Paola IOVINO | C.I. MEDICAL SCIENCES I

cod. 1060200017

C.I. MEDICAL SCIENCES I

	1060200017
	DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL"
	EQF7
	DENTISTRY
	2024/2025

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2023
	SPRING SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	C.I. SCIENZE MEDICHE I - MOD. ANESTESIOLOGIA E TRATTAMENTO DELL’EMERGENZA
	MED/41	2	22	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	C.I. SCIENZE MEDICHE I - MOD. PATOLOGIA CLINICA
	MED/05	2	22	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
3	C.I. SCIENZE MEDICHE I - MOD. MEDICINA INTERNA
	MED/09	5	55	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
4	C.I. SCIENZE MEDICHE I - MOD. MALATTIE DEL SANGUE
	MED/15	1	11	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
5	C.I. SCIENZE MEDICHE I - MOD. MALATTIE INFETTIVE
	MED/17	1	11	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
6	C.I. SCIENZE MEDICHE I - MOD. MALATTIE INFETTIVE
	MED/17	1	11	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS
7	C.I. SCIENZE MEDICHE I - MOD. GASTROENTEROLOGIA
	MED/12	1	11	LESSONS	SUPPLEMENTARY COMPULSORY SUBJECTS
8	SCIENZE MEDICHE I - AFP MOD. MEDICINA INTERNA
	MED/09	2	0	INTERNAL STAGE	VARIOUS EDUCATIONAL ACTIVITIES

PROFESSORS

	CRISTIANA STELLATO2 T Curriculum
	-321
	MARIO MASARONE3 Curriculum
	CARMINE SELLERI4 Curriculum
	PASQUALE PAGLIANO65 Curriculum
	PAOLA IOVINO7 Curriculum

	Objectives
	EDUCATIONAL OBJECTIVES AT THE END OF THE COURSE THE STUDENT WILL BE ABLE TO USE RATIONALLY THE LABORATORY TEST IN ORDER TO OPTIMIZE THE DIAGNOSTIC-THERAPEUTIC PATHWAYS. STUDENTS WILL CRITICALLY EVALUATE THE DIAGNOSTIC METHODOLOGIES AND THE MEANING OF THE CLINICAL RESULTS OBTAINED IN DIFFERENT PATHOLOGICAL CONDITIONS. STUDENT WILL BE ALSO ABLE TO EVALUATE THE ANALYTICAL AND BIOLOGICAL CIRCUMSTANCES THAT CAN LEAD TO A MISINTERPRETATION OF THE RESULTS AND TO RELATE THEM TO THE DIFFERENT PHYSIOPATHOLOGICAL SITUATIONS TO ARRIVE AT A FINAL MEDICAL DECISION. DUBLIN DESCRIPTORS ACCORDING TO THE DUBLIN DESCRIPTORS, AT THE END OF THE COURSE AND TO PASS THE EXAM, THE STUDENT MUST DEVELOP: • A KNOWLEDGE AND A DEEP UNDERSTANDING OF THE MAIN PROCESSES IN CLINICAL PATHOLOGY. KNOWING THE STANDARD VALUES OF CLINICAL LABORATORY TEST IN ORDER TO DIFFERENTIATE PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. A DEEP UNDERSTANDING AND CRITICAL EVALUATION OF LABORATORY AND DIAGNOSTIC TEST INTERPRETATION • A THEORETICAL KNOWLEDGE OF THE CLINICAL AND LABORATORY FIELD, BY RECOGNIZING THE GENERAL DIAGNOSTIC ASPECTS OF GENETIC, BIOCHEMICAL, HAEMATOLOGICAL AND INFECTIOUS DISEASES. THE STUDENT MUST TO DISCUSS AND PERFORM CORRELATIONS ON SIMPLE DATA OR HYPOTHESES AND TO BE AWARE OF THE USEFULNESS OF THE MAIN GENETIC, HAEMATOLOGICAL AND BIOCHEMICAL PROFILES IN ORDER TO PROVIDE A DIFFERENTIAL DIAGNOSIS BASED ON SPECIFIC CLINICAL DATA. • THEORETICAL SKILLS TO INDEPENDENTLY AND CRITICALLY EVALUATE ANY DIFFERENT OPINIONS PRESENT IN CERTAIN TOPICS COVERED IN THE COURSE. RECOGNIZE THE FUNDAMENTAL ROLE OF A CORRECT THEORETICAL KNOWLEDGE OF THE SUBJECT IN CLINICAL PRACTICE AND IN THE FUTURE MEDICAL PROFESSION. • SKILLS TO PRESENT THE ARGUMENTS ORALLY IN AN ORGANIZED WAY AND WITH SEMANTIC APPROPRIATENESS AND IN ACCORDANCE WITH THE TOPIC OF DISCUSSION. AT THE SAME TIME KNOWING HOW TO COMMUNICATE CRITICALLY WITH THEIR PEERS ON THE TOPICS STUDIED AND TO SUPPORT INTERDISCIPLINARY ARGUMENTS. • AWARENESS OF THE IMPORTANCE OF THE ACQUIRED SKILLS IN THE MEDICAL CAREER IN THE FUTURE.

EDUCATIONAL OBJECTIVES
AT THE END OF THE COURSE THE STUDENT WILL BE ABLE TO USE RATIONALLY THE LABORATORY TEST IN ORDER TO OPTIMIZE THE DIAGNOSTIC-THERAPEUTIC PATHWAYS. STUDENTS WILL CRITICALLY EVALUATE THE DIAGNOSTIC METHODOLOGIES AND THE MEANING OF THE CLINICAL RESULTS OBTAINED IN DIFFERENT PATHOLOGICAL CONDITIONS. STUDENT WILL BE ALSO ABLE TO EVALUATE THE ANALYTICAL AND BIOLOGICAL CIRCUMSTANCES THAT CAN LEAD TO A MISINTERPRETATION OF THE RESULTS AND TO RELATE THEM TO THE DIFFERENT PHYSIOPATHOLOGICAL SITUATIONS TO ARRIVE AT A FINAL MEDICAL DECISION.
DUBLIN DESCRIPTORS
ACCORDING TO THE DUBLIN DESCRIPTORS, AT THE END OF THE COURSE AND TO PASS THE EXAM, THE STUDENT MUST DEVELOP:
• A KNOWLEDGE AND A DEEP UNDERSTANDING OF THE MAIN PROCESSES IN CLINICAL PATHOLOGY. KNOWING THE STANDARD VALUES OF CLINICAL LABORATORY TEST IN ORDER TO DIFFERENTIATE PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. A DEEP UNDERSTANDING AND CRITICAL EVALUATION OF LABORATORY AND DIAGNOSTIC TEST INTERPRETATION
• A THEORETICAL KNOWLEDGE OF THE CLINICAL AND LABORATORY FIELD, BY RECOGNIZING THE GENERAL DIAGNOSTIC ASPECTS OF GENETIC, BIOCHEMICAL, HAEMATOLOGICAL AND INFECTIOUS DISEASES. THE STUDENT MUST TO DISCUSS AND PERFORM CORRELATIONS ON SIMPLE DATA OR HYPOTHESES AND TO BE AWARE OF THE USEFULNESS OF THE MAIN GENETIC, HAEMATOLOGICAL AND BIOCHEMICAL PROFILES IN ORDER TO PROVIDE A DIFFERENTIAL DIAGNOSIS BASED ON SPECIFIC CLINICAL DATA.
• THEORETICAL SKILLS TO INDEPENDENTLY AND CRITICALLY EVALUATE ANY DIFFERENT OPINIONS PRESENT IN CERTAIN TOPICS COVERED IN THE COURSE. RECOGNIZE THE FUNDAMENTAL ROLE OF A CORRECT THEORETICAL KNOWLEDGE OF THE SUBJECT IN CLINICAL PRACTICE AND IN THE FUTURE MEDICAL PROFESSION.
• SKILLS TO PRESENT THE ARGUMENTS ORALLY IN AN ORGANIZED WAY AND WITH SEMANTIC APPROPRIATENESS AND IN ACCORDANCE WITH THE TOPIC OF DISCUSSION. AT THE SAME TIME KNOWING HOW TO COMMUNICATE CRITICALLY WITH THEIR PEERS ON THE TOPICS STUDIED AND TO SUPPORT INTERDISCIPLINARY ARGUMENTS.
• AWARENESS OF THE IMPORTANCE OF THE ACQUIRED SKILLS IN THE MEDICAL CAREER IN THE FUTURE.

	Prerequisites
	A COMPREHENSIVE KNOWLEDGE OF HUMAN PHYSIOLOGY AND GENERAL PATHOLOGY AND PHYSIOPATHOLOGY IS REQUIRED.

	Contents
	HEMATOLOGY: IRON DEFICIENCY ANEMIA; MEGALOBLASTIC ANEMIA; AUTOIMMUNE HEMOLYTIC ANEMIAS; TALASSEMICAL SYNDROMES; BONE MARROW APLASIA; ACUTE AND CHRONIC LEUKEMIA; MULTIPLE MYELOMA; HODGKIN’S LYMPHOMA AND NON-HODGKIN’S LYMPHOMA; THROMBOCYTOPENIA; HEMOPHILIAS AND VON WILLEBRAND DISEASE. INFECTIOUS DISEASE: ETIOLOGY, PATHOGENESIS, DIAGNOSTICS, CLINICAL PRESENTATION AND THERAPEUTIC APPROACH FOR THE MAIN INFECTIOUS DISEASES OF BACTERIAL, VIRAL, PROTOZOIC AND HELMINTIC AETIOLOGY. GASTROENTEROLOGY: GASTROINTESTINAL SYMPTOMS: ABDOMINAL PAIN, NAUSEA, DIARRHEA, CONSTIPATION; DISEASES OF ESOPHAGUS AND STOMACH; MALABSORPTION: PATHOPHYSIOLOGY, DIAGNOSIS; INFLAMMATORY BOWEL DISEASES, FUNCTIONAL GASTROINTESTINAL DISORDERS; LIVER: CHRONIC HEPATITIS, CIRRHOSIS AND ITS COMPLICATIONS; DIAGNOSTICS FOR LIVER DISEASE. ANESTHESIOLOGY AND CRITICAL CARE: CARDIOPULMONARY RESUSCITATION; GENDER VARIATION IN CARDIAC ARREST EPIDEMIOLOGY AND PROGNOSIS; LOCAL ANAESTHESIA; GENERAL ANAESTHESIA;GENDER VARIATION IN CLINICAL ANAETSHESIA; NARCOSIS AND CONSCIOUS SEDATION. INTERNAL MEDICINE: IMMUNE SYSTEM DISEASES: SYSTEMIC LUPUS ERYTHEMATOSUS, SARCOIDOSIS, SJOGREN'S SYNDROME, VASCULITIS, BEHCET'S DISEASE, RHEUMATIC DISEASE, RHEUMATOID ARTHRITIS, SCLERODERMA, AMYLOIDOSIS. INTERNAL APPROACH TO PATIENTS WITH FEVER. IMMUNODEFICIENCIES. INTERNAL MEDICINE APPROACH TO THE PATIENT WITH COUGH. CHRONIC RESPIRATORY DISEASES (BRONCHIAL ASTHMA, COPD). RECURRENT ORAL APHTHOSIS. ANAPHYLAXIS. URTICARIA AND ANGIOEDEMA. ALLERGIC DISEASES: GENERAL NOTIONS OF PATHOPHYSIOLOGY AND CLINICAL PRESENTATIONS. ADVERSE DRUG REACTIONS. LATEX ALLERGY. ALLERGY TO LOCAL ANESTHETICS. CHRONIC HEART FAILURE. SEPSIS. DISSEMINATED INTRAVASCULAR COAGULATION. DISCUSSION OF SCIENTIFIC ARTICLES AND CLINICAL CASES. CLINICAL PATHOLOGY • 1. CLINICAL PATHOLOGY: GENERAL CONCEPTS CORRECT USE OF LABORATORY TESTS. GENERAL INFORMATION ON BIOLOGICAL FLUIDS. UNITS OF MEASUREMENT, REFERENCE VALUES PRECISION AND ACCURACY OF A TEST. ERRORS IN DIAGNOSTICS (PRE-ANALYTICAL, ANALYTICAL, POST-ANALYTICAL PHASE). BIOLOGICAL VARIABILITY, INTRA AND INTERINDIVIDUAL VARIABILITY CONCEPTS OF SENSITIVITY, SPECIFICITY, PREDICTIVE VALUE (POSITIVE AND NEGATIVE). 2. DIAGNOSTICS OF BLOOD CELLS: BLOOD COUNT. BLOOD CELLS AND ERYTHROCYTE INDICES: MAIN ALTERATIONS LEUKOCYTES: LEUKOCYTOSIS AND LEUKOPENIA PLATELETS: HEMOSTATIC FUNCTION AND THROMBOTIC RISK TRANSFUSION MEDICINE: AB0 GROUP, RH TYPING, DIRECT AND INDIRECT COOMBS TEST 3. DIAGNOSTICS OF SERUM PROTEINS INFLAMMATION INDICES: ESR, PCR ELECTROPHORETIC PROTIDOGRAM MAIN ENZYME BIOMARKERS IMMUNOLOGICAL PARAMETERS: IMMUNOGLOBULINS; AUTOANTIBODIES DIAGNOSTICS OF LIVER FUNCTION 4. DIAGNOSTICS OF LIPOPROTEINS AND PLASMA LIPIDS. GLYCEMIA. LABORATORY DIAGNOSTICS IN DIABETES MELLITUS. INDICATORS OF CARDIOVASCULAR PATHOLOGY. 5. DIAGNOSTICS OF RENAL FUNCTION. URINE TEST.

Contents

HEMATOLOGY: IRON DEFICIENCY ANEMIA; MEGALOBLASTIC ANEMIA; AUTOIMMUNE HEMOLYTIC ANEMIAS; TALASSEMICAL SYNDROMES; BONE MARROW APLASIA; ACUTE AND CHRONIC LEUKEMIA; MULTIPLE MYELOMA; HODGKIN’S LYMPHOMA AND NON-HODGKIN’S LYMPHOMA; THROMBOCYTOPENIA; HEMOPHILIAS AND VON WILLEBRAND DISEASE.
INFECTIOUS DISEASE: ETIOLOGY, PATHOGENESIS, DIAGNOSTICS, CLINICAL PRESENTATION AND THERAPEUTIC APPROACH FOR THE MAIN INFECTIOUS DISEASES OF BACTERIAL, VIRAL, PROTOZOIC AND HELMINTIC AETIOLOGY.
GASTROENTEROLOGY: GASTROINTESTINAL SYMPTOMS: ABDOMINAL PAIN, NAUSEA, DIARRHEA, CONSTIPATION; DISEASES OF ESOPHAGUS AND STOMACH; MALABSORPTION: PATHOPHYSIOLOGY, DIAGNOSIS; INFLAMMATORY BOWEL DISEASES, FUNCTIONAL GASTROINTESTINAL DISORDERS; LIVER: CHRONIC HEPATITIS, CIRRHOSIS AND ITS COMPLICATIONS; DIAGNOSTICS FOR LIVER DISEASE.
ANESTHESIOLOGY AND CRITICAL CARE: CARDIOPULMONARY RESUSCITATION; GENDER VARIATION IN CARDIAC ARREST EPIDEMIOLOGY AND PROGNOSIS; LOCAL ANAESTHESIA; GENERAL ANAESTHESIA;GENDER VARIATION IN CLINICAL ANAETSHESIA; NARCOSIS AND CONSCIOUS SEDATION.
INTERNAL MEDICINE: IMMUNE SYSTEM DISEASES: SYSTEMIC LUPUS ERYTHEMATOSUS, SARCOIDOSIS, SJOGREN'S SYNDROME, VASCULITIS, BEHCET'S DISEASE, RHEUMATIC DISEASE, RHEUMATOID ARTHRITIS, SCLERODERMA, AMYLOIDOSIS. INTERNAL APPROACH TO PATIENTS WITH FEVER. IMMUNODEFICIENCIES. INTERNAL MEDICINE APPROACH TO THE PATIENT WITH COUGH. CHRONIC RESPIRATORY DISEASES (BRONCHIAL ASTHMA, COPD). RECURRENT ORAL APHTHOSIS. ANAPHYLAXIS. URTICARIA AND ANGIOEDEMA. ALLERGIC DISEASES: GENERAL NOTIONS OF PATHOPHYSIOLOGY AND CLINICAL PRESENTATIONS. ADVERSE DRUG REACTIONS. LATEX ALLERGY. ALLERGY TO LOCAL ANESTHETICS. CHRONIC HEART FAILURE. SEPSIS. DISSEMINATED INTRAVASCULAR COAGULATION. DISCUSSION OF SCIENTIFIC ARTICLES AND CLINICAL CASES.
CLINICAL PATHOLOGY
• 1. CLINICAL PATHOLOGY: GENERAL CONCEPTS CORRECT USE OF LABORATORY TESTS. GENERAL INFORMATION ON BIOLOGICAL FLUIDS. UNITS OF MEASUREMENT, REFERENCE VALUES PRECISION AND ACCURACY OF A TEST. ERRORS IN DIAGNOSTICS (PRE-ANALYTICAL, ANALYTICAL, POST-ANALYTICAL PHASE). BIOLOGICAL VARIABILITY, INTRA AND INTERINDIVIDUAL VARIABILITY CONCEPTS OF SENSITIVITY, SPECIFICITY, PREDICTIVE VALUE (POSITIVE AND NEGATIVE). 2. DIAGNOSTICS OF BLOOD CELLS: BLOOD COUNT. BLOOD CELLS AND ERYTHROCYTE INDICES: MAIN ALTERATIONS LEUKOCYTES: LEUKOCYTOSIS AND LEUKOPENIA PLATELETS: HEMOSTATIC FUNCTION AND THROMBOTIC RISK TRANSFUSION MEDICINE: AB0 GROUP, RH TYPING, DIRECT AND INDIRECT COOMBS TEST 3. DIAGNOSTICS OF SERUM PROTEINS INFLAMMATION INDICES: ESR, PCR ELECTROPHORETIC PROTIDOGRAM MAIN ENZYME BIOMARKERS IMMUNOLOGICAL PARAMETERS: IMMUNOGLOBULINS; AUTOANTIBODIES DIAGNOSTICS OF LIVER FUNCTION
4. DIAGNOSTICS OF LIPOPROTEINS AND PLASMA LIPIDS. GLYCEMIA. LABORATORY DIAGNOSTICS IN DIABETES MELLITUS. INDICATORS OF CARDIOVASCULAR PATHOLOGY. 5. DIAGNOSTICS OF RENAL FUNCTION. URINE TEST.

	Teaching Methods
	COURSE INFORMATIONS THE COURSE CONSISTS IN FRONTAL LESSONS THROUGH WHICH THE STUDENT WILL ACQUIRE THE KNOWLEDGE OF CLINICAL PATHOLOGY AND MAIN LABORATORY TECHNIQUES USEFUL FOR THE QUALITATIVE AND QUANTITATIVE STUDY OF PATHOGENETIC DETERMINANTS AND RELEVANT PROCESSES IN MEDICINE.

	Verification of learning
	EVALUATION PROCESS THE EXAM CONSISTS OF AN ORAL TEST AIMED AT VERIFYING THEORETICAL KNOWLEDGE OF THE FUNDAMENTALS OF MEDICAL GENETICS AND CLINICAL PATHOLOGY AND OF THE MAIN LABORATORY TECHNIQUES OF DIAGNOSTIC INTERVENTIONS AND THERAPEUTIC APPROACHES. THE SCORE OF THE ORAL EXAM IS AIMED AT EVALUATING THE THEORETICAL IN-DEPTH STUDY OF THE STUDENT. THE MINIMUM MARK IN THE ORAL EXAM IS ACHIEVED BY THE STUDENT WHO DEVELOP KNOWLEDGE OF THE TOPICS INCLUDED IN THE COURSE. THE MAXIMUM MARK IS ACHIEVED WHEN THE STUDENT DEMONSTRATES THAT HE CAN CORRECTLY ILLUSTRATE AND DISCUSS THE MAIN TOPICS IN THE PROGRAM WITH THE ABILITY TO ANALYZE AND SYNTHESIZE CORRECTLY AND WITH A COHERENT LOGICAL ARGUMENT. EXCELLENCE REQUIRES ACHIEVING THE MAXIMUM SCORE IN ALL EXAM MODULES AND HAVING DEMONSTRATED AN EXCELLENT LEVEL OF KNOWLEDGE AND UNDERSTANDING OF THE TOPICS AND A STRONG ABILITY TO CORRECTLY APPLY THE METHODOLOGIES DESIGNED TO DETECT CLINICAL, FUNCTIONAL AND LABORATORY RESULTS, ALSO CRITICALLY INTERPRETING THEM FROM A PHYSIOPATHOLOGICAL POINT OF VIEW, FOR THE PURPOSES OF DIAGNOSIS AND PROGNOSIS.

Verification of learning

EVALUATION PROCESS
THE EXAM CONSISTS OF AN ORAL TEST AIMED AT VERIFYING THEORETICAL KNOWLEDGE OF THE FUNDAMENTALS OF MEDICAL GENETICS AND CLINICAL PATHOLOGY AND OF THE MAIN LABORATORY TECHNIQUES OF DIAGNOSTIC INTERVENTIONS AND THERAPEUTIC APPROACHES.
THE SCORE OF THE ORAL EXAM IS AIMED AT EVALUATING THE THEORETICAL IN-DEPTH STUDY OF THE STUDENT. THE MINIMUM MARK IN THE ORAL EXAM IS ACHIEVED BY THE STUDENT WHO DEVELOP KNOWLEDGE OF THE TOPICS INCLUDED IN THE COURSE. THE MAXIMUM MARK IS ACHIEVED WHEN THE STUDENT DEMONSTRATES THAT HE CAN CORRECTLY ILLUSTRATE AND DISCUSS THE MAIN TOPICS IN THE PROGRAM WITH THE ABILITY TO ANALYZE AND SYNTHESIZE CORRECTLY AND WITH A COHERENT LOGICAL ARGUMENT. EXCELLENCE REQUIRES ACHIEVING THE MAXIMUM SCORE IN ALL EXAM MODULES AND HAVING DEMONSTRATED AN EXCELLENT LEVEL OF KNOWLEDGE AND UNDERSTANDING OF THE TOPICS AND A STRONG ABILITY TO CORRECTLY APPLY THE METHODOLOGIES DESIGNED TO DETECT CLINICAL, FUNCTIONAL AND LABORATORY RESULTS, ALSO CRITICALLY INTERPRETING THEM FROM A PHYSIOPATHOLOGICAL POINT OF VIEW, FOR THE PURPOSES OF DIAGNOSIS AND PROGNOSIS.

	Texts
	TESTI DI RIFERIMENTO LESSONS' HANDOUTS MEDICINA DI LABORATORIO - LOGICA & PATOLOGIA CLINICA ISBN: 978-88-299-2973-3 CODICE PICCIN: 0110090 AUTORI: ANTONOZZI - GULLETTA EMATOLOGIA SMART ISBN: 8879477714 AUTORI: GIONA EDITORE: IDELSON-GNOCCHI (2022)

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Paola IOVINO | C.I. MEDICAL SCIENCES I