Vincenzo CASOLARO | PATOLOGIA GENERALE
Vincenzo CASOLARO PATOLOGIA GENERALE
cod. 1060200013
PATOLOGIA GENERALE
1060200013 | |
DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA" | |
EQF7 | |
DENTISTRY | |
2018/2019 |
OBBLIGATORIO | |
YEAR OF COURSE 2 | |
YEAR OF DIDACTIC SYSTEM 2015 | |
SECONDO SEMESTRE |
SSD | CFU | HOURS | ACTIVITY | |
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MED/04 | 9 | 99 | LESSONS |
Objectives | |
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THE STUDENT WILL LEARN THE MECHANISMS BY WHICH THE VARIOUS AGENTS CAUSING ILLNESS INTERACT WITH BIOLOGICAL SYSTEMS AND THEREBY INDUCE DAMAGE AND ALTERATIONS IN THE STRUCTURE AND FUNCTIONS OF CELLS, TISSUES AND ORGANS, DISRUPTING THE HOMEOSTATIC BALANCE AND CAUSIN ILLNESS ONSET AND PROGRESSION, INCLUDING THE ABILTY TO EVALUATE THE POTENTIAL PRACTICAL IMPACT OF SUCH NOTION. TO THIS END, THE CONCEPTUAL BASES FOR UNDERSTANDING THE CAUSES OF DISEASES IN HUMANS WILL BE PROVIDED, TOGETHER WITH GENERAL PATHOGENIC MECHANISMS AND PATHOPHYSIOLOGICAL PROCESSES AFFECTING CELLS, APPARATA AND SYSTEMS, INCLUDING GENDER-RELATED DIFFERENCES. THE STUDENT WILL ALSO LEARN THE BASIS OF HUMAN, MOLECULAR AND MEDICAL GENETICS; IN PARTICULAR THE STUDENT WILL GAIN KNOWLEDGE ON MENDELIAN, CHROMOSOMIC, MITOCHONDRIAL AND MULTIFACTORIAL DISORDERS AND RELATED LABORATORY TECHNIQUES TO STUDY THEM; CONCEPTS OF PHARMACOGENETICS, GENETIC COUNSELLING AND GENETIC TESTING. UPON COMPLETION OF THE COURSE, THE STUDENT WILL BE ABLE TO ANALYZE, IDENTIFY AND INTERPRET THE PATHOGENIC MECHANISMS THAT CAUSE HUMAN DISEASES AND THEIR CONSEQUENCES, AND MUST HAVE ACQUIRED BASIC INFORMATION ON THE MAIN DIAGNOSTIC TECHNIQUES, PARTICULARLY AT THE MOLECULAR LEVEL. THE KNOWLEDGE ACQUIRED WILL REPRESENT THE ESSENTIAL SUBSTRATE FOR A SUBSEQUENT CORRECT TO APPROACH CLINICAL SCIENCES. MOREOVER, THE COURSE WILL AIM AT PROVIDING STUDENTS WITH THE KNOWLEDGE REQUIRED TO UNDERSTAND THE MECHANISMS RESPONSIBLE FOR THE PRINCIPAL ALTERATIONS OF THE HOMEOSTATIC SYSTEMS OF THE ORGANISM, THEIR FUNCTIONAL CONSEQUENCES ON ORGANS AND SYSTEMS, THE COMPENSATORY MECHANISMS ACTIVATED AND THE PATHOPHYSIOLOGICAL MECHANISMS OF DISEASE, FOCUSING IN PARTICULAR ON: HEMATOPOIESIS AND BLOOD COMPONENTS, THE CARDIOVASCULAR, RESPIRATORY, URINARY, GASTROINTESTINAL, AND ENDOCRINE SYSTEMS, LIPID AND CARBOHYDRATE METABOLISM, FLUID AND ELECTROLYTE BALANCE AND ACID-BASE BALANCE. |
Prerequisites | |
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BASIC ANATOMY AND HISTOLOGY, BIOLOGY AND MOLECULAR BIOLOGY, CHEMISTRY AND BIOCHEMISTRY, MEDICAL PHYSICS, PHYSIOLOGY AND GENERAL GENETICS, MICROBIOLOGY. IN PARTICULAR, DETAILED KNOWLEDGE OF THE STRUCTURE AND FUNCTIONS OF EUKARYOTIC CELLS, TISSUES, ORGANS AND SYSTEMS; DEVELOPMENT AND SEXUAL DETERMINATION; DNA AND CHROMOSOME ORGANIZATION, RNA AND PROTEINS, INCLUDING ENZYMOLOGY; PATHOGENIC MICROORGANISMS. |
Contents | |
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THE CONCEPT OF DISEASE: THE DISEASE, AS LOSS OF THE HEALTH STATUS AND HOMEOSTATIC UNBALANCE. ETIOLOGY: THE CONCEPT OF "CAUSE" IN PATHOLOGY. PATHOGENESIS: KEY PATHOGENIC MECHANISMS, INCLUDING GENDER-RELATED CASES. GENERAL ETIOLOGY: CHEMICAL, PHYSICAL AND BIOLOGICAL AGENTS OF DISEASE.THE COMPONENTS AND PHASES OF BLOOD CLOTTING (HAEMOSTASIS); THE ROLE OF THE ENDOTHELIUM; THE PRO-COAGULANT ACTIVITY OF ENDOTHELIAL CELLS; THE ANTI-COAGULANT ACTIVITY OF ENDOTHELIAL CELLS; THE ROLE OF PLATELETS; THE RELATIONSHIP BETWEEN STRUCTURAL AND FUNCTIONAL ELEMENTS OF PLATELETS; MEDIATORS OF PLATELET ACTIVATION; THE ACTIVATION AND AGGREGATION OF PLATELETS; THE PRO-COAGULANT FUNCTION OF PLATELETS; COAGULATION; COAGULATION FACTORS; FIBRIN POLYMERISATION; ACTIVATION OF THE COAGULATION CASCADE; THE REGULATION OF COAGULATION; THE NATURAL ANTI-COAGULANTS; FIBRINOLYSIS; PATHOLOGY GENOMICS: THE GENOME AS A CAUSE OF DISEASE, THE “MOLECULAR LOGIC” OF LIVING ORGANISMS, CONGENITAL AND HEREDITARY GENOMIC, CHROMOSOMAL AND GENE MUTATIONS; CAUSES, TAXONOMY, PATHOGENIC MECHANISMS AND CONSEQUENCES OF MUTATIONS. DISEASES RELATED TO MUTATIONS OF MITOCHONDRIAL DNA. GENOME INSTABILITY. GENERAL ONCOLOGY: THE CONCEPT OF NEOPLASIA; PHYSIOLOGICAL AND PATHOLOGICAL PROLIFERATIONS; HISTOGENETIC AND CLINICAL CLASSIFICATION OF NEOPLASMS, BENIGNITY AND MALIGNANCY; TUMOR ATYPIA, TUMOR MARKERS. NATURAL HISTORY OF CANCER: MULTIPHASIC CARCINOGENESIS, THE CONCEPT OF TUMOR PROGRESSION, ANGIOGENESIS, INFILTRATIVE GROWTH. METASTASIS: DEFINITION AND GENERAL CONCEPTS; PRIMARY AND METASTATIC TUMORS; MOLECULAR MECHANISMS OF METASTASIS; METASTASTIC ROUTES; ORGANOTROPISM OF METASTASES. ETIOLOGY OF CANCER: IONIZING AND EXCITING RADIATIONS, DNA AND RNA TUMOR VIRUSES, CHEMICAL CARCINOGENESIS, PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES. REGULATION OF NORMAL AND TRANSFORMED CELL PROLIFERATION: GENES THAT CONTROL CELL CYCLE PROGRESSION AND CELLULAR SENESCENCE. CANCER CACHEXIA. PRECANCEROUS LESIONS. MEDICAL GENETICS: CELLULAR DIVISION, MITOSIS AND MEIOSIS; DNA REPLICATION AND TRANSCRIPTION; PROTEIN SYNTHESIS; CONCEPT OF MUTATION, RARE VARIANT AND POLYMORPHISM; PEDIGREE DRAWING; INHERITANCE OF MONOGENIC TRAITS, MENDEL LAWS; AUTOSOMAL DOMINANT, AUTOSOMAL RECESSIVE, X-LINKED TRANSMISSION; CONCEPTS OF PENETRANCE, EXPRESSION, ANTICIPATION, FITNESS, MOSAICISM, PHENOCOPY, IMPRINTING, DE NOVO MUTATIONS; DYNAMIC MUTATIONS; GENETIC AND ALLELIC HETEROGENEITY; OLIGOGENIC INHERITANCE; MITOCHONDRIAL DNA AND INHERITANCE; KARYOTYPE AND CHROMOSOMAL CLASSIFICATION; NUMERICAL AND STRUCTURAL CHROMOSOMAL ABERRATIONS; MULTIFACTORIAL INHERITANCE, QUANTITATIVE TRAITS, THRESHOLD EFFECT; MULTIFACTORIAL DISEASES, CASE-CONTROL STUDIES; CONCEPTS OF PHARMACOGENETICS AND PHARMACOGENOMICS; CONCEPTS OF LINKAGE, LINKAGE DISEQUILIBRIUM AND FOUNDER EFFECT; CLASSIFICATIONS AND APPLICATIONS OF GENETIC TESTING; GENETIC COUNSELING; THERAPEUTIC STRATEGIES IN GENETIC DISEASES; MAIN TECHNIQUES OF GENOTYPING, SEQUENCING AND MOLECULAR CYTOGENETICS. PHYSIOPATHOLOGY OF BLOOD AND HEMATOPOIESIS; ANEMIA; HEMOSTASIS AND COAGULATION. PHYSIOPATHOLOGY OF BLOOD VESSELS. PHYSIOPATHOLOGY OF CARDIOVASCULAR SYSTEM. PHYSIOPATHOLOGY OF RESPIRATORY SYSTEM.. PHYSIOPATHOLOGY OF KIDNEY AND ITS COLLECTING SYSTEM. PHYSIOPATHOLOGY OF HYDRO-ELECTROLYTIC BALANCE AND ACID-BASE BALANCE. PHYSIOPATHOLOGY OF ENDOCRINE SYSTEM. PHYSIOPATHOLOGY OF METABOLISM. PHYSIOPATHOLOGY OF GASTROINTESTINAL SYSTEM (INCL. LIVER). PHYSIOPATHOLOGY OF THERMOREGULATION. PHYSIOPATHOLOGY OF OBESITY. PHYSIOPATHOLOGY OF AGING. PHYSIOPATHOLOGY OF PAIN. |
Teaching Methods | |
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FORMAL LECTURES AND INFORMAL COLLOQUIA WITH THE STUDENTS. |
Verification of learning | |
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THE FINAL EXAM WITH CONSIST OF AN ORAL EXAMINATION, RIRECTED TO EVALUATE THE UNDERSTANDING AND KNOWLEDGE OF THE STUDENT OF THE BASIC PATHOLOGICAL PROCESSES AND OFORGAN PHYSIOPATHOLOGY. THE SCORE WILL RANGE FROM 18 (POR) TO 30 (EXCELLENT), WITH THE POSSIBILITY TO ASSIGN 'CUM LAUDE' TO THOSE STUDENTS DEMONSTRATING ALSO THE ABILITY TO ADDRESS COMPLEX PHYSIOPATHOLOGICAL QUESTIONS WITH RATIONALE, KNOWLEDGE AND APPROPIATE LANGUAGE. |
Texts | |
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- ROBBINS AND COTRAN, PATHOLOGIC BASIS OF DISEASE, VIII EDITION, ELSEVIER |
More Information | |
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THE PROFESSORS OF GENERAL PATHOLOGY AND PHYSIOPATHOLOGY AND THE COURSE COORDINATOR MEET THE STUDENTS ON TUESDAY AND THURSDAY AFTERNOON (H 14:30-16:30), UPON EMAIL APPOINTMENT. INTERESTED STUDENTS WILL BE ABLE TO ATTEND HIS RESEARCH LABORATORY TO DEEPEN THEIR KNOWLEDGE ON SPECIFIC SUBJECTS TREATED DURING HIS FORMAL LECTURES AND TO PREPARE AN EXPEIRIMENTAL DOCTORAL THESIS. THE PROFESSOR OF MEDICAL GENETICS MEETS THE STUDENTS ON WEDNESDAY AFTERNOON (H 14:00-15:00), UPON EMAIL APPOINTMENT. |
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