BASIS BIOLOGICAL MOLECULAR AND STATISTICS

Rosanna MARTINELLI BASIS BIOLOGICAL MOLECULAR AND STATISTICS

1012200001
DIPARTIMENTO DI MEDICINA, CHIRURGIA E ODONTOIATRIA "SCUOLA MEDICA SALERNITANA"
EQF6
PHYSIOTHERAPY
2020/2021

OBBLIGATORIO
YEAR OF COURSE 1
YEAR OF DIDACTIC SYSTEM 2013
PRIMO SEMESTRE
CFUHOURSACTIVITY
1BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD. FISICA
224LESSONS
2BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD. BIOCHIMICA
224LESSONS
3BASI BIOLOGICO MOLECOLARI E STATISTICA - MOD. STATISTICA MEDICA
224LESSONS
Objectives
THE MAIN OBJECTIVE OF THE COURSE IS TO PROVIDE STUDENTS WITH THE BASIS OF PHYSICS , BIOCHEMISTRY AND STATISTICS TO EFFECTIVELY ADDRESS THE ISSUES OF THE DEGREE COURSE IN FISIOTERAPY. IN PARTICULAR, THE KNOWLEDGE AND SKILLS THAT THE STUDENT WILL ACQUIRE DURING THE COURSE ARE:


KNOWLEDGE OF THE MAIN ISSUES OF PHYSICS, BIOCHEMISTRY AND STATISTICS CRITICALLY UNDERSTANDING ALSO LIMITS OF VALIDITY AND APPLICABILITY IN REAL CONTEXTS (KNOWLEDGE AND UNDERSTANDING).

ABILITY TO APPLY THE MODELS OF PHYSICS, BIOCHEMISTRY AND STATISTICS TO QUALITATIVE AND QUANTITATIVE DESCRIPTION OF REAL CASES IN INTERDISCIPLINARY CONTEXTS OF INTEREST TO THE DEGREE COURSE, ALSO IN CONNECTION TO THEIR INTRINSIC APPROXIMATIONS (APPLIED KNOWLEDGE AND UNDERSTANDING).

ABILITY TO INTEGRATE THE NECESSARY KNOWLEDGE AND MANAGE THE COMPLEXITY OF THE INFORMATION IN THE APPLICATION OF THE KNOWLEDGE OF PHYSICS, BIOCHEMISTRY AND STATISTICS (INDEPENDENT JUDGMENT).

ABILITY TO PRESENT TOPICS COVERED IN THE COURSE OF PHYSICS, BIOCHEMISTRY AND STATISTICS WITH PROPERTIES AND SIMPLICITY OF LANGUAGE, AIMED ALSO TO A CLEAR AND EFFECTIVE TRANSMISSION OF CONTENTS AND RESULTS IN INTERDISCIPLINARY CONTEXTS (COMMUNICATION).

ABILITY TO EXPAND AND DEEPEN THE THEMES OF PHYSICS, BIOCHEMISTRY AND STATISTICS AND THEIR INTERDISCIPLINARY APPLICATIONS IN AN AUTONOMOUS WAY (LEARNING SKILLS).

AT THE END OF THE COURSE THE STUDENT WILL KNOW THE STRUCTURE OF THE MAIN MOLECULES OF BIOCHEMICAL INTEREST AND HAVE UNDERSTOOD THE BASIC PRINCIPLES OF BIOENERGETICS FOR THE STUDY OF METABOLISM. MOREOVER, IT SHOULD KNOW THE MAIN TECHNOLOGIES USED IN MOLECULAR DIAGNOSTICS.
Prerequisites
THE STUDENT MUST HAVE ACQUIRED THE BASIC KNOWLEDGE OF MATHEMATICS AND GEOMETRY PROVIDED BY NORMAL STUDY PROGRAMS OF HIGH SCHOOLS.
Contents
THE COURSE (6 CFU) CONSISTS OF 3 MODULES: PHYSICS (2 CFU), BIOCMEMISTRY (2 CFU) AND STATISTICS (2 CFU).

IN THE FOLLOWING THE CONTENTS OF EACH MODULE ARE REPORTED.

MODULE 1 – PHYSICS
INTRODUCTION: THE SCIENTIFIC METHOD; PHYSICAL QUANTITIES; SYSTEMS OF UNITS OF MEASUREMENT.
MECHANICS OF SOLIDS: VELOCITY AND ACCELERATION; LINEAR MOTION; CIRCULAR MOTION; PRINCIPLES OF DYNAMICS; GRAVITATIONAL FORCE; WEIGHT FORCE; SPRING FORCE; CONSTRAINTS AND CONSTRAINT FORCES; FRICTIONAL FORCES; WORK; ENERGY; THEOREM OF KINETIC ENERGY; MECHANICAL ENERGY AND ITS CONSERVATION.
MECHANICS OF LIQUIDS: PROPERTIES; PRESSURE; STEVIN'S LAW; ARCHIMEDES' PRINCIPLE; PASCAL'S PRINCIPLE; CONTINUITY EQUATION; BERNOULLI'S THEOREM; TORRICELLI’S THEOREM; REAL LIQUIDS.
MECHANICS OF GASES: TEMPERATURE AND HEAT; MECHANISMS OF HEAT TRANSFER; IDEAL GAS LAW; PRINCIPLES OF THERMODYNAMICS; ACOUSTIC WAVES; VELOCITY OF PROPAGATION; DOPPLER EFFECT; ULTRASOUNDS.
ELECTROMAGNETICS: ELECTRIC CHARGE; COULOMB'S LAW; ELECTRIC FIELD; FIELD LINES; DIELECTRICS; ELECTRIC POLARIZATION; MAGNETS; MAGNETIC FIELDS; FORCES ON MOVING CHARGES; LORENTZ FORCE; ELECTROMAGNETIC WAVES.
OPTICS: GEOMETRICAL OPTICS; REFLECTION AND REFRACTION; INDICES OF REFRACTION; TOTAL REFLECTION AND CRITICAL ANGLE; MIRRORS AND LENSES; THIN LENSES; LAW OF CONJUGATE POINTS.

MODULE 2 - BIOCHEMISTRY
ELEMENTS OF CHEMISTRY: PHYSICAL QUANTITIES AND UNITS OF MEASURE; MULTIPLES AND SUBMULTIPLES; PROPERTIES OF MATTER, HOMOGENEOUS AND HETEROGENEOUS SYSTEMS; THE CHEMICAL BONDS; IONIC BOND; COVALENT BOND; HYDROGEN BOND; STATES OF MATTER; CHEMICAL REACTIONS, CHEMICAL EQUILIBRIUM; SOLUTIONS; SOLUBILITY; COLLIGATIVE PROPERTIES OF SOLUTIONS; THE CONCENTRATIONS OF THE SOLUTIONS; THE WATER; PH AND BUFFER SOLUTIONS.
THE CELL UNIT OF LIFE:PROKARYOTIC AND EUKARYOTIC CELLS; THE MAIN BIOCHEMICAL COMPONENTS OF THE HUMAN BODY; CELLULAR LOCALIZATION OF METABOLIC PROCESSES.
AMINO ACIDS AND PROTEINS: STRUCTURAL PROPERTIES AND CLASSIFICATION OF AMINO ACIDS; THE PEPTIDE BOND; PROTEIN STRUCTURE: PRIMARY, SECONDARY, TERTIARY AND QUATERNARY; MYOGLOBIN AND HEMOGLOBIN.
ENZYMES: GENERAL PROPERTIES OF ENZYMES; ENZYME KINETICS; ENZYME INHIBITION; MULTISUBSTRATE REACTIONS; REGULATION OF ENZYME ACTIVITY; CLINICAL SIGNIFICANCE OF ENZYMES.
NUCLEOTIDE AND NUCLEIC ACIDS: STRUCTURE OF NUCLEIC ACIDS, DNA; RNA; MOLECULAR DIAGNOSTICS; MUTATIONS; PURIFICATION OF NUCLEIC ACIDS; RESTRICTION ENZYMES; PCR; ELECTROPHORESIS.
BIOENERGETICS AND METABOLISM: BIOENERGETICS AND TYPES OF BIOCHEMICAL REACTIONS; PRINCIPLES OF METABOLIC REGULATION
GLYCOLYSIS: THE CHEMISTRY OF CARBOHYDRATES; THE DIGESTION OF CARBOHYDRATES; THE GLYCOLYTIC PATHWAY.


MODULE 3 – STATISTICS
PROBABILITY: CONDITIONAL AND COMPOSED PROBABILITY; COMBINATORIAL ANALYSIS; LINK BETWEEN A PRIORI PROBABILITY AND RELATIVE FREQUENCY.
DISTRIBUTIONS: DISTRIBUTIONS AND FREQUENCIES; INDICES OF THE DISTRIBUTION; MEASURES OF DISPERSION; CONTINUOUS PROBABILITY DISTRIBUTIONS; DISCRETE PROBABILITY DISTRIBUTIONS; DISTRIBUTION T OF STUDENT; 2; DISTRIBUTION F OF FISCHER; DEGREES OF FREEDOM; INTRODUCTION TO SIMULATION TECHNIQUES OF EXPERIMENTS.
STATISTICAL INFERENCE: THEORY OF THE SAMPLES; ESTIMATION THEORY; THEORY OF DECISIONS; THE 2 TEST; ANALYSIS OF THE VARIANCE; THE FISHER TEST FOR THE VARIANCES; THE T TEST OF STUDENT; THE MC NEMAR TEST.
INTERPOLATION AND LEAST SQUARES: INTERPOLATION; EXTRAPOLATION; LEAST SQUARES; OPERATIONAL REQUIREMENTS FOR THE METHOD OF LEAST SQUARES; NUMERICAL EXAMPLES; TIME SERIES.
THEORY OF ERRORS: MEASUREMENT ERRORS; SYSTEMATIC ERRORS; ACCIDENTAL ERRORS; INDIRECT MEASUREMENTS; ERROR PROPAGATION.
Teaching Methods
THE COURSE (6 CFU) CONSISTS OF LECTURES.

ATTENDANCE TO LECTURES IS MANDATORY. TO DO THE FINAL EXAM THE STUDENT MUST HAVE AT LEAST 75% OF THE TOTAL AMOUNT OF THE HOURS. THE MODE OF CHECKING THE ATTENDANCE IS MADE KNOWN BY THE PROFESSOR AT THE BEGINNING OF THE LESSONS.
Verification of learning
THE ACHIEVEMENT OF THE OBJECTIVES OF THE COURSE IS CERTIFIED BY THE EXTENSION OF AN EXAMINATION WITH EVALUATION IN THIRTIETHS. THE TEST GLOBALLY ALLOWS TO ASSESS THE CAPABILITY OF KNOWLEDGE AND COMPREHENSION, THE CAPBILITY TO APPLY THE ACQUIRED KNOWLEDGE, THE CAPABILITY OF EXPOSURE AND THE CAPABILITY TO EXPLAIN AND TO PROCESS SOLUTIONS WITH AN INDEPENDENT JUDGEMENT. THE LECTURERS OF THE COORDINATED MODULES PARTICIPATE TO THE COLLEGAL ASSESSMENT OF THE STUDENT PROFIT.

IN PARTICULAR, FOR WHAT CONCERNES EACH MODULE:

MODULE 1 - PHYSICS

THE FINAL EXAM CONSISTS OF:

AN INTERVIEW AIMED TO ASSESS THE KNOWLEDGE OF THE STUDENT OF ISSUES PRESENTED IN THE COURSE AND HIS DISCUSSION ABILITY.


MODULE 2 – BIOCHEMISTRY

THE FINAL EXAM CONSISTS OF:

MULTIPLE CHOICE EXAM


MODULE 3 – STATISTICS

THE FINAL EXAM CONSISTS OF:

AN INTERVIEW AIMED TO ASSESS THE KNOWLEDGE OF THE STUDENT OF ISSUES PRESENTED IN THE COURSE AND HIS DISCUSSION ABILITY.
Texts
MODULE 1 - PHYSICS

R.A. SERWAY, J.W. JEWETT, PRINCIPI DI FISICA, ED. EDISES, NAPOLI.

DESMOND M.BURNS, SIMON G.G. MACDONALD, FISICA PER STUDENTI DI BIOLOGIA E MEDICINA, ZANICHELLI.

LECTURES NOTES.


MODULE 2 – BIOCHEMISTRY
SUGGESTED TEXT: CHIMICA E BIOCHIMICA PER LE LAUREE TRIENNALI DELL'AREA BIOMEDICA
M. SAMAJA- R. PARONI II EDIZIONE PICCIN

INTRODUZIONE ALLA BIOCHIMICA DI LEHNINGER. NELSON D.L., COX MM. ZANICHELLI
TEACHING MATERIALS: SLIDES OF THE LECTURES.


MODULE 3 – STATISTICS

JOHN R. TAYLOR, INTRODUZIONE ALL’ANALISI DEGLI ERRORI, ED. ZANICHELLI.

PHILIP BEVINGTON, D. KEITH ROBINSON, DATA REDUCTION AND ERROR ANALYSIS FOR THE PHYSICAL SCIENCES, ED. MCGRAW-HILL.
More Information
MODULE 1 - PHYSICS

FOR MORE DETAILED INFORMATION ON THE PROGRAM, NOTICES AND COMMUNICATIONS ABOUT THE COURSE OF PHYSICS, REFER TO THE WEBSITE OF THE PROFESSOR:

PROF. FABRIZIO BARONE

HTTP://WWW.UNISA.IT/DOCENTI/FABRIZIOBARONE/INDEX

MODULE 2 - BIOCHEMISTRY

FOR MORE DETAILED INFORMATION ON THE PROGRAM, NOTICES AND COMMUNICATIONS ABOUT THE COURSE OF BIOCHEMISTRY, REFER TO THE WEBSITE OF THE PROFESSOR:

PROF. ROSANNA MARTINELLI

HTTP://WWW.UNISA.IT/DOCENTI/ROSANNAMARTINELLI/INDEX

MODULE 3 - STATISTICS

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