Anna Maria D'URSI | MEDICINAL CHEMISTRY I
Anna Maria D'URSI MEDICINAL CHEMISTRY I
cod. 0760200018
MEDICINAL CHEMISTRY I
| 0760200018 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2016/2017 |
| OBBLIGATORIO | |
| YEAR OF COURSE 3 | |
| YEAR OF DIDACTIC SYSTEM 2010 | |
| SECONDO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 10 | 80 | LESSONS |
| Objectives | |
|---|---|
| KNOWLEDGE OF DESIGN, SYNTHESIS, STRUCTURE, MECHANISM OF ACTION, OF DRUGS USED AS ANTIMICROBIAL, ANTIVIRAL, ANTITUMORAL. |
| Prerequisites | |
|---|---|
| ADVANCED KNOWLEDGE OF ORGANIC CHEMISTRY, MICROBIOLOGY, ANATOMY, PHYSIOLOGY, PATHOLOGY |
| Contents | |
|---|---|
| STRUCTURE, MECHANISM OF ACTION, STRUCTURE-ACTIVITY RELATIONSHIP, PHARMACOKINETICS AND PHARMACODYNAMICS, SYNTHESIS OF COMPOUNDS SELECTED FOR THE FOLLOWING THERAPEUTIC CLASSES: ANTIBACTERIALS FOR TOPICAL USE. SYNTHETIC ANTIBACTERIAL FOR SYSTEMIC USE: SULFONAMIDES AND DRUGS THAT ACT ON THE SYNTHESIS OF FOLIC ACID; ANTIBACTERIAL FLUOROQUINOLONE, NITROFURAN AND NITROIMIDAZOLES; OXAZOLIDINONES. ANTIBIOTICS THAT INTERFERE WITH PROTEIN SYNTHESIS: MACROLIDES, LINCOSAMIDES; AMPHENICOLS, TETRACYCLINES, AMINOGLYCOSIDES. ANTIBIOTICS ACTING ON THE CELL WALL SYNTHESIS: PENICILLINS AND CEPHALOSPORINS, BETA-LACTAMASE INHIBITORS; FOSFOMYCIN AND CYCLOSERINE. GLYCOPEPTIDE ANTIBIOTICS AND POLYPEPTIDE ANSAMICINE. ANTIMYCOBACTERIAL DRUGS: ANTI-TUBERCULOSIS AND LEPROSTATICS. ANTIFUNGAL AGENTS: INHIBITORS OF THE SYNTHESIS OF ERGOSTEROL; ANTIFUNGAL ACTIVE ON THE FUNGAL CELL MEMBRANE: CANDINE, POLYMYXINS AND NIKKOMICINE; GRISEOFULVIN. ANTIPROTOZOAL DRUGS: QUINOLINE, ANTIMALARIAL AGENTS, ARTEMISININ DERIVATIVES. ANTIVIRAL DRUGS: ANTI-HERPES, ANTI-HEPATITIS, ANTI-HIV, ANTI-INFLUENZA. ANTICANCER DRUGS: ANTICANCER TARGETING DNA AND RELATED ENZYMES; ANTIMETABOLITES: INHIBITORS OF FOLATE; ANTITUMOR NATURAL PRODUCTS; NEW GENERATION ANTICANCER DRUGS. SERM. ESTRO-PROGESTIN DRUGS. |
| Teaching Methods | |
|---|---|
| LECTURES, INTERACTIVE TEACHING, TUTORIALS |
| Verification of learning | |
|---|---|
| WRITTEN EXAMINATION ORAL EXAMINATION |
| Texts | |
|---|---|
| CHIMICA FARMACEUTICA A CURA DI ALBERTO GASCO, FULVIO GUALTIERI, CARLO MELCHIORRE. CASA EDITRICE AMBROSIANA. DISTRIBUZIONE ESCLUSIVA ZANICHELLI 2015 PATRICK - INTRODUZIONE ALLA CHIMICA FARMACEUTICA - EDISES THOMAS L. LEMKE, DAVID A. WILLIAMS FOYE - FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA- PICCIN •GRECO GIOVANNI FARMACI ANTIBATTERICI - LOGHIA COURSE MATERIALS |
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