Enzymology and Bioorganic Catalysis

Giorgio DELLA SALA Enzymology and Bioorganic Catalysis

0522300033
DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
EQF7
CHEMISTRY
2016/2017

YEAR OF COURSE 2
YEAR OF DIDACTIC SYSTEM 2010
PRIMO SEMESTRE
CFUHOURSACTIVITY
648LESSONS
Objectives
TO GIVE KNOWLEDGE OF THE PROPERTIES OF ENZYMES, AND OF THE METHODS OF ENANTIOSELECTIVE ORGANIC CATALYSIS BASED ON THE USE OF BIOORGANIC MOLECULES SUCH AS ENZYMES, AMINO ACIDS AND THEIR DERIVATIVES.
KNOWLEDGE AND UNDERSTANDING: BY THE END OF THE TEACHING THE STUDENT WILL HAVE ACQUIRED EXTENSIVE KNOWLEDGE OF THE MODES OF ACTION OF ENZYMES, AND OF THE MAIN STRATEGIES AND METHODS OF ASYMMETRIC ORGANIC SYNTHESIS BASED ON BIOCATALYSIS AND ORGANOCATALYSIS.
APPLYING KNOWLEDGE AND UNDERSTANDING: THE STUDENT WILL BE ABLE TO APPLY THE KNOWLEDGE TO SOLVE PROBLEMS RELATED TO THE ENANTIOSELECTIVE SYNTHESIS OF ORGANIC MOLECULES.
Prerequisites
FUNDAMENTALS OF ORGANIC CHEMISTRY I AND II.
Contents
•BASIC NOTIONS OF STEREOCHEMISTRY.
•THE SIGNIFICANCE OF THE SYNTHESIS OF NON-RACEMIC PRODUCTS.
•GENERAL ASPECTS OF THE ENZYMATIC CATALYSIS. MODES OF ACTION OF ENZYMES AND COENZYMES.
•APPLICATION OF BIOCATALYSTS IN ASYMMETRIC SYNTHESIS.
•ORGANOCATALYSTS DERIVED FROM NATURAL ORGANIC COMPOUNDS AND THEIR APPLICATIONS IN ASYMMETRIC SYNTHESIS.
Teaching Methods
LECTURES
Verification of learning
THROUGH AN ORAL EXAMINATION, IT WILL BE ASSESSED THE STUDENT’S ABILITY TO DISCUSS , ORALLY AND THROUGH A RESEARCH PAPER, A SPECIFIC TOPIC OF BIOCATALYSIS OR ORGANOCATALYSIS PREVIOUSLY AGREED WITH THE TEACHER.
Texts
INTRODUCTION TO ENZYME AND COENZYME CHEMISTRY, TIM BUGG, 1997, BLACKWELL PUBLISHING LTD;
BIOTRANSFORMATIONS IN ORGANIC CHEMISTRY, KURT FABER, 2011, SPRINGER-VERLAG;
SINTESI ASIMMETRICA, GARRY PROCTER, 2000, EDISES S.R.L. – NAPOLI;
CHIMICA ORGANICA, PAULA YURKANIS BRUICE, 2005, EDISES S.R.L. – NAPOLI.
More Information
SUPPORTING MATERIAL (LECTURE SLIDES) AVAILABLE IN PDF
FURTHER INFORMATION CAN BE REQUESTED VIA E-MAIL: GDSALA@UNISA.IT
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