JESSICA DAL COL | Progetti

Ruolo delle RNA-binding proteins nel tumore del polmone

Study objectives are: (1) To investigate the impact of HuR silencing/inhibition on the architecture and growth of 3D tumor spheroids in TKI-sensitive and TKI-resistant NSCLC cell lines; (2) To evaluate the spatial distribution of cancer cells with preserved/ablated HuR expression within co-cultured 3D spheroids, providing insights into their interactions and localization;(3) To analyse cytokine/p

Study aim is understanding RBPs role in (1) EGFR-TKI-induced modification of immune-related proteins levels, such as CD47 and PD-L1, with consequent impact on evasion of NK cell-mediated cytotoxicity; (2) EGFR-TKI-promoted cytokine secretion and impact on EGFR-TKI-resistance acquisition, tumor cell migration and invasion. We will use sensitive/resistant NSCLC cell lines with physiological and exog