Giovanni NASSA | GENERAL PATHOLOGY
Giovanni NASSA GENERAL PATHOLOGY
cod. 1060200013
GENERAL PATHOLOGY
| 1060200013 | |
| DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL" | |
| EQF7 | |
| DENTISTRY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 2 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| MED/04 | 9 | 99 | LESSONS |
| Objectives | |
|---|---|
| THE STUDENT WILL LEARN THE MECHANISMS BY WHICH THE VARIOUS AGENTS CAUSING ILLNESS INTERACT WITH BIOLOGICAL SYSTEMS AND THEREBY INDUCE DAMAGE AND ALTERATIONS IN THE STRUCTURE AND FUNCTIONS OF CELLS, TISSUES AND ORGANS, DISRUPTING THE HOMEOSTATIC BALANCE AND CAUSIN ILLNESS ONSET AND PROGRESSION, INCLUDING THE ABILTY TO EVALUATE THE POTENTIAL PRACTICAL IMPACT OF SUCH NOTION. TO THIS END, THE CONCEPTUAL BASES FOR UNDERSTANDING THE CAUSES OF DISEASES IN HUMANS WILL BE PROVIDED, TOGETHER WITH GENERAL PATHOGENIC MECHANISMS AND PATHOPHYSIOLOGICAL PROCESSES AFFECTING CELLS, APPARATA AND SYSTEMS, INCLUDING GENDER-RELATED DIFFERENCES. THE STUDENT WILL ALSO LEARN THE BASIS OF HUMAN, MOLECULAR AND MEDICAL GENETICS; IN PARTICULAR THE STUDENT WILL GAIN KNOWLEDGE ON MENDELIAN, CHROMOSOMIC, MITOCHONDRIAL AND MULTIFACTORIAL DISORDERS AND RELATED LABORATORY TECHNIQUES TO STUDY THEM; CONCEPTS OF PHARMACOGENETICS, GENETIC COUNSELLING AND GENETIC TESTING. UPON COMPLETION OF THE COURSE, THE STUDENT WILL BE ABLE TO ANALYZE, IDENTIFY AND INTERPRET THE PATHOGENIC MECHANISMS THAT CAUSE HUMAN DISEASES AND THEIR CONSEQUENCES, AND MUST HAVE ACQUIRED BASIC INFORMATION ON THE MAIN DIAGNOSTIC TECHNIQUES, PARTICULARLY AT THE MOLECULAR LEVEL. THE KNOWLEDGE ACQUIRED WILL REPRESENT THE ESSENTIAL SUBSTRATE FOR A SUBSEQUENT CORRECT TO APPROACH CLINICAL SCIENCES. MOREOVER, THE COURSE WILL AIM AT PROVIDING STUDENTS WITH THE KNOWLEDGE REQUIRED TO UNDERSTAND THE MECHANISMS RESPONSIBLE FOR THE PRINCIPAL ALTERATIONS OF THE HOMEOSTATIC SYSTEMS OF THE ORGANISM, THEIR FUNCTIONAL CONSEQUENCES ON ORGANS AND SYSTEMS, THE COMPENSATORY MECHANISMS ACTIVATED AND THE PATHOPHYSIOLOGICAL MECHANISMS OF DISEASE, FOCUSING IN PARTICULAR ON: HEMATOPOIESIS AND BLOOD COMPONENTS, THE CARDIOVASCULAR, RESPIRATORY, URINARY, GASTROINTESTINAL, AND ENDOCRINE SYSTEMS, THE IMMUNE SYSTEM, LIPID AND CARBOHYDRATE METABOLISM, FLUID AND ELECTROLYTE BALANCE AND ACID-BASE BALANCE. |
| Prerequisites | |
|---|---|
| ACCORDING TO SECTION 11 OF THE PUBLISHED DIDACTIC GUIDELINES |
| Contents | |
|---|---|
| THE CONCEPT OF DISEASE: THE DISEASE AS LOSS OF THE HEALTH STATUS AND HOMEOSTATIC UNBALANCE ETIOLOGY: THE CONCEPT OF CAUSE IN PATHOLOGY; CHEMICAL, PHYSICAL AND BIOLOGICAL AGENTS OF DISEASE PATHOGENESIS: KEY PATHOGENIC MECHANISMS, INCLUDING GENDER-RELATED CASES THE COMPONENTS AND PHASES OF BLOOD CLOTTING (HAEMOSTASIS): THE PRO-COAGULANT ACTIVITY OF ENDOTHELIAL CELLS; THE ANTI-COAGULANT ACTIVITY OF ENDOTHELIAL CELLS; THE RELATIONSHIP BETWEEN STRUCTURAL AND FUNCTIONAL ELEMENTS OF PLATELETS; MEDIATORS OF PLATELET ACTIVATION; THE ACTIVATION AND AGGREGATION OF PLATELETS; THE PRO-COAGULANT FUNCTION OF PLATELETS; COAGULATION FACTORS; FIBRIN POLYMERISATION; ACTIVATION OF THE COAGULATION CASCADE; NATURAL ANTI-COAGULANTS; FIBRINOLYSIS PATHOLOGY GENOMICS: THE GENOME AS A CAUSE OF DISEASE, THE MOLECULAR LOGIC OF LIVING ORGANISMS; CONGENITAL AND HEREDITARY GENOMIC; CHROMOSOMAL AND GENE MUTATIONS; CAUSES, TAXONOMY, PATHOGENIC MECHANISMS AND CONSEQUENCES OF MUTATIONS; DISEASES RELATED TO MUTATIONS OF MITOCHONDRIAL DNA; GENOME INSTABILITY GENERAL ONCOLOGY: THE CONCEPT OF NEOPLASIA; PHYSIOLOGICAL AND PATHOLOGICAL PROLIFERATIONS; HISTOGENETIC AND CLINICAL CLASSIFICATION OF NEOPLASMS, BENIGNITY AND MALIGNANCY; TUMOR ATYPIA, TUMOR MARKERS NATURAL HISTORY OF CANCER: MULTIPHASIC CARCINOGENESIS, THE CONCEPT OF TUMOR PROGRESSION, ANGIOGENESIS, INFILTRATIVE GROWTH METASTASIS: DEFINITION AND GENERAL CONCEPTS; PRIMARY AND METASTATIC TUMORS; MOLECULAR MECHANISMS OF METASTASIS; METASTASTIC ROUTES; ORGANOTROPISM OF METASTASES ETIOLOGY OF CANCER: IONIZING AND EXCITING RADIATIONS, DNA AND RNA TUMOR VIRUSES, CHEMICAL CARCINOGENESIS, PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES REGULATION OF NORMAL AND TRANSFORMED CELL PROLIFERATION: GENES THAT CONTROL CELL CYCLE PROGRESSION AND CELLULAR SENESCENCE CANCER CACHEXIA PRECANCEROUS LESIONS MEDICAL GENETICS: CELLULAR DIVISION, MITOSIS AND MEIOSIS; DNA REPLICATION AND TRANSCRIPTION; PROTEIN SYNTHESIS; CONCEPT OF MUTATION, RARE VARIANT AND POLYMORPHISM; PEDIGREE DRAWING; INHERITANCE OF MONOGENIC TRAITS, MENDEL LAWS; AUTOSOMAL DOMINANT, AUTOSOMAL RECESSIVE, X-LINKED TRANSMISSION; CONCEPTS OF PENETRANCE, EXPRESSION, ANTICIPATION, FITNESS, MOSAICISM, PHENOCOPY, IMPRINTING, DE NOVO MUTATIONS; DYNAMIC MUTATIONS; GENETIC AND ALLELIC HETEROGENEITY; OLIGOGENIC INHERITANCE; MITOCHONDRIAL DNA AND INHERITANCE; KARYOTYPE AND CHROMOSOMAL CLASSIFICATION; NUMERICAL AND STRUCTURAL CHROMOSOMAL ABERRATIONS; MULTIFACTORIAL INHERITANCE, QUANTITATIVE TRAITS, THRESHOLD EFFECT; MULTIFACTORIAL DISEASES, CASE-CONTROL STUDIES; CONCEPTS OF PHARMACOGENETICS AND PHARMACOGENOMICS; CONCEPTS OF LINKAGE, LINKAGE DISEQUILIBRIUM AND FOUNDER EFFECT; CLASSIFICATIONS AND APPLICATIONS OF GENETIC TESTING; GENETIC COUNSELING; THERAPEUTIC STRATEGIES IN GENETIC DISEASES; MAIN TECHNIQUES OF GENOTYPING, SEQUENCING AND MOLECULAR CYTOGENETICS PHYSIOPATHOLOGY OF BLOOD AND HEMATOPOIESIS: ANEMIA PHYSIOPATHOLOGY OF BLOOD VESSELS PHYSIOPATHOLOGY OF CARDIOVASCULAR SYSTEM PHYSIOPATHOLOGY OF RESPIRATORY SYSTEM PHYSIOPATHOLOGY OF KIDNEY AND ITS COLLECTING SYSTEM PHYSIOPATHOLOGY OF HYDRO-ELECTROLYTIC BALANCE AND ACID-BASE BALANCE PHYSIOPATHOLOGY OF ENDOCRINE SYSTEM PHYSIOPATHOLOGY OF METABOLISM PHYSIOPATHOLOGY OF GASTROINTESTINAL SYSTEM (INCL. LIVER) PHYSIOPATHOLOGY OF THERMOREGULATION PHYSIOPATHOLOGY OF OBESITY PHYSIOPATHOLOGY OF AGING PHYSIOPATHOLOGY OF PAIN IMMUNOLOGY: B- AND T-CELL DEVELOPMENT; ANTIGEN PRESENTATION; CELLULAR AND HUMORAL RESPONSES; TOLERANCE; INNATE AND ADAPTIVE IMMUNITY; IMMUNITY TO INFECTIONS; IMMUNE MEMORY AND VACCINES; CANCER IMMUNITY; HYPERSENSITIVITY REACTIONS; AUTOIMMUNITY; MUCOSAL IMMUNITY |
| Teaching Methods | |
|---|---|
| FORMAL LECTURES AND INFORMAL COLLOQUIA WITH THE STUDENTS. |
| Verification of learning | |
|---|---|
| THE FINAL EXAMINATION WILL CONSIST OF AN ORAL INTERVIEW EXAMINATION, AIMED AT ASSESSING THE STUDENT'S ABILITY TO HAVE LEARNED THE FUNDAMENTAL PRINCIPLES OF THE MAIN PATHOLOGICAL PROCESSES AND ORGAN PATHOPHYSIOLOGY. THE MARK, EXPRESSED OUT OF THIRTY WITH POSSIBLE LAUD, WILL DEPEND ON THE MATURITY ACQUIRED IN THE COURSE CONTENT. FOR THE PURPOSE OF THE COMMUNICATION, THE QUALITY OF THE EXHIBITION WILL BE TAKEN INTO ACCOUNT, IN TERMS OF THE USE OF APPROPRIATE SCIENTIFIC LANGUAGE, AND THE DEMONSTRATED JUDGMENT INDEPENDENCE. |
| Texts | |
|---|---|
| ROBBINS AND COTRAN, PATHOLOGIC BASIS OF DISEASE, VIII EDITION, ELSEVIER - P. PARHAM, THE IMMUNE SYSTEM, 4TH EDITION, GARLAND SCIENCE, NEW YORK, 2015 - A.K. ABBAS, A.H. LICHTMAN, S. PILLAI, CELLULAR AND MOLECULAR IMMUNOLOGY, 8TH EDITION, SAUNDERS, PHILADELPHIA, 2015 (OR MORE RECENT EDITIONS OF THESE TEXTBOOKS) |
| More Information | |
|---|---|
| THE PROFESSORS OF GENERAL PATHOLOGY AND PHYSIOPATHOLOGY AND THE COURSE COORDINATOR MEET THE STUDENTS ON TUESDAY AND THURSDAY AFTERNOON (H 14:30-16:30), UPON EMAIL APPOINTMENT. THE PROFESSOR OF MEDICAL GENETICS MEETS THE STUDENTS ON WEDNESDAY AFTERNOON (H 14:00-15:00), UPON EMAIL APPOINTMENT. THE PROFESSOR OF IMMUNOLOGY MEETS THE STUDENTS ON WEDNESDAY MORNING (H 10:00-13:00), UPON EMAIL APPOINTMENT. INTERESTED STUDENTS WILL BE ABLE TO ATTEND THEIR RESEARCH LABORATORIES TO DEEPEN THEIR KNOWLEDGE ON SPECIFIC SUBJECTS TREATED DURING FORMAL LECTURES AND TO PREPARE AN EXPERIMENTAL DOCTORAL THESIS |
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