ADVANCED ORGANIC CHEMISTRY

Alessandra LATTANZI ADVANCED ORGANIC CHEMISTRY

0522300012
DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
EQF7
CHEMISTRY
2016/2017



OBBLIGATORIO
YEAR OF COURSE 1
YEAR OF DIDACTIC SYSTEM 2016
PRIMO SEMESTRE
CFUHOURSACTIVITY
756LESSONS
224EXERCISES
336LAB
Objectives
A deeper knowledge of the most important reactions for the regio- and stereocontrolled formation of C-C and C=C bonds, as well as fundamental aspects of the reactivity of organometallic reagents, devoted to the preparation of complex molecules and/or to the functionalisation of organic substrates. Capability of exploitation of advanced analytical and spectroscopic techniques for the resolution of problems of preparative, mechanistic and stereochemical type.
Prerequisites
Passing the examinations “Organic Chemistry I” and “Organic Chemistry II” courses
Contents
GENERATION OF ENOLATES AND THEIR SYNTHETIC EQUIVALENTS.PROCESSES OF ALKYLATION, ACYLATION, CONJUGATE ADDITION AND ALDOL TYPE CONDENSATION OF ENOLATES AND THEIR SYNTHETIC EQUIVALENTS; MECHANISTIC AND STEREOCHEMICAL ASPECTS OF REGIO-, STEREO- AND ENANTIOCONTROLLED REACTIONS. OLEFINATION REACTIONS.
REGIO- AND STEREOSELECTIVE PROCESSES OF OXYFUNCTIONALIZATION OF ORGANIC COMPOUNDS. REDUCTIONS OF ORGANIC COMPOUNDS
CONTENT OF THE LABORATORY: C-C BOND FORMATION BY MEANS OF C-ALKYLATION
C-C BOND FORMATION BY CONJUGATE ADDITION OF ENOLATES
FUNCTIONAL GROUP EXCHANGE BY MEANS OF WITTIG REACTION
ALCOHOL ACETOACETILATION BY THE USE OF A SYNTHON EQUIVALENT
NUCLEOPHILIC CARBONYL ADDITION
NMR IDENTIFICATION OF THE COMPOUNDS
Teaching Methods
LECTURES, LABORATORY PRACTISE
Verification of learning
oral examination
Texts
F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Plenum
Press; New York and London (V ed.)
J. March, Advanced Organic Chemistry, J. Wiley & Sons; New York (IV ed.)
B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell, VOGEL’s “ textbook of practical organic chemistry” Longman Scientific & Technical, Harlow (UK)
More Information
FOR MORE INFORMATION CONTACT: LATTANZI@UNISA.IT
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