Curriculum

Curriculum Docente

Curriculum Vitae

Informazioni personali

Nome(i) / Cognome(i)

Mario Vitale

Indirizzo(i)

40, Via Francesco Petrarca 80122, Napoli, Italia

Telefono(i)

Cellulare: 3482652847

Fax

E-mail

mavitale@unisa.it

Codice fiscale

VTLMRA58E07F839S

Luogo e Data di nascita

Napoli, il 7 Maggio 1958

Occupazione attuale e qualifica

Professore Universitario II Fascia, Università di Salerno

Direttore della UOC Clinica Endocrinologia e Diabetologica, AOU S. Leonardo e Ruggi D’Aragona, Salerno

Carriera accademica

2011 - oggi

Professore Universitario di II Fascia presso il Dipartimento di Medicina e Chirurgia dell'Università degli Studi di Salerno

2002-2011

Professore Universitario di II Fascia presso la Facoltà di Medicina e Chirurgia dell'Università degli Studi di Napoli “Federico II”

1993-2002

Ricercatore Universitario Raggruppamento F07, Medicina Interna e Specialità Mediche presso il Dipartimento di “Biologia e Patologia Cellulare e Molecolare”

Istruzione e formazione

1985

Diploma di Specializzazione in Endocrinologia e Malattie del Metabolismo, con voti 50/50 e lode.

1983

Abilitazione all’esercizio della professione Medica ed iscrizione all’Ordine dei Medici della provincia di Napoli.

1982

Diploma di Laurea in Medicina e Chirurgia con voti 110/110 con lode conferito dall’Università degli Studi di Napoli “Federico II”.

Esperienza lavorativa in ambito extra-didattico

1990 luglio-settembre

Visiting Scientist, International Researchers Exchange Program, National Institutes of Health, U.S.A. Institute of Cancer Research, Columbia University, New York, NY, U.S.A.

1989 luglio-settembre

Visiting Scientist, International Researchers Exchange Program, National Institutes of Health, U.S.A. Institute of Cancer Research, Columbia University, New York, NY, U.S.A.

1989-1990

Interno volontario, Istituto di Endocrinologia e Medicina del Lavoro, Università di Pisa, Pisa

1987-1989

Borsista dell’Associazione Italiana per la Ricerca sul Cancro A.I.R.C., Dipartimento di Biologia e Patologia Cellulare e Molecolare, dell’Università di Napoli Federico II

1985-1986

Research fellow, Banting and Best Department of Medical Research, University of Toronto

Toronto Ontario, Canada

1981 Luglio-Settembre

Summer student, Aematologycal Department, Haddenbroock Hospital, University of Cambridge

Cambridge, Great Britain

Attività assistenziale

2017- oggi

Direttore della UOC Clinica Endocrinologia e Diabetologica, AOU S. Leonardo e Ruggi D’Aragona, Salerno

2011-2017

Direttore del Programma “Patologia Tiroidea”, Dipartimento di Specialità Mediche, Azienda Ospedaliera S. Giovanni di Dio e Ruggi D’Aragona, Salerno

2003-2011

Primario dell’Area Funzionale “Tumori della Tiroidei”, Dipartimento di Oncologia e Endocrinologia Clinica, Azienda Ospedaliera Universitaria Federico II, Napoli

1996-2003

Aiuto primario, Sezione di Endocrinologia, Dipartimento di Oncologia e Endocrinologia Clinica, Azienda Ospedaliera Universitaria Federico II, Napoli

1993-1996

Assistente medico, Sezione di Endocrinologia, Dipartimento di Oncologia e Endocrinologia Clinica, Azienda Ospedaliera Universitaria Federico II, Napoli

1987-1993

Collaborazione straordinaria retribuita ,Sezione di Endocrinologia, Dipartimento di Oncologia e Endocrinologia Clinica, Azienda Ospedaliera Universitaria Federico II, Napoli

1982-1985

Collaborazione straordinaria retribuita, Servizio di Immunopatologia, Azienda Ospedaliera Universitaria Federico II, Napoli

Collaborazioni scientifiche con riviste

Editor di: Journal of Thyroid Cancer

Editorial board di: J Clin Endocrinol & Metab, Frontiers Endocrinology, Cytology and Tissue Biology

Reviewer di numerose riviste tra le quali: Frontiers in Endocrinology, J Clin Endocrinol & Metab, Eur J Endocrinol, Endocrinology, J Biol Chem, Oncogene, Clin Endocrinol

Affiliazione a Società scientifiche

European Society of Endocrinology, European Thyroid Associacion, Società Italiana di Endocrinologia, Associazione Italiana della Tiroide

Pubblicazioni

1: Caleo A, Vitale M, Valvano L, Siano M, Angrisani B, Forlenza M, Massari A, Puzziello A, Salzano F, Zeppa P. Fine needle cytology pre-surgical differentiation of parathyroid neoplasms: Is it reliable? Cytopathology. 2017 Aug;28(4):273-279. doi: 10.1111/cyt.12413. Epub 2017 Feb 20. PubMed PMID: 28217943.

2: Ciaglia E, Abate M, Laezza C, Pisanti S, Vitale M, Seneca V, Torelli G, Franceschelli S, Catapano G, Gazzerro P, Bifulco M. Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor. Int J Cancer. 2017 Feb 15;140(4):959-972. doi: 10.1002/ijc.30505. Epub 2016 Nov 16. PubMed PMID: 27813087.

3: Di Crescenzo V, Vitale M, Valvano L, Napolitano F, Vatrella A, Zeppa P, De Rosa G, Amato B, Laperuta P. Surgical management of cervico-mediastinal goiters: Our experience and review of the literature. Int J Surg. 2016 Apr;28 Suppl 1:S47-53. doi: 10.1016/j.ijsu.2015.12.048. Epub 2015 Dec 23. Review. PubMed PMID: 26721191.

4: Caleo A, Landolfi L, Vitale M, Di Crescenzo V, Vatrella A, De Rosa G, Peluso AL, Zeppa P. The diagnostic accuracy of fine-needle cytology of Hurthle cell lesions; A comprehensive cytological, clinical and ultrasonographic experience. Int J Surg. 2016 Apr;28 Suppl 1:S65-9. doi: 10.1016/j.ijsu.2015.12.049. Epub 2015 Dec 17. PubMed PMID: 26708845.

5: Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells. Cancer Biol Ther. 2016 Aug 2;17(8):849-58. doi: 10.1080/15384047.2015.1078028. PubMed PMID: 26392056; PubMed Central PMCID: PMC5004676.

6: Puzziello A, Guerra A, Murino A, Izzo G, Carrano M, Angrisani E, Zeppa P, Marotta V, Faggiano A, Vitale M. Benign thyroid nodules with RAS mutation grow faster. Clin Endocrinol (Oxf). 2016 May;84(5):736-40. doi: 10.1111/cen.12875. Epub 2015 Sep 28. PubMed PMID: 26260959.

7: Pisanti S, Picardi P, Pallottini V, Martini C, Petrosino S, Proto MC, Vitale M, Laezza C, Gazzerro P, Di Marzo V, Bifulco M. Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. J Cell Physiol. 2015 Dec;230(12):2905-14. doi: 10.1002/jcp.24959. PubMed PMID: 25684344.

8: Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014. pii: bcr2014206330. doi: 10.1136/bcr-2014-206330. PubMed PMID: 25355748; PubMed Central PMCID: PMC4216876.

9: Bifulco M, Vitale M. Thyroid adiponcosis: more than an hypothesis. Endocrine. 2015 Feb;48(1):353-4. doi: 10.1007/s12020-014-0379-7. Epub 2014 Sep 2. PubMed PMID: 25178646.

10: Ciaglia E, Pisanti S, Picardi P, Laezza C, Sosa S, Tubaro A, Vitale M, Gazzerro P, Malfitano AM, Bifulco M. N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice. Pharmacol Res. 2014 Nov;89:1-10. doi: 10.1016/j.phrs.2014.07.003. Epub 2014 Jul 22. PubMed PMID: 25063359.

11: Puzziello A, Carrano M, Angrisani E, Marotta V, Faggiano A, Zeppa P, Vitale M. Evolution of benign thyroid nodules under levothyroxine non-suppressive therapy. J Endocrinol Invest. 2014 Dec;37(12):1181-6. doi: 10.1007/s40618-014-0128-z. Epub 2014 Jul 10. PubMed PMID: 25008459.

12: Guerra A, Carrano M, Angrisani E, Puzziello A, Izzo G, Di Crescenzo V, Vatrella A, Vitale M. Detection of RAS mutation by pyrosequencing in thyroid cytology samples. Int J Surg. 2014;12 Suppl 1:S91-4. doi: 10.1016/j.ijsu.2014.05.045. Epub 2014 May 24. PubMed PMID: 24866065.

13: Salzano M, Russo E, Salzano S, Bifulco M, Vitale M. Ras oncoprotein disrupts the TSH/CREB signaling upstream adenylyl cyclase in human thyroid cell. J Cell Physiol. 2014 Dec;229(12):2137-41. doi: 10.1002/jcp.24672. PubMed PMID: 24819468.

14: Zeppa P, Vitale M. Fine-needle cytology of Hürthle cell tumors and morphometry. Cancer Cytopathol. 2014 Jul;122(7):553. doi: 10.1002/cncy.21420. Epub 2014 Apr 4. PubMed PMID: 24706512.

15: Zeppa P, Vitale M. Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. Acta Cytol. 2014;58(3):318. doi: 10.1159/000360067. Epub 2014 Mar 12. PubMed PMID: 24642841.

16: Russo E, Salzano M, De Falco V, Mian C, Barollo S, Secondo A, Bifulco M, Vitale M. Calcium/Calmodulin-dependent protein kinase II and its endogenous inhibitor α in medullary thyroid cancer. Clin Cancer Res. 2014 Mar 15;20(6):1513-20. doi: 10.1158/1078-0432.CCR-13-1683. Epub 2014 Jan 21. PubMed PMID: 24449826.

17: Guerra A, Di Crescenzo V, Garzi A, Cinelli M, Carlomagno C, Pepe S, Zeppa P, Tonacchera M, Vitale M. Diagnostic utility of BRAFV600E mutation testing in thyroid nodules in elderly patients. BMC Surg. 2013;13 Suppl 2:S37. doi: 10.1186/1471-2482-13-S2-S37. Epub 2013 Oct 8. PubMed PMID: 24267957; PubMed Central PMCID: PMC3850960.

18: Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Garzi A, Vitale M. Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. BMC Surg. 2013;13 Suppl 2:S34. doi: 10.1186/1471-2482-13-S2-S34. Epub 2013 Oct 8. PubMed PMID: 24267748; PubMed Central PMCID: PMC3851145.

19: Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Garzi A, Vitale M. An unusual case of primary choriocarcinoma of the lung. BMC Surg. 2013;13 Suppl 2:S33. doi: 10.1186/1471-2482-13-S2-S33. Epub 2013 Oct 8. PubMed PMID: 24267667; PubMed Central PMCID: PMC3851001.

20: Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Danzi M, Amato B, Garzi A, Vitale M. Migration of surgical clips through a right lobectomy stump mimicking an asthmatic syndrome. BMC Surg. 2013;13 Suppl 2:S32. doi: 10.1186/1471-2482-13-S2-S32. Epub 2013 Oct 8. PubMed PMID: 24267611; PubMed Central PMCID: PMC3851273.

21: Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Danzi M, Amato B, Garzi A, Vitale M. Unusual case of exacerbation of sub-acute descending necrotizing mediastinitis. BMC Surg. 2013;13 Suppl 2:S31. doi: 10.1186/1471-2482-13-S2-S31. Epub 2013 Oct 8. PubMed PMID: 24267540; PubMed Central PMCID: PMC3851208.

22: Vigliar E, Caleo A, Vitale M, Di Crescenzo V, Garzi A, Zeppa P. Early cytological diagnosis of extranodal stage I, primary thyroid Non-Hodgkin lymphoma in elderly patients. Report of two cases and review of the literature. BMC Surg. 2013;13 Suppl 2:S49. doi: 10.1186/1471-2482-13-S2-S49. Epub 2013 Oct 8. Review. PubMed PMID: 24267471; PubMed Central PMCID: PMC3851195.

23: Guerra A, Di Crescenzo V, Garzi A, Cinelli M, Carlomagno C, Tonacchera M, Zeppa P, Vitale M. Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review. BMC Surg. 2013;13 Suppl 2:S44. doi: 10.1186/1471-2482-13-S2-S44. Epub 2013 Oct 8. Review. PubMed PMID: 24267151; PubMed Central PMCID: PMC3851243.

24: Di Crescenzo V, Garzi A, Petruzziello F, Cinelli M, Catalano L, Zeppa P, Vitale M. Nodular goiter with amyloid deposition in an elderly patient: fine-needle cytology diagnosis and review of the literature. BMC Surg. 2013;13 Suppl 2:S43. doi: 10.1186/1471-2482-13-S2-S43. Epub 2013 Oct 8. Review. PubMed PMID: 24267036; PubMed Central PMCID: PMC3851267.

25: Cozzolino I, Caleo A, Di Crescenzo V, Cinelli M, Carlomagno C, Garzi A, Vitale M. Cytological diagnosis of adult-type fibrosarcoma of the neck in an elderly patient. Report of one case and review of the literature. BMC Surg. 2013;13 Suppl 2:S42. doi: 10.1186/1471-2482-13-S2-S42. Epub 2013 Oct 8. Review. PubMed PMID: 24266985; PubMed Central PMCID: PMC3850999.

26: Caleo A, Vigliar E, Vitale M, Di Crescenzo V, Cinelli M, Carlomagno C, Garzi A, Zeppa P. Cytological diagnosis of thyroid nodules in Hashimoto thyroiditis in elderly patients. BMC Surg. 2013;13 Suppl 2:S41. doi: 10.1186/1471-2482-13-S2-S41. Epub 2013 Oct 8. PubMed PMID: 24266923; PubMed Central PMCID: PMC3851014.

27: Ricchi P, Ammirabile M, Spasiano A, Costantini S, Vitale M, Di Matola T, Cinque P, Filosa A, Serino D. Unexpected prevalence of hyperprolactinaemia associated with microprolactinoma and empty sella in a cohort of adult patients with non-transfusion-dependent thalassaemia: a prospective study. Br J Haematol. 2014 Mar;164(5):743-5. doi: 10.1111/bjh.12668. Epub 2013 Nov 20. PubMed PMID: 24251449.

28: Malfitano AM, Laezza C, Saccomanni G, Tuccinardi T, Manera C, Martinelli A, Ciaglia E, Pisanti S, Vitale M, Gazzerro P, Bifulco M. Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives. J Neuroimmune Pharmacol. 2013 Dec;8(5):1077-86. doi: 10.1007/s11481-013-9494-0. Epub 2013 Oct 1. PubMed PMID: 24081326.

29: D'Amico G, Di Crescenzo V, Caleo A, Garzi A, Vitale M. [Sub-acute thyroiditis in a patient on immunosuppressive treatment]. Recenti Prog Med. 2013 Jul-Aug;104(7-8):459-61. doi: 10.1701/1315.14597. Italian. PubMed PMID: 24042429.

30: Guerra A, Carrano M, Angrisani E, Vitale M. [Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates]. Recenti Prog Med. 2013 Jul-Aug;104(7-8):415-9. doi: 10.1701/1315.14588. Italian. PubMed PMID: 24042420.

31: D'Amico G, Di Crescenzo V, Muto M, Amato M, Grassi R, Lanza J, Garzi A, Vitale M. [Cytological diagnosis of lymph nodes by instrumental guide: ultrasonography and CT]. Recenti Prog Med. 2013 Jul-Aug;104(7-8):367-70. doi: 10.1701/1315.14577. Review. Italian. PubMed PMID: 24042409.

32: Di Crescenzo V, D'Antonio A, Tonacchera M, Carlomagno C, Vitale M. Human herpes virus associated with Hashimoto's thyroiditis. Infez Med. 2013 Sep;21(3):224-8. PubMed PMID: 24008857.

33: Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M. PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines. Eur J Pharmacol. 2013 Aug 15;714(1-3):379-87. doi: 10.1016/j.ejphar.2013.07.011. Epub 2013 Jul 16. Retraction in: Eur J Pharmacol. 2014 Apr 5;728:190. PubMed PMID: 23872382.

34: Ciaglia E, Pisanti S, Picardi P, Laezza C, Malfitano AM, D'Alessandro A, Gazzerro P, Vitale M, Carbone E, Bifulco M. N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation. J Leukoc Biol. 2013 Dec;94(6):1207-19. doi: 10.1189/jlb.0413190. Epub 2013 Jul 11. PubMed PMID: 23847096.

35: Guerra A, Zeppa P, Bifulco M, Vitale M. Concomitant BRAF(V600E) mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma. Thyroid. 2014 Feb;24(2):254-9. doi: 10.1089/thy.2013.0235. Epub 2013 Aug 24. PubMed PMID: 23806056.

36: Guerra A, Di Stasi V, Zeppa P, Faggiano A, Marotta V, Vitale M. BRAF(V600E) assessment by pyrosequencing in fine needle aspirates of thyroid nodules with concurrent Hashimoto's thyroiditis is a reliable assay. Endocrine. 2014 Mar;45(2):249-55. doi: 10.1007/s12020-013-9994-y. Epub 2013 Jun 18. PubMed PMID: 23775008.

37: Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M. Radioiodide induces apoptosis in human thyroid tissue in culture. Endocrine. 2013 Dec;44(3):729-34. doi: 10.1007/s12020-013-9940-z. Epub 2013 Mar 31. PubMed PMID: 23543460.

38: Marotta V, Guerra A, Zatelli MC, Uberti ED, Di Stasi V, Faggiano A, Colao A, Vitale M. BRAF mutation positive papillary thyroid carcinoma is less advanced when Hashimoto's thyroiditis lymphocytic infiltration is present. Clin Endocrinol (Oxf). 2013 Nov;79(5):733-8. doi: 10.1111/cen.12194. Epub 2013 Apr 1. PubMed PMID: 23469895.

39: Guerra A, Marotta V, Deandrea M, Motta M, Limone PP, Caleo A, Zeppa P, Esposito S, Fulciniti F, Vitale M. BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma. Endocrine. 2013 Aug;44(1):165-71. doi: 10.1007/s12020-012-9843-4. Epub 2012 Dec 1. PubMed PMID: 23203004.

40: Vitale M, Zeppa P, Esposito I, Esposito S. [Infected lesions of diabetic foot]. Infez Med. 2012;20 Suppl 1:14-9. Review. Italian. PubMed PMID: 22982693.

41: Pascale R, Vitale M, Zeppa P, Russo E, Esposito S. [Diabetic foot: definitions]. Infez Med. 2012;20 Suppl 1:5-7. Review. Italian. PubMed PMID: 22982691.

42: Cozzolino I, Vigliar E, Sosa Fernandez LV, Selleri C, Pepe S, Vitale M, Triggiani M, Zeppa P. Non lymphomatous clonal B-Cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. Infez Med. 2012;20 Suppl 2:35-42. PubMed PMID: 23042004.

43: Russo E, Salzano M, Postiglione L, Guerra A, Marotta V, Vitale M. Interferon-γ inhibits integrin-mediated extracellular signal-regulated kinase activation stimulated by fibronectin binding in thyroid cells. J Endocrinol Invest. 2013 Jun;36(6):375-8. doi: 10.3275/8649. Epub 2012 Oct 1. PubMed PMID: 23027776.

44: Salzano M, Russo E, Postiglione L, Guerra A, Marotta V, Esposito S, Vitale M. Interferon-γ inhibits integrin-mediated adhesion to fibronectin and survival signaling in thyroid cells. J Endocrinol. 2012 Dec;215(3):439-44. doi: 10.1530/JOE-12-0335. Epub 2012 Oct 1. PubMed PMID: 23027608.

45: Guerra A, Sapio MR, Carrano M, Di Stasi V, Volpe A, Murino A, Izzo G, Vitale M. Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity. J Endocrinol Invest. 2013 May;36(5):303-6. doi: 10.3275/8618. Epub 2012 Sep 24. PubMed PMID: 23013882.

46: Salzano M, Rusciano MR, Russo E, Bifulco M, Postiglione L, Vitale M. Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation. Cell Cycle. 2012 Jun 1;11(11):2100-6. doi: 10.4161/cc.20543. Epub 2012 Jun 1. PubMed PMID: 22592532.

47: Guerra A, Fugazzola L, Marotta V, Cirillo M, Rossi S, Cirello V, Forno I, Moccia T, Budillon A, Vitale M. A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome. J Clin Endocrinol Metab. 2012 Jul;97(7):2333-40. doi: 10.1210/jc.2011-3106. Epub 2012 Apr 16. PubMed PMID: 22508706.

48: Guerra A, Sapio MR, Marotta V, Campanile E, Rossi S, Forno I, Fugazzola L, Budillon A, Moccia T, Fenzi G, Vitale M. The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma. J Clin Endocrinol Metab. 2012 Feb;97(2):517-24. doi: 10.1210/jc.2011-0618. Epub 2011 Dec 14. PubMed PMID: 22170714.

49: Marotta V, Guerra A, Sapio MR, Vitale M. RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint. Eur J Endocrinol. 2011 Oct;165(4):499-507. doi: 10.1530/EJE-11-0499. Epub 2011 Jul 12. Review. PubMed PMID: 21750045.

50: Marotta V, Sapio MR, Guerra A, Vitale M. BRAF mutation in cytology samples as a diagnostic tool for papillary thyroid carcinoma. Expert Opin Med Diagn. 2011 Jul;5(4):277-90. doi: 10.1517/17530059.2011.575058. Epub 2011 Apr 21. PubMed PMID: 23484549.

51: Sapio MR, Guerra A, Marotta V, Campanile E, Formisano R, Deandrea M, Motta M, Limone PP, Fenzi G, Rossi G, Vitale M. High growth rate of benign thyroid nodules bearing RET/PTC rearrangements. J Clin Endocrinol Metab. 2011 Jun;96(6):E916-9. doi: 10.1210/jc.2010-1599. Epub 2011 Mar 16. PubMed PMID: 21411555.

52: Guerra A, Sapio MR, Marotta V, Campanile E, Moretti MI, Deandrea M, Motta M, Limone PP, Fenzi G, Rossi G, Vitale M. Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application. Endocr J. 2011;58(1):31-8. Epub 2010 Dec 14. PubMed PMID: 21173509.

53: Marotta V, Guerra A, Sapio MR, Campanile E, Motta M, Fenzi G, Rossi G, Vitale M. Growing thyroid nodules with benign histology and RET rearrangement. Endocr J. 2010;57(12):1081-7. Epub 2010 Oct 30. PubMed PMID: 21048359.

54: Andreucci M, Lucisano G, Faga T, Bertucci B, Tamburrini O, Pisani A, Sabbatini M, Salzano S, Vitale M, Fuiano G, Michael A. Differential activation of signaling pathways involved in cell death, survival and inflammation by radiocontrast media in human renal proximal tubular cells. Toxicol Sci. 2011 Feb;119(2):408-16. doi: 10.1093/toxsci/kfq332. Epub 2010 Oct 29. PubMed PMID: 21036957.

55: Marotta V, Guerra A, Sapio MR, Campanile E, Motta M, Fenzi G, Rossi G, Vitale M. Are RET/PTC rearrangements in benign thyroid nodules of biological significance? Thyroid. 2010 Oct;20(10):1191-2. doi: 10.1089/thy.2010.0061. PubMed PMID: 20860421.

56: Rusciano MR, Salzano M, Monaco S, Sapio MR, Illario M, De Falco V, Santoro M, Campiglia P, Pastore L, Fenzi G, Rossi G, Vitale M. The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC. Endocr Relat Cancer. 2010 Jan 29;17(1):113-23. doi: 10.1677/ERC-09-0214. Print 2010 Mar. PubMed PMID: 19903742.

57: Vitale M, Bifulco M. Thyroid cellular models: a warning concerning their application. Thyroid. 2009 Sep;19(9):1021-2. doi: 10.1089/thy.2009.0129. PubMed PMID: 19678747.

58: Monaco S, Illario M, Rusciano MR, Gragnaniello G, Di Spigna G, Leggiero E, Pastore L, Fenzi G, Rossi G, Vitale M. Insulin stimulates fibroblast proliferation through calcium-calmodulin-dependent kinase II. Cell Cycle. 2009 Jul 1;8(13):2024-30. Epub 2009 Jul 21. PubMed PMID: 19502797.

59: Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea L, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M. Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake. Cell Signal. 2009 May;21(5):786-92. doi: 10.1016/j.cellsig.2009.01.022. Epub 2009 Jan 9. PubMed PMID: 19171190.

60: Laezza C, Fiorentino L, Pisanti S, Gazzerro P, Caraglia M, Portella G, Vitale M, Bifulco M. Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state. J Mol Med (Berl). 2008 Dec;86(12):1341-51. doi: 10.1007/s00109-008-0396-1. Epub 2008 Sep 9. PubMed PMID: 18779944.

61: Sapio MR, Guerra A, Posca D, Limone PP, Deandrea M, Motta M, Troncone G, Caleo A, Vallefuoco P, Rossi G, Fenzi G, Vitale M. Combined analysis of galectin-3 and BRAFV600E improves the accuracy of fine-needle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma. Endocr Relat Cancer. 2007 Dec;14(4):1089-97. PubMed PMID: 18045960.

62: Illario M, Giardino-Torchia ML, Sankar U, Ribar TJ, Galgani M, Vitiello L, Masci AM, Bertani FR, Ciaglia E, Astone D, Maulucci G, Cavallo A, Vitale M, Cimini V, Pastore L, Means AR, Rossi G, Racioppi L. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood. 2008 Jan 15;111(2):723-31. Epub 2007 Oct 1. PubMed PMID: 17909078; PubMed Central PMCID: PMC2200860.

63: Libertini S, Iacuzzo I, Ferraro A, Vitale M, Bifulco M, Fusco A, Portella G. Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells. Endocrinology. 2007 Nov;148(11):5186-94. Epub 2007 Aug 9. PubMed PMID: 17690162.

64: Sapio MR, Posca D, Raggioli A, Guerra A, Marotta V, Deandrea M, Motta M, Limone PP, Troncone G, Caleo A, Rossi G, Fenzi G, Vitale M. Detection of RET/PTC, TRK and BRAF mutations in preoperative diagnosis of thyroid nodules with indeterminate cytological findings. Clin Endocrinol (Oxf). 2007 May;66(5):678-83. Epub 2007 Mar 23. PubMed PMID: 17381488.

65: Sapio MR, Posca D, Troncone G, Pettinato G, Palombini L, Rossi G, Fenzi G, Vitale M. Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA). Eur J Endocrinol. 2006 Feb;154(2):341-8. PubMed PMID: 16452550.

66: Grimaldi C, Pisanti S, Laezza C, Malfitano AM, Santoro A, Vitale M, Caruso MG, Notarnicola M, Iacuzzo I, Portella G, Di Marzo V, Bifulco M. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res. 2006 Feb 15;312(4):363-73. Epub 2005 Dec 15. PubMed PMID: 16343481.

67: Illario M, Cavallo AL, Monaco S, Di Vito E, Mueller F, Marzano LA, Troncone G, Fenzi G, Rossi G, Vitale M. Fibronectin-induced proliferation in thyroid cells is mediated by alphavbeta3 integrin through Ras/Raf-1/MEK/ERK and calcium/CaMKII signals. J Clin Endocrinol Metab. 2005 May;90(5):2865-73. Epub 2005 Feb 1. PubMed PMID: 15687337.

68: Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R, Vitale M, Rossi G, Fenzi G, Salvatore D. Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells. Mol Cell Biol. 2004 Sep;24(18):7863-77. PubMed PMID: 15340050; PubMed Central PMCID: PMC515029.

69: Illario M, Cavallo AL, Bayer KU, Di Matola T, Fenzi G, Rossi G, Vitale M. Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation. J Biol Chem. 2003 Nov 14;278(46):45101-8. Epub 2003 Sep 3. PubMed PMID: 12954639.

70: Postiglione L, Di Domenico G, Ramaglia L, Montagnani S, Salzano S, Di Meglio F, Sbordone L, Vitale M, Rossi G. Behavior of SaOS-2 cells cultured on different titanium surfaces. J Dent Res. 2003 Sep;82(9):692-6. PubMed PMID: 12939352.

71: Dentice M, Morisco C, Vitale M, Rossi G, Fenzi G, Salvatore D. The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors. Mol Endocrinol. 2003 Aug;17(8):1508-21. Epub 2003 May 29. PubMed PMID: 12775767.

72: Maio M, Coral S, Sigalotti L, Elisei R, Romei C, Rossi G, Cortini E, Colizzi F, Fenzi G, Altomonte M, Pinchera A, Vitale M. Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1. J Clin Endocrinol Metab. 2003 Feb;88(2):748-54. PubMed PMID: 12574209.

73: Illario M, Amideo V, Casamassima A, Andreucci M, di Matola T, Miele C, Rossi G, Fenzi G, Vitale M. Integrin-dependent cell growth and survival are mediated by different signals in thyroid cells. J Clin Endocrinol Metab. 2003 Jan;88(1):260-9. PubMed PMID: 12519863.

74: Di Matola T, D'Ascoli F, Luongo C, Bifulco M, Rossi G, Fenzi G, Vitale M. Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B. Eur J Endocrinol. 2001 Nov;145(5):645-50. PubMed PMID: 11720884.

75: Bifulco M, Laezza C, Portella G, Vitale M, Orlando P, De Petrocellis L, Di Marzo V. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J. 2001 Dec;15(14):2745-7. Epub 2001 Oct 29. PubMed PMID: 11687506.

76: Bogazzi F, Bartalena L, Brogioni S, Burelli A, Raggi F, Ultimieri F, Cosci C, Vitale M, Fenzi G, Martino E. Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level. Eur J Endocrinol. 2001 Jul;145(1):59-64. PubMed PMID: 11415853.

77: Macchia PE, Bagattini M, Lupoli G, Vitale M, Vitale G, Fenzi G. High-dose intravenous corticosteroid therapy for Graves' ophthalmopathy. J Endocrinol Invest. 2001 Mar;24(3):152-8. PubMed PMID: 11314743.

78: Di Matola T, D'Ascoli F, Fenzi G, Rossi G, Martino E, Bogazzi F, Vitale M. Amiodarone induces cytochrome c release and apoptosis through an iodine-independent mechanism. J Clin Endocrinol Metab. 2000 Nov;85(11):4323-30. PubMed PMID: 11095475.

79: Di Matola T, Mueller F, Fenzi G, Rossi G, Bifulco M, Marzano LA, Vitale M. Serum withdrawal-induced apoptosis in thyroid cells is caused by loss of fibronectin-integrin interaction. J Clin Endocrinol Metab. 2000 Mar;85(3):1188-93. PubMed PMID: 10720060.

80: Vitale M, Di Matola T, D'Ascoli F, Salzano S, Bogazzi F, Fenzi G, Martino E, Rossi G. Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress. Endocrinology. 2000 Feb;141(2):598-605. PubMed PMID: 10650940.

81: Santillo M, Migliaro A, Mondola P, Laezza C, Damiano S, Stingo S, Fiorentino L, Andreozzi A, Vitale M, Bifulco M. Dietary and hypothyroid hypercholesterolemia induces hepatic apolipoprotein E expression in the rat: direct role of cholesterol. FEBS Lett. 1999 Dec 10;463(1-2):83-6. PubMed PMID: 10601643.

82: Vitale M, Di Matola T, Bifulco M, Casamassima A, Fenzi G, Rossi G. Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. FEBS Lett. 1999 Nov 26;462(1-2):57-60. PubMed PMID: 10580091.

83: Vitale M, De Riu S, Fenzi GF, Casamassima A, Salzano S, Müeller F, Marzano LA, Rossi G. Expression of integrins of the beta1 family in thyroid cells from patients with Graves' disease in vivo and in vitro. Biochimie. 1999 May;81(5):477-84. PubMed PMID: 10403178.

84: Montuori N, Müller F, De Riu S, Fenzi G, Sobel ME, Rossi G, Vitale M. Laminin receptors in differentiated thyroid tumors: restricted expression of the 67-kilodalton laminin receptor in follicular carcinoma cells. J Clin Endocrinol Metab. 1999 Jun;84(6):2086-92. PubMed PMID: 10372715.

85: Pagliara S, Spagnuolo E, D'Avanzo A, Vitale M, Macchia PE, Salvatore D, Ramundo V, Ciasullo M, Macchia V, Fenzi G. [Widespread endemic goiter and iodine deficiency in the province of Avellino]. Ann Ist Super Sanita. 1998;34(3):417-21. Italian. PubMed PMID: 10052187.

86: Vitale M, Di Matola T, Rossi G, Laezza C, Fenzi G, Bifulco M. Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism. Endocrinology. 1999 Feb;140(2):698-704. PubMed PMID: 9927296.

87: Vitale M, Di Matola T, Fenzi G, Illario M, Rossi G. Fibronectin is required to prevent thyroid cell apoptosis through an integrin-mediated adhesion mechanism. J Clin Endocrinol Metab. 1998 Oct;83(10):3673-80. PubMed PMID: 9768683.

88: Piazza M, Tosone G, Borgia G, Orlando R, Fenzi G, Vitale M, Bloise A, Mariano A, Macchia V. Long-term interferon-alpha therapy does not affect sex hormones in males with chronic hepatitis C. J Interferon Cytokine Res. 1997 Sep;17(9):525-9. PubMed PMID: 9335429.

89: Vitale M, Illario M, Di Matola T, Casamassima A, Fenzi G, Rossi G. Integrin binding to immobilized collagen and fibronectin stimulates the proliferation of human thyroid cells in culture. Endocrinology. 1997 Apr;138(4):1642-8. PubMed PMID: 9075726.

90: Santillo M, Mondola P, Gioielli A, Serù R, Iossa S, Annella T, Vitale M, Bifulco M. Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells. Biochem Biophys Res Commun. 1996 Dec 24;229(3):739-45. PubMed PMID: 8954966.

91: Vitale M, Casamassima A, Illario M, Bassi V, Fenzi G, Rossi G. Cell-to-cell contact modulates the expression of the beta 1 family of integrins in primary cultures of thyroid cells. Exp Cell Res. 1995 Sep;220(1):124-9. PubMed PMID: 7545127.

92: Bassi V, Vitale M, Feliciello A, De Riu S, Rossi G, Fenzi G. Retinoic acid induces intercellular adhesion molecule-1 hyperexpression in human thyroid carcinoma cell lines. J Clin Endocrinol Metab. 1995 Apr;80(4):1129-35. PubMed PMID: 7714081.

93: Vitale M, Bassi V, Illario M, Fenzi G, Casamassima A, Rossi G. Loss of polarity and de novo expression of the beta 1 family of integrins in thyroid tumors. Int J Cancer. 1994 Oct 15;59(2):185-90. PubMed PMID: 7927917.

94: Pucillo CE, Colombatti A, Vitale M, Salzano S, Rossi G, Formisano S. Interactions of promonocytic U937 cells with proteins of the extracellular matrix. Immunology. 1993 Oct;80(2):248-52. PubMed PMID: 8262552; PubMed Central PMCID: PMC1422182.

95: Vitale M, Bassi V, Fenzi G, Macchia PE, Salzano S, Rossi G. Integrin expression in thyroid cells from normal glands and nodular goiters. J Clin Endocrinol Metab. 1993 Jun;76(6):1575-9. PubMed PMID: 8501165.

96: Pucillo C, Salzano S, Pepe S, Vitale M, Formisano S, Rossi G. Regulation of the expression of the low-affinity IgE receptor (Fc epsilon RII) in the human monocyte-like cell line U-937 by phorbol esters and IgE. Int Arch Allergy Appl Immunol. 1990;93(4):330-7. PubMed PMID: 2151634.

97: Troncone R, Vitale M, Donatiello A, Farris E, Rossi G, Auricchio S. A sandwich enzyme immunoassay for wheat gliadin. J Immunol Methods. 1986 Aug 21;92(1):21-3. PubMed PMID: 3528299.

Capacità e competenze personali

Madrelingua(e)

Italiana

Altra(e) lingua(e)

Inglese

Data 30.10.2018


Firma

Dichiaro di essere informato ai sensi e per gli effetti dell’art. 13 del D.lgs 196/2003, che il presente curriculum verrà allegato al programma dell’evento formativo e pubblicato nella banca dati presente nel sito http://ecm.agenas.it, e a tal fine presto il consenso al trattamento dei dati personali ivi contenuti