Pietro CAMPIGLIA | MEDICINAL CHEMISTRY II
Pietro CAMPIGLIA MEDICINAL CHEMISTRY II
cod. 0760100023
MEDICINAL CHEMISTRY II
| 0760100023 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACY | |
| 2020/2021 |
| OBBLIGATORIO | |
| YEAR OF COURSE 4 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| SECONDO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 10 | 80 | LESSONS |
| Objectives | |
|---|---|
| THE AIM OF THE COURSE IS TO PROVIDE STUDENTS BASIC KNOWLEDGE ABOUT GENERAL STRATEGIES OF DESIGN, SYNTHESIS, THE STUDY OF THE MECHANISM AND CHEMICAL-TOXICOLOGICAL ASPECTS AND THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY OF DRUGS THAT AFFECT THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM, CARDIOVASCULAR AND GASTROINTESTINAL SYSTEM. THE STUDENT APPLYING THE ACQUIRED SKILLS WILL BE ABLE TO DESIGN DRUGS ON A RATIONAL BASIS. |
| Prerequisites | |
|---|---|
| STUDENTS HAVE TO KNOW ORGANIC AND INORGANIC CHEMISTRY, BIOLOGY, BIOCHEMISTRY, ELEMENTS OF ANATOMY AND PHYSIOLOGY. |
| Contents | |
|---|---|
| PART I: PRINCIPLES OF DRUG DISCOVERY DRUGDISCOVERY FROM NATURAL PRODUCTSDRUG DESIGN AND RELATIONSHIP OF FUNCTIONAL GROUPS TO PHARMACOLOGIC ACTIVITY .MOLECULARMODELING .RECEPTORS AND DRUG ACTION PART II: DRUG RECEPTORS AFFECTING NEUROTRANSMISSION AND ENZYMES AS CATALYTIC RECEPTORS DRUGSAFFECTINGCHOLINERGICNEUROTRANSMISSION. ADRENERGIC RECEPTORS AND DRUGS AFFECTING ADRENERGIC NEUROTRANSMISSION .SEROTONIN RECEPTORS AND DRUGS AFFECTING SEROTONERGIC NEUROTRANSMISSION . AMINO ACID NEUROTRANSMITTERS IN THE CENTRAL NERVOUS SYSTEM . INHIBITORS OF NERVE CONDUCTION: LOCAL ANESTHETICS .PHOSPHODIESTERASEINHIBITORS PART III: PHARMACODYNAMIC AGENTS SECTION 1: DRUGS AFFECTING CENTRAL NERVOUS SYSTEM GENERAL ANESTHETICS. SEDATIVE-HYPNOTICS. ANTISEIZURE AGENTS . ANTIDEPRESSANTS. PSYCHOTHERAPEUTIC DRUGS: ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS .HALLUCINOGENS, STIMULANTS AND RELATED DRUGS OF ABUSE OPIOIDANALGESICS. DRUGS USED TO TREAT NEUROMUSCULAR DISORDERS: ANTIPARKINSONIAN AND SPASMOLYTIC AGENTS SECTION 2: DRUGS AFFECTING THE CARDIOVASCULAR SYSTEM CARDIAC AGENTS: CARDIAC GLYCOSIDES, ANTIANGINAL, AND ANTIARRHYTHMIC DRUGS . DIURETICS. ANGIOTENSIN CONVERTING ENZYME INHIBITORS, ANTAGONISTS AND CALCIUM BLOCKERS .CENTRAL AND PERIPHERAL SYMPATHOLYTICS AND VASODILATORS .ANTIHYPERLIPOPROTEINEMICS AND INHIBITORS OF CHOLESTEROL BIOSYNTHESIS |
| Teaching Methods | |
|---|---|
| 80 HOURS OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE. |
| Verification of learning | |
|---|---|
| ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 120 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 40-MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS WITH THEORETICAL CONTENT. |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS GASCO GUALTIERI MELCHIORRE CHIMICA FARMACEUTICA. CEA |
| More Information | |
|---|---|
THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY |
BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2022-05-23]
