Pasquale DEL GAUDIO | DRUG DELIVERY AND TARGETING
Pasquale DEL GAUDIO DRUG DELIVERY AND TARGETING
cod. 0760400028
DRUG DELIVERY AND TARGETING
| 0760400028 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 5 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/09 | 6 | 48 | LESSONS |
| Objectives | |
|---|---|
| Learning outcome: Student is able to explain the key points of controlled drug delivery and the factors affecting the rate of drug delivery. Student can classify different drug delivery systems and explain the theories behind them, compare different applications of each delivery system. Student is able to describe the drug release characterization methods and explain different manufacturing methods. Student can design an improvement for existing drug delivery device and justify its improvements as well as analyze its future views in the field of drug delivery devices. |
| Prerequisites | |
|---|---|
| BASIC KNOWLEDGE OF INORGANIC AND ORGANIC CHEMISTRY, ANALITICAL CHEMISTRY, PHYSICAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY. |
| Contents | |
|---|---|
| - BASIC CONCEPTS RELATED TO THE CONTROLLED RELEASE OF THE DRUGS - SOLID PHARMACEUTICAL DOSAGE FORMS (MATRIX AND RESERVOIR SYSTEMS). - WETTING AND DISSOLUTION RATE OF PHARMACEUTICAL DOSAGE FORMS. - FICK LAWS APPLIED TO DRUG RELEASE. - MECHANISMS TO CONTROL DRUG RELEASE RATE FOR DIFFERENT ADMINISTRATION ROUTES. - CONTROLLED DRUG RELEASE DOSAGE FORMS: RESERVOIR SYSTEMS. OSMOTIC PUMP. ENTERIC MATRICES. POLYMERIC SWELLING/EROSION SYSTEMS. - CONTROLLED RELEASE DOSAGE FORMS MANUFACTURING METHODS. - MICROPARTICLES FOR CONTROLLED DRUG RELEASE: - BASIC CONCEPTS RELATED TO THE CONTROLLED RELEASE OF THE DRUGS – (4 H) - SOLID PHARMACEUTICAL DOSAGE FORMS (MATRIX AND RESERVOIR SYSTEMS) – (4 H) - WETTING AND DISSOLUTION RATE OF PHARMACEUTICAL DOSAGE FORMS – (2 H) - FICK LAWS APPLIED TO DRUG RELEASE – (2 H) - MECHANISMS TO CONTROL DRUG RELEASE RATE FOR DIFFERENT ADMINISTRATION ROUTES – (2 H) - CONTROLLED DRUG RELEASE DOSAGE FORMS: RESERVOIR SYSTEMS. OSMOTIC PUMP. ENTERIC MATRICES. POLYMERIC SWELLING/EROSION SYSTEMS – (6 H) - CONTROLLED RELEASE DOSAGE FORMS MANUFACTURING METHODS – (4 H) - MICROPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (4 H) - NANOPARTICLES FOR CONTROLLED DRUG RELEASE: CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H) - LIPOSOMES: MANUFACTURING METHODS AND CHARACTERIZATION BOTH IN VITRO AND IN VIVO – (2 H) - IMPLANTS FOR CONTROLLED DRUG DELIVERY – (4 H) - TRANSDERMAL DRUG DELIVERY SYSTEMS – (4 H) |
| Teaching Methods | |
|---|---|
| FRONTAL LESSONS, INTERACTIVE LEARNING AND LAB EXPERIENCE. FRONTAL LESSONS ARE CONDUCTED BY MULTIMEDIA PRESENTATIONS. THE LAB EXPERINCES ARE CONDUCTED INTO A LABORATORY DEDICATED TO THE PHARMACEUTICAL TECHNOLOGY, ALLOW TO APPLY THE LEARNED THEORETICAL NOTIONS TO THE PREPARATION OF CONTROLLED DRUG RELEASE FORMULATIONS |
| Verification of learning | |
|---|---|
| ORAL EXAMINATION CONSISTING IN A DISCUSSION OF APPROXIMATELY 20 MINUTES, TO VERIFY THE COMPREHENSION OF THE ARGUMENTS SUBJECT TO THE COURSE AND THE ABILITY TO SOLVE PROBLEMS RELATED TO THE FORMULATION OF INNOVATIVE PHARMACEUTICAL DOSAGE FORMS RELATED TO SPECIFIC DRUG RELEASE KINETICS, CONTROL OF THE DRUG ABSORPTION AND DRUG FORMULATIONS FOR DIFFERENT ADMINISTRATION ROUTE |
| Texts | |
|---|---|
| COLOMBO P., CATELLANI P. L., GAZZANIGA A., MENEGATTI E., VIDALE E., PRINCIPI DI TECNOLOGIE FARMACEUTICHE, ED. AMBROSIANA, 2016 WISE D. L., HANDBOOK OF PHARMACEUTICAL CONTROLLED RELEASE TECHNOLOGY, M. DEKKER, 2015 LI X., DESIGN OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS, MCGRAW-HILL, 2016 WILSON C. G., CROWLEY P. J., CONTROLLED RELEASE IN ORAL DRUG DELIVERY, SPRINGER, 2011 |
| More Information | |
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