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CHEMICAL PLANTS IN GALENIC PRODUCTIONS

Anna Angela BARBA CHEMICAL PLANTS IN GALENIC PRODUCTIONS

0760300044
DIPARTIMENTO DI FARMACIA
EQF7
PHARMACY
2024/2025

YEAR OF COURSE 5
YEAR OF DIDACTIC SYSTEM 2023
SPRING SEMESTER
CFUHOURSACTIVITY
648LESSONS
ANNA ANGELA BARBA T Curriculum
Objectives
THE TEACHING IS AIMED TO GIVE KNOWLEDGE AND UNDERSTANDING THE METHODS OF ANALYSIS, DEVELOPMENT AND DESIGN OF PHYSICAL, CHEMICAL-PHYSICAL AND BIOLOGICAL TRANSFORMATION PROCESSES OF MATTER, ON DIFFERENT SCALES (LABORATORY, PILOT, INDUSTRIAL), BASED ON INNOVATIVE SUSTAINABLE TECHNOLOGIES, WITH REDUCED ENVIRONMENTAL IMPACT.
AT THE END OF THE COURSE THE STUDENT WILL KNOW:
- THE PHENOMENA PHENOMENA INVOLVED IN TRANSFORMATION PROCESSES;
- THE BASIC PLANT ELEMENTS AND THE MOST RELEVANT PROCESS VARIABLES;
- SOME TRANSFORMATION PROCESSES TYPICAL OF PHARMACEUTICAL PRODUCTIONS;
- THE FUNDAMENTALS OF TECHNOLOGICAL INNOVATIONS FOR MORE SUSTAINABLE TRANSFORMATIONS AND THE CHARACTERISTICS OF THE INDUSTRIAL AUTOMATION PROGRAM INDUSTRY 4.0.
AT THE END OF THE COURSE THE STUDENT WILL HAVE:
- ABILITY TO EVALUATE THE BASIC PROCESSES INVOLVED IN A TRANSFORMATION PROCESS;
- ABILITY TO IDENTIFY THE ESSENTIAL PLANT ENGINEERING TOOLS;
- ABILITY TO SELECT TECHNOLOGICAL SUITABLE TOOLS FOR SUSTAINABLE PRODUCTIONS BY BALANCING POSSIBLE ELEMENTS OF PROCESS INNOVATION AND STANDARDIZED MANUFACTURING PROCEDURES.
Prerequisites
BASIC KNOWLEDGE OF CHEMISTRY, PHYSICS AND MATHEMATICS.
Contents
INTRODUCTION TO THE PROGRAM CONTENTS; TEACHING AND EVALUATION METHODS; DIDACTIC MATERIALS. ELEMENTS OF METROLOGY: INTERNATIONAL SYSTEM – INRIM. PHYSICAL, CHEMICAL-PHYSICAL AND BIOLOGICAL TRANSFORMATIONS OF MATTER. PRODUCTION SCALES. GALENIC PREPARATIONS AND PRODUCTION OF INDUSTRIAL GALENICS. THE ANATOMY OF A PRODUCTION PROCESS: BASIC PLANT ELEMENTS - REGULATION AND CONTROL EQUIPMENT AND TOOLS; PROCESS LINES AND SERVICE LINES. LAYOUT OF PRODUCTION LINES. REPRESENTATION WITH WORKFLOW AND PIPING AND INSTRUMENTATION DIAGRAM (PI&D). 4 HOURS
INTRODUCTION TO THE MOST COMMONLY USED PROCESSES AND EQUIPMENT FOR PHARMACEUTICAL TRANSFORMATIONS INVOLVING HEAT TRANSFER, SIMULTANEOUS HEAT AND MATTER TRANSFER MODELS FOR THE STUDY OF UNIT OPERATIONS: EQUILIBRIUM STAGES MODEL, TRANSPORT PHENOMENA MODEL. 4 HOURS
HEAT EXCHANGE PROCESS. HEAT TRANSPORT PHENOMENA. MAIN TYPES OF EXCHANGERS WITH SCHEMATIC REPRESENTATIONS. STEAM PRODUCTION. 6 HOURS
PROCESS FOR CONCENTRATION BY EVAPORATION OF SOLVENT. SATURATED STEAM TABLE. SINGLE EFFECT EVAPORATOR, MULTIPLE EFFECTS WITH THERMAL RECOVERY. MAIN TYPES OF CONCENTRATORS WITH SCHEMATIC REPRESENTATIONS. 4 HOURS
DRYING PROCESS. DRYING METHODS. AIR HYGROMETRY. PHASES OF THE DRYING PROCESS, DRYING CURVES. EQUIPMENT OF MOST INTEREST FOR DRYING PRODUCTS OF THE PHARMACEUTICAL INDUSTRY WITH SCHEMATIC REPRESENTATIONS. 6 HOURS
PROCESSES BASED ON STAGES OF EQUILIBRIUM. PRESENTATION OF THE EQUILIBRIUM STAGE. LIQUID-SOLID AND LIQUID-LIQUID EXTRACTION: PHYSICAL PRINCIPLES. MOST COMMONLY USED EXTRACTORS WITH SCHEMATIC REPRESENTATIONS. DISTILLATION: PHYSICAL PRINCIPLES, EQUIPMENT WITH SCHEMATIC REPRESENTATIONS. 6 HOURS
MANAGEMENT OF SOLID MATERIALS OF INTEREST FOR THE PHARMACEUTICAL INDUSTRY. FUNDAMENTAL AND DERIVATIVE PROPERTIES OF SOLIDS. FLOW INDEXE. NOTES RELATING TO: AUXILIARIES AND DOSING SYSTEMS; FIFO, LIFO DISCHARGE MODELS; STORAGE AND TRANSPORT OF SOLID MATERIALS. SOLID GAS SEPARATION SYSTEMS BASED ON PRINCIPLES: INERTIAL, ELECTROSTATIC, SIEVE. 8 HOURS
PROCESSES AND EQUIPMENT FOR THE SIZE REDUCTION OPERATION. PROCESSES AND EQUIPMENT FOR THE ENLARGEMENT OPERATION. SOLID SOLID MIXING, EQUIPMENT. RELEVANCE OF PROCESSES IN THE PHARMACEUTICAL FIELD. 8 HOURS
PROCESS INTENSIFICATION, SUSTAINABLE AND RESPONSIBLE PRODUCTION: APPROACHES AND STRATEGIES IN GALENIC PREPARATIONS. INDUSTRY 4.0. CONCLUSIVE REMARKS ON THE TOPICS PRESENTED IN LESSON. 2 HOURS
Teaching Methods
LECTURES IN CLASSROOM (48 HOURS - 6 CFU).
Verification of learning
THE LEARNING ASSESSMENT PROCESS REQUIRES AN ORAL TEST. THE AVERAGE DURATION STARTS FROM 20 MINUTES (IF THE ANSWERS ARE GIVEN RAPIDLY AND CORRECTLY), UP TO 30 MINUTES IF THE CANDIDATE IS NOT SURE IN HIS/HER ANSWERS AND TAKES TIME TO GIVE THE ANSWERS.
THE SUFFICIENCY IS ACHIEVED IF THE CANDIDATE DEMONSTRATES THE CAPABILITY TO DESCRIBE THE FUNDAMENTAL ASPECTS OF THE DIFFERENT TOPICS OF THE TEACHING PROGRAM (PHYSICAL PRINCIPLES, CONSTRUCTIVE ASPECTS, FIELDS OF APPLICATION).
THE EXCELLENCE IS OBTAINED WHEN THE CANDIDATE IS ABLE TO FACE OUT SUCCESSFULLY EVEN ASPECTS OF THE TOPIC NOT ANALYZED DURING THE COURSE.
THE OVERALL EVALUATION DEPENDS FROM THE LEVEL OF EXPOSITION AND FROM THE CONFIDENCE SHOWN WITH THE TEACHING’S TOPICS.
Texts
REFERENCE TEXTS:
L. FABRIS, S. RIGAMONTI, LA FABBRICAZIONE INDUSTRIALE DEI MEDICINALI, SOC. EDITRICE ESCULAPIO-BOLOGNA 2008
MCCABE W., SMITH., HARRIOT P., UNIT OPERATION OF CHEMICAL ENGINEERING, MCGRAW HILL, NEW YORK, 1993
CONSULTATION TEXTS:
HICKEY A.J.; GANDERTON D., PHARMACEUTICAL PROCESS ENGEERING, DRUG AND PHARMACEUTICAL SCIENCES VOL. 112, MARCEL DEKKER, INC. 2001
FRISO D., INGEGNERIA DELL’INDUSTRIA AGROALIMRENTARE, VOL. I E II, CLEUP ED., PADOVA 2018
COULSON AND RICHARDSON’S CHEMICAL ENGINEERING SERIES CHEMICAL ENGINEERING DESIGN SIXTH EDITION, RAY SINNOTT, GAVIN TOWLER, 2019 ELSEVIER BUTTERWORTH HEINEMANN
FOUST AS, WENZEL LA, MAUS ANDERSEN I PRINCIPI DELLE OPERAZIONI UNITARIE, CASA EDITRICE AMBROSIANA BOLOGNA 1992
OTHER :
DIDACTIC MATERIAL WILL BE MADE AVAILABLE BY THE TEACHER AT THE LINK: HTTPS://DOCENTI.UNISA.IT/005842/RISORSE
More Information
PLACE AND TIME OF DELIVERY.
THE TEACHING IS DELIVERED AT THE DEPARTMENT OF PHARMACY; TIMETABLE AND CLASSROOM ARE AVAILABLE FROM DEPARTMENT WEBSITE.
ATTENTION: PLEASE CHECK GUIDELINES ON ATENEO WEBSITE FOR POSSIBLE EDUCATION ACTIVITIES PERFORMED AS SMART WORKING (VIA MS TEAMS) FOR THE EXTENSION OF THE COVID 19 EMERGENCY.
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