Pietro CAMPIGLIA | MEDICINAL CHEMISTRY II
Pietro CAMPIGLIA MEDICINAL CHEMISTRY II
cod. 0760100023
MEDICINAL CHEMISTRY II
| 0760100023 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACY | |
| 2021/2022 |
| OBBLIGATORIO | |
| YEAR OF COURSE 4 | |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 10 | 80 | LESSONS |
| Objectives | |
|---|---|
| THE AIM OF THE COURSE IS TO CONVEY A RATIONAL APPROACH TO THE INTERACTION OF DRUG ACTIVITY AND THEIR DESIGN. AT THE END OF THE COURSE, THE PARTICIPANTS WILL BE ABLE TO UNDERSTAND THE RELATIONSHIPS THAT LINK THE CHEMICAL STRUCTURE OF A DRUG TO ITS PHARMACOLOGICAL ACTIVITY THROUGH THE STUDY OF THE CHEMICAL-PHYSICAL AND STEREO-ELECTRONIC PROPERTIES, AND OF THE MECHANISM OF ACTION. THE PURPOSE OF THE COURSE IS ALSO THE STUDY OF THE MAIN CHEMICAL-PHARMACEUTICAL STRATEGIES USEFUL FOR OPTIMIZING THE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF DRUGS. IN PARTICULAR, THE COURSE DEALS WITH THE STUDY OF DRUGS ACTIVE ON THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM, DRUGS OF THE CARDIO-CIRCULATORY SYSTEM, NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, ANTIHISTAMINES, ANTI-ULCERS AND LIPID-LOWERING DRUGS. |
| Prerequisites | |
|---|---|
| STUDENTS HAVE TO KNOW ORGANIC AND INORGANIC CHEMISTRY, BIOLOGY, BIOCHEMISTRY, ELEMENTS OF ANATOMY AND PHYSIOLOGY. |
| Contents | |
|---|---|
| DISCOVERY, DESIGN AND DEVELOPMENT, STUDY OF STRUCTURE-ACTIVITY RELATIONSHIPS AND MECHANISMS OF ACTION AT THE MOLECULAR LEVEL OF THE FOLLOWING DRUG CLASSES: SEDATIVE ANXIOLYTICS AND HYPNOTIC DRUGS (6 H), LOCAL ANESTHETICS (2 H), ANTIARRHYTHMICS (2 H), ANTIEPILEPTICS (2 H), CARDIOTONICS (4 H), ANTIANGINOSIS (2 H) ANTIEPILEPTICS (2 H), CHOLINERGIC: ANTICHOLINERGIC AND ANTICHOLINESTERASE DRUGS (8 H), DRUGS ACTIVE ON THE ADRENERGIC NERVOUS SYSTEM (8 H), ANTIDEPRESSANTS (2 H), OPIOID ANALGESICS (4 H), NEUROLEPTICS (2 H), ANTIPARKINSON'S (2 H), ANTI-MIGRAINE AND ANTIEMETIC DRUGS (2 H), ANTI-HYPERTENSIVE DRUGS (6 H), DIURECTICS (2H) NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) (4 H), LIPID-LOWERING AGENTS (2 H) STEROIDAL ANTI-INFLAMMATORY DRUGS (FAS) (2 H), ANTIHISTAMINES (5 H), ANTIULCERS (2 H). SYNTHESIS OF THE MAIN DRUGS TREATED (9 H). |
| Teaching Methods | |
|---|---|
| 80 HOURS OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE. |
| Verification of learning | |
|---|---|
| ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 150 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 25 MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS WITH THEORETICAL CONTENT. |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. GASCO, GUALTIERI, MELCHIORRE: "CHIMICA FARMACEUTICA" CASA EDITRICE AMBROSIANA, ULTIMA EDIZIONE. • G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE • WILSON&GISVOLD CHIMICA FARMACEUTICA .ED.CEA • T. NOGRADY, D. WEAVER, MEDICINAL CHEMISTRY – A MOLECULAR AND BIOCHEMICAL APPROACH, 3RD ED., OXFORD UNIVERSITY PRESS. C. WERMUTH, LE APPLICAZIONI DELLA CHIMICA FARMACEUTICA, EDISES. • P. KROGSGAARD-LARSEN, T. LILJEFORS, U. MADSEN ED., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, TAYLOR & FRANCIS. • GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL MEDICAL PUBLISHING DIVISION (2011). • WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC MEDICINAL AND PHARMACEUTICAL CHEMISTRY-LIPPINCOTT WILLIAMS & WILKINS GASCO GUALTIERI MELCHIORRE CHIMICA FARMACEUTICA. CEA |
| More Information | |
|---|---|
THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY |
BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2022-11-21]
