Rosanna MARTINELLI | BIOCHEMISTRY AND MOLECULAR BIOLOGY

cod. 1060100050

BIOCHEMISTRY AND MOLECULAR BIOLOGY

	1060100050
	DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"
	EQF7
	MEDICINE AND SURGERY
	2017/2018

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2016
	ANNUALE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	BIOCHIMICA E BIOLOGIA MOLECOLARE - MOD. BIOCHIMICA
	BIO/10	10	120	LESSONS	BASIC COMPULSORY SUBJECTS
2	BIOCHIMICA E BIOLOGIA MOLECOLARE - MOD. BIOLOGIA MOLECOLARE
	BIO/11	5	60	LESSONS	BASIC COMPULSORY SUBJECTS

PROFESSORS

	ROSANNA MARTINELLI2 T Curriculum
	MARIA CATERINA TURCO1 Curriculum

	Objectives
	THIS COURSE IS DESIGNED TO PROVIDE STUDENTS WITH: FUNDAMENTALS OF BIOMOLECULES STRUCTURES AND FUNCTIONS. FUNDAMENTALS OF MAIN METABOLIC PATHWAYS. FURTHERMORE THE STUDENT WILL LEARN THE FUNDAMENTAL MOLECULAR MECHANISMS RELATED TO THE PROPAGATION AND MAINTENANCE OF GENETIC INFORMATION; WILL KNOW THE MOLECULAR MECHANISMS OF GENE EXPRESSION AND ITS REGULATIONS; WILL BE ABLE TO DESCRIBE AND SELECT APPROPRIATE TECHNOLOGIES FOR THE ANALYSIS OF BIOMOLECULAR MECHANISMS AND THE IDENTIFICATION OF MOLECULAR ORIGIN OF THE DISEASE, WILL KNOW THE GENERAL PROCESSES THROUGH WHICH GENETIC INFORMATION IS TRANSMITTED AND EXPRESSED. IN AGREEMENT WITH THE DUBLIN DESCRIPTORS, AT THE END OF THE COURSE THE STUDENT WILL DEMONSTRATE: 1.HAVE REACHED A BASIC KNOWLEDGE AND UNDERSTANDING OF BIOCHEMISTRY THAT ALLOWS HIM TO SET UP THE ANALYSIS OF THE CORRELATIONS BETWEEN THE STRUCTURE OF BIOMOLECULES AND THEIR FUNCTIONS IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS; 2.ABILITY TO ANALYZE, DISCUSS AND PERFORM SIMPLE CORRELATIONS OF DATA OR ASSUMPTIONS; 3.BEING ABLE EVALUATE INDEPENDENTLY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS TREATED IN THE COURSE; 4.BEING ABLE TO PROPERLY EXPOSE IN ITALIAN AND WITH PROPERTIES OF LANGUAGE KNOWLEDGE ACQUIRED; 5.KNOWING HOW TO COMMUNICATE WITH THEIR PEERS IN A CRITICAL MANNER THE THEMES STUDIED AND TO SUPPORT INTERDISCIPLINARY ARGUMENTS.

THIS COURSE IS DESIGNED TO PROVIDE STUDENTS WITH:
FUNDAMENTALS OF BIOMOLECULES STRUCTURES AND FUNCTIONS.
FUNDAMENTALS OF MAIN METABOLIC PATHWAYS.
FURTHERMORE THE STUDENT WILL LEARN THE FUNDAMENTAL MOLECULAR MECHANISMS RELATED TO THE PROPAGATION AND MAINTENANCE OF GENETIC INFORMATION; WILL KNOW THE MOLECULAR MECHANISMS OF GENE EXPRESSION AND ITS REGULATIONS; WILL BE ABLE TO DESCRIBE AND SELECT APPROPRIATE TECHNOLOGIES FOR THE ANALYSIS OF BIOMOLECULAR MECHANISMS AND THE IDENTIFICATION OF MOLECULAR ORIGIN OF THE DISEASE, WILL KNOW THE GENERAL PROCESSES THROUGH WHICH GENETIC INFORMATION IS TRANSMITTED AND EXPRESSED.
IN AGREEMENT WITH THE DUBLIN DESCRIPTORS, AT THE END OF THE COURSE THE STUDENT WILL DEMONSTRATE:
1.HAVE REACHED A BASIC KNOWLEDGE AND UNDERSTANDING OF BIOCHEMISTRY THAT ALLOWS HIM TO SET UP THE ANALYSIS OF THE CORRELATIONS BETWEEN THE STRUCTURE OF BIOMOLECULES AND THEIR FUNCTIONS IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS;
2.ABILITY TO ANALYZE, DISCUSS AND PERFORM SIMPLE CORRELATIONS OF DATA OR ASSUMPTIONS;
3.BEING ABLE EVALUATE INDEPENDENTLY ANY DIFFERENT OPINIONS EXIST IN CERTAIN TOPICS TREATED IN THE COURSE;
4.BEING ABLE TO PROPERLY EXPOSE IN ITALIAN AND WITH PROPERTIES OF LANGUAGE KNOWLEDGE ACQUIRED;
5.KNOWING HOW TO COMMUNICATE WITH THEIR PEERS IN A CRITICAL MANNER THE THEMES STUDIED AND TO SUPPORT INTERDISCIPLINARY ARGUMENTS.

	Prerequisites
	IN ORDER TO UNDERSTAND AND KNOW HOW TO APPLY THE TOPICS DISCUSSED IN TO THE COURSE STUDENTS MUST HAVE PASSED THE CHEMISTRY AND PROPEDEUTIC BIOCHEMISTRY AND APPLIED BIOLOGY

	Contents
	THE COURSE IS SUPPLEMENTED BY TWO MODULES: MODULE A BIOCHEMISTRY (10 CFU) AND MODULE B MOLECULAR BIOLOGY (5CFU) OF LESSONS AND SUPPLEMENTARY TEACHING. THE TOPICS COVERED IN THE BIOCHEMISTRY MODULE ARE: AMINO ACIDS AND PEPTIDES: CLASSIFICATION BASED ON THEIR CHEMICAL-PHYSICAL PROPERTIES. PROTEIC AND NON PROTEIC AMINOACIDES. PEPTIDIC BOND. LEVELS OF STRUCTURAL PROTEIN ORGANIZATION: PRIMARY STRUCTURE, SECONDARY STRUCTURE (ALPHA HELIX, THE BETA SHEET, RANDOM COIL); TERTIARY STRUCTURE STRUCTURE AND ORGANIZATION IN DOMAIN; QUATERNARY STRUCTURE, PROTEIN-PROTEIN INTERACTIONS. FIBROSE PROTEINS: CHERATIN, COLLAGEN. GLOBULAR PROTEINS: MYOGLOBIN AND HEMOGLOBIN. ENZYMES: GENERAL PROPERTIES AND CLASSIFICATION; MECHANISM OF ACTION OF ENZYMES: SERINE PROTEASES AND RIBONUCLEASE. KINETICS OF ENZYMATIC REACTIONS: EQUATION OF MICHAELIS-MENTEN. (MEANING OF KM, VMAX). DOUBLE-RECIPROCAL PLOTS. DEPENDENCE OF THE SPEED OF AN ENZYMATIC REACTION FROM THE CONCENTRATION OF THE SUBSTRATE, BY THE PRESENCE OF ACTIVATORS AND INHIBITORS, BY THE TEMPERATURE AND PH. ENZYMATIC INHIBITION: HIS IMPORTANCE. REVERSIBLE AND IRREVERSIBLE INHIBITION. COMPETITIVE, INCOMPETITIVE AND NON -COMPETITIVE INHIBITORS: DOUBLE-RECIPROCAL PLOTS FOR INDIVIDUALIZATION OF INHIBITION TYPE. ENZYME REACTIONS WITH TWO OR MORE SUBSTRATES: CASUAL MECHANISM, ORDERED, PING PONG. COENZYMES AND PROSTHETIC GROUPS. METALLIC IONES IN THE ENZYMES. COENZYMES AND VITAMINS, STRUCTURE AND FUNCTION OF VITAMINS B1, B2, B6, B12, NIACIN, BIOTIN, FOLIC ACID, LIPOIC ACID, PANTOTENIC ACID. REGULATION OF ENZYMATIC ACTIVITY: ALLOSTERIC REGULATION; POST-TRASLATIONAL MODIFICATIONS OF THE ENZYME PROTEINS AND THEIR FUNCTIONAL DESCRIPTION. GLYCOGEN PHOSPHORYLASE AND GLYCOGEN SYNTHASE. ZYMOGENS. AMPLIFICATION OF THE SIGNAL THROUGH ENZYME CASCADE: BLOOD COAGULATION. DIGESTION AND ABSORPTION OF PROTEINS. ISOENZYMES. MULTIENZYME COMPLEXES: PYRUVATE DEHYDROGENASE AND FATTY ACID SYNTHASE. THE TOPICS COVERED IN THE MOLECULAR BIOLOGY MODULE ARE: STRUCTURE OF NUCLEIC ACIDS AND THEIR INTERACTIONS WITH PROTEINS: STRUCTURE AND TOPOLOGY OF DNA; STRUCTURE OF RNA, RIBOZYMES, CHROMATIN, HISTONES AND NUCLEOSOMES, REGULATION OF CHROMATIN STRUCTURE REPLICATION AND REPAIR OF DNA DAMAGE: MECHANISM OF ACTION OF DNA POLYMERASE, STAGE OF START AND TERMINATION OF REPLICATION, TELOMERES AND TELOMERASE; REPLICATION ERRORS AND THEIR REPAIR; DIFFERENT TYPES OF MUTATION. TRANSCRIPTION AND POST-TRANSCRIPTIONAL MODIFICATIONS, STRUCTURE AND FUNCTION OF RNA POLYMERASE, PROMOTERS OF RNA POLYMERASE I AND III; PROMOTERS OF RNA POLYMERASE II, GENERAL TRANSCRIPTION FACTORS, THE MEDIATOR COMPLEX; MESSENGER RNA PROCESSING: CAPPING, SPLICING AND POLYADENYLATION; THE SPLICEOSOME, SELF-SPLICING INTRONS, ALTERNATIVE SPLICING. TRANSLATION: OPEN READING FRAME; STRUCTURE AND FUNCTION OF TRNA, AMINOACYL-TRNA SYNTHETASES, THE RIBOSOME, INITIATION, ELONGATION AND TERMINATION OF TRANSLATION, THE GENETIC CODE. REGULATION OF GENE EXPRESSION: TRANSCRIPTIONAL ACTIVATORS; SIGNAL INTEGRATION AND COMBINATORIAL CONTROL, SIGNAL TRANSDUCTION AND CONTROL OF TRANSCRIPTIONAL REGULATORS; GENE SILENCING, EPIGENETICS, RNA INTERFERENCE; SYNTHESIS AND FUNCTION OF MIRNAS RECOMBINANT DNA TECHNOLOGY AND GENE EXPRESSION ANALYSIS: ELECTROPHORESIS OF NUCLEIC ACIDS, RESTRICTION ENZYMES, VECTORS AND CLONING STRATEGIES; EMSA; FOOTPRINTING; SOUTHERN AND NORTHERN BLOT; PCR, RT-PCR, DNA SEQUENCING, HIGH THROUGHPUT TECHNOLOGIES.

Contents

THE COURSE IS SUPPLEMENTED BY TWO MODULES: MODULE A BIOCHEMISTRY (10 CFU) AND MODULE B MOLECULAR BIOLOGY (5CFU) OF LESSONS AND SUPPLEMENTARY TEACHING.
THE TOPICS COVERED IN THE BIOCHEMISTRY MODULE ARE:
AMINO ACIDS AND PEPTIDES: CLASSIFICATION BASED ON THEIR CHEMICAL-PHYSICAL PROPERTIES. PROTEIC AND NON PROTEIC AMINOACIDES. PEPTIDIC BOND. LEVELS OF STRUCTURAL PROTEIN ORGANIZATION: PRIMARY STRUCTURE, SECONDARY STRUCTURE (ALPHA HELIX, THE BETA SHEET, RANDOM COIL); TERTIARY STRUCTURE STRUCTURE AND ORGANIZATION IN DOMAIN; QUATERNARY STRUCTURE, PROTEIN-PROTEIN INTERACTIONS. FIBROSE PROTEINS: CHERATIN, COLLAGEN. GLOBULAR PROTEINS: MYOGLOBIN AND HEMOGLOBIN.
ENZYMES: GENERAL PROPERTIES AND CLASSIFICATION; MECHANISM OF ACTION OF ENZYMES: SERINE PROTEASES AND RIBONUCLEASE. KINETICS OF ENZYMATIC REACTIONS: EQUATION OF MICHAELIS-MENTEN. (MEANING OF KM, VMAX). DOUBLE-RECIPROCAL PLOTS. DEPENDENCE OF THE SPEED OF AN ENZYMATIC REACTION FROM THE CONCENTRATION OF THE SUBSTRATE, BY THE PRESENCE OF ACTIVATORS AND INHIBITORS, BY THE TEMPERATURE AND PH. ENZYMATIC INHIBITION: HIS IMPORTANCE. REVERSIBLE AND IRREVERSIBLE INHIBITION. COMPETITIVE, INCOMPETITIVE AND NON -COMPETITIVE INHIBITORS: DOUBLE-RECIPROCAL PLOTS FOR INDIVIDUALIZATION OF INHIBITION TYPE. ENZYME REACTIONS WITH TWO OR MORE SUBSTRATES: CASUAL MECHANISM, ORDERED, PING PONG.
COENZYMES AND PROSTHETIC GROUPS. METALLIC IONES IN THE ENZYMES. COENZYMES AND VITAMINS, STRUCTURE AND FUNCTION OF VITAMINS B1, B2, B6, B12, NIACIN, BIOTIN, FOLIC ACID, LIPOIC ACID, PANTOTENIC ACID.
REGULATION OF ENZYMATIC ACTIVITY: ALLOSTERIC REGULATION; POST-TRASLATIONAL MODIFICATIONS OF THE ENZYME PROTEINS AND THEIR FUNCTIONAL DESCRIPTION. GLYCOGEN PHOSPHORYLASE AND GLYCOGEN SYNTHASE.
ZYMOGENS. AMPLIFICATION OF THE SIGNAL THROUGH ENZYME CASCADE: BLOOD COAGULATION. DIGESTION AND ABSORPTION OF PROTEINS.
ISOENZYMES. MULTIENZYME COMPLEXES: PYRUVATE DEHYDROGENASE AND FATTY ACID SYNTHASE.
THE TOPICS COVERED IN THE MOLECULAR BIOLOGY MODULE ARE:
STRUCTURE OF NUCLEIC ACIDS AND THEIR INTERACTIONS WITH PROTEINS: STRUCTURE AND TOPOLOGY OF DNA; STRUCTURE OF RNA, RIBOZYMES, CHROMATIN, HISTONES AND NUCLEOSOMES, REGULATION OF CHROMATIN STRUCTURE
REPLICATION AND REPAIR OF DNA DAMAGE: MECHANISM OF ACTION OF DNA POLYMERASE, STAGE OF START AND TERMINATION OF REPLICATION, TELOMERES AND TELOMERASE; REPLICATION ERRORS AND THEIR REPAIR; DIFFERENT TYPES OF MUTATION.
TRANSCRIPTION AND POST-TRANSCRIPTIONAL MODIFICATIONS, STRUCTURE AND FUNCTION OF RNA POLYMERASE, PROMOTERS OF RNA POLYMERASE I AND III; PROMOTERS OF RNA POLYMERASE II, GENERAL TRANSCRIPTION FACTORS, THE MEDIATOR COMPLEX; MESSENGER RNA PROCESSING: CAPPING, SPLICING AND POLYADENYLATION; THE SPLICEOSOME, SELF-SPLICING INTRONS, ALTERNATIVE SPLICING.
TRANSLATION: OPEN READING FRAME; STRUCTURE AND FUNCTION OF TRNA, AMINOACYL-TRNA SYNTHETASES, THE RIBOSOME, INITIATION, ELONGATION AND TERMINATION OF TRANSLATION, THE GENETIC CODE.
REGULATION OF GENE EXPRESSION: TRANSCRIPTIONAL ACTIVATORS; SIGNAL INTEGRATION AND COMBINATORIAL CONTROL, SIGNAL TRANSDUCTION AND CONTROL OF TRANSCRIPTIONAL REGULATORS; GENE SILENCING, EPIGENETICS, RNA INTERFERENCE; SYNTHESIS AND FUNCTION OF MIRNAS
RECOMBINANT DNA TECHNOLOGY AND GENE EXPRESSION ANALYSIS: ELECTROPHORESIS OF NUCLEIC ACIDS, RESTRICTION ENZYMES, VECTORS AND CLONING STRATEGIES; EMSA; FOOTPRINTING; SOUTHERN AND NORTHERN BLOT; PCR, RT-PCR, DNA SEQUENCING, HIGH THROUGHPUT TECHNOLOGIES.

	Teaching Methods
	THE COURSE IS DIVIDED INTO TWO MODULES AND PROVIDES 180 HOURS OF ASSISTED LEARNING (15 CFU) ALLOCATED BETWEEN THE TEACHING HOURS IN THE FORM OF CLASSROOM LECTURES AND HOURS OF SUPPLEMENTARY ACTIVITIES (ADI) CONSIST OF SEMINARS, LABORATORY EXERCISES, PRACTICE EXAMS, CORRECTIONS, STUDY GROUPS FOR THE ANALYSIS AND ELABORATION OF SCIENTIFIC PUBLICATIONS. 120 HOURS (10CFU) ARE OCCUPIED BY THE BIOCHEMISTRY MODULE, AND 60 HOURS (6 CFUS) FROM THE MOLECULAR BIOLOGY MODULE. IN THE BIOCHEMISTRY MODULE, 80 HOURS OF LESSON ARE DELIVERED IN THE CLASSROOM WITH THE AID OF PROJECTIONS AND IN THE 40 HOURS, THERE ARE GUIDED LABORATORY EXERCISES, PRACTICE EXAMS AND CORRECTIONS. IN THE MOLECULAR BIOLOGY MODULE, 40 HOURS ARE DELIVERED AS FRONTAL LECTURES IN THE CLASSROOM WITH THE AID OF PROJECTIONS AND 20 HOURS OF SUPPLEMENTARY DIDACTICS DURING WHICH THE STUDENTS, SUBDIVIDED INTO STUDY GROUPS, WILL UNDERTAKE THE DEEPENING OF REGULATORY PROCESSES AND MOLECULAR MECHANISMS INVOLVED IN THE DEVELOPMENT OF HUMAN PATHOLOGIES THROUGH THE ANALYSIS AND ELABORATION OF SCIENTIFIC PUBLICATIONS SELECTED BY THE TEACHER. THE FREQUENCY OF CLASSROOM LESSONS AND LABORATORY EXERCISES IS COMPULSORY. TO QUALIFY FOR THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 70% OF THE TUITION HOURS. THE ATTENDANCE VERIFICATION MODE IS ANNOUNCED BY THE TEACHER AT THE BEGINNING OF THE LESSONS.

Teaching Methods

THE COURSE IS DIVIDED INTO TWO MODULES AND PROVIDES 180 HOURS OF ASSISTED LEARNING (15 CFU) ALLOCATED BETWEEN THE TEACHING HOURS IN THE FORM OF CLASSROOM LECTURES AND HOURS OF SUPPLEMENTARY ACTIVITIES (ADI) CONSIST OF SEMINARS, LABORATORY EXERCISES, PRACTICE EXAMS, CORRECTIONS, STUDY GROUPS FOR THE ANALYSIS AND ELABORATION OF SCIENTIFIC PUBLICATIONS.
120 HOURS (10CFU) ARE OCCUPIED BY THE BIOCHEMISTRY MODULE, AND 60 HOURS (6 CFUS) FROM THE MOLECULAR BIOLOGY MODULE. IN THE BIOCHEMISTRY MODULE, 80 HOURS OF LESSON ARE DELIVERED IN THE CLASSROOM WITH THE AID OF PROJECTIONS AND IN THE 40 HOURS, THERE ARE GUIDED LABORATORY EXERCISES, PRACTICE EXAMS AND CORRECTIONS. IN THE MOLECULAR BIOLOGY MODULE, 40 HOURS ARE DELIVERED AS FRONTAL LECTURES IN THE CLASSROOM WITH THE AID OF PROJECTIONS AND 20 HOURS OF SUPPLEMENTARY DIDACTICS DURING WHICH THE STUDENTS, SUBDIVIDED INTO STUDY GROUPS, WILL UNDERTAKE THE DEEPENING OF REGULATORY PROCESSES AND MOLECULAR MECHANISMS INVOLVED IN THE DEVELOPMENT OF HUMAN PATHOLOGIES THROUGH THE ANALYSIS AND ELABORATION OF SCIENTIFIC PUBLICATIONS SELECTED BY THE TEACHER.
THE FREQUENCY OF CLASSROOM LESSONS AND LABORATORY EXERCISES IS COMPULSORY. TO QUALIFY FOR THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 70% OF THE TUITION HOURS. THE ATTENDANCE VERIFICATION MODE IS ANNOUNCED BY THE TEACHER AT THE BEGINNING OF THE LESSONS.

	Verification of learning
	THE LEVEL OF ACHIEVEMENT OF THE OBJECTIVES OF TEACHING IS CERTIFIED BY PASSING AN EXAM WITH EVALUATION OF THIRTY. VERIFICATION INVOLVES A WRITTEN TEST PASSED WHICH THE STUDENT WILL BE ABLE TO TAKE THE ORAL TEST THAT TAKES PLACE ON THE SAME DAY. THE WRITTEN TEST CONSISTS OF 30 MULTIPLE CHOICE QUESTIONS ON TOPICS OF THE TEACHING PROGRAM TEST. THE TEST TAKES PLACE PRIOR TO THE ORAL TEST AND IS PASSED WITH THE ACHIEVEMENT OF THE PREDETERMINED MINIMUM SCORE OF 18/30. THE WRITTEN TEST WILL NORMALLY HAVE A DURATION OF 30 MINUTES AND IS DESIGNED TO TEST THE ABILITY TO PROPERLY APPLY THE THEORETICAL KNOWLEDGE AND THE PROPOSALS ISSUES UNDERSTANDING. THE ORAL TEST IS INTENDED TO ASCERTAIN THE LEVEL OF KNOWLEDGE OF THEORETICAL CONTENTS IN THE EVENT OF ERRORS IN THE WRITTEN TEST; THE LEVEL OF EXPERTISE ACHIEVED IN THE EXHIBITION SUCH AS LANGUAGE PROPERTY, LOGICAL - DEDUCTIVE AND SYNTHESIS SKILLS. THE FINAL VOTE COMES FROM THE TWO TRIALS. THE MINIMUM VOTE FOR PASSING THE EXAM IS 18/30. PRAISE MAY BE ATTRIBUTED TO STUDENTS WHO DEMONSTRATE THAT THEY ARE ABLE TO APPLY THEIR OWN KNOWLEDGE AND SKILLS ACQUIRED IN CONTEXTS OTHER THAN THOSE PROPOSED IN LESSONS.

Verification of learning

THE LEVEL OF ACHIEVEMENT OF THE OBJECTIVES OF TEACHING IS CERTIFIED BY PASSING AN EXAM WITH EVALUATION OF THIRTY. VERIFICATION INVOLVES A WRITTEN TEST PASSED WHICH THE STUDENT WILL BE ABLE TO TAKE THE ORAL TEST THAT TAKES PLACE ON THE SAME DAY.
THE WRITTEN TEST CONSISTS OF 30 MULTIPLE CHOICE QUESTIONS ON TOPICS OF THE TEACHING PROGRAM TEST. THE TEST TAKES PLACE PRIOR TO THE ORAL TEST AND IS PASSED WITH THE ACHIEVEMENT OF THE PREDETERMINED MINIMUM SCORE OF 18/30. THE WRITTEN TEST WILL NORMALLY HAVE A DURATION OF 30 MINUTES AND IS DESIGNED TO TEST THE ABILITY TO PROPERLY APPLY THE THEORETICAL KNOWLEDGE AND THE PROPOSALS ISSUES UNDERSTANDING.
THE ORAL TEST IS INTENDED TO ASCERTAIN THE LEVEL OF KNOWLEDGE OF THEORETICAL CONTENTS IN THE EVENT OF ERRORS IN THE WRITTEN TEST; THE LEVEL OF EXPERTISE ACHIEVED IN THE EXHIBITION SUCH AS LANGUAGE PROPERTY, LOGICAL - DEDUCTIVE AND SYNTHESIS SKILLS. THE FINAL VOTE COMES FROM THE TWO TRIALS. THE MINIMUM VOTE FOR PASSING THE EXAM IS 18/30. PRAISE MAY BE ATTRIBUTED TO STUDENTS WHO DEMONSTRATE THAT THEY ARE ABLE TO APPLY THEIR OWN KNOWLEDGE AND SKILLS ACQUIRED IN CONTEXTS OTHER THAN THOSE PROPOSED IN LESSONS.

	Texts
	BAYNES AND DOMINICZAK, BIOCHIMICA MEDICA, ED. ELSEVIER LEHNINGER, NELSON & COX, PRINCIPI DI BIOCHIMICA, ED. ZANICHELLI MATHEWS, VAN HOLD, AHEREN, BIOCHIMICA, ED. AMBROSIANA STRYER, BIOCHIMICA, ED. ZANICHELLI DEVLIN BIOCHIMICA CON ASPETTI CLINICI ED EDISES CAMPBELL & FARRELL, BIOCHIMICA, ED. EDISES J.D. WATSON ET AL, BIOLOGIA MOLECOLARE DEL GENE, SETTIMA EDIZIONE CASA ED. ZANICHELLI LEWIN ET AL., CELLULE, CASA ED. ZANICHELLI ALBERTS ET AL., “BIOLOGIA MOLECOLARE DELLA CELLULA”, V EDIZIONE, CASA ED. ZANICHELLI TEACHING MATERIALS, PROVIDED BY THE TUTORS

Texts

BAYNES AND DOMINICZAK, BIOCHIMICA MEDICA, ED. ELSEVIER
LEHNINGER, NELSON & COX, PRINCIPI DI BIOCHIMICA, ED. ZANICHELLI
MATHEWS, VAN HOLD, AHEREN, BIOCHIMICA, ED. AMBROSIANA
STRYER, BIOCHIMICA, ED. ZANICHELLI
DEVLIN BIOCHIMICA CON ASPETTI CLINICI ED EDISES
CAMPBELL & FARRELL, BIOCHIMICA, ED. EDISES
J.D. WATSON ET AL, BIOLOGIA MOLECOLARE DEL GENE, SETTIMA EDIZIONE CASA ED. ZANICHELLI
LEWIN ET AL., CELLULE, CASA ED. ZANICHELLI
ALBERTS ET AL., “BIOLOGIA MOLECOLARE DELLA CELLULA”, V EDIZIONE, CASA ED. ZANICHELLI
TEACHING MATERIALS, PROVIDED BY THE TUTORS

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Rosanna MARTINELLI | BIOCHEMISTRY AND MOLECULAR BIOLOGY