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Curriculum

Curriculum Docente

NOME

Elizabeth Anne Illingworth

TITOLO

Professore Ordinario


LAUREE

BSc (1980) Applied Zoology, University College of North Wales (UK)

PhD (1991) Experimental Pathology, University of London (UK)

INCARICHI ACCADEMICI

1992 - 1999 Research Associate: Department of Molecular & Human Genetics,

Baylor College of Medicine, Houston, Texas.

1999 - 2001 Instructor: Department of Pediatrics (Cardiology), Baylor College of Medicine.

2001 - 2006 Assistant Professor: Department of Pediatrics (Cardiology), Baylor College of Medicine,

2006 - 2010 Adjunct Associate Professor, IBT, TAMHSC, Houston, Texas

2006 - 2010 Associate Telethon Scientist, Dulbecco Telethon Institute, c/o TIGEM, Naples, Italy

2007 - 2021 Professore Associato, Dip. Chimica e Biologia, Università degli Studi di Salerno, Fisciano, Italy

2021 - presente Professore Ordinario, Dip. Chimica e Biologia, Università degli Studi di Salerno, Fisciano, Italy

INTERESSA DI RICERCA

Le basi patogeniche sottostante i disordini comportamentali e psichiatrici associati alla sindrome da delezione 22q11.2; il ruolo del fattore di trascrizione TBX1 nello sviluppo vascolare

PUBBLICAZIONI (SELEZIONATI)

    1. Aurigemma I, Lanzetta O, Cirino A, Allegretti S, Lania G, Ferrentino R, Poondi Krishnan V, Angelini C, Illingworth E, Baldini A. Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation. In press. Communications Biology, 7(1):351. doi: 10.1038/s42003-024-06017-8. 2024.
    2. Cioffi S, Flore G, Martucciello S, Bilio M, Turturo MG, Illingworth E. VEGFR3 modulates brain vessel branching in a mouse models of 22q11.2 deletion syndrome. Life Science Alliance, 5 (12): 1-12, DOI: 10.26508/lsa.202101308 (2022).

    3. Favicchia I, Flore G, Cioffi S, Lania G, Baldini A, Illingworth E. Pharmacological rescue of the brain cortex phenotype of Tbx1 mutants: significance for 22q11.2 deletion syndrome. Front. Mol. Neurosci. 14:663598 (2021). DOI: 10.3389/fnmol.2021.663598

    4. Martucciello S, Turturo MG, Bilio M, Cioffi S, Chen L, Baldini A, Illingworth E. A dual role for Tbx1 in cardiac lymphangiogenesis through interaction with Vegfr3. The FASEB Journal, 34: 15062-15079. DOI. org/10.1096/fj.201902202R (2020).

    5. Gentile MT, Russo R, Pastorino O, Cioffi S, Barbieri F, Illingworth E, Grieco M, Chambery A, Colucci-D'Amato L. Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway. Exp Cell Res. 364:50-58, DOI:10.1016/j.yexcr.2018.01.025 (2018).
    6. Baldini, A., Fulcoli, F.G., Illingworth, E. Tbx1: transcriptional and developmental functions. Current Topics in Developmental Biology. Epub 2016 Sep 1, 122:223-243 (2017).
    7. Flore, G., Cioffi, S., Bilio, M., Illingworth, E. Cortical development requires mesodermal expression of Tbx1, a gene haploinsufficient in 22q11.2 deletion syndrome. Cerbral Cortex Epub 2016 Mar 21, 27(3):2210-2225 (2017).
    8. Cioffi S, Martucciello S, Fulcoli FG, Bilio M, Ferrentino R, Nusco E, Illingworth E. Tbx1 regulates brain vascularization Human Molecular Genetics. Epub 2013 Aug 14, 23:78-89 (2014).
    9. Toritsuka M, Kimoto S, Muraki K, Landek-Salgado M, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11-deletion syndrome mouse model. PNAS, 110:17552-7 (2013)
    10. R De Cegli, S Iacobacci, G Flore, G Gambardella, L Mao, L Cutillo, M Lauria, J Klose, E Illingworth,S Banfi, D di Bernardo. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. Nucleic Acids Research. 41:711-726 (2012)
    11. S Kimoto, K Muraki, M Toritsuka, S Mugikura, K Kajiwara, T Kishimoto, E Illingworth, K Tanigaki. Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome. Translational Psychiatry. 2:e146, Pag.1-16 (2012).
    12. L. Chen, G. Fulcoli, R. Ferrentino, S. Martucciello, E. A. Illingworth, A. Baldini. Transcriptional Control in Cardiac Progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genetics, 8(3): e1002571, p. 1-17 (2012).