Amalia PORTA | MICROBIOLOGY AND PATHOLOGY
Amalia PORTA MICROBIOLOGY AND PATHOLOGY
cod. 0760400013
MICROBIOLOGY AND PATHOLOGY
| 0760400013 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2024/2025 |
| OBBLIGATORIO | |
| YEAR OF COURSE 2 | |
| YEAR OF DIDACTIC SYSTEM 2023 | |
| SPRING SEMESTER |
| SSD | CFU | HOURS | ACTIVITY | ||
|---|---|---|---|---|---|
| MICROBIOLOGIA MODULO DI MICROBIOLOGIA E PATOLOGIA | |||||
| BIO/19 | 5 | 40 | LESSONS | ||
| PATOLOGIA GENERALE MODULO DI MICROBIOLOGIA E PATOLOGIA | |||||
| MED/04 | 5 | 40 | LESSONS | ||
| Objectives | |
|---|---|
| THE COURSE AIMS TO PROVIDE THE STUDENT WITH FUNDAMENTAL CONCEPTS OF GENERAL MICROBIOLOGY IN ORDER TO STUDY THE EVENTS RELATED TO THE ONSET OF INFECTIOUS AND THE DEVELOPMENT OF CHEMOTHERAPY. THE PATHOLOGY MODULE AIMS TO PROVIDE KNOWLEDGE OF THE MAIN EXOGENOUS AND ENDOGENOUS CAUSES OF HUMAN DISEASES AND TO FRAME THE PATHOGENESIS ACCORDING TO THE POTENTIAL SITES OF THERAPEUTIC INTERVENTION. AT THE END OF THE COURSE THE STUDENT WILL KNOW: -STRUCTURES AND FUNCTIONS OF DISTINCTIVE COMPONENTS, AND VIRULENCE FACTORS OF THE MAIN MICROORGANISMS AND VIRUSES; - THE MAIN MECHANISMS OF DAMAGE TO THE HUMAN BODY, THE ETIO-PATHOGENESIS OF CELLULAR AND MOLECULAR ALTERATIONS, THE CHANGE IN HOMEOSTASIS OF INTEGRATED PROCESSES IN ORGANS AND SYSTEMS. AT THE END OF THE COURSE THE STUDENT WILL BE ABLE TO: - IDENTIFY MICROBIAL CHARACTERISTICS THAT CAN BE USED AS TARGETS OF POTENTIAL DRUGS; - ADDRESS ISSUES RELATED TO THE DEVELOPMENT OF PATHOGENETIC PROCESSES CAUSED BY MICROORGANISMS AND VIRUSES. -ELABORATE THE PATHOGENETIC NETWORKS ACCORDING TO SPECIFIC CAUSES OF DAMAGE -IDENTIFY THE POTENTIAL CELLULAR OR MOLECULAR SITES FOR THERAPEUTIC INTERVENTIONS. |
| Prerequisites | |
|---|---|
| THE PREREQUISITES OF ALL THE EXAMS OF THE I YEAR ARE REQUIRED. |
| Contents | |
|---|---|
| THE COURSE IS DIVIDED INTO TWO MODULES: MODULE OF MICROBIOLOGY (40 H, 5 CFU) AND GENERAL PATHOLOGY (40 H, 5 CFU) FOR A TOTAL OF 80 H OF FRONTAL LECTURES (10 CFU). MODULE OF MICROBIOLOGY: -THE FILE ORIGIN OF BACTERIA; BACTERIA, ARCHAEOBACTERIA AND EUKARYOTES (2 H) -KOCH POSTULATES, CELL THEORY (1 H) -DIFFERENCES BETWEEN PROKARYOTES AND EUKARYOTES, BACTERIAL MORPHOLOGY, BACTERIAL CAPSULE, BACTERIAL WALL, FLAGELLA, PILI (4 H) -MICROBIAL COLORING METHODS, G RAM STAINING(1 H) -BACTERIAL GROWTH CURVE, SPORULATION (3 H OF THEORETICAL LESSON) -BACTERIAL TOXINS: LPS, EXOTOXINS AND THEIR MECHANISMS OF ACTION (2 H) -CELL CULTURES (1 H) -BACTERIA -CLASSIFICATION, STRUCTURE, PHYSIOLOGY, PATHOGENESIS AND VIRULENCE FACTORS OF: •ENTEROBACTERIACEE, E. COLI, SALMONELLA AND ANTIGEN VARIATION OF SALMONELLA. HELICOBACTER PYLORI (6 H) •STAPHYLOCOCCUS; STREPTOCOCCUS; (2 H) •PSEUDOMONAS; BACILLACEAE, BACILLUS ANTHRACIS, CLOSTRIDIUM TETANI, C. BOTULINUM, C. PERFRINGENS, C. DIFFICILE (4 H) QUORUM SENSING, FLUCTUATION TEST, ANTIBIOTIC RESISTANCE AND SUSCEPTIBILITY (4 H) -MYCOLOGY (4 H): •YEAST, MYCELIUM, MYCOSES, YEAST TRANSITION IFA •DIMORPHIC FUNGI: C. ALBICANS •PATHOGENIC FUNGI: ASPERGILLUS, C. NEOFORMANS -VIRUS (6 H) •MORPHOLOGY, NAKED AND COATED VIRUSES, HELICAL SYMMETRY VIRUSES, ICOSAEDRIC AND COMPLEX; VIRAL GENOME; BALTIMORE CLASSIFICATION; VIRAL REPLICATION CYCLE; PATHOGENEAE OF VIRAL INFECTIONS; HUMAN HERPESVIRUSES. BACTERIOPHAGES MODULE OF GENERAL PATHOLOGY: - GENERAL ETIOLOGY (10 H): DEFINITION OF DISEASE. ENDOGENOUS AND EXOGENOUS FACTORS OF DISEASE. INTRINSIC AND EXTRINSIC PATHOGENS. -CELLULAR PATHOLOGY (6 H): REVERSIBLE AND IRREVERSIBLE CELLULAR DAMAGE. HYPOXIA, FREE RADICAL DAMAGE, CELLULAR RESPONSE TO STRESS. CELL DEATH: NECROSIS AND APOPTOSIS. CELLULAR ADAPTATION MECHANISMS. - INFLAMMATION (6 HOURS OF THEORETICAL LESSON): ACUTE AND CHRONIC INFLAMMATION. GRANULOMAS. THE FEVER. - IMMUNOLOGY AND IMMUNOPATHOLOGY (6 H): LYMPHOCYTE POPULATIONS. SPECIFICITY, MEMORY, ANTIGENS, ANTIBODIES. IMMEDIATE AND DELAYED HYPERSENSITIVITY. AUTOIMMUNE DISEASES. - ONCOLOGY (6 H): CELL CYCLE AND CELL PROLIFERATION CONTROL. BENIGN AND MALIGNANT TUMORS. ONCOGENES AND ONCOSUPPRESSORS. METASTASIS. - ALTERATIONS IN METABOLISM (6 H): DIABETES, HYPERLIPIDEMIA, ATHEROSCLEROSIS |
| Teaching Methods | |
|---|---|
| THE COURSE INCLUDES LECTURES FOR A TOTAL OF 80 HOURS (10 CREDITS), WHICH TAKE PLACE IN THE CLASSROOM WITH THE HELP OF POWERPOINT PROJECTIONS. ATTENDANCE OF LESSONS IN THE CLASSROOM IS MANDATORY. IN ORDER TO TAKE THE FINAL EXAM, THE STUDENT MUST HAVE ATTENDED AT LEAST 70% OF THE HOURS PROVIDED FOR IN THE COURSE |
| Verification of learning | |
|---|---|
| THE ACHIEVEMENT OF THE OBJECTIVES OF THE COURSE IS CERTIFIED BY PASSING A SINGLE EXAM WITH EVALUATION IN THIRTIETHS. THE EXAM INCLUDES AN ORAL TEST LASTING AN AVERAGE OF 20-30 MINUTES, DURING WHICH, FOR THE MICROBIOLOGY MODULE, QUESTIONS WILL BE ASKED ABOUT THE ORIGIN OF MICROBIOLOGY AS SCIENCE; ABOUT CLASSIFICATION, STRUCTURE, PHYSIOLOGY, VIRULENCE FACTORS UNDERLYING BACTERIAL AND FUNGAL PATHOLOGY; ABOUT THE MORPHOLOGY AND CLASSIFICATION OF VIRUSES AND THE DIFFERENT REPLICATION MECHANISMS, STARTING FROM THE CLASSIFICATION OF BALTIMORE. FOR THE GENERAL PATHOLOGY MODULE, THE EXAM INCLUDES AN ORAL TEST LASTING AN AVERAGE OF 20-30 MINUTES, DURING WHICH KNOWLEDGE OF CELLULAR PATHOGENIC MECHANISMS, PHLOGISTIC PROCESSES AND COMPLEX ALTERATIONS WILL BE VERIFIED. THE MINIMUM MARK FOR PASSING EACH MODULE IS 18/30 AND WILL BE ASSIGNED, FOR THE MICROBIOLOGY MODULE, TO THE STUDENT WHO SHOWS KNOWLEDGE ON CLASSIFICATION, STRUCTURE, PHYSIOLOGY, BACTERIAL, FUNGAL AND VIRAL, BUT LIMITED ABILITY TO CONNECT THE ACTION OF THE DIFFERENT VIRULENCE FACTORS WITH THE MANIFESTATION OF THE PATHOLOGY. THE HONORS CAN BE ATTRIBUTED TO STUDENTS WHO WILL REACH THE MAXIMUM MARK OF 30/30 AND DEMONSTRATE THAT THEY HAVE COMPLETE MASTERY OF THE MECHANISMS OF COMPETITION AND MICROBIAL VIRULENCE, DEMONSTRATING THAT THEY ARE ABLE TO INDEPENDENTLY APPLY KNOWLEDGE AND SKILLS ACQUIRED EVEN IN CONTEXTS OTHER THAN THOSE PROPOSED IN CLASS. FOR THE GENERAL PATHOLOGY MODULE THE MINIMUM MARK OF 18/30 WILL BE ATTRIBUTED, TO THE STUDENT WHO SHOWS THE ABILITY TO RELATE SPECIFIC ETIOLOGICAL FACTORS TO THE PATHOGENETIC AND PROGRESSION OF THE MORBID PROCESS. THE PRAISE CAN BE ATTRIBUTED TO STUDENTS WHO WILL REACH THE MAXIMUM MARK OF 30/30 AND DEMONSTRATE THAT THEY HAVE COMPLETE MASTERY OF PATHOGENEAE, THE CELLULAR AND MOLECULAR MECHANISMS INVOLVED, THE FACTORS OF PROGRESSION AND RESOLUTION OF SPECIFIC DISEASES, DEMONSTRATING COMPLETE ACQUISITION OF ADEQUATE TERMINOLOGY AND THE ABILITY TO INDEPENDENTLY APPLY KNOWLEDGE AND SKILLS EVEN IN CONTEXTS OTHER THAN THOSE PROPOSED IN CLASS. FOR THE GENERAL PATHOLOGY MODULE, STUDENTS REGULARLY ATTENDING (AT LEAST 70% OF ATTENDANCE) ARE OFFERED THE OPPORTUNITY TO TAKE TWO WRITTEN TESTS (NORMALLY ADMINISTERED AT THE END OF MARCH AND THE END OF APRIL) CONSISTING OF 30 MULTIPLE CHOICE QUESTIONS (TRIAL TIME NOT EXCEEDING 45 MINUTES). THESE LEARNING PROCESS CHECK TESTS, IF PASSED WITH A POSITIVE RESULT, WILL EXEMPT THE STUDENT DURING THE FINAL ORAL EXAM, SUPPORTED IN THE FIRST 2 USEFUL SCHEDULED EXAMINATION DATE (JUNE AND JULY) BY THE FURTHER EVALUATION OF THE TOPICS COVERED IN THE INTERNAL QUESTIONNAIRES. THE FINAL GRADE IS GIVEN BY THE AVERAGE OF THE VOTES REPORTED FOR EACH MODULE. |
| Texts | |
|---|---|
| ALTERNATIVE REFERENCE TEXTS FOR THE MICROBIOLOGY MODULE: MICROBIOLOGIA MEDICA - PATRICK R. MURRAY ET AL. EDITORE, EDRA MICROBIOLOGIA FARMACEUTICA- N. CARLONE, R. POMPEI, V. TULLIO – EDISES 978-88-3623-021-1 PRINCIPI DI MICROBIOLOGIA MEDICA; ANTONELLI ET AL.- CASA EDITRICE AMBROSIANA. ALTERNATIVE REFERENCE TEXTS FOR THE GENERAL PATHOLOGY MODULE: -AUTORI VARI: PATOLOGIA GENERALE, IDELSON-GNOCCHI, ED. 2018 OR LATER -KUMAR, ABBAS, ASTER. ROBBINS. FONDAMENTI DI PATOLOGIA E DI FISIOPATOLOGIA; EDRA EDS.,IX EDIZIONE-2013 OR LATER -PONTIERI, PATOLOGIA E FISIOPATOLOGIA GENERALE - PICCIN EDITORE V EDIZIONE-2015 OR LATER |
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