2. Professors
  3. GUIDA MICHELE
  4. Teaching

PHYSICS FOR BIOMEDICAL APPLICATIONS

MICHELE GUIDA PHYSICS FOR BIOMEDICAL APPLICATIONS

0623200017
DEPARTMENT OF INFORMATION AND ELECTRICAL ENGINEERING AND APPLIED MATHEMATICS
EQF7
INFORMATION ENGINEERING FOR DIGITAL MEDICINE
2024/2025



YEAR OF COURSE 2
YEAR OF DIDACTIC SYSTEM 2022
SPRING SEMESTER
CFUHOURSACTIVITY
432LESSONS
216EXERCISES
MARIAROSARIA FALANGA T Curriculum
MICHELE GUIDA Curriculum
Objectives
IT REPRESENTS AN ADVANCED COURSE ABOUT APPLIED PHYSICS TO BIOMEDICAL SCIENCES. IT IS FINALIZED TO PROVIDE THE KNOW-HOW ABOUT THE BIOMEDICAL APPLICATIONS OF THE EFFECTS OF THE INTERACTION OF BIOLOGICAL SYSTEMS WITH IONIZING RADIATIONS, MECHANICAL STRESSES, ACOUSTIC AND ELECTROMAGNETIC VIBRATIONS, FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES, TOGETHER WITH THE ASSESSMENT OF THE HEALTH RISKS ASSOCIATED WITH HUMAN EXPOSURE TO POLLUTING PHYSICAL AGENTS LIKE IONIZING RADIATIONS, E.M. FIELDS, AND NOISE.
APPLYING KNOWLEDGE AND UNDERSTANDING:
BASICS OF THE INTERACTION BETWEEN IONIZING RADIATIONS AND THE BIOLOGICAL MATTER.
CHARACTERISTICS OF THE MECHANICAL OSCILLATIONS IN BIOLOGICAL SYSTEMS.
PRINCIPLES OF OPERATION OF RELEVANT ADVANCED BIOMEDICAL EQUIPMENTS FOR DIAGNOSTICS AND THERAPY.
KNOWLEDGE AND UNDERSTANDING:

•TO BE ABLE TO OPERATE WITH DOSIMETRIC QUANTITIES;
•TO BE ABLE TO APPLY THE THEORETICAL CONCEPTS TO SPECIFIC BIOLOGICAL CASES OF INTEREST;
•TO BE ABLE TO ASSESS ALSO WITH THE HELP OF SIMPLE EXPERIMENTAL SESSIONS THE BIOLOGICAL IMPACT OF THE PHYSICAL PHENOMENA STUDIED DURING THE COURSE.


Prerequisites
KNOWLEDGE OF PHYSICS AND MATHEMATICS GAINED DURING THE FIRST LEVEL (LAUREA TRIENNALE) UNIVERSITY PROGRAM.
Contents
DIDACTIC UNIT 1: BASICS OF ATOMIC AND NUCLEAR PHYSICS. RADIOACTIVITY AND ALPHA, BETA AND GAMMA RADIATIONS.
(Lecture/Practice/Laboratory: 4/0/0)
-1 (2 HOURS LECTURE): BASICS OF ATOMIC AND NUCLEAR PHYSICS. EXAMPLES
-2 (2 HOURS LECTURE): RADIOACTIVITY AND ALPHA, BETA AND GAMMA RADIATIONS. EXAMPLES.
KNOWLEDGE AND UNDERSTANDING ABOUT:
Acquisition of the basic concepts of the phenomenology of nuclear processes like radioactivity.
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability of distinguishing among the different ionizing radiations, like alpha, beta and gamma, through their ionizing and penetration power inside matter.
DIDACTIC UNIT 2: ENVIROMENTAL RADIOACTIVITY AND NON-NUCLEAR INDUSTRY.
NATURALLY OCCURRING RADIOACTIVE MATERIALS (NORM) AND TECHNOLOGICAL ENHANCED NATURALLY OCCURRING RADIOACTIVE MATERIALS (TENORM).
(Lecture/Practice/Laboratory: 2/0/0)
-1 (2 hours Lecture): ENVIROMENTAL RADIOACTIVITY AND NON-NUCLEAR INDUSTRY. NORM and TENORM.
KNOWLEDGE AND UNDERSTANDING ABOUT:
Acquisition of the concept of NORM
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability in distinguishing the different contexts in which population and workers are exposed to naturally occurring radioactivity.

DIDACTIC UNIT 3: BIOLOGICAL DAMAGES ASSOCIATED TO EXPOSURE TO IONIZING RADIATION.
(Lecture/Practice/Laboratory: 4/0/0)
-1 (2 HOURS LECTURE): INTERACTION OF IONIZING RADIATIONS WITH MATTER.
-2 (2 HOURS LECTURE): BIOLOGICAL EFFECTS OF IONIZING RADIATIONS.
KNOWLEDGE AND UNDERSTANDING ABOUT:
Acquisition of the basic phenomenology of the interactions of ionizing radiations with matter.
APPLYING KNOWLEDGE AND UNDERSTANDING:

Ability in solving simple calculations of attenuation of gamma radiation across different thicknesses of materials.

DIDACTIC UNIT 4: DOSIMETRY, HEALTH RISK AND NATIONAL/INTERNATIONAL LEGISLATION.
(Lecture/Practice/Laboratory: 3/1/0)
-1 (1 HOUR LECTURE + 1 HOUR PRACTICE): Radioprotection, dosimetry. Examples.
-2 (2 hours Lecture): health risk. NATIONAL/INTERNATIONAL LEGISLATION.
KNOWLEDGE AND UNDERSTANDING ABOUT:
Knowledge of the scientific elements for the realization of a legislation aimed at the health protection of population and workers.
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability in distinguishing among the different dosimetric quantities.
Didactic Unit 5: methods and techniques for measuring radon and the natural gamma background.
(Lecture/Practice/Laboratory: 0/2/2)
-1 (2 hours of Practice) methods and techniques for measuring radon in different environmental matrices.
-2 (2 hours of Laboratory) practical performance of radon and natural gamma background measurements.
KNOWLEDGE AND UNDERSTANDING ABOUT:
Acquisition of the basic methods for measuring Radon
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability in designing a radon measurement in a confined space.
Didactic unit 6: BIOMEDICAL EQUIPMENT:
(Lecture/Practice/Laboratory: 2/2/0)
-1 (1 HOUR LECTURE + 1 HOUR PRACTICE): Computerized Axial Tomography. Physical principles. Examples of calculations concerning simple apparatuses.
-2 (1 HOUR LECTURE + 1 HOUR PRACTICE): Nuclear Magnetic Resonance. Physical principles. Examples of calculations concerning simple apparatuses.
KNOWLEDGE AND UNDERSTANDING ABOUT:
acquisition of the basic physical mechanisms occurring in Buclear Magnetic Resonance and Computerized Axial Tomography

APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability in describing, approximately, the PROs and the CONs of the most common biomedical apparatuses illustrated during the course.
Didactic unit 7: Project activities with students
(Lecture/Practice/Laboratory: 0/2/0)
-1 (2 hours of Practice): Discussion of project activities with students.
KNOWLEDGE AND UNDERSTANDING ABOUT:
acquisition of the main concepts regarding the interaction between ionizing radiations and matter .
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability of using the tools of AI, IoT, Machine Learning to the topics discussed in the course to realize innovative individual applied projects






DIDACTIC UNIT 8: THEORY Of MECHANICAL WAVES
(Lecture/Practice/Laboratory: 6/2/0)
- 1 (2 hours Lecture): RECALLS ON THE THEORY OF MECHANICAL WAVES, properties and characteristics; - 2 (2 hours Lecture): EQUATIONS OF MECHANICAL WAVES; POLARIZATION;
- 3 (2 hours Lecture): REFLECTION AND TRANSMISSION; Examples
- 4 (2 hours Practice): Exercises regarding the mechanical waves and their propagation
KNOWLEDGE AND UNDERSTANDING ABOUT: understanding the mechanic wave properties and the related mathematical equations
APPLYING KNOWLEDGE AND UNDERSTANDING: Knowing how to applying the theory of mechanical waves and solving simple physical problems

DIDACTIC UNIT 9: THEORY OF ACOUSTIC WAVES
(Lecture/Practice/Laboratory: 4/2/0)
- 1 (2 hours Lecture): RECALLS ON THE THEORY OF ACOUSTIC WAVES, properties; - 2 (2 hours Lecture): EQUATIONS OF ACOUSTIC WAVES; PITCH; NORMAL MODES
- 3 (2 hours of Practice): Exercises on Doppler effect ; BIOMEDICAL APPLICATIONS.
KNOWLEDGE AND UNDERSTANDING ABOUT: understanding the acoustic wave properties and the related mathematical equations; knowledge of the DOPPLER EFFECT
APPLYING KNOWLEDGE AND UNDERSTANDING: Knowing how to applying the theory of acoustic waves and solving simple Doppler effect-based physical problems.

DIDACTIC UNIT 10: Theory of ELECTROMAGNETIC WAVES; DOPPLER LASER VIBROMETRY
(Lecture/Practice/Laboratory: 5/3/0)
- 1 (2 hours Lecture): RECALLS ON THE THEORY OF ELECTROMAGNETIC WAVES, PROPERTIES; - 2 (2 hours Lecture):, WAVE EQUATION; INTERACTION WITH MATTER; Ray Theory; Snell’s laws
- 3 (1 hour Lecture + 1 hour of Practice): DOPPLER LASER VIBROMETRY; Examples
- 4 (2 hours of Practice): APPLICATION TO THE CARDIO-CIRCULATORY SYSTEm; APPLICATION TO THE VOICE AND PHONATION SYSTEM.
KNOWLEDGE AND UNDERSTANDING ABOUT: Knowledge of electromagnetic waves ; Knowledge of basic principles of a Doppler effect- based Laser
APPLYING KNOWLEDGE AND UNDERSTANDING: Knowing how to apply the theory of electromagnetic waves and solving simple physical problems.

Didactic unit 11: Project activities with students
(Lecture/Practice/Laboratory: 0/2/0)
-1 (2 hours of Practice): Discussion of project activities with students.
KNOWLEDGE AND UNDERSTANDING ABOUT: acquisition of the main concepts regarding the mechanic acoustic and electromagnetic waves and their use in biomedical context.
APPLYING KNOWLEDGE AND UNDERSTANDING:
Ability of using the tools of AI, IoT, Machine Learning to the topics discussed in the course to realize innovative individual applied projects
Teaching Methods
THE DEPLOYMENT OF THE COURSE IS ARTICULATED IN FRONT CLASS-ROOM LECTURES (THEORY AND PRACTICE/PROJECT ACTIVITIES, AT LEAST 16 HOURS), FOR A TOTAL DURATION OF 48 HOURS (6 CFU), DIVIDED INTO 12 WEEKS, PERFORMED IN THE CLASS-ROOM ALSO WITH THE HELP OF MULTIMEDIA MATERIAL AND LABORATORY EXPERIMENTS.
Verification of learning
AT THE END OF THE COURSE THE LEARNING VERIFICATION IS AIMED AT THE ASSESSMENT THE KNOWLEDGE AND KNOW-HOW GAINED BY THE STUDENTS ABOUT THE CONCEPTS ILLUSTRATED AND THEIR CAPABILITY TO USE SUCH KNOW-HOW TO THE BIOMEDICAL APPLICATIONS OF INTEREST.
SUCH VERIFICATION WILL BE PERFORMED WITH
•PROJECT ACTIVITY
•ORAL INTERVIEW
DURING THE INTERVIEW THE CANDIDATE ILLUSTRATES THE INDIVIDUAL PROJECT REALIZED: THE FINAL EVALUATION TAKES INTO ACCOUNT THE GAINED KNOWLEDGE OF THE TOPICS ILLUSTRATED DURING THE COURSE, THE SKILLS CONSISTING IN THE GRASP OF THE ISSUES, CORRECT AND PROPER USE OF THE SCIENTIFIC LANGUAGE, ABILITY TO ANALYSE, COMMUNICATE AND DRAW CONCLUSIONS.
THE FINAL EVALUATION IS EXPRESSED IN THIRTIES. AN EVALUATION OF MAGNA CUM LAUDE CAN BE GIVEN TO CANDIDATES SHOWING EXCELLENT ANALYTICAL ABILITIES.
Texts
LECTURE NOTES AND MULTIMEDIA MATERIAL ON THE E-LEARNING PLATFORM MOODLE.
SUGGESTED TEXTBOOKS:
PART I:
AA.VV. 2010. "RADIATION BIOLOGY: A HANDBOOK FOR TEACHERS AND STUDENTS", IAEA TRAINING COURSE SERIES 42, INTERNATIONAL ATOMIC ENERGY AGENCY IAEA, WIEN, 2010.
C. POLVANI, 1993. "ELEMENTI DI RADIOPROTEZIONE, ENEA, ROMA , 1993.
PARTE II:
ELEMENTARY REFERENCE TEXTBOOK FOR BEGINNERS:
F S CRAWFORD, 1972. "ONDE ED OSCILLAZIONI" LA FISICA DI BERKELEY, VOL. 3, ZANICHELLI, BOLOGNA, 1972.
HALLIDAY, D., RESNICK, R., & WALKER, J. (2013). FUNDAMENTALS OF PHYSICS. JOHN WILEY & SONS.
SELECTED CHAPTERS FROM THE FOLLOWING TEXTBOOKS:
E. OTT, 2002 “CHAOS IN DYNAMICAL SYSTEMS”, CAMBRIDGE UNIVERSITY PRESS; 2 EDIZIONE (22 AGOSTO 2002)
P. CASTELLINI, E P TOMASINI AND GM REVEL, 2001 “LASER BASED MEASUREMENT” IN “ENCYCLOPAEDIA OF VIBRATION” (EDITED BY SIMON G BRAUN ET AL.) (LONDON: ACADEMIC).
SUGGESTED ADVANCED READINGS:
PART I:
GUIDA DOMENICO; GUIDA MICHELE; CUOMO ALBINA; GUADAGNUOLO DAVIDE; SIERVO VINCENZO. 2013. "ASSESSMENT AND MAPPING OF RADON-PRONE AREAS ON A REGIONAL SCALE AS APPLICATION OF A HIERARCHICAL ADAPTIVE AND MULTI-SCALE APPROACH FORTHE ENVIRONMENTAL PLANNING. CASE STUDY OF CAMPANIA REGION, SOUTHERN ITALY". WSEAS TRANSACTIONS ON SYSTEMS. VOL. 12. PAG.105-120, 2013.
JULIE A. REISZ, NIDHI BANSAL, JIANG QIAN, WEILING ZHAO, AND CRISTINA M. FURDUI. 2014. "EFFECTS OF IONIZING RADIATION ON BIOLOGICAL MOLECULES—MECHANISMS OF DAMAGE AND EMERGING METHODS OF DETECTION". FORUM REVIEW ARTICLE. ANTIOXIDANTS & REDOX SIGNALING
VOLUME 21, NUMBER 2, 2014, DOI: 10.1089/ARS.2013.5489.
PARTE II:
G BUCCHERI , E DE LAURO E, S DE MARTINO, M FALANGA, EXPERIMENTAL STUDY OF SELF-OSCILLATIONS OF THE TRACHEA–LARYNX TRACT BY LASER DOPPLER VIBROMETRY, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 2 (5), 055009, 2016.
LIN, C.D., FALANGA, M., DE LAURO, E., DE MARTINO, S., VITIELLO, G., BIOCHEMICAL AND BIOPHYSICAL MECHANISMS UNDERLYING THE HEART AND THE BRAIN DIALOG, AIMS BIOPHYSICS, 2021, 8(1), PP. 1–33.
More Information
ALL THE LECTURES WILL BE DELIVERED IN ENGLISH.
Lessons Timetable

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