Stefania MARZOCCO | GENERAL AND MOLECULAR PHARMACOLOGY

cod. 0522100023

GENERAL AND MOLECULAR PHARMACOLOGY

	0522100023
	DEPARTMENT OF CHEMISTRY AND BIOLOGY "ADOLFO ZAMBELLI"
	EQF7
	BIOLOGY
	2024/2025

CURRICULUM BIOMEDICAL

	OBBLIGATORIO
	YEAR OF COURSE 2
	YEAR OF DIDACTIC SYSTEM 2022
	SPRING SEMESTER

TEACHING UNITS

SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
BIO/14	5	40	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
BIO/14	1	12	LAB	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	STEFANIA MARZOCCO T Curriculum
	ADA POPOLO Curriculum

	Objectives
	• KNOWLEDGE AND UNDERSTANDING: THE STUDENT WILL ACQUIRE KNOWLEDGE OF THE PRINCIPLES OF PHARMACOLOGY ACQUIRING THE CONCEPT OF DRUG AS A MEANS FOR THE STUDY OF CELLULAR FUNCTION THROUGH ITS INTERACTION WITH THE MOLECULAR TARGET. ALSO ACQUIRE THE KNOWLEDGE ON DRUG DEVELOPMENT AND ON THE EFFECTS AND MECHANISMS OF ACTION OF DIFFERENT CLASSES OF DRUGS SUCH AS, FOR EXAMPLE, ANTI-INFLAMMATORY AND CHEMIOTERAPIC DRUGS. • APPLYING KNOWLEDGE AND UNDERSTANDING: THE COURSE PROVIDES THE ABILITY TO APPLY THE KNOWLEDGE IN THE FIELD OF PHARMACOLOGY IN THE BIO-ACTIVE COMPOUNDS USED IN THERAPY. • MAKING JUDGMENTS: THE ABILITY TO APPLY THE KNOWLEDGE ACQUIRED IN PRACTICE. THE KNOWLEDGE IMPARTED WILL COLLECT INFORMATION USEFUL IN THE CRITICAL EVALUATION OF THE EVOLUTION OF DRUG THERAPY AND ITS RELATION TO THE PROFESSION OF BIOLOGIST. • COMMUNICATION SKILLS: THE ABILITY TO CLEARLY COMMUNICATE THEIR KNOWLEDGE AND JUDGMENT BOTH TO A SPECIALIST AND NOT OF ANY GRADE. • LEARNING SKILLS: THE OBTAINED KNOWLEDGE WILL BE A SOLID AND BROAD CULTURAL BASE TO ALLOW, ALSO MAKING USE OF ELECTRONIC DATABASES, NATIONAL AND INTERNATIONAL, A CONTINUOUS UPDATE NEED TO PRACTICE THE PROFESSION.

• KNOWLEDGE AND UNDERSTANDING:
THE STUDENT WILL ACQUIRE KNOWLEDGE OF THE PRINCIPLES OF PHARMACOLOGY ACQUIRING THE CONCEPT OF DRUG AS A MEANS FOR THE STUDY OF CELLULAR FUNCTION THROUGH ITS INTERACTION WITH THE MOLECULAR TARGET. ALSO ACQUIRE THE KNOWLEDGE ON DRUG DEVELOPMENT AND ON THE EFFECTS AND MECHANISMS OF ACTION OF DIFFERENT CLASSES OF DRUGS SUCH AS, FOR EXAMPLE, ANTI-INFLAMMATORY AND CHEMIOTERAPIC DRUGS.

• APPLYING KNOWLEDGE AND UNDERSTANDING:
THE COURSE PROVIDES THE ABILITY TO APPLY THE KNOWLEDGE IN THE FIELD OF PHARMACOLOGY IN THE BIO-ACTIVE COMPOUNDS USED IN THERAPY.

• MAKING JUDGMENTS:
THE ABILITY TO APPLY THE KNOWLEDGE ACQUIRED IN PRACTICE. THE KNOWLEDGE IMPARTED WILL COLLECT INFORMATION USEFUL IN THE CRITICAL EVALUATION OF THE EVOLUTION OF DRUG THERAPY AND ITS RELATION TO THE PROFESSION OF BIOLOGIST.

• COMMUNICATION SKILLS:
THE ABILITY TO CLEARLY COMMUNICATE THEIR KNOWLEDGE AND JUDGMENT BOTH TO A SPECIALIST AND NOT OF ANY GRADE.

• LEARNING SKILLS:
THE OBTAINED KNOWLEDGE WILL BE A SOLID AND BROAD CULTURAL BASE TO ALLOW, ALSO MAKING USE OF ELECTRONIC DATABASES, NATIONAL AND INTERNATIONAL, A CONTINUOUS UPDATE NEED TO PRACTICE THE PROFESSION.

	Prerequisites
	FOR UNDERSTANDING AND APPLY THE MAJORITY OF THE SUBJECTS COVERED IN THIS TEACHING COURSE, IT IS NECESSARY TO HAVE KNOWLEDGE OF BIOCHEMISTRY, GENERAL PHYSIOLOGY AND PATHOLOGY.

	Contents
	AFTER INTRODUCING THE PRINCIPLES OF GENERAL AND MOLECULAR PHARMACOLOGY, THE TEACHING WILL BE FOCUSED ON:ROUTES OF ADMINISTRATION, ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF DRUGS (6 H OF LESSON). MEANING OF MEDICATION. DRUG-RECEPTOR INTERACTION. AGONISTS, ANTAGONISTS, INVERSE AGONISTS. POTENCY AND EFFICACY OF A DRUG. THERAPEUTIC INDEX (2 H OF LESSON). PRINCIPLES OF DRUG TRIAL (4 H OF LESSON). COUPLED RECEPTOR AND ION CHANNEL DRUGS THAT MODULATE THE ACTIVITY. METABOTROPIC RECEPTOR AND DRUGS THAT MODULATE THE ACTIVITY. CONCEPT OF CYTOSOLIC RECEPTOR AND DRUGS THAT MODULATE THE ACTIVITY. CONCEPT OF RECEPTOR TYROSINE KINASE AND DRUGS THAT MODULATE THE ACTIVITY. BIOLOGICAL DRUGS (14H OF LESSON). FEATURES OF THE MAIN CLASSES OF CHEMOTHERAPY AND ANTI-INFLAMMATORY DRUGS, AUTACOIDS (14 H OF LESSON). . BIOLOGICAL LABORATORY EXERCISES ON SELECTED TOPICS OF THE COURSE (12 H OF EXERCISES).

Contents

AFTER INTRODUCING THE PRINCIPLES OF GENERAL AND MOLECULAR PHARMACOLOGY, THE TEACHING WILL BE FOCUSED ON:ROUTES OF ADMINISTRATION, ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF DRUGS (6 H OF LESSON).
MEANING OF MEDICATION. DRUG-RECEPTOR INTERACTION. AGONISTS, ANTAGONISTS, INVERSE AGONISTS. POTENCY AND EFFICACY OF A DRUG. THERAPEUTIC INDEX (2 H OF LESSON).
PRINCIPLES OF DRUG TRIAL (4 H OF LESSON).
COUPLED RECEPTOR AND ION CHANNEL DRUGS THAT MODULATE THE ACTIVITY. METABOTROPIC RECEPTOR AND DRUGS THAT MODULATE THE ACTIVITY. CONCEPT OF CYTOSOLIC RECEPTOR AND DRUGS THAT MODULATE THE ACTIVITY. CONCEPT OF RECEPTOR TYROSINE KINASE AND DRUGS THAT MODULATE THE ACTIVITY. BIOLOGICAL DRUGS (14H OF LESSON).
FEATURES OF THE MAIN CLASSES OF CHEMOTHERAPY AND ANTI-INFLAMMATORY DRUGS, AUTACOIDS (14 H OF LESSON). .
BIOLOGICAL LABORATORY EXERCISES ON SELECTED TOPICS OF THE COURSE (12 H OF EXERCISES).

	Teaching Methods
	THE TEACHING PROVIDES LECTURES AND LABORATORY EXERCISE. THE LECTURES, FOR 40 HOURS (5CFU), ARE LOCATED IN THE CLASSROOM WITH THE AUXILIARY PROJECTION. THE LABORATORY EXERCISE, FOR 12 HOURS (1CFU), ARE LOCATED IN A LABORATORY ON TOPICS OF THE COURSE.

	Verification of learning
	THE ACHIEVEMENT OF THE OBJECTIVES OF TEACHING IS CERTIFIED BY AN EXAMINATION GRADED IN 30/30. THE EXAMINATION WILL BE PROVIDED AS AN ORAL TEST. THE ORAL TEST WILL BE ORGANIZED WITH QUESTIONS AND DISCUSSION ON THE METHODOLOGICAL CONTENTS INDICATED IN THE PROGRAM OF THE COURSE. THE ORAL TEST IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE AND THE UNDERSTANDING REACHED BY THE STUDENT. THE TEST ALSO HAVE THE PURPOSE TO VERIFY THE EXPOSURE CAPABILITY AND THE USE OF AN THE APPROPRIATE TERMINOLOGY BY THE STUDENT. MOREOVER THE ORAL TEST WILL ASSESS THE CAPACITY OF THE AUTONOMOUS ORGANIZATION OF THE EXPOSURE OF THE SAME SUBJECT TO THEORETICAL CONTENT.

Verification of learning

THE ACHIEVEMENT OF THE OBJECTIVES OF TEACHING IS CERTIFIED BY AN EXAMINATION GRADED IN 30/30. THE EXAMINATION WILL BE PROVIDED AS AN ORAL TEST.
THE ORAL TEST WILL BE ORGANIZED WITH QUESTIONS AND DISCUSSION ON THE METHODOLOGICAL CONTENTS INDICATED IN THE PROGRAM OF THE COURSE. THE ORAL TEST IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE AND THE UNDERSTANDING REACHED BY THE STUDENT. THE TEST ALSO HAVE THE PURPOSE TO VERIFY THE EXPOSURE CAPABILITY AND THE USE OF AN THE APPROPRIATE TERMINOLOGY BY THE STUDENT. MOREOVER THE ORAL TEST WILL ASSESS THE CAPACITY OF THE AUTONOMOUS ORGANIZATION OF THE EXPOSURE OF THE SAME SUBJECT TO THEORETICAL CONTENT.

	Texts
	THERE ARE MANY TEXTS, BOTH ITALIAN AND FOREIGN, CAN PROVIDE AN EXTENT EQUIVALENT TO EACH OTHER ELEMENTS NECESSARY FOR THE STUDY OF THE TOPICS IN THE SYLLABUS. 1) PAOLETTI R., NICOSIA S., CLEMENTI F., G. FUMAGALLI, GENERAL AND MOLECULAR PHARMACOLOGY, UTET. 2) GOODMAN & GILMAN, THE PHARMACOLOGICAL BASIS OF THERAPY, X ITALIAN EDITION, FREEMAN. WE RECOMMEND THE USE OF TEXTS PUBLISHED IN RECENT YEARS.

	More Information
	THE COURSE FREQUENCY IS STRONGLY RECOMMENDED.

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Stefania MARZOCCO | GENERAL AND MOLECULAR PHARMACOLOGY