Gianluigi FRANCI | BASIC BIOCHEMISTRY BIOLOGY AND MICROBIOLOGY

cod. 1012100001

BASIC BIOCHEMISTRY BIOLOGY AND MICROBIOLOGY

	1012100001
	DEPARTMENT OF MEDICINE, SURGERY AND DENTISTRY "SALERNITANA MEDICAL SCHOOL"
	EQF6
	NURSING
	2024/2025

PERCORSO STUDY PATHWAY IN COMMON NURSING

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2013
	AUTUMN SEMESTER

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	NOZIONI DI BIOCHIMICA BIOLOGIA E MICROBIOLOGIA - MOD. BIOCHIMICA
	BIO/10	1	12	LESSONS	BASIC COMPULSORY SUBJECTS
2	NOZIONI DI BIOCHIMICA BIOLOGIA E MICROBIOLOGIA - MOD. MICROBIOLOGIA
	MED/07	1	12	LESSONS	BASIC COMPULSORY SUBJECTS
3	NOZIONI DI BIOCHIMICA BIOLOGIA E MICROBIOLOGIA - MOD. BIOLOGIA APPLICATA
	BIO/13	1	12	LESSONS	BASIC COMPULSORY SUBJECTS

PROFESSORS

	MARIA CATERINA TURCO1 T Curriculum
	GIANLUIGI FRANCI2 Curriculum
	GIUSEPPINA AMODIO3 Curriculum

	Objectives
	THE COURSE OF NOTIONS OF BIOCHEMISTRY, BIOLOGY AND MICROBIOLOGY IS ARTICULATED IN 3 DIDACTIC MODULES. AT THE END OF THE COURSE THE STUDENT WILL HAVE TO KNOW THE STRUCTURE OF CELLS AND OF THE MAIN MOLECULES OF BIOCHEMICAL INTEREST. ALSO SHOULD HAVE LEARNED THE BASIC PRINCIPLES OF BIOENERGETICS FOR THE STUDY OF CELLULAR METABOLISM. IN ADDITION, THE NECESSARY KNOWLEDGE ON THE PROCESSES AND ON THE AGENTS WHICH CAUSES INFECTION IN HUMANS WILL BE ACQUIRED. AT THE END OF THE COURSE AND FOR PASSING THE EXAM, THE STUDENT SHOULD DEMONSTRATE: 1. TO HAVE REACHED A KNOWLEDGE AND UNDERSTANDING ABOUT THE MAIN BIOLOGICAL MOLECULES THAT ALLOWS TO SET THE ANALYSIS OF THEIR FUNCTION IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS 2. BEING ABLE OF ANALYZING, DISCUSSING AND PERFORMING CORRELATIONS ON SIMPLE DATA OR HYPOTHESIS 3. TO COMMUNICATE IN CORRECT ITALIAN LANGUAGE AND WITH APPROPRIATE SPEAKING THE ACQUIRED KNOWLEDGE 4. TO KNOW HOW TO COMMUNICATE WITH THEIR PEERSIN A CRITICAL MANNER ON CERTAIN TOPICS STUDIED DURING THE COURSE AND TO SUPPORT INTERDISCIPLINARY ARGUMENTATIONS 5. TO KNOW HOW TRANSFER THE KNOWLEDGE ACQUIRED TO THE CLINICAL PRACTICE.

THE COURSE OF NOTIONS OF BIOCHEMISTRY, BIOLOGY AND MICROBIOLOGY IS ARTICULATED IN 3 DIDACTIC MODULES.
AT THE END OF THE COURSE THE STUDENT WILL HAVE TO KNOW THE STRUCTURE OF CELLS AND OF THE MAIN MOLECULES OF BIOCHEMICAL INTEREST. ALSO SHOULD HAVE LEARNED THE BASIC PRINCIPLES OF BIOENERGETICS FOR THE STUDY OF CELLULAR METABOLISM. IN ADDITION, THE NECESSARY KNOWLEDGE ON THE PROCESSES AND ON THE AGENTS WHICH CAUSES INFECTION IN HUMANS WILL BE ACQUIRED.
AT THE END OF THE COURSE AND FOR PASSING THE EXAM, THE STUDENT SHOULD DEMONSTRATE:
1. TO HAVE REACHED A KNOWLEDGE AND UNDERSTANDING ABOUT THE MAIN BIOLOGICAL MOLECULES THAT ALLOWS TO SET THE ANALYSIS OF THEIR FUNCTION IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS
2. BEING ABLE OF ANALYZING, DISCUSSING AND PERFORMING CORRELATIONS ON SIMPLE DATA OR HYPOTHESIS
3. TO COMMUNICATE IN CORRECT ITALIAN LANGUAGE AND WITH APPROPRIATE SPEAKING THE ACQUIRED KNOWLEDGE
4. TO KNOW HOW TO COMMUNICATE WITH THEIR PEERSIN A CRITICAL MANNER ON CERTAIN TOPICS STUDIED DURING THE COURSE AND TO SUPPORT INTERDISCIPLINARY ARGUMENTATIONS
5. TO KNOW HOW TRANSFER THE KNOWLEDGE ACQUIRED TO THE CLINICAL PRACTICE.

	Prerequisites
	THE STUDENT MUST HAVE ACQUIRED BASIC KNOWLEDGE IN THE FIELD OF BIOLOGY AND CHEMISTRY PROVIDED BY NORMAL HIGH SCHOOL CURRICULA.

	Contents
	BIOCHEMISTRY MODULE: THE MAIN BIOCHEMICAL COMPONENTS OF THE HUMAN BODY; CELLULAR LOCALIZATION OF METABOLIC PROCESSES. AMINO ACIDS AND PROTEINS: STRUCTURAL PROPERTIES AND CLASSIFICATION OF AMINO ACIDS; PEPTIDIC BOND; THE STRUCTURE OF THE PROTEINS; MYGLOBINE AND HEMOGLOBINE. THE ENZYMES: GENERAL PROPERTY OF ENZYMES; ENZYMATIC KINETICS; ENZYMATIC INHIBITION; REGULATION OF ENZYMATIC ACTIVITY; CLINICAL SIGNIFICANCE OF ENZYMES. BIOENERGETICS AND METABOLISM: BIOENERGETICS AND TYPES OF BIOCHEMICAL REACTIONS; PRINCIPLES OF METABOLIC REGULATION. GLYCOLYSIS: THE CHEMISTRY OF CARBOHYDRATES; CARBOHYDRATE DIGESTION; THE GLYCOLITIC WAY. THE KREBS CYCLE: DECARBOXYLATION REACTIONS; KREBS CYCLE OVERVIEW; ATP RETURNS; REGULATION OF PIRUVATE OXIDATION AND ACETYL-COA LEVELS; CLINICAL ASPECTS OF OXIDATIVE METABOLISM. OXIDATION OF AMINO ACIDS: METABOLIC DESTINY OF THE AMINOUS GROUPS; EXCRETION OF NITROGEN AND CYCLE OF UREA. BIOLOGY MODULE: STRUCTURE AND FUNCTION OF BIOLOGICAL MEMBRANES. PROPERTIES OF MEMBRANES IN RELATION TO THEIR LIPID AND PROTEIN COMPOSITION. MODE OF TRANSPORT OF SMALL MOLECULES THROUGH THE MEMBRANES. MITOCHONDRIA. GENERAL ORGANIZATION OF CELL METABOLISM. MITOCHONDRIA AND CELLULAR RESPIRATION AND ATP BIOSYNTHESIS. STRUCTURE AND FUNCTION OF THE GENOME. THE NUCLEUS OF THE EUKARYOTIC CELL. CHROMOSOME ORGANIZATION OF EUKARYOTIC DNA. CONCEPT OF GENE, GENERAL MECHANISMS AND BIOLOGICAL SIGNIFICANCE OF TRANSCRIPTION AND TRANSLATION. GENETIC CODE - MUTATIONS ORGANIZATION AND FUNCTIONS OF CELLULAR COMPARTMENTS. ORGANIZATION AND FUNCTIONS OF THE ENDOPLASMIC RETICULUM. ORGANIZATION AND FUNCTIONS OF THE GOLGI APPARATUS. CONSTITUTIVE SECRETION AND REGULATED SECRETION. EXOCYTOSIS. MECHANISMS OF ENDOCYTOSIS AND THEIR FUNCTIONAL SIGNIFICANCE. CELL DIVISION AND REPRODUCTION. ORGANIZATION OF THE CELL CYCLE. BIOLOGICAL SIGNIFICANCE AND STAGES OF MITOSIS. STRUCTURAL MODIFICATIONS OF THE CELL DURING MITOSIS. STAGES OF MEIOSIS AND THEIR BIOLOGICAL MEANING. SEXUAL REPRODUCTION. FERTILIZATION. MICROBIOLOGY AND HUMAN HEALTH: PROKARYOTIC AND EUKARYOTIC CELLS. STRUCTURE AND REPLICATION OF BACTERIA. INTERACTIONS BETWEEN THE PARASITE AND THE HOST CELL. INFECTION, PATHOGENICITY AND VIRULENCE. MICROBIOLOGICAL COLTURES AND CLINICAL SAMPLES TREATMENTS, LABORATORY TECHNIQUES USED IN BACTERIOLOGICAL FIELD, WITH PARTICULAR ATTENTION TO THE METHODS OF CULTURAL ISOLATION AND DETERMINATION OF ANTIBIOTICS CHEMOSENSITIVITY. IDENTIFICATION OF THE MOST COMMONLY BACTERIAL CLASSES ISOLATED IN THE LABORATORY: GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA, GRAM-POSITIVE BACILLI, BRUCELLA, ENTEROBACTERIA, VIBRIONACEAE, SPIROCHETE, ANAEROBIC BACTERIA, ACTINOMYCETES AND MICOBACTERIA STRUCTURE AND METABOLISM OF MYCETES; MICROBIOLOGICAL CULTURAL EXAM, ISOLATION AND IDENTIFICATION OF MYCETES; COLLECTION AND HANDLING OF BIOLOGICAL SAMPLES IN THE MICOLOGICAL DIAGNOSTICS; PHYSIOPATHOLOGICAL CHARACTERISTICS AND METHOD OF IDENTIFICATION OF THE MAIN FUNGINE SPECIES INVOLVED IN HUMAN PATHOLOGY. VIRUSES AND PRIONS: STRUCTURE OF VIRAL PARTICLES, DNA AND RNA VIRUSES, CLASSIFICATION, REPLICATION. MAIN VIRUSES OF HUMAN INTEREST. PARASSITOLOGY: GENERAL ON PARASITES AND DISEASES CAUSED IN HUMANS.

Contents

BIOCHEMISTRY MODULE:
THE MAIN BIOCHEMICAL COMPONENTS OF THE HUMAN BODY; CELLULAR LOCALIZATION OF METABOLIC PROCESSES. AMINO ACIDS AND PROTEINS: STRUCTURAL PROPERTIES AND CLASSIFICATION OF AMINO ACIDS; PEPTIDIC BOND; THE STRUCTURE OF THE PROTEINS; MYGLOBINE AND HEMOGLOBINE.
THE ENZYMES: GENERAL PROPERTY OF ENZYMES; ENZYMATIC KINETICS; ENZYMATIC INHIBITION; REGULATION OF ENZYMATIC ACTIVITY; CLINICAL SIGNIFICANCE OF ENZYMES.
BIOENERGETICS AND METABOLISM: BIOENERGETICS AND TYPES OF BIOCHEMICAL REACTIONS; PRINCIPLES OF METABOLIC REGULATION.
GLYCOLYSIS: THE CHEMISTRY OF CARBOHYDRATES; CARBOHYDRATE DIGESTION; THE GLYCOLITIC WAY.
THE KREBS CYCLE: DECARBOXYLATION REACTIONS; KREBS CYCLE OVERVIEW; ATP RETURNS; REGULATION OF PIRUVATE OXIDATION AND ACETYL-COA LEVELS; CLINICAL ASPECTS OF OXIDATIVE METABOLISM.
OXIDATION OF AMINO ACIDS: METABOLIC DESTINY OF THE AMINOUS GROUPS; EXCRETION OF NITROGEN AND CYCLE OF UREA.

BIOLOGY MODULE:
STRUCTURE AND FUNCTION OF BIOLOGICAL MEMBRANES. PROPERTIES OF MEMBRANES IN RELATION TO THEIR LIPID AND PROTEIN COMPOSITION. MODE OF TRANSPORT OF SMALL MOLECULES THROUGH THE MEMBRANES.
MITOCHONDRIA. GENERAL ORGANIZATION OF CELL METABOLISM. MITOCHONDRIA AND CELLULAR RESPIRATION AND ATP BIOSYNTHESIS.
STRUCTURE AND FUNCTION OF THE GENOME. THE NUCLEUS OF THE EUKARYOTIC CELL. CHROMOSOME ORGANIZATION OF EUKARYOTIC DNA. CONCEPT OF GENE, GENERAL MECHANISMS AND BIOLOGICAL SIGNIFICANCE OF TRANSCRIPTION AND TRANSLATION. GENETIC CODE - MUTATIONS
ORGANIZATION AND FUNCTIONS OF CELLULAR COMPARTMENTS. ORGANIZATION AND FUNCTIONS OF THE ENDOPLASMIC RETICULUM. ORGANIZATION AND FUNCTIONS OF THE GOLGI APPARATUS. CONSTITUTIVE SECRETION AND REGULATED SECRETION. EXOCYTOSIS. MECHANISMS OF ENDOCYTOSIS AND THEIR FUNCTIONAL SIGNIFICANCE.
CELL DIVISION AND REPRODUCTION. ORGANIZATION OF THE CELL CYCLE. BIOLOGICAL SIGNIFICANCE AND STAGES OF MITOSIS. STRUCTURAL MODIFICATIONS OF THE CELL DURING MITOSIS. STAGES OF MEIOSIS AND THEIR BIOLOGICAL MEANING. SEXUAL REPRODUCTION. FERTILIZATION.

MICROBIOLOGY AND HUMAN HEALTH:
PROKARYOTIC AND EUKARYOTIC CELLS. STRUCTURE AND REPLICATION OF BACTERIA. INTERACTIONS BETWEEN THE PARASITE AND THE HOST CELL. INFECTION, PATHOGENICITY AND VIRULENCE.
MICROBIOLOGICAL COLTURES AND CLINICAL SAMPLES TREATMENTS, LABORATORY TECHNIQUES USED IN BACTERIOLOGICAL FIELD, WITH PARTICULAR ATTENTION TO THE METHODS OF CULTURAL ISOLATION AND DETERMINATION OF ANTIBIOTICS CHEMOSENSITIVITY.
IDENTIFICATION OF THE MOST COMMONLY BACTERIAL CLASSES ISOLATED IN THE LABORATORY: GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA, GRAM-POSITIVE BACILLI, BRUCELLA, ENTEROBACTERIA, VIBRIONACEAE, SPIROCHETE, ANAEROBIC BACTERIA, ACTINOMYCETES AND MICOBACTERIA
STRUCTURE AND METABOLISM OF MYCETES; MICROBIOLOGICAL CULTURAL EXAM, ISOLATION AND IDENTIFICATION OF MYCETES; COLLECTION AND HANDLING OF BIOLOGICAL SAMPLES IN THE MICOLOGICAL DIAGNOSTICS; PHYSIOPATHOLOGICAL CHARACTERISTICS AND METHOD OF IDENTIFICATION OF THE MAIN FUNGINE SPECIES INVOLVED IN HUMAN PATHOLOGY.
VIRUSES AND PRIONS: STRUCTURE OF VIRAL PARTICLES, DNA AND RNA VIRUSES, CLASSIFICATION, REPLICATION. MAIN VIRUSES OF HUMAN INTEREST. PARASSITOLOGY: GENERAL ON PARASITES AND DISEASES CAUSED IN HUMANS.

	Teaching Methods
	LECTURES

	Verification of learning
	THE ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY PASSING AN EXAM WITH A WRITTEN AND ORAL EXAM WITH AN EVALUATION IN THIRTIETHS. THE TEST, AS A WHOLE, MAKES IT POSSIBLE TO ASCERTAIN BOTH THE CAPACITY FOR KNOWLEDGE AND UNDERSTANDING, AND THE ABILITY TO APPLY THE SKILLS ACQUIRED, BOTH THE ABILITY TO EXHIBIT, AND THE ABILITY TO LEARN AND DEVELOP SOLUTIONS INDEPENDENTLY. ALL THE PROFESSORS WILL PARTICIPATE IN THE OVERALL COLLECTIVE ASSESSMENT OF THE STUDENT'S PROFIT.

Verification of learning

THE ACHIEVEMENT OF THE TEACHING OBJECTIVES IS CERTIFIED BY PASSING AN EXAM WITH A WRITTEN AND ORAL EXAM WITH AN EVALUATION IN THIRTIETHS. THE TEST, AS A WHOLE, MAKES IT POSSIBLE TO ASCERTAIN BOTH THE CAPACITY FOR KNOWLEDGE AND UNDERSTANDING, AND THE ABILITY TO APPLY THE SKILLS ACQUIRED, BOTH THE ABILITY TO EXHIBIT, AND THE ABILITY TO LEARN AND DEVELOP SOLUTIONS INDEPENDENTLY. ALL THE PROFESSORS WILL PARTICIPATE IN THE OVERALL COLLECTIVE ASSESSMENT OF THE STUDENT'S PROFIT.

	Texts
	“INTRODUZIONE ALLA BIOCHIMICA” DI LEHNINGER. NELSON D.L., COX MM. ZANICHELLI “ELEMENTI DI BIOLOGIA E GENETICA”, EDISES UNIVERSITÀ 2020. AUTORI: BONALDO P, CRISAFULLI C, D’ANGELO R, FRANCOLINI M. “MICROBIOLOGIA MEDICA, BATTERIOLOGIA E VIROLOGIA” DI MARIA PIA CONTE, PAOLA MASTROMARINO. SOCIETÀ EDITRICE ESCULAPIO.

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Gianluigi FRANCI | BASIC BIOCHEMISTRY BIOLOGY AND MICROBIOLOGY