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PHARMACOLOGICAL ASSAYS AND PRECLINICAL TESTING

Rosalinda SORRENTINO PHARMACOLOGICAL ASSAYS AND PRECLINICAL TESTING

0760200040
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY
2023/2024

YEAR OF DIDACTIC SYSTEM 2020
AUTUMN SEMESTER
CFUHOURSACTIVITY
648LESSONS
ROSALINDA SORRENTINO T Curriculum
Objectives
THE COURSE HAS THE SCOPE TO TRANSFER AND PROVIDE STUDENTS WITH THE BASIC NOTIONS OF THE
PRECLINICAL EXPERIMENTATION. KNOWLEDGE AND UNDERSTANDING
STUDENTS WILL LEARN: -SCIENTIFIC METHODS TO APPROACH A PRECLINICAL STUDY -METHODOLOGIES COMMONLY USED -LEGISLATIVE RULES FOR THE USE OF LABORATORY ANIMALS IN PRECLINICAL STUDIES
APPLYING KNOWLEDGE AND UNDERSTANDING
AT THE END OF THE COURSE, STUDENTS WILL BE ABLE TO: -DEFINE SCIENTIFIC AND TECHNICAL CRITERIA TO APPROACH A PHARMACOLOGICAL STUDY -DEFINE WHAT EXPERIMENTAL MODEL IS APPROPRIATE FOR A SPECIFIC STUDY APPLYING THE CORRECT
STATISTICAL ANALYSIS
MAKING JUDGMENTS:
STUDENTS WILL BE ABLE TO: -EVALUATE MOLECULAR AND CELLULAR MECHANISM/S UNDERLYING THE PHARMACOLOGICAL ACTIVITY OF
DRUGS -ANALYZE AND INTERPRET EXPERIMENTAL DATA
COMMUNICATION SKILLS:
STUDENTS WILL BE ABLE TO: -ANALYZE, INTERPRET, AND DESCRIBE EXPERIMENTAL RESULTS -COMMUNICATE USING AN APPROPRIATE TECHNICAL LANGUAGE
Prerequisites

STUDENTS SHOULD HAVE CONFIDENTIALITY IN ANATOMY, PHYSIOLOGY, PATHOLOGY.
Contents
THE CLASS WILL FOLLOW THESE SUBJECTS:
1. PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS
2. ANTYHYPERTENSIVE DRUGS: EXPERIMENTAL MODELS
3. ANTI-CLOTTING DRUGS: EXPERIMENTAL MODELS
4. HYPOGLYCEMIC DRUGS. EXPERIMENTAL MODELS
5. ANTI-INFLAMMATORY DRUGS: EXPERIMENTAL MODELS
6. ANTI-ASTHMATIC/COPD/FIBROTIC DRUGS: EXPERIMENTAL MODELS
7. ANALGESICS: EXPERIMENTAL MODELS
8. ANTI-ULCER DRUGS: EXPERIMENTAL MODELS
9. ANTI-TUMORAL DRUGS
10. IMMUNOTHERAPEUTICS: EXPERIMENTAL MODELS
11. STATISTICAL ANALYSIS

LESSONS ARE INTEGRATED WITH PRACTICAL DEMONSTRATIONS.
Teaching Methods
THE COURSE WILL BE OF 48 HOURS, OF WHICH, 36 HOURS ARE FOR REGULAR CLASSES AND 12 HOURS ARE SPENT IN THE LABORATORY FOR PRACTICAL DEMONSTRATION.

Verification of learning
THE STUDENT WILL HELD THE EXAM AND THE FOLLOWING POINTS WILL BE FUNDEMENTAL TO BE SUCCESSFUL (30/30):
1. USE OF AN APPROPRIATE SCIENTIFIC APPROACH
2. CONFIDENCE AT CORRELATING DIFFERENT SUBJECTS
3. CRITICAL APPROACH TO THE EXPERIMENTAL PLAN
Texts
1. EXPERIMENTAL PHARMACOLOGY ISBN: 978-88-9295-444-1
2. DRUG DISCOVERY AND EVALUATION-PHARMACOLOGICAL ASSAYS, HANS G. VOGEL, ISBN 9783540423966, SPRINGER.
4. ANY TYPE OF BOOK EXPLAING EXPERIMENTAL PRECLINICAL STUDIES .
5. FONDAMENTI DI STATISTICA PER LE DISCIPLINE BIOMEDICHE, MM. TRIOLA, M. TRIOLA. ISBN9788891902580B, PEARSON

OR

3'. ANALISI STATISTICA DEI DATI BIOLOGICI, MC WITHLOCK, D. SCHLUTER, ISBN 9788808062970, ZANICHELLI.

BOOKS WILL BE INTEGRATED WITH PROVIDED MATERIAL
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