Pietro CAMPIGLIA | VETERINARY MEDICINAL CHEMISTRY
Pietro CAMPIGLIA VETERINARY MEDICINAL CHEMISTRY
cod. 0712300020
VETERINARY MEDICINAL CHEMISTRY
| 0712300020 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF6 | |
| PHARMACEUTICALS AND NUTRACEUTICALS FOR ANIMALS | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 3 | |
| YEAR OF DIDACTIC SYSTEM 2022 | |
| AUTUMN SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 12 | 96 | LESSONS |
| Objectives | |
|---|---|
| THE COURSE AIMS TO PROVIDE STUDENTS WITH KNOWLEDGE OF THE STRUCTURE, THE MOLECULAR MECHANISM OF ACTION AND THE STRUCTURE-ACTIVITY RELATIONSHIP OF MOST COMMON VETERINARY DRUGS. AT THE END OF THE COURSE, THE STUDENT WILL ACQUIRE THE KNOWLEDGE OF THE PROBLEMS RELATED TO THE STRUCTURE OF DRUGS AND THE PRINCIPLES THAT REGULATE THEIR CHEMICAL-PHYSICAL BEHAVIOR, AS WELL AS THE KNOWLEDGE OF THE PROBLEMS RELATED TO THE MOLECULAR MECHANISM OF ACTION WITH SPECIFIC REFERENCE TO THE BASICS OF THE INTERACTION WITH THE BIOLOGICAL TARGETS, THE METABOLISM, THE INTERACTION WITH OTHER DRUGS AND THE PREFERENTIAL ADMINISTRATION ROUTE. THE STUDENT WILL GAIN THE CAPABILITY TO APPLY THE ACQUIRED KNOWLEDGE TO DESIGN POSSIBLE STRUCTURAL CHANGES, WHICH ALLOW TO MODULATE THE PROFILE OF A DRUG TO ITS THERAPEUTIC USE |
| Prerequisites | |
|---|---|
| ACQUISITION REQUIRED FOR THE FOLLOWING DISCIPLINES: ORGANIC CHEMISTRY AND APPLIED MICROBIOLOGY TO PRODUCTS FOR ANIMALS |
| Contents | |
|---|---|
| DEFINITION OF DRUG, ACTIVE INGREDIENT AND PHARMACEUTICAL FORMS. DRUG DISCOVERY: THE MODERN TECHNOLOGIES IN DISCOVERY AND DRUG DEVELOPMENT. NATURAL AND SYNTHETIC DRUGS. PHYSICO-CHEMICAL PROPERTIES OF DRUGS. PHARMACOKINETICS: ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION. DRUG-DRUG AND DRUG-FOOD INTERACTIONS. BIOAVAILABILITY AND BIOEQUIVALENCE. GENERIC DRUG. PHARMACODYNAMICS. AGONISTS, ANTAGONISTS, PARTIAL AGONISTS AND INVERSE AGONISTS. DRUG-METABOLIC INDUCTION AND INHIBITION. ENZYME INHIBITION. DRUGS CLASSIFICATION. DRUGS’ ROUTES OF ADMINISTRATION AND EXCRETION (16H). STRUCTURE, MECHANISM OF ACTION, STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIPS, PHARMACOKINETIC AND PHARMACODYNAMIC FEATURES OF THE FOLLOWING CLASSES OF DRUGS: ANTIMICROBIAL CHEMIOTERAPY ANTISEPTICS AND DISINFECTANTS (2H) SYNTHETIC SISTEMIC ANTIBIOTICS: SULFONAMIDES AND DRUGS ACTING ON FOLIC ACID SYNTHESIS(2H). ANTIBIOTICS INTERFERING WITH CELL WALL SYNTHESIS: PENICILLINS, CEPHALOSPORINS, BETALATTAMASES INHIBITORS, CARBAPENEMS (6H). ANTIBIOTICS INTERFERING WITH PROTEIC SYNTHESIS: MACROLIDS, LINCOSAMIDES, AMFENICOLS, TETRACYCLINE, AMINOGLYCOSIDES (6H). FLUOROQUINOLONIC ANTIBACTERIALS(2H). ANTIFUNGAL DRUGS: INHIBITORS OF ERGOSTEROL SYNTHESIS, ANTIFUNGAL ACTING ON CELL MEMBRANE: POLYENIC MACROLIDES, GRISEOFULVIN (4H). ANTIVIRAL DRUGS (4H). ANTIPARASITIC CHEMIOTERAPY ANTINEMATODES; ANTICESTODES; ANTI TREMATODES; ENDECTOCIDES; ANTIPROTOZOALS(4H).. ANCANCER CHEMIOTERAPY ANTICANCER DRUGS ACTING ON DNA AND CORRELATED ENZYMES, ANTIMETABOLITES, FOLATE INHIBITORS, PURINIC AND PYRIMIDINIC ANALOGUES, NATURAL ANTICANCER DRUGS (6H).. DESCRIPTION OF THE STRUCTURE AND FUNCTIONALITY OF THE MAIN CLASSES OF RECEPTORS (4H). DISCOVERY, DESIGN AND DEVELOPMENT, STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MECHANISM OF THE FOLLOWING CLASSES OF DRUGS: NARCOTIC ANALGESICS (2H), CHOLINERGIC DRUGS (4H), LOCAL ANESTHETICS (2H), GENERAL ANESTHETICS (2H), ANTIEPILEPTICS (2H), SEDATIVES-HYPNOTICS (2H), ANTIARRHYTHMICS (2H), CARDIOTONICS (2H), DRUGS ACTIVE ON THE RENIN-ANGIOTENSIN SYSTEM (2H), ANTI-HYPERTENSIVES (4H), DIURETIC DRUGS (2H) NON-STEROID ANTI-INFLAMATORS (2H), GLUCOCORTICOID AND MINERALCORTICOID DRUGS (2H), ANTIDIABETICS (2H), HYPOLIPIDEMIC DRUGS (2H), STEROIDS (2H). |
| Teaching Methods | |
|---|---|
| 96 HOURS OF CLASSROOM LESSONS ARE PROVIDED ON ALL THE SUBJECTS OF THE COURSE. |
| Verification of learning | |
|---|---|
| ACHIEVEMENT OF THE OBJECTIVES IS CERTIFIED BY PASSING AN EXAM.THE EXAM PROVIDES FOR A PRELIMINARY WRITTEN EXAM TO AN ORAL EXAM THAT TAKES PLACE ON DIFFERENT CALENDARED DAYS. THE WRITTEN TEST CONSISTS OF FIVE ANSWER AND IT HAS A DURATION NOT EXCEEDING 120 MINUTES AND IS AIMED AT VERIFYING THE ABILITY TO PROPERLY APPLY THEORETICAL KNOWLEDGE AND THE ABILITY TO COMMUNICATE IN WRITING. THE ORAL TEST CONSISTS OF A 40-MINUTE DISCUSSION AIMED AT ASSESSING THE LEVEL OF KNOWLEDGE AND UNDERSTANDING ACQUIRED BY THE STUDENT ON THE THEORETICAL CONTENTS OF THE PROGRAM. THE ORAL TEST WILL ALSO ALLOW STUDENTS TO COMMUNICATE WITH THE LANGUAGE SKILLS AND AUTONOMOUS EXPOSURE ORGANIZATION ON THE SAME SUBJECTS WITH THEORETICAL CONTENT. THE FINAL EVALUATION WILL NOT BE BASED EXCLUSIVELY ON THE CALCULATION OF THE ARITHMETIC MEAN OF THE SCORES OBTAINED IN THE INDIVIDUAL TESTS, BUT WILL TAKE INTO CONSIDERATION THE EVALUATIONS OBTAINED IN EACH TEST INDEPENDENTLY. |
| Texts | |
|---|---|
| D.A. WILLIAMS, T.L. LEMKE, FOYE’S PRINCIPI DI CHIMICA FARMACEUTICA, PICCIN. G.L. PATRICK, INTRODUZIONE ALLA CHIMICA FARMACEUTICA, EDISES, II EDIZIONE WILSON&GISVOLD CHIMICA FARMACEUTICA.ED.CEA GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, TWELFTH EDITION, MCGRAW-HILL JIM E. RIVIERE, MARK G. PAPICH VETERINARY PHARMACOLOGY AND THERAPEUTICS, 10TH EDITION WILEY |
| More Information | |
|---|---|
| THE COURSE IS TAUGHT IN ITALIAN THE ATTENDANCE IS MANDATORY LOCATION: DEPARTMENT OF PHARMACY |
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