Carmine SELLERI | Projects
Carmine SELLERI Projects
13 Funded projects
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In this translational study, we will investigate mechanisms of action of potential novel anti-MM agents in newly diagnosed MM patients or in who relapsed or were refractory to previous regimens, including those daratumumab-based regimens and those in maintenance therapy with lenalidomide. Understanding pathophysiology of relapse/refractory MM and mechanisms of action of new drugs will improve clin
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 2.316,36 euro | |
| Project duration | 25 November 2024 - 25 November 2027 | |
| Detail |
In this study, we aim at investigating the impact of ruxolitinib on marrow fibrosis in MPNs using a well-established 3D in vitro model of BM niche mimicking cell-to-cell contacts and paracrine pathways intercurrent between stromal cells and BMMCs in normal and pathological hematopoiesis.Specific aims: 1. Establishment of a 3D in vitro co-culture model of myelofibrosis.2. Ruxolitinib effects on
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Cost | 3.505,26 euro | |
| Project duration | 31 July 2023 - 31 July 2026 | |
| Detail |
Based on findings showing the involvement of proinflammatory low-density granulocytes (LDGs) in activation of type 1 helper responses, and on the predominant role of cytotoxic T cells and type I immune responses in myelodysplastic syndromes (MDS), we hypothesize that LDGs and other immunoregulatory molecules might play an important role in MDS pathophysiology. Specific aims are to: 1) detect and q
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 3.455,31 euro | |
| Project duration | 25 July 2022 - 25 July 2025 | |
| Proroga | 31 dicembre 2025 | |
| Detail |
The discovery of checkpoint inhibitors and engineered T cells has opened a new era in cancer immunotherapy and has changed clinical outcomes of several tumors. T cells expressing chimeric antigen receptors (CARs) are directed against specific tumor-related antigens. To date, only two CD19-specific CAR-T cells have been approved for B-cell acute lymphoblastic leukemia and diffuse large B cell lymph
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 1.947,43 euro | |
| Project duration | 22 November 2021 - 22 November 2024 | |
| Proroga | 25 Luglio 2025 | |
| Detail |
Concluded
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 3.496,03 euro | |
| Project duration | 15 February 2021 - 30 September 2024 | |
| Detail |
The research is aimed to establish a simplified hematopoietic stem cell (HSC) niche in vitro, in order to study pathophysiological mechanisms in the bone marrow (BM) niche using an acute myeloid leukemia (AML) model. We propose a 3-D porous collagen 1-based dynamic culture system as a model of choice to reproduce in vitro the BM niche and a 2-D classical colture model to investigate the role of b
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 2.350,80 euro | |
| Project duration | 18 May 2020 - 18 May 2023 | |
| Detail |
Lo studio è focalizzato sulla definizione del ruolo svolto dalle cellule staminali mesenchimali (MSC) residenti nel midollo osseo (BM) nel sequestro, rilascio e metabolismo del Ruxolitinib, inibitore delle Janus chinasi 1 e 2 (JAK1/2) ampiamente usato nel trattamento della Mielofibrosi idiopatica (IMF).In particolare, saranno studiati gli effetti modulatori di cellule staminali mesenchimali midol
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 3.411,83 euro | |
| Project duration | 11 March 2019 - 10 March 2022 | |
| Detail |
Le cellule staminali ematopoietiche (HSCs) risiedono nel midollo osseo (BM) e possono essere mobilizzate nella circolazione per il trapianto. L¿uPAR è un recettore di membrana che lega urochinasi (uPA) e vitronectina (VN) e interagisce con integrine, recettori per chemochine e per fattori di crescita. Abbiamo dimostrato il coinvolgimento dell' uPAR solubile nella mobilizzazione e attecchimento al
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 4.087,00 euro | |
| Project duration | 20 November 2017 - 20 November 2020 | |
| Proroga | 20 febbraio 2021 | |
| Detail |
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 3.834,90 euro | |
| Project duration | 11 December 2013 - 11 December 2019 | |
| Proroga | 11 dicembre 2019 | |
| Detail |
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 2.073,02 euro | |
| Project duration | 29 July 2016 - 20 September 2018 | |
| Detail |
Concluded
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 1.549,37 euro | |
| Project duration | 30 May 2011 - 29 May 2018 | |
| Detail |
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 4.068,25 euro | |
| Project duration | 7 November 2014 - 6 November 2016 | |
| Detail |
Concluded
| Department | Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED | |
| Principal Investigator | SELLERI Carmine (Project Coordinator) | |
| Funding | University funds | |
| Funders | Università degli Studi di SALERNO | |
| Cost | 3.867,35 euro | |
| Project duration | 28 July 2015 - 28 July 2016 | |
| Detail |
Data source U-GOV dal 1 Gennaio 2013
