Stefania MARZOCCO | TOXICOLOGY AND CHEMOTHERAPY
Stefania MARZOCCO TOXICOLOGY AND CHEMOTHERAPY
cod. 0760400027
TOXICOLOGY AND CHEMOTHERAPY
| 0760400027 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2025/2026 |
| OBBLIGATORIO | |
| YEAR OF COURSE 5 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| AUTUMN SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| BIO/14 | 10 | 80 | LESSONS |
| Objectives | |
|---|---|
| THE COURSE AIMS TO PROVIDE THE STUDENT WITH KNOWLEDGE OF THE PHARMACOLOGICAL PROPERTIES OF CHEMOTHERAPEUTIC DRUGS AND THE RATIONAL BASIS OF THE CLINICAL USE OF THESE CLASSES OF DRUGS. KNOWLEDGE AND UNDERSTANDING AT THE END OF THE COURSE THE STUDENT WILL KNOW: -PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES OF ANTI-INFECTIVE AND ANTI-TUMOR CHEMOTHERAPEUTIC DRUGS; -SIDE EFFECTS AND TOXICITIES, AND CLINICAL USES OF CHEMOTHERAPEUTIC DRUGS; -INTERACTIONS BETWEEN DRUGS AND BETWEEN THEM AND BIOACTIVE MOLECULES -MECHANISMS OF DRUG RESISTANCE; -TYPES AND MECHANISMS OF CELLULAR AND MOLECULAR TOXICITY AND ADVERSE REACTIONS TO DRUGS; -FACTORS THAT ALTER THE RESPONSE AND TOXIC EFFECTS OF DRUGS, INCLUDING GENETIC FACTORS; -TOXICITY AND DRUG-DEPENDENCE MECHANISMS OF DRUGS AND SUBSTANCES OF ABUSE; -TOXICOKINETIC AND TOXICODYNAMIC MECHANISMS OF MOLECULES OF FOOD AND ENVIRONMENTAL ORIGIN; -RATIONAL BASIS OF THE TREATMENT OF THE INTOXICATED PATIENT. ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING THE STUDENT APPLYING THE SKILLS ACQUIRED MUST BE ABLE TO -ANALYZE PROBLEMS RELATED TO THE RATIONALIZATION OF CHEMOTHERAPY THERAPIES AND THEIR CORRECT USE, IN TERMS OF EFFICACY AND SAFETY AND ADHERENCE TO THERAPY; -EVALUATE THE RISK-BENEFIT RATIO IN EXPOSURE TO XENOBIOTICS. |
| Prerequisites | |
|---|---|
| PREREQUISITES ALL EXAMS OF THE FIRST AND SECOND YEAR, PHARMACEUTICAL CHEMISTRY AND TOXICOLOGY I; PHARMACOLOGY AND PHARMACOTHERAPY |
| Contents | |
|---|---|
| CHEMOTHERAPY CONTENTS CONCEPTS OF ANTIBIOTIC THERAPY, SELECTIVE TOXICITY AND DRUG RESISTANCE (4 H) ANTIBIOTIC DRUGS (2 H) STRUCTURE, PROPERTIES, MECHANISM OF ACTION, MECHANISMS OF RESISTANCE, ASPECTS OF PHARMACOKINETICS, THERAPEUTIC USES AND SIDE EFFECTS OF THE FOLLOWING CLASSES OF DRUG: 1) ANTIMICROBIAL DRUGS (12 H) BETA-LACTAMICS, SULFAMIDES, TETRACYCLINES, MACROLIDES AND AMINOGLICOSIDS. 2) ANTI-TUBERCULAR DRUGS (2 H) ISONIAZIDE, RIFAMPICIN, ETAMBUTOL, STREPTOMICIN, PYRAZINAMIDE. 3) ANTIMALARIC DRUGS (2 H) CHLOROQINE, QUININE, MEFLOCHINE, PRIMACHINE, PROGUANIL AND ARTEMISININ. 4) ANTIFUNGAL DRUGS (2 H) 5) ANTINEOPLASTIC DRUGS (12 H) ALKYLATING DRUGS, ANTIMETABOLITES, ANTIMITOTICS, CYTOTOXIC ANTIBIOTICS, HORMONE ANTAGONISTS, MONOCLONAL ANTIBODY AND SMALL MOLECULES. 6) ANTIVIRAL DRUGS (4 H) ANTIHERPETIC AND ANTICYTOMEGALOVIRUS DRUGS ANTIRETROVIRAL DRUGS DRUGS ACTIVE AGAINST THE FLU VIRUS. TOXICOLOGY CONTENTS 1) INTRODUCTION TO TOXICOLOGY (6 H) PHARMACOALLERGY IMMEDIATE AND DELAYED TOXICITY - REVERSIBLE AND IRREVERSIBLE TOXIC EFFECTS. LOCAL AND SYSTEMIC TOXICITY. ORGANS TOXICITY 2) CARCENOGENESIS (4 H) GENOTOXIC CARGENIOGENS. ALKYLATING DRUGS - INORGANIC CARGENOGENS - NON GENOTOXIC CARGENOGENS - PARABENS - BISPHENOL A. GENOTOXIC RISK AND ITS ASSESSMENT. MUTAGENESIS AND GENOTOXICITY TESTS 3) PHARMACOIDIOSYNCRASIA – PHARMACOGENETICS (2 H) PHARMACOGENETICS AND PHARMACOGENOMICS. ADVERSE REACTIONS TO ADR DRUGS. GENE POLYMORPHISM AND VARIABILITY OF RESPONSE TO DRUG. 4) DRUGS AND SUBSTANCES OF ABUSE (14 H) DRUG ADDICTION – TOLERANCE – WITHDRAWAL – REINFORCEMENT – SENSITIZATION - PHARMACOTHERAPY ETHYL ALCOHOL, METHANOL, NICOTINE, CAFFEINE BENZODIAZEPINES, BARBITURICS, COCAINE AND AMPHETAMINE, MORPHINE, HEROINACANNABINOIDS, MDMA AND MDA KETAMINE. 5) FOOD TOXICOLOGY (4 H) FOOD SAFETY. ADVERSE FOOD REACTIONS. FOOD IDIOSYNCRASIES: CELIAC DISEASE, LACTOSE INTOLERANCE, MICOTOXINS 6) BACTERIAL TOXINS AND MARINE TOXINS (2 H) 7) ENVIRONMENTAL TOXICOLOGY (8 H) HEAVY METALS GENERALITY. TOXICOKINETICS. MECHANISM OF ACTION. TOXICITY LEAD – MERCURY – ARSENIC – CADMIUM- CHROMIUM – IRON-NICKEL PHARMACOLOGICAL TREATMENT DRUGS IN THE ENVIRONMENT |
| Teaching Methods | |
|---|---|
| THE COURSE INCLUDES 80 HOURS OF FRONTAL ASSISTED TEACHING (10 CFU). ATTENDANCE OF LESSONS IS REQUIRED. IN ORDER TO TAKE THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 75% OF THE HOURS OF THE COURSE. THE METHOD OF VERIFYING ATTENDANCE IS GENERALLY ELECTRONIC, I.E. IT IS MADE KNOWN BY THE TEACHER AT THE BEGINNING OF THE COURSE.SUGGESTED BY THE TEACHER AT THE BEGINNING OF THE COURSE. |
| Verification of learning | |
|---|---|
| ORAL INTERVIEW IT IS FINALIZED TO ASSESS THE LEVEL OF KNOWLEDGE OF THE APPROPRIATE TERMINOLOGY OF BOTH MODULES AS WELL AS THE STUDENT CAPACITY OF EXPOSITION. THE MAXIMUM SCORE IS 30/30 AND IS INTENDED TO BE PASSED WITH THE MINIMUM VOTE OF 18/30. |
| Texts | |
|---|---|
| CHEMOTHERAPY 1) GOODMAN & GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, XIII ED. ITALIANA, ZANICHELLI EDITORE. 2) ANNUNZIATO & DI RENZO, TRATTATO DI FARMACOLOGIA. IDELSON-GNOCCHI (3A EDITION) - GOODMAN & GILMAN LE BASI TOXICOLOGY KLAASSEN CD, WATKINS III JB, CASARETT & DOULL, ELEMENTI DI TOSSICOLOGIA, EDIZIONE ITALIANA A CURA DI PATRIZIA HRELIA E GIORGIO CANTELLI FORTI, CASA EDITRICE AMBROSIANA PAOLETTI R, NICOSIA S, CLEMENTI F, FUMAGALLI G, FARMACOLOGIA GENERALE E MOLECOLARE, UTET. GOODMAN &GILMAN, LE BASI FARMACOLOGICHE DELLA TERAPIA, X EDIZIONE ITALIAN, ZANICHELLI. DOLARA, TOSSICOLOGIA GENERALE ED AMBIENTALE, EDITORE PICCIN. KATZUNG, FARMACOLOGIA, EDITORE PICCIN |
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