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PHARMACOLOGICAL ASSAYS AND PRECLINICAL TESTING

Rosalinda SORRENTINO PHARMACOLOGICAL ASSAYS AND PRECLINICAL TESTING

0760200040
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
2022/2023

YEAR OF COURSE 5
YEAR OF DIDACTIC SYSTEM 2016
AUTUMN SEMESTER
CFUHOURSACTIVITY
540LESSONS
ROSALINDA SORRENTINO T Curriculum
Objectives
THE COURSE AIMS TO PROVIDE THE BASICS TO DEVELOP A PRECLINICAL DRUG TRIAL, THROUGH THE KNOWLEDGE OF THE MOST COMMONLY USED METHODS IN IVO AND IN VITRO TECHNIQUES AS WELL AS THE FUNDAMENTALS OF STATISTICAL ANALYSIS. PARTICULAR HIGHLIGHT IS GIVEN TO THE CURRENT LAWS APPLIED TO IN VIVO STUDIES.
THE STUDENT AT THE END OF THE COURSE WILL DEMONSTRATE THAT HE CAN MANAGE: 1) IDENTIFICATION OF IN VITRO AND IN VIVO TECHNIQUE TO TEST THE PHARMACOLOGICAL ACTIVITY; 2 ) ACTUAL LAWAS FOR IN VIVO STUDIES ; 3 ) STATISTICAL ANALYSIS OF THE EXPERIMENTAL DATA.
Prerequisites
PHARMACOLOGY AND THERAPY IS NECESSARY TO BE HELD BEFORE APPLYING FOR THIS COURSE.
STUDENTS SHOULD HAVE CONFIDENTIALITY IN ANATOMY, PHYSIOLOGY, PATHOLOGY.
Contents
THE CLASS WILL FOLLOW THESE SUBJECTS:
1. ANTYHYPERTENSIVE DRUGS: EXPERIMENTAL MODELS
2. ANTI-CLOTTING DRUGS: EXPERIMENTAL MODELS
3. HYPOGLYCEMIC DRUGS. EXPERIMENTAL MODELS
4. ANTI-INFLAMMATORY DRUGS: EXPERIMENTAL MODELS
5. ANTI-ASTHMATIC/COPD/FIBROTIC DRUGS: EXPERIMENTAL MODELS
6. ANALGESICS: EXPERIMENTAL MODELS
7. ANTI-ULCER DRUGS: EXPERIMENTAL MODELS
8. ANTI-TUMORAL DRUGS
9. IMMUNOTHERAPEUTICS: EXPERIMENTAL MODELS
10 STATISTICAL ANALYSIS

LESSONS ARE INTEGRATED WITH PRACTICAL DEMONSTRATIONS.
Teaching Methods
THE COURSE WILL BE OF 40 HOURS, OF WHICH, 30 HOURS ARE FOR REGULAR CLASSES AND 10 HOURS ARE SPENT IN THE LABORATORY FOR PRACTICAL DEMONSTRATION.

Verification of learning
THE STUDENT WILL HELD THE EXAM AND THE FOLLOWING POINTS WILL BE FUNDEMENTAL TO BE SUCCESSFUL (30/30):
1. USE OF AN APPROPRIATE SCIENTIFIC APPROACH
2. CONFIDENCE AT CORRELATING DIFFERENT SUBJECTS
3. CRITICAL APPROACH TO THE EXPERIMENTAL PLAN
Texts
1. EXPERIMENTAL PHARMACOLOGY ISBN: 978-88-9295-444-1
2. DRUG DISCOVERY AND EVALUATION-PHARMACOLOGICAL ASSAYS, HANS G. VOGEL, ISBN 9783540423966, SPRINGER.
4. ANY TYPE OF BOOK EXPLAING EXPERIMENTAL PRECLINICAL STUDIES .
5. FONDAMENTI DI STATISTICA PER LE DISCIPLINE BIOMEDICHE, MM. TRIOLA, M. TRIOLA. ISBN9788891902580B, PEARSON

OR

3'. ANALISI STATISTICA DEI DATI BIOLOGICI, MC WITHLOCK, D. SCHLUTER, ISBN 9788808062970, ZANICHELLI.

BOOKS WILL BE INTEGRATED WITH PROVIDED MATERIAL
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