Viviana IZZO | Progetti

Dapagliflozin is a selective inhibitor of sodiumâ¿¿glucose cotransporter 2 (SGLT2), which blocks glucose resorption in the proximal tubule of the kidney and promotes glycosuria. It is indicated in adults for the treatment of inadequately controlled type 2 diabetes mellitus (T2DM) in combination with diet and exercise. Several studies have shown cardioprotective benefits of dapagliflozin,contributing

To assess the relationship between adherence to the Mediterranean diet and secondary bile acid levels in obese children. To analyse the relationship of bile acids profile and metabolic syndrome determinants. To analyse the relationship between bile acid profile and mood tone in obese children. To describe a bile acids risk profile of metabolic syndrome in children.

Studiare la potenzialità del rapporto diidrouracile (UH2)/uracile(U), misurato nel plasma, di predire di rischio di tossicità da fluoropirimidine;Investigare l'associazione tra il rapporto UH2/U e i polimorfismi del gene DPYD codificante l'enzima diidropirimidina deidrogenasi (DPD);Determinare il cut-off del rapporto UH2/U utile a predire tossicità di grado moderato-grave sia nei pazienti portat