTICULAR, AT THE END OF THE COURSE THE STUDENT MUST DEMONSTRATE: KNOWLEDGE AND UNDER STANDING OF THE: -ENDOGENOUS AND EXOGENOUS ETIOLOGICAL FACTORS RESPONSIBLE FOR ALTERATIONS OF CELL FUNCTION; -CELLULAR AND MOLECULAR MECHANISMS OF PATHOLOGICAL PROCESSES; -DEFENSIVE RESPONSES OF THE ORGANISM; -CONTROL OF CELL PROLIFERATION AND APOPTOSIS; -MECHANISMS OF NEOPLASTIC CELL TRANSFORMATION IN RELATION TO THE CAUSES OF CARCINOGENESIS; -PATHO-PHYSIOLOGY OF METABOLIC DISEASES AND MAJOR ORGANS AND SYSTEMS. APPLYING KNOWLEDGE AND UNDERSTANDING: ABILITY TO DISTINGUISH THE BASIS OF HUMAN DISEASES ARISING FROM GENETIC, INFLAMMATORY, INFECTIOUS, IMMUNE OR METABOLIC IMBALANCE OR FROM NEOPLASTIC TRANSFORMATION. ABILITY TO ORIENT IN THE SELECTION OF CLASSES OF DRUGS THAT LEAD TO CONTROL OR REGRESSION OF THE CELLULAR AND MOLECULAR PROCESSES UNDERLYING THE PATHOGENESIS. MAKING JUDGEMENTS ABILITY TO PERCEIVE THE SOCIAL IMPACT OF DIFFERENT DISEASES, THE RISK OF TRANSMISSION OR INFECTION, THE ROLE OF A PROPER EVALUATION OF THE CAUSES OF DISEASE IN THE DEFINITION OF THERAPEUTIC TREATMENTS COMMUNICATION SKILLS ABILITY TO SIMPLY AND COMPLETELY EXPOSE THE MECHANISMS OF PATHOLOGY, THE POSSIBILITY OF IDENTIFYING THE CAUSES, THE POTENTIAL TARGETS OF THERAPY. ABILITY TO DISSEMINATE THE CONTENTS LEARNED LEARNING SKILLS ABILITY TO IMPROVE THE KNOWLEDGE GAINED BY CONSULTING THE UPDATED BIBLIOGRAPHY, SCIENTIFIC ADVANCES PRESENTED IN WORKSHOPS AND SPECIFIC LITERATURE, PROFESSIONAL WEBSITES AND TEXTS.

THE COURSE OF GENERAL PATHOLOGY HAS THE OBJECTIVE TO PROVIDE THE STUDENT WITH THE MASTERY OF MEDICAL TERMINOLOGY AND START TO UNDERSTAND THE FUNDAMENTAL PATHOLOGICAL PROCESSES THAT UNDERLIE DISEASES. IN PARTICULAR, AT THE END OF THE COURSE THE STUDENT MUST DEMONSTRATE:
KNOWLEDGE AND UNDER STANDING OF THE:
-ENDOGENOUS AND EXOGENOUS ETIOLOGICAL FACTORS RESPONSIBLE FOR ALTERATIONS OF CELL FUNCTION;
-CELLULAR AND MOLECULAR MECHANISMS OF PATHOLOGICAL PROCESSES;
-DEFENSIVE RESPONSES OF THE ORGANISM;
-CONTROL OF CELL PROLIFERATION AND APOPTOSIS;
-MECHANISMS OF NEOPLASTIC CELL TRANSFORMATION IN RELATION TO THE CAUSES OF CARCINOGENESIS;
-PATHO-PHYSIOLOGY OF METABOLIC DISEASES AND MAJOR ORGANS AND SYSTEMS.

APPLYING KNOWLEDGE AND UNDERSTANDING:
ABILITY TO DISTINGUISH THE BASIS OF HUMAN DISEASES ARISING FROM GENETIC, INFLAMMATORY, INFECTIOUS, IMMUNE OR METABOLIC IMBALANCE OR FROM NEOPLASTIC TRANSFORMATION. ABILITY TO ORIENT IN THE SELECTION OF CLASSES OF DRUGS THAT LEAD TO CONTROL OR REGRESSION OF THE CELLULAR AND MOLECULAR PROCESSES UNDERLYING THE PATHOGENESIS.

MAKING JUDGEMENTS
ABILITY TO PERCEIVE THE SOCIAL IMPACT OF DIFFERENT DISEASES, THE RISK OF TRANSMISSION OR INFECTION, THE ROLE OF A PROPER EVALUATION OF THE CAUSES OF DISEASE IN THE DEFINITION OF THERAPEUTIC TREATMENTS

COMMUNICATION SKILLS
ABILITY TO SIMPLY AND COMPLETELY EXPOSE THE MECHANISMS OF PATHOLOGY, THE POSSIBILITY OF IDENTIFYING THE CAUSES, THE POTENTIAL TARGETS OF THERAPY. ABILITY TO DISSEMINATE THE CONTENTS LEARNED

LEARNING SKILLS
ABILITY TO IMPROVE THE KNOWLEDGE GAINED BY CONSULTING THE UPDATED BIBLIOGRAPHY, SCIENTIFIC ADVANCES PRESENTED IN WORKSHOPS AND SPECIFIC LITERATURE, PROFESSIONAL WEBSITES AND TEXTS.

	Prerequisites
	KNOWLEDGE OF THE BASIC THEORETICAL PRINCIPLES OF GENERAL AND INORGANIC CHEMISTRY, MATHEMATICS, PHYSICS, ANIMAL BIOLOGY AND HUMAN ANATOMY, ORGANIC CHEMISTRY, BIOCHEMISTRY AND APPLIED GENERAL, GENERAL PHYSIOLOGY

	Contents
	DEFINITION OF DISEASE. ENDOGENOUS AND EXOGENOUS FACTORS OF DISEASE. PATHOGENIC FACTORS INTRINSIC (GENETIC AND METABOLIC DISEASES) AND EXTRINSIC (PHYSICAL, CHEMICAL, FOOD, BIOLOGICAL). CELLULAR PATHOLOGY: CAUSES OF CELL DAMAGE; REVERSIBLE AND IRREVERSIBLE CELLULAR DAMAGE; DAMAGE FROM HYPOXIA, FROM FREE RADICALS. ALTERATIONS OF THE CELL STRUCTURE IN DAMAGE. THE CELLULAR RESPONSE TO STRESS. STEATOSIS. CELL DEATH: NECROSIS AND APOPTOSIS. MECHANISMS OF CELLULAR ADAPTATION. INFLAMMATION: PROCESSES AND STAGES. ACUTE INFLAMMATION: CELLS AND SOLUBLE MEDIATORS. CHRONIC INFLAMMATION. GRANULOMAS. ALTERATIONS OF THERMOREGULATION: HYPOTHERMIA, HYPERTHERMIA, FEVER. IMMUNOLOGY AND IMMUNOPATHOLOGY: THE IMMUNE SYSTEM; LYMPHOCYTE POPULATIONS; SPECIFICITY AND MEMORY; ANTIGENS AND ANTIBODIES; HISTOCOMPATIBILITY ANTIGENS. IMMUNE DEFICIENCIES. IMMUNOSUPPRESSION. IMMEDIATE AND DELAYED-TYPE HYPERSENSITIVITY. AUTOIMMUNE DISEASES. ONCOLOGY: CELL CYCLE CONTROL AND CELL PROLIFERATION. BENIGN AND MALIGNANT TUMORS. CARCINOGENESIS. ONCOGENES AND TUMOR SUPPRESSOR GENES. METASTASES. METABOLISM: DIABETES, IPERLIPOPROTINEMIE, ATHEROSCLEROSIS

Contents

DEFINITION OF DISEASE. ENDOGENOUS AND EXOGENOUS FACTORS OF DISEASE. PATHOGENIC FACTORS INTRINSIC (GENETIC AND METABOLIC DISEASES) AND EXTRINSIC (PHYSICAL, CHEMICAL, FOOD, BIOLOGICAL). CELLULAR PATHOLOGY: CAUSES OF CELL DAMAGE; REVERSIBLE AND IRREVERSIBLE CELLULAR DAMAGE; DAMAGE FROM HYPOXIA, FROM FREE RADICALS. ALTERATIONS OF THE CELL STRUCTURE IN DAMAGE. THE CELLULAR RESPONSE TO STRESS. STEATOSIS. CELL DEATH: NECROSIS AND APOPTOSIS. MECHANISMS OF CELLULAR ADAPTATION. INFLAMMATION: PROCESSES AND STAGES. ACUTE INFLAMMATION: CELLS AND SOLUBLE MEDIATORS. CHRONIC INFLAMMATION. GRANULOMAS. ALTERATIONS OF THERMOREGULATION: HYPOTHERMIA, HYPERTHERMIA, FEVER. IMMUNOLOGY AND IMMUNOPATHOLOGY: THE IMMUNE SYSTEM; LYMPHOCYTE POPULATIONS; SPECIFICITY AND MEMORY; ANTIGENS AND ANTIBODIES; HISTOCOMPATIBILITY ANTIGENS. IMMUNE DEFICIENCIES. IMMUNOSUPPRESSION. IMMEDIATE AND DELAYED-TYPE HYPERSENSITIVITY. AUTOIMMUNE DISEASES. ONCOLOGY: CELL CYCLE CONTROL AND CELL PROLIFERATION. BENIGN AND MALIGNANT TUMORS. CARCINOGENESIS. ONCOGENES AND TUMOR SUPPRESSOR GENES. METASTASES. METABOLISM: DIABETES, IPERLIPOPROTINEMIE, ATHEROSCLEROSIS

	Teaching Methods
	LECTURES ANALYSIS OF CASE STUDIES

	Verification of learning
	ORAL EXAM WHERE THE ACHIEVEMENT OF LEARNING OBJECTIVES WILL BE ASSESSED

	Texts
	-AUTORI VARI: PATOLOGIA GENERALE, IDELSON-GNOCCHI, ED. 2012 -ROBBINS, LE BASI PATOLOGICHE DELLE MALATTIE - EDIZIONE ITALIANA A CURA DI RS COTRAN , V. KUMAR E T. COLLINS, PICCIN -PONTIERI, PATOLOGIA E FISIOPATOLOGIA GENERALE - PICCIN EDITORE

	More Information
	THE FREQUENCY OF THE COURSE AND EXPERIMENTS EXECUTION ARE HIGHLY RECOMMENDED. A SATISFACTORY PREPARATION TAKES ON AVERAGE AT LEAST TWO HOURS OF STUDY FOR EACH HOUR SPENT IN THE CLASSROOM. GIVEN THE CONTINUOUS SCIENTIFIC PROGRESS IN THE KNOWLEDGE OF THE CELLULAR AND MOLECULAR MECHANISMS AT THE BASIS OF HUMAN DISEASE, INSIGHTS ABOUT THE TOPICS COVERED CAN BE OBTAINED FROM TEACHERS IN THE SECTOR MED/04 E-MAIL ADDRESS OF THE PROFESSORS PGAZZERRO@UNISA.IT; MAUBIFUL@UNISA.IT; FUSCOBR@UNISA.IT WEBSITE ADDRESS OF THE COURSE ACTIVITIES

More Information

THE FREQUENCY OF THE COURSE AND EXPERIMENTS EXECUTION ARE HIGHLY RECOMMENDED. A SATISFACTORY PREPARATION TAKES ON AVERAGE AT LEAST TWO HOURS OF STUDY FOR EACH HOUR SPENT IN THE CLASSROOM. GIVEN THE CONTINUOUS SCIENTIFIC PROGRESS IN THE KNOWLEDGE OF THE CELLULAR AND MOLECULAR MECHANISMS AT THE BASIS OF HUMAN DISEASE, INSIGHTS ABOUT THE TOPICS COVERED CAN BE OBTAINED FROM TEACHERS IN THE SECTOR MED/04

E-MAIL ADDRESS OF THE PROFESSORS
PGAZZERRO@UNISA.IT; MAUBIFUL@UNISA.IT; FUSCOBR@UNISA.IT
WEBSITE ADDRESS OF THE COURSE ACTIVITIES

BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2019-03-11]

Patrizia GAZZERRO | GENERAL PATHOLOGY