Carmine SELLERI | Progetti

In this translational study, we will investigate mechanisms of action of potential novel anti-MM agents in newly diagnosed MM patients or in who relapsed or were refractory to previous regimens, including those daratumumab-based regimens and those in maintenance therapy with lenalidomide. Understanding pathophysiology of relapse/refractory MM and mechanisms of action of new drugs will improve clin

In this study, we aim at investigating the impact of ruxolitinib on marrow fibrosis in MPNs using a well-established 3D in vitro model of BM niche mimicking cell-to-cell contacts and paracrine pathways intercurrent between stromal cells and BMMCs in normal and pathological hematopoiesis.Specific aims: 1. Establishment of a 3D in vitro co-culture model of myelofibrosis.2. Ruxolitinib effects on

Based on findings showing the involvement of proinflammatory low-density granulocytes (LDGs) in activation of type 1 helper responses, and on the predominant role of cytotoxic T cells and type I immune responses in myelodysplastic syndromes (MDS), we hypothesize that LDGs and other immunoregulatory molecules might play an important role in MDS pathophysiology. Specific aims are to: 1) detect and q