Biochemistry Of Movement And Performance

Antonietta SANTORO Biochemistry Of Movement And Performance

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DIPARTIMENTO DI SCIENZE UMANE, FILOSOFICHE E DELLA FORMAZIONE
SPORT AND MOVEMENT SCIENCE AND TECHNIQUES FOR ANALYSING AND PLANNING SPORTS FOR THE DISABLES
2015/2016

OBBLIGATORIO
YEAR OF COURSE 2
YEAR OF DIDACTIC SYSTEM 2014
PRIMO SEMESTRE
CFUHOURSACTIVITY
636LESSONS
Objectives
THE GOALS OF THE COURSE ARE: A) TO KNOW THE BIOCHEMICAL PROCESSES UNDERLYING PHYSICAL EXERCISE AND HUMAN MOVEMENTS; B) TO UNDERSTAND THE CHANGES OF METABOLISM FOLLOWING EXCERCISE ALSO IN RELATION TO THE PRESENCE OF METABOLIC DESEASE.
Prerequisites
FUNDAMENTAL OF GENERAL CHEMISTRY AND BIOLOGY.
Contents
BASIC BIOCHEMISTRY
WATER PROPERTIES AND HYDROGEN BOND, POLARITY OF MOLECULES AND ITS ABILITY TO FORM HYDROGEN BONDS, HYDROPHILIC AND HYDROPHOBIC ORGANIC MOLECULES, AMPHIPATHIC ORGANIC MOLECULES. CHEMICAL EQUILIBRIUM. THE IONIC PRODUCT FOR WATER. ACIDS, BASES AND THE PH SCALE. BUFFER SOLUTIONS AND THE BICARBONATE BUFFERING SYSTEM OF PLASMA BLOOD. CARBON FUNCTIONAL GROUPS.

STRUCTURAL BIOCHEMISTRY
CARBOHYDRATES: GLUCOSE STRUCTURE. DISACCHARIDES ALPHA AND BETA. POLYSACCHARIDES
FATTY ACIDS: GENERAL STRUCTURES OF MONOACYL-, DIACYL- AND TRIACYLGLYCEROLS, PHOSPHOLIPIDS, GLYCEROLPHOSPHOLIPIDS, SPHINGOLIPIDS. TERPENS AND STEROIDS. SATURATED AND UNSATURATED (OMEGA) FATTY ACIDS.
AMINOACIDS AND PROTEINS: AMINO ACIDS STRUCTURE, PEPTIDE BOND AND ITS PROPERTIES. PRIMARY, SECONDARY STRUCTURE OF PROTEINS (ALPHA-HELIX, BETA-SHEET), TERTIARY AND QUATERNARY STRUCTURE. FIBROUS PROTEIN: COLLAGEN.
NUCLEOTIDES, COENZYMES INCLUDING NUCLEOTIDES.

FUNCTIONAL BIOCHEMISTRY
MYOGLOBIN AND HAEMOGLOBIN STRUCTURES. SATURATION CURVES OF MYOGLOBIN AND HAEMOGLOBIN HETEROTROPHIC LIGANDS: CARBON DIOXIDE, BOHR’S EFFECT, 2,3 BISPHOSPHOGLYCERATE. F AND S HAEMOGLOBIN. ERYTHROPOIETIN AND DOPING.
SIGNAL TRANSDUCTION MECHANISMS. HORMONES AND RECEPTORS. ENDOCRINE GLANDS: HYPOPHISIS, THYROID AND PARATHYROID, PANCREAS. LIVER. MECHANISMS OF REGULATION OF GLUCOSE AND CALCIUM CONTENT IN THE BLOOD. HORMONE VARIATIONS DURING PHYSICAL EXERCISE.
INTRODUCTION TO METABOLISM: EXERGONIC AND ENDERGONIC REACTIONS. ATP MOIETY. CARBOHYDRATES METABOLISM: ASSIMILATION, DEGRADATION, GLYCOLYSIS REACTIONS AND REGULATION. PYRUVATE DESTINY. CORI’S CYCLE. LACTATE THRESHOLD. GLYCOGEN METABOLISM: SYNTHESIS, DEGRADATION AND METABOLIC REGULATION.
LIPID METABOLISM: ASSIMILATION, TRANSPORT, LIPOPROTEINS. GLYCEROL DEGRADATION. OXIDATION OF FATTY ACIDS, SATURATED AND UNSATURATED, PROPIONYL MOIETY, METABOLIC REGULATION DURING EXCERCISE. KETONE BODIES AND THEIR METABOLISM.
PYRUVATE DEHYDROGENASE COMPLEX, MECHANISM, ACETYL-COA PRODUCTION, METABOLIC REGULATION. THE TRICARBOXYLIC ACID CYCLE, REACTIONS AND METABOLIC REGULATION. MITOCHONDRIAL ELECTRON TRANSPORT CHAIN COMPLEXES. OXIDATIVE PHOSPHORYLATION: CHEMIOSMOTIC THEORY, F0F1 ATP SYNTHASE STRUCTURE AND FUNCTION, ENERGETIC YIELD.
MUSCLE CELL BIOCHEMISTRY
MUSCLE TISSUE AND CELLS: MORPHOLOGICAL FEATURES. TYPE I AND II MUSCLE FIBERS AND THEIR BIOCHEMICAL CHARACTERISTICS. BIOCHEMICAL MECHANISM OF CONTRACTION.
Teaching Methods
LECTURES
Verification of learning
EXAMINATION
Texts
DI GIULIO A, FIORILLI A, STEFANELLI C. BIOCHIMICA PER LE SCIENZE MOTORIE. CASA EDITRICE AMBROSIANA, I ED 2011.
FIORILLI A, ARIENTI G. BIOCHIMICA DELL’ATTIVITÀ MOTORIA. ED. PICCIN, 2007

NELSON DL, COX M. INTRODUZIONE ALLA BIOCHIMICA DI LEHNINGER, ED. ZANICHELLI, IV/2011.
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