Vincenzo VENDITTO | POLYMERS IN BIOMEDICAL APPLICATIONS

cod. 0522300038

POLYMERS IN BIOMEDICAL APPLICATIONS

	0522300038
	DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
	EQF7
	CHEMISTRY
	2017/2018

CURRICULUM BIOMOLECULAR CHEMISTRY

	OBBLIGATORIO
	YEAR OF COURSE 1
	YEAR OF DIDACTIC SYSTEM 2016
	ANNUALE

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
2	MATERIALI POLIMERICI PER APPLICAZIONI BIOMEDICHE
	CHIM/04	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
3	MATERIALI POLIMERICI PER APPLICAZIONI BIO MEDICHE
	CHIM/04	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	LEONE OLIVA2 T Curriculum
	VINCENZO VENDITTO T Curriculum

	Objectives
	THE PURPOSE OF THE COURSE IS TO PRESENT TO THE STUDENT THE MOST WIDELY USED AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN THIS FIRST PART ARE DESCRIBED THE PHYSICAL AND ORGANIC CHEMISTRY OF THE REACTIONS BY WHICH MACROMOLECULES ARE SYNTHESIZED. POLYMERIZATION REACTIONS ARE CHARACTERIZED AS TO THEIR KINETIC AND THERMODYNAMIC FEATURES, THEIR SCOPE AND UTILITY FOR THE SYNTHESIS OF DIFFERENT TYPES OF POLYMER STRUCTURES, AND THE PROCESS CONDITIONS, WHICH ARE USED TO CARRY THEM OUT. EMPHASIS IS PLACED ON UNDERSTANDING THE REACTION PARAMETERS, WHICH ARE RESPONSIBLE IN CONTROLLING POLYMERIZATION RATES, POLYMER MOLECULAR WEIGHT AND STRUCTURAL FEATURES SUCH AS BRANCHING AND CROSS-LINKS. THE PHYSICAL, CHEMICAL AND BIOCOMPATIBILITY PROPERTIES OF SUCH MATERIALS WILL BE DESCRIBED. PARTICULAR EMPHASIS WILL BE GIVEN TO POLYMERIC MATERIALS AND MEDICAL ISSUES (EG CONTROLLED DRUG RELEASE, JOINT PROSTHESIS, TISSUE SCAFFOLDS, ETC.) THAT CAN BE ADDRESSED AND SOLVED BY THE USE OF THESE MATERIALS.

THE PURPOSE OF THE COURSE IS TO PRESENT TO THE STUDENT THE MOST WIDELY USED AND USED MATERIALS FOR BIOMEDICAL APPLICATIONS. IN THIS FIRST PART ARE DESCRIBED THE PHYSICAL AND ORGANIC CHEMISTRY OF THE REACTIONS BY WHICH MACROMOLECULES ARE SYNTHESIZED. POLYMERIZATION REACTIONS ARE CHARACTERIZED AS TO THEIR KINETIC AND THERMODYNAMIC FEATURES, THEIR SCOPE AND UTILITY FOR THE SYNTHESIS OF DIFFERENT TYPES OF POLYMER STRUCTURES, AND THE PROCESS CONDITIONS, WHICH ARE USED TO CARRY THEM OUT. EMPHASIS IS PLACED ON UNDERSTANDING THE REACTION PARAMETERS, WHICH ARE RESPONSIBLE IN CONTROLLING POLYMERIZATION RATES, POLYMER MOLECULAR WEIGHT AND STRUCTURAL FEATURES SUCH AS BRANCHING AND CROSS-LINKS.
THE PHYSICAL, CHEMICAL AND BIOCOMPATIBILITY PROPERTIES OF SUCH MATERIALS WILL BE DESCRIBED. PARTICULAR EMPHASIS WILL BE GIVEN TO POLYMERIC MATERIALS AND MEDICAL ISSUES (EG CONTROLLED DRUG RELEASE, JOINT PROSTHESIS, TISSUE SCAFFOLDS, ETC.) THAT CAN BE ADDRESSED AND SOLVED BY THE USE OF THESE MATERIALS.

	Prerequisites
	NECESSARY KNOWLEDGE OF PHYSICS AND CHEMISTRY, AS WELL AS THOSE OF POLYMER CHEMISTRY

	Contents
	FIRST PART: TYPES OF POLYMERS AND POLYMERIZATIONS. POLYMER COMPOSITION AND STRUCTURE. POLYMERIZATION MECHANISM. MOLECULAR WEIGHT. PHYSICAL STATE OF POLYMERS. STEP POLYMERIZATION. REACTIVITY OF FUNCTIONAL GROUPS. ANALYSIS OF POLYMERIZATION KINETICS: EXPERIMENTAL EVIDENCES AND THEORETICAL CONSIDERATIONS. THERMODYNAMICS. MOLECULAR WEIGHT CONTROL AND MOLECULAR WEIGHT DISTRIBUTION. CHAIN POLYMERIZATIONS. RADICAL VERSUS IONIC POLYMERIZATION. MODES OF PROPAGATION. INITIATION IN RADICAL POLYMERIZATION. KINETICS OF CHAIN POLYMERIZATION. SOME INDUSTRIAL POLYMERIZATION PROCESSES. SECOND PART: BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INNERITY AND BIO-ACTIVITIES, DEFINITIONS. (0.5 CFU) INTRODUCTION TO CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITE). (0.5 CFU) THERAPEUTIC DISORDERS AND PROBLEMS (ORTHOPEDICS, ODONTIATRY, CARDIOVASCULAR DEVICES, CATHETERS, PATHOLOGY, NEFROLOGY, CONTROLLED PHARMACY RELEASE, ETC.) (0.5 CFU) CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTIES-STRUCTURE REPORTS, ADVANTAGES AND ADJUSTMENTS, APPLICATIONS) (0.5 CFU) METALLIC BIOMATERIALS (METALS AND LINES, PROPERTY-STRUCTURE RELATIONSHIPS, BENEFITS AND FAULTS, APPLICATIONS). (0.5 CFU) POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SYNTHESIS, SOLID STATUS AND PROPERTY-STRUCTURE RELATIONSHIPS, POLYMER CLASS APPLICATIONS). (1 CFU) COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, APPLICATIONS). (1 CFU) PROBLEMS ASSOCIATED WITH THE SYSTEM (INFECTIONS) AND POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU) BIOMATERIALS WITH ANTIMICROBIC ACTIVITY. (0.5 CFU) IDROGEN (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, APPLICATIONS) (0.5 CFU)

Contents

FIRST PART: TYPES OF POLYMERS AND POLYMERIZATIONS. POLYMER COMPOSITION AND STRUCTURE. POLYMERIZATION MECHANISM. MOLECULAR WEIGHT. PHYSICAL STATE OF POLYMERS.
STEP POLYMERIZATION. REACTIVITY OF FUNCTIONAL GROUPS. ANALYSIS OF POLYMERIZATION KINETICS: EXPERIMENTAL EVIDENCES AND THEORETICAL CONSIDERATIONS. THERMODYNAMICS. MOLECULAR WEIGHT CONTROL AND MOLECULAR WEIGHT DISTRIBUTION. CHAIN POLYMERIZATIONS. RADICAL VERSUS IONIC POLYMERIZATION. MODES OF PROPAGATION. INITIATION IN RADICAL POLYMERIZATION. KINETICS OF CHAIN POLYMERIZATION. SOME INDUSTRIAL POLYMERIZATION PROCESSES.
SECOND PART: BIOMATERIALS AND BIOCOMPATIBILITY, BIO-INNERITY AND BIO-ACTIVITIES, DEFINITIONS. (0.5 CFU)
INTRODUCTION TO CLASSES OF MATERIALS USED IN MEDICINE (CERAMIC, METALLIC, POLYMERIC, COMPOSITE). (0.5 CFU)
THERAPEUTIC DISORDERS AND PROBLEMS (ORTHOPEDICS, ODONTIATRY, CARDIOVASCULAR DEVICES, CATHETERS, PATHOLOGY, NEFROLOGY, CONTROLLED PHARMACY RELEASE, ETC.) (0.5 CFU)
CERAMIC BIOMATERIALS (PREPARATION TECHNIQUES, PROPERTIES-STRUCTURE REPORTS, ADVANTAGES AND ADJUSTMENTS, APPLICATIONS) (0.5 CFU)
METALLIC BIOMATERIALS (METALS AND LINES, PROPERTY-STRUCTURE RELATIONSHIPS, BENEFITS AND FAULTS, APPLICATIONS). (0.5 CFU)
POLYMERIC BIOMATERIALS (DEFINITIONS AND CLASSIFICATIONS, SYNTHESIS, SOLID STATUS AND PROPERTY-STRUCTURE RELATIONSHIPS, POLYMER CLASS APPLICATIONS). (1 CFU)
COMPOSITE BIOMATERIALS (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, APPLICATIONS). (1 CFU)
PROBLEMS ASSOCIATED WITH THE SYSTEM (INFECTIONS) AND POSSIBLE SOLUTION (STERILIZATION TECHNIQUES). (0.5 CFU)
BIOMATERIALS WITH ANTIMICROBIC ACTIVITY. (0.5 CFU)
IDROGEN (DEFINITIONS, PREPARATION, PROPERTY-STRUCTURE REPORT, APPLICATIONS) (0.5 CFU)

	Teaching Methods
	THE COURSE IS ESSENTIALLY CONSTITUTED FROM FRONT LESSONS. VISITS TO MATERIAL CHARACTERIZATION LABORATORIES ARE ALSO PLANNED, DURING WHICH THE MAIN INSTRUMENTS USED IN THIS FIELD WILL BE DESCRIBED.

	Verification of learning
	THE EXAMINATION SHOULD PURSE THE READING OF THE FORMATIVE OBJECTIVES REACHED BY THE STUDENT. EXAMINATION TYPE: WRITE TEST (WITH QUESTIONNAIRE MULTIPLE ANSWERS AND QUESTIONS OPEN OPEN) AND EVENTLY ORAL. IF THE STUDENT DOES NOT SUPPLY THE WRITTEN TEST, OR IF NOT SUFFICIENT OF THE VOTED PROPOSED, IT IS FORMED ORAL TEST

	Texts
	THE USE OF LECTURE TRANSPARENCIES IS STRONGLY RECOMMENDED. THE REFERENCE TEXTS IARE AS FOLLOWS: G. ODIAN, PRINCIPLES OF POLYMERIZATION, WILEY-INTERSCIENCE BIOMATERIALS SCIENCE (THIRD EDITION) AN INTRODUCTION TO MATERIALS IN MEDICINE EDITED BY:BUDDY D. RATNER, ALLAN S. HOFFMAN, FREDERICK J. SCHOEN AND JACK E. LEMONS ISBN: 978-0-12-374626-9

BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2019-05-14]

Vincenzo VENDITTO | POLYMERS IN BIOMEDICAL APPLICATIONS