Rosanna MARTINELLI | BASIS BIOLOGICAL MOLECULAR AND STATISTICS
Rosanna MARTINELLI BASIS BIOLOGICAL MOLECULAR AND STATISTICS
cod. 1012200001
BASIS BIOLOGICAL MOLECULAR AND STATISTICS
| 1012200001 | |
| DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA" | |
| EQF6 | |
| PHYSIOTHERAPY | |
| 2016/2017 |
| OBBLIGATORIO | |
| YEAR OF COURSE 1 | |
| YEAR OF DIDACTIC SYSTEM 2013 | |
| PRIMO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | ||
|---|---|---|---|---|---|
| BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD FISICA | |||||
| FIS/07 | 2 | 24 | LESSONS | ||
| BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD BIOCHIMICA | |||||
| BIO/10 | 2 | 24 | LESSONS | ||
| BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD STATISTICA | |||||
| MED/01 | 2 | 24 | LESSONS | ||
| Objectives | |
|---|---|
| THE STUDENT WILL ACQUIRE KNOWLEDGE OF THE MAIN ISSUES OF PHYSICS AND STATISTICS CRITICALLY UNDERSTANDING ALSO LIMITS OF VALIDITY AND APPLICABILITY IN REAL CONTEXTS (KNOWLEDGE AND UNDERSTANDING). THE STUDENT WILL BE ABLE TO SUCCESSFULLY APPLY THE MODELS OF PHYSICS AND STATISTICS TO QUALITATIVE AND QUANTITATIVE DESCRIPTION OF REAL CASES IN INTERDISCIPLINARY CONTEXTS OF INTEREST TO THE DEGREE COURSE, ALSO IN CONNECTION TO THEIR INTRINSIC APPROXIMATIONS (APPLIED KNOWLEDGE AND UNDERSTANDING). THE STUDENT WILL BE ABLE TO INTEGRATE THE NECESSARY KNOWLEDGE AND MANAGE THE COMPLEXITY OF THE INFORMATION IN THE APPLICATION OF THE KNOWLEDGE OF PHYSICS AND STATISTICS (INDEPENDENT JUDGMENT). THE STUDENT WILL ACQUIRE THE ABILITY TO PRESENT TOPICS COVERED IN THE COURSE OF PHYSICS AND STATISTICS WITH PROPERTIES AND SIMPLICITY OF LANGUAGE, AIMED ALSO TO A CLEAR AND EFFECTIVE TRANSMISSION OF CONTENTS AND RESULTS IN INTERDISCIPLINARY CONTEXTS (COMMUNICATION). THE STUDENT WILL ACQUIRE SKILLS ALLOWING HIM TO EXPANDING AND DEEPENING THE THEMES OF PHYSICS AND STATISTICS AND THEIR INTERDISCIPLINARY APPLICATIONS IN AN AUTONOMOUS WAY (LEARNING SKILLS). AT THE END OF THE COURSE THE STUDENT WILL KNOW THE STRUCTURE OF THE MAIN MOLECULES OF BIOCHEMICAL INTEREST AND HAVE UNDERSTOOD THE BASIC PRINCIPLES OF BIOENERGETICS FOR THE STUDY OF METABOLISM. MOREOVER IT SHOULD KNOW THE MAIN TECHNOLOGIES USED IN MOLECULAR DIAGNOSTICS. |
| Prerequisites | |
|---|---|
| MODULE 1 - PHYSICS BASIC KNOWLEDGE OF ALGEBRA, GEOMETRY AND TRIGONOMETRY. MODULE 2 - BIOCHEMISTRY NONE MODULE 3 – STATISTICS BASIC KNOWLEDGE OF MATHEMATICS. |
| Contents | |
|---|---|
| MODULE 1 – PHYSICS INTRODUCTION: THE SCIENTIFIC METHOD; PHYSICAL QUANTITIES; SYSTEMS OF UNITS OF MEASUREMENT. MECHANICS OF SOLIDS: VELOCITY AND ACCELERATION; LINEAR MOTION; CIRCULAR MOTION; PRINCIPLES OF DYNAMICS; GRAVITATIONAL FORCE; WEIGHT FORCE; SPRING FORCE; CONSTRAINTS AND CONSTRAINT FORCES; FRICTIONAL FORCES; WORK; ENERGY; THEOREM OF KINETIC ENERGY; MECHANICAL ENERGY AND ITS CONSERVATION. MECHANICS OF LIQUIDS: PROPERTIES; PRESSURE; STEVIN'S LAW; ARCHIMEDES' PRINCIPLE; PASCAL'S PRINCIPLE; CONTINUITY EQUATION; BERNOULLI'S THEOREM; TORRICELLI’S THEOREM; REAL LIQUIDS. MECHANICS OF GASES: TEMPERATURE AND HEAT; MECHANISMS OF HEAT TRANSFER; IDEAL GAS LAW; PRINCIPLES OF THERMODYNAMICS; ACOUSTIC WAVES; VELOCITY OF PROPAGATION; DOPPLER EFFECT; ULTRASOUNDS. ELECTROMAGNETICS: ELECTRIC CHARGE; COULOMB'S LAW; ELECTRIC FIELD; FIELD LINES; DIELECTRICS; ELECTRIC POLARIZATION; MAGNETS; MAGNETIC FIELDS; FORCES ON MOVING CHARGES; LORENTZ FORCE; ELECTROMAGNETIC WAVES. OPTICS: GEOMETRICAL OPTICS; REFLECTION AND REFRACTION; INDICES OF REFRACTION; TOTAL REFLECTION AND CRITICAL ANGLE; MIRRORS AND LENSES; THIN LENSES; LAW OF CONJUGATE POINTS. APPLICATIONS: APPLICATIONS OF THE ABOVE TOPICS TO MAIN TOPICS OF THE COURSE. MODULE 2 - BIOCHEMISTRY ELEMENTS OF CHEMISTRY: PHYSICAL QUANTITIES AND UNITS OF MEASURE; MULTIPLES AND SUBMULTIPLES; PROPERTIES OF MATTER, HOMOGENEOUS AND HETEROGENEOUS SYSTEMS; THE CHEMICAL BONDS; IONIC BOND; COVALENT BOND; HYDROGEN BOND; STATES OF MATTER; CHEMICAL REACTIONS, CHEMICAL EQUILIBRIUM; SOLUTIONS; SOLUBILITY; COLLIGATIVE PROPERTIES OF SOLUTIONS; THE CONCENTRATIONS OF THE SOLUTIONS; THE WATER; PH AND BUFFER SOLUTIONS. THE CELL UNIT OF LIFE:PROKARYOTIC AND EUKARYOTIC CELLS; THE MAIN BIOCHEMICAL COMPONENTS OF THE HUMAN BODY; CELLULAR LOCALIZATION OF METABOLIC PROCESSES. AMINO ACIDS AND PROTEINS: STRUCTURAL PROPERTIES AND CLASSIFICATION OF AMINO ACIDS; THE PEPTIDE BOND; PROTEIN STRUCTURE: PRIMARY, SECONDARY, TERTIARY AND QUATERNARY; MYOGLOBIN AND HEMOGLOBIN. ENZYMES: GENERAL PROPERTIES OF ENZYMES; ENZYME KINETICS; ENZYME INHIBITION; MULTISUBSTRATE REACTIONS; REGULATION OF ENZYME ACTIVITY; CLINICAL SIGNIFICANCE OF ENZYMES. NUCLEOTIDE AND NUCLEIC ACIDS: STRUCTURE OF NUCLEIC ACIDS, DNA; RNA; MOLECULAR DIAGNOSTICS; MUTATIONS; PURIFICATION OF NUCLEIC ACIDS; RESTRICTION ENZYMES; PCR; ELECTROPHORESIS. BIOENERGETICS AND METABOLISM: BIOENERGETICS AND TYPES OF BIOCHEMICAL REACTIONS; PRINCIPLES OF METABOLIC REGULATION GLYCOLYSIS: THE CHEMISTRY OF CARBOHYDRATES; THE DIGESTION OF CARBOHYDRATES; THE GLYCOLYTIC PATHWAY. MODULE 3 – STATISTICS PROBABILITY: CONDITIONAL AND COMPOSED PROBABILITY; COMBINATORIAL ANALYSIS; LINK BETWEEN A PRIORI PROBABILITY AND RELATIVE FREQUENCY. DISTRIBUTIONS: DISTRIBUTIONS AND FREQUENCIES; INDICES OF THE DISTRIBUTION; MEASURES OF DISPERSION; CONTINUOUS PROBABILITY DISTRIBUTIONS; DISCRETE PROBABILITY DISTRIBUTIONS; DISTRIBUTION T OF STUDENT; 2; DISTRIBUTION F OF FISCHER; DEGREES OF FREEDOM; INTRODUCTION TO SIMULATION TECHNIQUES OF EXPERIMENTS. STATISTICAL INFERENCE: THEORY OF THE SAMPLES; ESTIMATION THEORY; THEORY OF DECISIONS; THE 2 TEST; ANALYSIS OF THE VARIANCE; THE FISHER TEST FOR THE VARIANCES; THE T TEST OF STUDENT; THE MC NEMAR TEST. INTERPOLATION AND LEAST SQUARES: INTERPOLATION; EXTRAPOLATION; LEAST SQUARES; OPERATIONAL REQUIREMENTS FOR THE METHOD OF LEAST SQUARES; NUMERICAL EXAMPLES; TIME SERIES. THEORY OF ERRORS: MEASUREMENT ERRORS; SYSTEMATIC ERRORS; ACCIDENTAL ERRORS; INDIRECT MEASUREMENTS; ERROR PROPAGATION. APPLICATIONS: APPLICATIONS OF THE ABOVE TOPICS TO THE MAIN THEMES OF THE COURSE. |
| Teaching Methods | |
|---|---|
| MODULE 1 – PHYSICS LECTURES AND NUMERICAL EXERCISES. MODULE 2 - BIOCHEMISTRY LECTURES. MODULE 3 – STATISTICS LECTURES. |
| Verification of learning | |
|---|---|
| MODULE 1 - PHYSICS THE FINAL EXAM CONSISTS OF: AN INTERVIEW AIMED TO ASSESS THE KNOWLEDGE OF THE STUDENT OF ISSUES PRESENTED IN THE COURSE AND HIS DISCUSSION ABILITY. MODULE 2 – BIOCHEMISTRY THE FINAL EXAM CONSISTS OF: MULTIPLE CHOICE EXAM MODULE 3 – STATISTICS THE FINAL EXAM CONSISTS OF: AN INTERVIEW AIMED TO ASSESS THE KNOWLEDGE OF THE STUDENT OF ISSUES PRESENTED IN THE COURSE AND HIS DISCUSSION ABILITY. |
| Texts | |
|---|---|
| MODULE 1 - PHYSICS R.A. SERWAY, J.W. JEWETT, PRINCIPI DI FISICA, ED. EDISES, NAPOLI. DESMOND M.BURNS, SIMON G.G. MACDONALD, FISICA PER STUDENTI DI BIOLOGIA E MEDICINA, ZANICHELLI. LECTURES NOTES. MODULE 2 – BIOCHEMISTRY SUGGESTED TEXT: INTRODUZIONE ALLA BIOCHIMICA DI LEHNINGER. NELSON D.L., COX MM. ZANICHELLI TEACHING MATERIALS: SLIDES OF THE LECTURES. MODULE 3 – STATISTICS JOHN R. TAYLOR, INTRODUZIONE ALL’ANALISI DEGLI ERRORI, ED. ZANICHELLI. PHILIP BEVINGTON, D. KEITH ROBINSON, DATA REDUCTION AND ERROR ANALYSIS FOR THE PHYSICAL SCIENCES, ED. MCGRAW-HILL. |
| More Information | |
|---|---|
| MODULE 1 - PHYSICS FOR MORE DETAILED INFORMATION ON THE PROGRAM, NOTICES AND COMMUNICATIONS ABOUT THE COURSE OF PHYSICS, REFER TO THE WEBSITE OF THE PROFESSOR: PROF. FABRIZIO BARONE HTTP://WWW.UNISA.IT/DOCENTI/FABRIZIOBARONE/INDEX MODULE 2 - BIOCHEMISTRY FOR MORE DETAILED INFORMATION ON THE PROGRAM, NOTICES AND COMMUNICATIONS ABOUT THE COURSE OF BIOCHEMISTRY, REFER TO THE WEBSITE OF THE PROFESSOR: PROF. ROSANNA MARTINELLI HTTP://WWW.UNISA.IT/DOCENTI/ROSANNAMARTINELLI/INDEX MODULE 3 - STATISTICS FOR MORE DETAILED INFORMATION ON THE PROGRAM, NOTICES AND COMMUNICATIONS ABOUT THE COURSE OF BIOCHEMISTRY, REFER TO THE WEBSITE OF THE PROFESSOR. |
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