Cristiana STELLATO | Progetti

Study aim is understanding RBPs role in (1) EGFR-TKI-induced modification of immune-related proteins levels, such as CD47 and PD-L1, with consequent impact on evasion of NK cell-mediated cytotoxicity; (2) EGFR-TKI-promoted cytokine secretion and impact on EGFR-TKI-resistance acquisition, tumor cell migration and invasion. We will use sensitive/resistant NSCLC cell lines with physiological and exog

“Sistema di Monitoraggio ed Analisi basato su intelligenza aRTificiale per pazienti affetti da scompenso CARdiaco cronico con dispositivi medici mini-invasivi e indossabili Evoluti “SMART-CARE”, Codice locale progetto T2-AN-10

The mechanisms accounting for sustained airway inflammation in asthma, a chronic respiratory disease affecting 6-9% of the EU population, have yet to be fully elucidated. More research is needed to define practical, yet reliable biomarkers in the clinical characterization and management of this condition. Inflammation in asthma is driven by a type 2-biased, dysregulated adaptive response to enviro

Abbiamo dimostrato che concentrazioni terapeutiche di aspirina inibiscono l¿attivazione di geni NFAT-dipendenti, come la IL-4 e il CD154, nelle cellule T CD4+ attivate. Tuttavia, alle stesse concentrazioni l¿aspirina potenzia in queste cellule l¿attività del fattore NFATc2, verosimilmente attraverso il coinvolgimento di meccanismi alternativi. Desideriamo estendere queste osservazioni ai granuloci