Alessandro VATRELLA | Progetti

Study objectives are: (1) To investigate the impact of HuR silencing/inhibition on the architecture and growth of 3D tumor spheroids in TKI-sensitive and TKI-resistant NSCLC cell lines; (2) To evaluate the spatial distribution of cancer cells with preserved/ablated HuR expression within co-cultured 3D spheroids, providing insights into their interactions and localization;(3) To analyse cytokine/p

Study aim is understanding RBPs role in (1) EGFR-TKI-induced modification of immune-related proteins levels, such as CD47 and PD-L1, with consequent impact on evasion of NK cell-mediated cytotoxicity; (2) EGFR-TKI-promoted cytokine secretion and impact on EGFR-TKI-resistance acquisition, tumor cell migration and invasion. We will use sensitive/resistant NSCLC cell lines with physiological and exog

The mechanisms accounting for sustained airway inflammation in asthma, a chronic respiratory disease affecting 6-9% of the EU population, have yet to be fully elucidated. More research is needed to define practical, yet reliable biomarkers in the clinical characterization and management of this condition. Inflammation in asthma is driven by a type 2-biased, dysregulated adaptive response to enviro