CLINICAL IMMUNOLOGY AND ALLERGOLOGY - CUTANEOUS AND VENEREE DISEASES - REUMATOLOGY

ANNUNZIATA RAIMONDO CLINICAL IMMUNOLOGY AND ALLERGOLOGY - CUTANEOUS AND VENEREE DISEASES - REUMATOLOGY

1060100086
DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"
EQF7
MEDICINE AND SURGERY
2021/2022

OBBLIGATORIO
YEAR OF COURSE 4
YEAR OF DIDACTIC SYSTEM 2016
SECONDO SEMESTRE
CFUHOURSACTIVITY
1IMMUNOLOGIA CLINICA E ALLERGOLOGIA - MALATTIE CUTANEE E VENEREE - REUMATOLOGIA - MOD IMMUNOLOGIA CLINICA
112LESSONS
2IMMUNOLOGIA CLINICA E ALLERGOLOGIA - MALATTIE CUTANEE E VENEREE - REUMATOLOGIA - MOD ALLERGOLOGIA
224LESSONS
3IMMUNOLOGIA CLINICA E ALLERGOLOGIA - MALATTIE CUTANEE E VENEREE - REUMATOLOGIA - MOD ALLERGOLOGIA
112LESSONS
4IMMUNOLOGIA CLINICA E ALLERGOLOGIA - MALATTIE CUTANEE E VENEREE - REUMATOLOGIA - MOD MALATTIE CUTANEE VENEREE
224LESSONS
5IMMUNOLOGIA CLINICA E ALLERGOLOGIA - MALATTIE CUTANEE E VENEREE - REUMATOLOGIA - MOD REUMATOLOGIA
224LESSONS
Objectives
THIS COURSE REPRESENTS ONE OF THE FIRST APPROACH TO CLINICAL SPECIALTIES IN THE CURRICULUM OF THE STUDENT. THE MAIN OBJECTIVE IS TO DEVELOP SPECIFIC KNOWLEDGE ON THE CLINICAL COURSE, DIAGNOSIS, BASIC TREATMENT AND GLOBAL MANAGEMENT OF PATIENTS WITH ALLERGIC DISORDERS, AUTOIMMUNE AND RHEUMATOLOGIC DISEASES AND THE MAJOR CUTANEOUS DISEASES. AN INTEGRATED APPROACH TO THE THREE SPECIALTIES IS EMPHASIZED BY THE FUNDAMENTAL SHARING OF PATHOGENETIC MECHANISMS.

AT THE COMPLETION OF THE MODULE THE STUDENT SHALL:
- POSSESS KNOWLEDGE OF THE PATHOPHYSIOLOGICAL BASES OF ALLERGIC AND AUTOIMMUNE DISEASES AND OF PRIMARY AND SECONDARY IMMUNE DEFICIENCIES
- POSSESS KNOWLEDGE OF THE MAIN CLINICAL MANIFESTATIONS AND THE BASIC ELEMENTS OF THE DIAGNOSTIC AND THERAPEUTIC MANAGEMENT OF THE PATIENT WITH IMMUNE-MEDIATED CONDITIONS

KNOWLEDGE AND UNDERSTANDING:
KNOWLEDGE OF THE TOPICS LISTED IN THE COURSE PROGRAM AND ACQUIREMENT OF THE APPROPRIATE TERMINOLOGY USED IN CLINICAL SETTINGS FOR THE MEDICAL BRANCHES INCLUDED IN THE INTEGRATED COURSE; UNDERSTANDING OF THE CELLULAR AND MOLECULAR BASIS OF IMMUNE RESPONSE’S REGULATION AND OF THEIR ALTERATIONS IN ALLERGIC AND AUTOIMMUNE DISORDERS AND IMMUNODEFICIENCIES; SIMILAR REQUIREMENTS FOR DERMATOLOGICAL AND RHEUMATOLOGICAL DISEASES; KNOWLEDGE AND UNDERSTANDING OF HOW TO COLLECT A DISEASE-SPECIFIC MEDICAL HISTORY, TO REQUEST/INTERPRET THE RELATED LABORATORY AND INSTRUMENTAL DIAGNOSTICS TO SET UP APPROPRIATE THERAPIES ALSO IN RELATION TO DIFFERENT STAGES OF LIFE AND OF GENDER MEDICINE.

APPLYING KNOWLEDGE AND UNDERSTANDING:
THE STUDENT WILL BE REQUIRED TO DEMONSTRATE THE ABILITY TO APPLY THE ACQUIRED KNOWLEDGE IN THE FOLLOWING INSTANCES: 1) IDENTIFY THE UNDERLYING IMMUNE ALTERATIONS CAUSING ALLERGIC DISEASES, IMMUNE-MEDIATED DISEASES AND IMMUNODEFICIENCY AS WELL AS RHEUMATIC AND DERMATOLOGICAL PATHOLOGIES, ALSO IN RELATION TO DIFFERENT STAGES OF LIFE AND OF GENDER MEDICINE; 2) LEAD A CORRECT ANAMNESIS AND PHYSICAL EXAM ACCORDING TO CLINICAL PRESENTATIONS; 3) RECOGNIZE, DIAGNOSE AND EVALUATE THE MAIN SYMPTOMS AND CLINICAL PRESENTATIONS; 4) IDENTIFY THERAPEUTIC APPROACHES AND THEIR RATIONALE; 5) TRANSLATE THE KNOWLEDGE AND UNDERSTANDING OF THE DISEASES STUDIED IN EFFECTIVE COMMUNICATION WITH PATIENTS AND MEDICAL STAFF.

MAKING JUDGEMENTS:
THE STUDENT SHALL ACQUIRE THE ABILITY TO IMPROVE HIS/HER KNOWLEDGE THROUGH THE STUDY OF EXPERIMENTAL SYSTEMS AND COMPLEX CLINICAL CASES IN ORDER TO DEVELOP CRITICAL THINKING AND INDEPENDENT CLINICAL JUDGMENT

COMMUNICATION SKILLS:
THE STUDENT SHALL DEVELOP THE ABILITY TO EXPLAIN, IN SIMPLE, TERMINOLOGICALLY APPROPRIATE AND EXHAUSTIVE TERMS, THE ACQUIRED NOTIONS AND TERMINOLOGY

LEARNING SKILLS:
ON THE BASIS OF KNOWLEDGE ACQUIRED DURING THE MODULE AND WITH INDIVIDUAL STUDY, THE STUDENT SHALL EXHIBIT THE ABILITY TO UPDATE HER/HIS KNOWLEDGE BY READING AND UNDERSTANDING SCIENTIFIC PUBLICATIONS RELATED TO ALLERGY AND CLINICAL IMMUNOLOGY, DERMATOLOGY AND RHEUMATOLOGY
Prerequisites
KNOWLEDGE OF THE TOPICS COVERED BY THE COURSES OF HUMAN ANATOMY, BIOCHEMISTRY, IMMUNOLOGY, MICROBIOLOGY, AND PHYSIOPATHOLOGY
Contents
ALLERGY AND CLINICAL IMMUNOLOGY
ALLERGEN: DEFINITION AND MOLECULAR MECHANISMS OF ALLERGIC SENSITIZATION
PATHOPHYSIOLOGICAL BASIS:
-CELLULAR TYPES AND MEDIATORS INVOLVED IN ALLERGIC INFLAMMATION
-T CELL PHENOTYPES, IMMUNOREGULATION OF ALLERGIC /AUTOIMMUNE (A/A) DISEASES
-GELL&COOMBS IMMUNOPATHOGENIC REACTIONS IN A/A DISEASES
-CYTOKINES AND CHEMOKINES
THE ATOPIC PATIENT: DEFINITION OF THE “ATOPIC MARCH”
ATOPIC DERMATITIS
FOOD ALLERGY
ALLERGIC RHINOCONJUNCTIVITIS
ALLERGIC BRONCHIAL ASTHMA
CHRONIC ALLERGIC RHINOSINUSITIS
IMMUNOPATHOLOGY OF ACUTE AND CHRONIC URTICARIA
HEREDITARY AND ACQUIRED ANGIOEDEMA
SYSTEMIC ANAPHYLAXIS (ALLERGIC, IDIOPATHIC, EXERCISE-INDUCED)
IMMUNOTHERAPY
DRUG ALLERGY
SYSTEMIC AND ORGAN-SPECIFIC HYPEREOSINOPHILIC DISORDERS
MASTOCYTOSIS AND MAST CELL ACTIVATION-RELATED SYNDROMES
PRIMARY IMMUNODEFICIENCIES:
-SEVERE COMBINED IMMUNODEFICIENCY (SCID)
-BRUTON’S DISEASE
-HYPER-IGM SYNDROME
-HYPER-IGE SYNDROME
-COMMON VARIABLE IMMUNODEFICIENCY
SECONDARY IMMUNODEFICIENCIES
ORGAN-SPECIFIC AUTOIMMUNE DISEASES
MOLECULAR AND CELLULAR DIAGNOSTIC TECHNIQUES

DERMATOLOGICAL (DERM) AND VENEREAL DISEASES
ANATOMY AND PHYSIOLOGY OF THE SKIN
HYSTOPATHOLOGY OF CUTANEOUS ALTERATIONS
SIGNS AND SYMPTOMS OF DERM DISEASES
PSORIASIS, SEBORRHOIC DERMATITIS, ATOPIC DERMATITIS, ALLERGIC CONTACT DERMATITIS
ACUTE AND CHRONIC URTICARIA
ACNE. ROSACEA. PIODERMITIS. CUTANEOUS TUBERCOLOSIS. LEPROSY
CUTANEOUS MICOSIS
CUTANEOUS PARASITIC DISEASES (LEISHMANIOSIS, SCABIES, PEDICULOSIS AND OTHERS)
CUTANEOUS VIRAL DISEASES (HERPES, VIRAL WARTS AND PAPILLOMAS, WARTS, MOLLUSCUM CONTAGIOSUM)
PITYRIASIS ROSEA
PEMPHIGUS. PEMPHIGOID, DERMATITIS HERPETIFORMIS
LICHEN PLANUS, ERYTHEMA MULTIFORME AND RELATED SYNDROMES
DISCOID LUPUS ERYTHEMATOSUS. MORFEA
ALOPECIA. VITILIGO
PRECANCEROUS LESIONS. BASAL CELL CA. SQUAMOUS CELL CA. NEVI. MELANOMA
KAPOSI'S SARCOMA. MYCOSIS FUNGOIDES
SYPHILIS
GONOCOCCAL AND NON-GONOCOCCAL URETHRITIS, VENEREAL ULCERS
CLINICAL ASPECTS OF DERM DISEASES
• ALLERGY TESTING IN DERM PRACTICE
•DIGNOSTIC ANALYSIS FOR MICROSCOPIC MITE PESTS AND FUNGI IN DERM DISEASE
•SPUTUM CULTURE FOR DERMATOPHYTES AND YEASTS OF THE CANDIDA GENUS
•TZANK’S CYTODIAGNOSTIC EXAMINATION OF THE SKIN AND OF VISIBLE MUCOUS MEMBRANES: DERM INDICATIONS AND LIMITATIONS
•MICROSCOPIC EXAMINATION OF VAGINAL SECRETIONS AND URETHRAL EXUDATE IN VENEREAL DISEASES
•SEROLOGY OF LUE: INTERPRETATION OF RESULTS
•ELEMENTS OF DERM PHYSICAL THERAPY
•VIRAL WARTS AND PAPILLOMAS, WARTS, MOLLUSCUM CONTAGIOSUM

RHEUMATOLOGY
• ANATOMY AND PATHOPHYSIOLOGY OF THE JOINTS
• RHEUMATOID ARTHRITIS: PATHOGENESIS, CLINICAL DIAGNOSIS, DIFFERENTIAL DIAGNOSIS; ASSESSMENT OF DISEASE ACTIVITY; EXTRA-ARTICULAR MANIFESTATIONS; MONOCLONAL AB THERAPY
• SERONEGATIVE ARTHRITIS
• SJÖGREN'S SYNDROME
• SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): PATHOGENESIS, CLINICAL DIAGNOSIS, DIFFERENTIAL DIAGNOSIS; THERAPY; COMPLICATIONS OF IMMUNOSUPPRESSIVE THERAPY
• ANTI-PHOSPHOLIPID SYNDROME
• SARCOIDOSIS
• SYSTEMIC VASCULITIS
PANARTERITIS NODOSA
CHURG-STRAUSS SYNDROME
WEGENER'S GRANULOMATOSIS
• TAKAYASU'S ARTERITIS
• HORTON’S ARTERITIS
• SECONDARY VASCULITIS
• CRIOGLOBULINEMIAS
• ERYTHEMA NODOSUM
• DERMATOPOLYMYOSITIS
• PROGRESSIVE SYSTEMIC SCLEROSIS
• RHEUMATIC DISEASE (RHEUMATIC FEVER)
• GOUT
• OSTEOARTHRITIS
Teaching Methods
FRONTAL LESSONS AIDED WITH PROJECTION OF POWERPOINT PRESENTATIONS. IN ENGLISH AND ITALIAN. DISCUSSION OF CLINICAL CASES, RECENT INTERNATIONAL LITERATURE AND META-ANALYSES
Verification of learning
THE EXAM CONSISTS OF A WRITTEN TEST WITH THIRTY MULTIPLE-CHOICE ALLERGY AND CLINICAL IMMUNOLOGY QUESTIONS, FIFTEEN RHEUMATOLOGY QUESTIONS, AND FIFTEEN DERMATOLOGY QUESTIONS, FOLLOWED BY AN ORAL EXAMINATION FOR STUDENTS PASSING THE WRITTEN TEST, AIMED AT VERIFYING THEIR COMPREHENSION OF THE TOPICS LEARNED. PASSING THE WRITTEN TEST REQUIRES AT LEAST EIGHTEEN/THIRTY OR NINE/FIFTEEN CORRECT ANSWERS FOR EACH OF THE MODULES OF THE COURSE.
THE EXAM GRADE IS EXPRESSED IN THIRTIETHS.
COLLEGIAL EVALUATION OF THE MEMBERS OF THE EXAM COMMISSION.
Texts
ALLERGY AND CLINICAL IMMUNOLOGY:
PASSALACQUA, DE PAULIS, INCORVAIA, PARRONCHI: ALLERGOLOGIA E IMMUNOLOGIA CLINICA, PACINI EDITORE MEDICINA, PISA (2016)
HARRISON'S INTERNAL MEDICINE PRINCIPLES, XVIII ED., MCGRAW-HILL, MILAN (2012)
COURSE MATERIAL AND PDFS OF MAJOR INTERNATIONAL REVIEWS GIVEN DURING THE COURSE
DERMATOLOGY:
FABBRI, GELMETTI, LEIGHB: MANUALE DI DERMATOLOGIA MEDICA, ELSEVIER-MASSON
ALESSI, CAPUTO: LA CUTE E LA SUA PATOLOGIA. RAFFAELLO CORTINA EDITORE, MILANO
AYALA, LISI, MONFRECOLA: MALATTIE CUTANEEE E VENEREE, PICCIN NUOVA LIBRARIA, PADOVA (2007)
REUMATHOLOGY:
HARRISON'S INTERNAL MEDICINE PRINCIPLES, XVIII ED., MCGRAW-HILL, MILAN (2012)
PERRICONE: MALATTIE AUTOIMMUNI SISTEMICHE, SOCIETA’ EDITRICE UNIVERSO (2013)
More Information
-COURSE AND EXAMS TO BE HELD AT THE BARONISSI CAMPUS
-ADDITIONAL CREDITS AVAILABLE THROUGH ADE (ELECTIVE DIDACTIC ACTIVITIES) - SEE LIST OF ADE
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