Stefania MARZOCCO | MOLECULAR AND CELLULAR PHARMACOLOGY
Stefania MARZOCCO MOLECULAR AND CELLULAR PHARMACOLOGY
cod. 0760100030
MOLECULAR AND CELLULAR PHARMACOLOGY
| 0760100030 | |
| DIPARTIMENTO DI FARMACIA | |
| CORSO DI LAUREA MAGISTRALE A CICLO UNICO DI 5 ANNI | |
| PHARMACY | |
| 2015/2016 |
| YEAR OF DIDACTIC SYSTEM 2010 | |
| PRIMO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| BIO/14 | 5 | 40 | LESSONS |
| Objectives | |
|---|---|
THE COURSE AIMS TO PROVIDE STUDENTS WITH: • KNOWLEDGE AND UNDERSTANDING: THE STUDENT WILL GAIN KNOWLEDGE ABOUT THE CONCEPT OF DRUG AS A MEAN FOR THE STUDY OF CELLULAR FUNCTION THROUGH ITS INTERACTION WITH THE MOLECULAR TARGET. ACQUIRE KNOWLEDGE REGARDING THE STRUCTURE AND FUNCTION OF THE RECEPTORS, THE MECHANISMS OF SIGNAL TRANSDUCTION, OF THE BASIC MECHANISMS OF CELL PROLIFERATION AND OF DRUG ACTION, WITH PARTICULAR REFERENCE TO NEW BIOLOGICAL DRUGS. • APPLYING KNOWLEDGE AND UNDERSTANDING: THE COURSE PROVIDES THE ABILITY TO APPLY THE KNOWLEDGE IN THE FIELD OF CELLULAR AND MOLECULAR PHARMACOLOGY IN THE BIO-ACTIVE COMPOUNDS USED IN THERAPY. • MAKING JUDGMENTS: THE ABILITY TO APPLY THE KNOWLEDGE ACQUIRED IN PRACTICE. THE KNOWLEDGE IMPARTED WILL COLLECT INFORMATION USEFUL IN THE CRITICAL EVALUATION OF THE EVOLUTION OF DRUG THERAPY. • COMMUNICATION SKILLS: THE ABILITY TO CLEARLY COMMUNICATE THEIR KNOWLEDGE AND JUDGMENT BOTH TO A SPECIALIST AND NOT OF ANY GRADE. • LEARNING SKILLS: THE OBTAINED KNOWLEDGE WILL BE A SOLID AND BROAD CULTURAL BASE TO ALLOW, ALSO MAKING USE OF ELECTRONIC DATABASES, NATIONAL AND INTERNATIONAL, A CONTINUOUS UPDATE NEED TO PRACTICE PHARMACY. |
| Prerequisites | |
|---|---|
FOR UNDERSTANDING OF THIS COURSE THE ACQUISITION OF BIOCHEMISTRY, GENERAL PHYSIOLOGY AND PATHOLOGY MECHANISMS’ ARE REQUIRED. |
| Contents | |
|---|---|
CLASSIFICATION OF RECEPTORS. MODULATION OF RECEPTOR RESPONSES. THE RECEPTOR-CHANNEL: MOLECULAR ORGANIZATION AND MODULATION OF THEIR ACTIVITY. G PROTEIN-COUPLED RECEPTORS: MOLECULAR ORGANIZATION. MOLECULAR ORGANIZATION AND FUNCTION OF G PROTEIN THE EFFECTOR SYSTEMS. THE RECEPTORS FOR GROWTH FACTORS: MOLECULAR ORGANIZATION. ACTIVATION AND SIGNAL TRANSDUCTION OF RECEPTORS FOR GROWTH FACTORS - PHARMACOLOGICAL CONTROL OF THE ACTIVITY OF GROWTH FACTORS RECEPTORS. TRANSDUCTION SYSTEMS MEMBRANE, SECOND MESSENGERS: MECHANISMS OF INTRACELLULAR SIGNAL TRANSDUCTION PATHWAYS AND THEIR REGULATION BY DRUGS. CYTOKINES: RECEPTORS AND FUNCTIONS. PHARMACOLOGICAL MODULATION OF THE ACTIVITY OF CYTOKINES. RECEPTORS THAT MEDIATE CELL ADHESION. THE INTRACELLULAR RECEPTORS: MOLECULAR ORGANIZATION AND MODULATION OF THEIR ACTIVITY. MODULATION OF RESPONSES RECEPTOR: DESENSITIZATION - DOWN-REGULATION - UP-REGULATION. PHARMACOLOGY OF AUTACOIDS. |
| Teaching Methods | |
|---|---|
| LECTURES |
| Verification of learning | |
|---|---|
| ORAL TEST |
| Texts | |
|---|---|
| THERE ARE MANY TEXTS, BOTH ITALIAN AND FOREIGN, CAN PROVIDE AN EXTENT EQUIVALENT TO EACH OTHER ELEMENTS NECESSARY FOR THE STUDY OF THE TOPICS IN THE SYLLABUS. 1) PAOLETTI R., NICOSIA S., CLEMENTI F., G. FUMAGALLI, GENERAL AND MOLECULAR PHARMACOLOGY, UTET. 2) GOODMAN & GILMAN, THE PHARMACOLOGICAL BASIS OF THERAPY, X ITALIAN EDITION, FREEMAN. WE RECOMMEND THE USE OF TEXTS PUBLISHED IN RECENT YEARS. |
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