2. Docenti
  3. Curriculum

Curriculum

Curriculum Docente

Curriculum Vitae

Michele Ciccarelli

_____________________________________________________________

Department of Medicine, Surgery and Dentistry

University of Salerno

Via Salvador Allende

84081 Baronissi (SA), Italy

E-mail: mciccarelli@unisa.it

EDUCATION AND TRAINING

School of Medicine,

“Federico II” University of Naples September 1995- November 2001 MD, cum laude, 2001

GRADUATE MEDICAL EDUCATION

School of Cardiology,

“Federico II” University of Naples October 2002 – October 2006 Cardiologist, cum laude, 2006

GRADUATE/PROFESSIONAL SCHOOL

“Federico II” University of Naples January 2007 – January 2010 PhD, 2010

POSTDOCTORAL FELLOWSHIP EXPERIENCE (for PhD’s or MD/PhD’s)

INSTITUTION MONTH/YEAR

Laboratory of Prof Bruno Trimarco, “Federico II” University Naples, Italy

Role of the endothelial border in development of Hypertension September 2001 – August 2005

Laboratory of Prof Walter J Koch, Thomas Jefferson University,

Philadelphia, Pennsylvania

Mechanisms of neoangiogenesis: role of adrenergic system August 2005 - October 2005

Laboratory of Prof Bruno Trimarco, “Federico II” University Naples, Italy

Role of the beta 2 adrenergic receptor in neoangiogenesis October 2005 – May 2007

Laboratory of Prof Walter J Koch, Thomas Jefferson University,

Philadelphia, Pennsylvania

Heart failure and defective cardiac metabolism: role of GRKs May 2007 – February 2012

Laboratory of Prof Walter J Koch, Temple University,

Philadelphia, Pennsylvania

Heart failure and mitochondrial functions February 2012 – December 2012

EMPLOYMENT

Post-Doctoral fellow at Thomas Jefferson University of Philadelphia May 2007 – February 2012

Assistant Professor at Temple University of Philadelphia February 2012 - December 2012

Adjunct Professor at Temple University of Philadelphia April 2012 – April 2014

Assistant Professor at University of Salerno December 2012 – December 2017

Associate Professor at University of Salerno October 2018 - present

RESEARCH INTERST

Molecular and pathophysiological mechanisms of Cardiac diseases: Role of G protein coupled receptor Kinases (GRKs) on cardiac metabolism and functions

Role of the endothelium in regulation of vascular functions: Role of GRKs and GPCRs in vasomotor responses, angiogenesis and inflammations.

Development of new molecular target for treatment of cardiovascular diseases: identification, characterization and synthesis of new drugs.

TEACHING INTEREST

Molecular and Clinical Cardiology, new approaches for treatment of Cardiovascular diseases.

PROFESSIONAL ACTIVITIES

EDUCATIONAL

Course of Gene Therapy in Internal Medicine at

“Federico II” University of Naples 2004-2007

Member of the Academy Board of the PhD program “Healthy Aging” and

“Translational Medicine”- University of Salerno Sept 2013 – present

Course of Cardiovascular Disease at University of Salerno

for healthcare professions October 2013 - present

PROFESSIONAL PUBLICATIONS (Editor, Reviewer, etc):

British Journal of Pharmacology: Reviewer 2007-present

Atherosclerosis: Reviewer 2007-present

Journal of Molecular Cardiology: Reviewer 2012-present

Pharmacological Research: Reviewer 2013-present

Medicine: Reviewer 2015- present

Scientific Report: Reviewer 2016-present

ESC HF: Reviewer 2019-present

European Heart Journal: Reviewer 2019-present

Frontiers in cardiovascular Medicine: Editor 2013-present

Translational Medicine@UNISA: Editor 2016-present

ESC-Heart Failure: Associate Editor 2020-present

PROFESSIONAL MEMBERSHIP

Member of the following societies: American Heart Association (AHA), Nucleus member of the Working group on Myocardial function of European Society of Cardiology, HFA gold Member, ESC professional Member, Italian Society of Hypertension

NATIONAL AND INTERNATIONAL COLLABORATIONS

Walter J Koch, PhD Temple University of Philadelphia, PA, USA

Gerald W Dorn II, MD Washington University at St Lois, MO, USA

Anastasios Lymperoupoulos Nova University, Ft Lauderdale, FL, USA

Petronila Penela , PhD Universidad Autonoma de Madrid, Spain

Gaetano Santulli MD, PhD Columbia University, NY, USA

Guido Iaccarino MD, PhD “Federico II” University of Naples, Italy

Bruno Trimarco, MD “Federico II” University of Naples, Italy

Dr Nahza Hamdani Ruhr-University Bochum

AWARDS, HONORS AND FELLOWSHIP

Italian Society of Hypertension (SIIA) Prize for Young Investigator 2002

Italian Society of Internal Medicine (SIMI) – Sanofi Aventis award

for best presented project 2004

Italian Society of Hypertension Award

“Salvatore Campus” for young investigator abroad 2006

American Heart Association (AHA) Post-Doctoral Fellowship 2009-2011

Young Investigator Travel Award of

American Heart Association (AHA) 2010

RESEARCH PROJECT DEVISED AND MANAGED

American Heart Association grant for the project entitled: “GRK2 as a novel regulator of cardiac metabolism” (2009)

Operational Unit Manager within the project: "Blocking reciprocal down-regulation of sphingosine - 1 -phosphate receptor-1 and β1- adrenergic receptor as a new therapeutic strategy for improving post-ischemic left ventricular remodeling and dysfunction". Funding: Ministry of Health-Research for Young Researchers 2012.

Participation in the Beyond Silos project, funded by the European Commission under the FP7-CIP-ICT-PSP-2013-7 Call

Responsible of the Research project: "Mitochondrial Aging Mechanisms: Role of GRK2". Funding: FARB 2015

Responsible of the Research project: "NEW STRATEGIES FOR THE MANAGEMENT AND ADHERENCE TO POLYPHARMACOTHERAPY OF PATIENTS WITH HIGH CARDIOVASCULAR RISK: USE OF ICT". Funding: FARB 2016.

Responsible for the research project: "THE SUBCELLULAR LOCATION OF GRK2 AS A NEW THERAPEUTIC STRATEGY IN THE PREVENTION OF ORGAN DAMAGE INDUCED BY RHEUMATOID ARTHRITIS AND HYPERTENSION". Funding: FARB 2017

LIST OF PUBLICATIONS

H-index: 24; Total citations: 1677 (Scopus Database-Feb 2021)

78 peer-reviewed journal articles; 4 chapters; >300 Abstracts presented as poster and oral presentations at National and International meetings.

Peer Reviewed Journal Articles:

  1. Ciccarelli M, Dawson D, Falcao-Pires I, Giacca M, Hamdani N, Heymans S, Hooghiemstra A, Leeuwis A, Hermkens D, Tocchetti CG, van der Velden J, Zacchigna S, Thum T. Reciprocal organ interactions during heart failure-a position paper from the ESC working group on myocardial function. Cardiovasc Res. 2021 Jan 22:cvab009. doi: 10.1093/cvr/cvab009. Epub ahead of print. PMID: 33483724.
  2. Sorriento D, Rusciano MR, Visco V, Fiordelisi A, Cerasuolo FA, Poggio P, Ciccarelli M, Iaccarino G. The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. 2021 Jan 15;10(1):167. doi: 10.3390/cells10010167.PMID: 33467677; PMCID: PMC7830135.
  3. Izzo C, Vitillo P, Di Pietro P, Visco V, Strianese A, Virtuoso N, Ciccarelli M, Galasso G, Carrizzo A, Vecchione C. The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases. Life (Basel). 2021 Jan 15;11(1):60. doi: 10.3390/life11010060. PMID: 33467601; PMCID: PMC7829951.
  4. Silverio A, Di Maio M, Citro R, Esposito L, Iuliano G, Bellino M, Baldi C, De Luca G, Ciccarelli M, Vecchione C, Galasso G. Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients. BMC Cardiovasc Disord. 2021 Jan 7;21(1):23. doi: 10.1186/s12872-020-01816-3. PMID: 33413093; PMCID: PMC7789083.
  5. Visco V, Ferruzzi GJ, Nicastro F, Virtuoso N, Carrizzo A, Galasso G, Vecchione C, Ciccarelli M. Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: an Emerging Approach for Disease Detection and Treatment Optimization. Curr Med Chem. 2020 Dec 18. doi: 10.2174/0929867328666201218122633. Epub ahead of print. PMID: 33342402.
  6. Visco V, Pascale AV, Virtuoso N, Mongiello F, Cinque F, Gioia R, Finelli R, Mazzeo P, Manzi MV, Morisco C, Rozza F, Izzo R, Cerasuolo F, Ciccarelli M, Iaccarino G. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension. Front Cardiovasc Med. 2020 Nov 26;7:570000. doi: 10.3389/fcvm.2020.570000. PMID: 33324684; PMCID: PMC7725708.
  7. Gambardella J, Fiordelisi A, Santulli G, Ciccarelli M, Cerasuolo FA, Sala M, Sommella E, Campiglia P, Illario M, Iaccarino G, Sorriento D. Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis. Cancers (Basel). 2020 Nov 26;12(12):3530. doi: 10.3390/cancers12123530. PMID: 33256128; PMCID: PMC7760517.
  8. Conti V, Corbi G, Polito MV, Ciccarelli M, Manzo V, Torsiello M, De Bellis E, D'Auria F, Vitulano G, Piscione F, Carrizzo A, Di Pietro P, Vecchione C, Ferrara N, Filippelli A. Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes. Biomolecules. 2020 Nov 23;10(11):1590. doi: 10.3390/biom10111590. PMID: 33238655; PMCID: PMC7700185.
  9. Carrizzo A, Izzo C, Forte M, Sommella E, Di Pietro P, Venturini E, Ciccarelli M, Galasso G, Rubattu S, Campiglia P, Sciarretta S, Frati G, Vecchione C. A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases. Int J Mol Sci. 2020 Nov 18;21(22):8706. doi: 10.3390/ijms21228706. PMID: 33218062; PMCID: PMC7698807.
  10. Visco V, Esposito C, Vitillo P, Vecchione C, Ciccarelli M. It is easy to see, but it is better to foresee: a case report on the favourable alliance between CardioMEMS and levosimendan. Eur Heart J Case Rep. 2020 Jun 30;4(4):1-5. doi: 10.1093/ehjcr/ytaa205. PMID: 32974431; PMCID: PMC7501887.
  11. Silverio A, Di Maio M, Ciccarelli M, Carrizzo A, Vecchione C, Galasso G.Timing of national lockdown and mortality in COVID-19: The Italian experience. Int J Infect Dis. 2020 Nov;100:193-195. doi: 10.1016/j.ijid.2020.09.006. Epub 2020 Sep 5. PMID: 32898670; PMCID: PMC7833935.
  12. Gambardella J, Sorriento D, Bova M, Rusciano M, Loffredo S, Wang X, Petraroli A, Carucci L, Mormile I, Oliveti M, Bruno Morelli M, Fiordelisi A, Spadaro G, Campiglia P, Sala M, Trimarco B, Iaccarino G, Santulli G, Ciccarelli M. Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema. Hypertension. 2020 Nov;76(5):1625-1636. 10.1161/HYPERTENSIONAHA.120.15130. Epub 2020 Sep 8. PMID: 32895019; PMCID: PMC7544666.
  13. Tocchetti CG, Ameri P, de Boer RA, D'Alessandra Y, Russo M, Sorriento D, Ciccarelli M, Kiss B, Bertrand L, Dawson D, Falcao-Pires I, Giacca M, Hamdani N, Linke WA, Mayr M, van der Velden J, Zacchigna S, Ghigo A, Hirsch E, Lyon AR, Görbe A, Ferdinandy P, Madonna R, Heymans S, Thum T. Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovasc Res. 2020 Jul 19:cvaa222. doi: 10.1093/cvr/cvaa222. Online ahead of print. PMID: 32683451
  14. Strianese O, Rizzo F, Ciccarelli M, Galasso G, D'Agostino Y, Salvati A, Del Giudice C, Tesorio P, Rusciano MR. Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease. Genes (Basel). 2020 Jul 6;11(7):E747. doi: 10.3390/genes11070747.
  15. Bär C, Chatterjee S, Pires IF, Rodrigues P, Sluijter JPG, Boon RA, Nevado RM, Andrés V, Sansonetti M, de Windt L, Ciccarelli M, Hamdani N, Heymans S, Videira RF, Tocchetti CG, Giacca M, Zacchigna S, Engelhardt S, Dimmeler S, Madonna R, Thum T. Non-coding RNAs - Update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovasc Res. 2020 Jul 8:cvaa195. doi: 10.1093/cvr/cvaa195. Online ahead of print. PMID: 32638021
  16. Kolijn D, Pabel S, Tian Y, Lódi M, Herwig M, Carrizzo A, Zhazykbayeva S, Kovács Á, Fülöp GÁ, Falcão-Pires I, Reusch PH, Van Linthout S, Papp Z, van Heerebeek L, Vecchione C, Maier LS, Ciccarelli M, Tschöpe C, Mügge A, Bagi Z, Sossalla S, Hamdani N. Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation. Cardiovasc Res. 2020 May 12:cvaa123. doi: 10.1093/cvr/cvaa123. Online ahead of print.
  17. Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G, Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A, Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I, Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T. Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Working Group on Myocardial Function of the European Society of Cardiology. Cardiovasc Res. 2020 May 4:cvaa110. doi: 10.1093/cvr/cvaa110. Online ahead of print. PMID: 32365197
  18. Ciccarelli M, Sorriento D, Fiordelisi A, Gambardella J, Franco A, Del Giudice C, Sala M, Monti MG, Bertamino A, Campiglia P, Oliveti M, Poggio P, Trinchese G, Cavaliere G, Cipolletta E, Mollica MP, Bonaduce D, Trimarco B, Iaccarino G. Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure. ESC Heart Fail. 2020 Apr 30. doi: 10.1002/ehf2.12706. Online ahead of print. PMID: 3235222
  19. Polito MV, Silverio A, Rispoli A, Vitulano G, Auria F, De Angelis E, Loria F, Gigantino A, Bonadies D, Citro R, Carrizzo A, Galasso G, Iaccarino G, Vecchione C, Ciccarelli M. Clinical and echocardiographic benefit of Sacubitril/Valsartan in a real-world population with HF with reduced ejection fraction. Sci Rep. 2020 Apr 20;10(1):6665. doi: 10.1038/s41598-020-63801-2. PMID: 3231319.
  20. SilverioA, Di Maio M, Prota C, De Angelis E, Radano I, Citro R, Carrizzo A,Ciccarelli M, Vecchione C,Capodanno D, Galasso G. Safety and Efficacy of Non-Vitamin K Antagonist Oral Anticoagulants in Elderly Patients With Atrial Fibrillation. European Heart Journal - Cardiovascular Pharmacotherapy. PMID: 31830264DOI: 1093/ehjcvp/pvz073. 2019 Dec 12[Online ahead of print
  21. Santulli G, Pascale V, Finelli R, Visco V, Giannotti R, Massari A, Morisco C, Ciccarelli M, Illario M, Iaccarino G, Coscioni E. We Are What We Eat: Impact of Food From Short Supply Chain on Metabolic Syndrome. J Clin Med 8 (12) 2019 Nov 23. PMID: 31771147 DOI: 3390/jcm8122061
  22. De Angelis E, Pecoraro M, Rusciano MR, Ciccarelli M, Popolo A. Cross-Talk between Neurohormonal Pathways and the Immune System in Heart Failure: A Review of the Literature. Int J Mol Sci. 2019 Apr 5;20(7). pii: E1698. doi: 10.3390/ijms20071698. Review.
  23. Cipolletta E, Gambardella J, Fiordelisi A, Del Giudice C, Di Vaia E, Ciccarelli M, Sala M, Campiglia P, Coscioni E, Trimarco B, Sorriento D, Iaccarino G. Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice. Int J Mol Sci. 2019 Mar 25;20(6). pii: E1492. doi: 10.3390/ijms20061492
  24. Russo M, Guida F, Paparo L, Trinchese G, Aitoro R, Avagliano C, Fiordelisi A, Napolitano F, Mercurio V, Sala V, Li M, Sorriento D, Ciccarelli M, Ghigo A, Hirsch E, Bianco R, Iaccarino G, Abete P, Bonaduce D, Calignano A, Berni Canani R, Tocchetti CG. The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. Eur J Heart Fail. 2019 Apr;21(4):519-528. doi: 10.1002/ejhf.1439. Epub 2019 Mar 6
  25. Gambardella J, De Rosa M, Sorriento D, Prevete N, Fiordelisi A, Ciccarelli M, Trimarco B, De Luca N, Iaccarino G. Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications. Oxid Med Cell Longev. 2018 Dec 19;2018:9582319. doi: 10.1155/2018/9582319. eCollection 2018
  26. Gambardella J, Ciccarelli M, Del Giudice C, Fiordelisi A, De Rosa M, Sala M, Pacelli R, Campiglia P, Trimarco B, Iaccarino G, Sorriento D. A Novel Small Peptide Inhibitor of NFκB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer. Oxid Med Cell Longev. 2018 Nov 4;2018:5801807. doi: 10.1155/2018/5801807. eCollection 2018.
  27. D'Auria F, Polito MV, Vitulano G, Ciccarelli M, De Rosa R, Gigantino A, Piscione F, Galasso G.Predictors of left ventricular reverse remodeling in patients with chronic heart failure. J Cardiovasc Med (Hagerstown). 2018 Aug;19(8):465-469. doi: 10.2459/JCM.0000000000000679. No abstract available. PMID: 29952847
  28. Bondue A, Arbustini E, Bianco A, Ciccarelli M, Dawson D, De Rosa M, Hamdani N, Hilfiker-Kleiner D, Meder B, Leite-Moreira AF, Thum T, Tocchetti CG, Varricchi G, Van der Velden J, Walsh R, Heymans S. Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovasc Res. 2018 Aug 1;114(10):1287-1303. doi: 10.1093/cvr/cvy122.
  29. Visco V, Finelli R, Pascale AV, Mazzeo P, Ragosa N, Trimarco V, Illario M, Ciccarelli M, Iaccarino G. Difficult-to-control hypertension: identification of clinical predictors and use of ICT-based integrated care to facilitate blood pressure control. J Hum Hypertens. 2018 Jul;32(7):467-476. doi: 10.1038/s41371-018-0063-0. Epub 2018 May 1. PMID: 29713051
  30. Pascale V, Finelli R, Giannotti R, Coscioni E, Izzo R, Rozza F, Caputo D, Moscato P, Iaccarino G, Ciccarelli M. Cardiac eccentric remodeling in patients with rheumatoid arthritis. Sci Rep. 2018 Apr 12;8(1):5867. doi: 10.1038/s41598-018-24323-0. PMID: 29651025
  31. Sorriento D, Santulli G, Ciccarelli M, Maione AS, Illario M, Trimarco B, Iaccarino G. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors. Int J Mol Sci. 2018 Mar 15;19(3). pii: E861. doi: 10.3390/ijms19030861.
  32. Franco A, Sorriento D, Gambardella J, Pacelli R, Prevete N, Procaccini C, Matarese G, Trimarco B, Iaccarino G, Ciccarelli M. GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion. Cell Death Discov. 2018 Feb 14;4:25. doi: 10.1038/s41420-018-0028-7. eCollection 2018 Dec.
  33. Pecoraro M, Ciccarelli M, Fiordelisi A, Iaccarino G, Pinto A, Popolo A. Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity. Int J Mol Sci. 2018 Mar 7;19(3). pii: E757. doi: 10.3390/ijms19030757.
  34. Frantz S, Falcao-Pires I, Balligand JL, Bauersachs J, Brutsaert D, Ciccarelli M, Dawson D, de Windt LJ, Giacca M, Hamdani N, Hilfiker-Kleiner D, Hirsch E, Leite-Moreira A, Mayr M, Thum T, Tocchetti CG, van der Velden J, Varricchi G, Heymans S. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. Eur J Heart Fail. 2018 Mar;20(3):445-459. doi: 10.1002/ejhf.1138. Epub 2018 Jan 15. Review.
  35. Pascale AV, Finelli R, Giannotti R, Visco V, Fabbricatore D, Matula I, Mazzeo P, Ragosa N, Massari A, Izzo R, Coscioni E, Illario M, Ciccarelli M, Trimarco B, Iaccarino G. Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly. J Cardiovasc Med (Hagerstown). 2018 Feb;19(2):62-66. doi: 10.2459/JCM.0000000000000614.
  36. Pecoraro M, Rodríguez-Sinovas A, Marzocco S, Ciccarelli M, Iaccarino G, Pinto A, Popolo A Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment. Int J Mol Sci. 2017 Oct 11;18(10). pii: E2121. doi: 10.3390/ijms18102121.
  37. Visco V, Finelli R, Pascale AV, Giannotti R, Fabbricatore D, Ragosa N, Ciccarelli M, Iaccarino G. Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients. Transl Med UNISA. 2017 Jul 1;16:17-23. eCollection 2017 Jan
  38. Pignataro P, Pezone L, Di Gioia G, Franco D, Iaccarino G, Iolascon A, Ciccarelli M, Capasso M. Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population. J Cardiovasc Transl Res. 2017 Dec;10(5-6):455-458. doi: 10.1007/s12265-017-9758-9. Epub 2017 Jun 21. Erratum in: J Cardiovasc Transl Res. 2017 Dec;10(5-6):459.
  39. Sorriento D, Gambardella J, Fiordelisi A, Trimarco B, Ciccarelli M, Iaccarino G, Santulli G. Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness. Adv Exp Med Biol. 2017;982:521-528. doi: 10.1007/978-3-319-55330-6_26. Review.
  40. Gambardella J, Sorriento D, Ciccarelli M, Del Giudice C, Fiordelisi A, Napolitano L, Trimarco B, Iaccarino G, Santulli G. Functional Role of Mitochondria in Arrhythmogenesis. Adv Exp Med Biol. 2017;982:191-202. doi: 10.1007/978-3-319-55330-6_10. Review
  41. Maione AS, Cipolletta E, Sorriento D, Borriello F, Soprano M, Rusciano MR, D'Esposito V, Markabaoui AK, De Palma GD, Martino G, Maresca L, Nobile G, Campiglia P, Formisano P, Ciccarelli M, Marone G, Trimarco B, Iaccarino G, Illario M. Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque. Atherosclerosis. 2017 Jan;256:53-61. doi: 10.1016/j.atherosclerosis.2016.11.006. Epub 2016 Nov 5.
  42. Sorriento D, Ciccarelli M, Cipolletta E, Trimarco B, Iaccarino G. "Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors. Front Cardiovasc Med. 2016 Dec 6;3:48. doi: 10.3389/fcvm.2016.00048. eCollection 2016. Review.
  43. Pecoraro M, Del Pizzo M, Marzocco S, Sorrentino R, Ciccarelli M, Iaccarino G, Pinto A, Popolo A. Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity. Toxicol Appl Pharmacol. 2016 Feb 15;293:44-52. doi: 10.1016/j.taap.2016.01.006. Epub 2016 Jan 11.
  44. Ciccarelli M, Finelli R, Rivera N, Santulli G, Izzo R, De Luca N, Rozza F, Ceccarelli M, Pagnotta S, Uliano F, Tremigliozzi R, Condorelli G, Trimarco V, Iaccarino G. The possible role of chromosome X variability in hypertensive familiarity. J Hum Hypertens. 2016 Feb 25. doi: 10.1038/jhh.2016.9.
  45. Cimmino G, Ciccarelli G, Morello A, Ciccarelli M, Golino P. High Density Lipoprotein Cholesterol Increasing Therapy: The Unmet Cardiovascular Need. Transl Med UNISA. 2014 Sep 1;12:29-40. eCollection 2015 May-Aug
  46. Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.J Cardiovasc Transl Res. 2015 Jul 30.
  47. Soprano M, Rusciano MR, Ciccarelli M, Maione AS, Formisano P, Illario M. Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator. Curr Diabetes Rev. 2015 Jul 22.
  48. Sorriento D, Franco A, Rusciano MR, Maione AS, Soprano M, Illario M, Iaccarino G, Ciccarelli M. Good at Heart: Preserving Cardiac Metabolism during aging. Curr Diabetes Rev. 2015 Jul 22
  49. Esposito G, Schiattarella GG, Perrino C, Cattaneo F, Pironti G, Franzone A, Gargiulo G, Magliulo F, Serino F, Carotenuto G, Sannino A, Ilardi F, Scudiero F, Brevetti L, Oliveti M, Giugliano G, Del Giudice C, Ciccarelli M, Renzone G, Scaloni A, Zambrano N, Trimarco B. Cardiovasc Res. 2015 Sep 1;107(4):431-41. doi: 10.1093/cvr/cvv173. Epub 2015 Jun 22.
  50. Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, Del Giudice C, Ciccarelli M, Franco A, Crola C, Campiglia P, Sala M, Gomez-Monterrey I, De Luca N, Trimarco B, Iaccarino G, Illario M. Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy. PLoS One. 2015 Jun 25;10(6):e0130477. doi: 10.1371/journal.pone.0130477. eCollection 2015.
  51. Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M et al. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. BRITISH JOURNAL OF CANCER Volume: 112 Issue: 1 Pages:77-
85 Published: JAN 6 2015
  52. Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G. Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization. Transl Med UNISA. 2014 Apr 8;10:3-7. eCollection 2014 Sep. Review.
  53. Ciccarelli M, Rusciano MR, Sorriento D et al. CaMKII protects MKP-1 from proteasome degradation in endothelial cells CELLULAR SIGNALLING Volume: 26 Issue: 10 Pages: 2167-2174 Published: OCT 2014
  54. Ciccarelli M, M Rusciano, D Sorriento, AS Maione, M Soprano et al. Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis Journal of Cancer Therapy 6 (02), 199, 2015
  55. Woodall MC, Ciccarelli M; Woodall BP, et al. G Protein-Coupled Receptor Kinase 2 A Link Between Myocardial Contractile Function and Cardiac Metabolism CIRCULATION RESEARCH Volume: 114 Issue: 10 Pages: 1661-1670 Published: MAY 9 2014
  56. Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW 2nd, Trimarco B, Iaccarino G. Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages. FEBS Lett. 2013 Nov 1;587(21):3487-94. doi: 10.1016/j.febslet.2013.09.002. Epub 2013 Sep 10.
  57. Ciccarelli M, Santulli G, Pascale V, Trimarco B, Iaccarino Adrenergic Receptors and Metabolism: Role in development of cardiovascular disease. Front Physiol. 2013 Oct 3;4:265. eCollection 2013. Review.
  58. Santulli G, Ciccarelli M, Trimarco B, Iaccarino G Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system. Front Physiol. 2013;4:209.
  59. Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW 2nd, Trimarco B, Iaccarino G. Endothelial g protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2415-24. Epub 2013 Aug 15
  60. Fan Q, Chen M, Zuo L, Shang X, Huang MZ, Ciccarelli M, Raake P, Brinks H, Chuprun KJ, Dorn GW 2nd, Koch WJ, Gao E. Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. PLoS One. 2013 Jun 21;8(6):e66234. Print 2013.
  61. Galasso G., De Rosa R., Ciccarelli M., Sorriento D., Del Giudice C., Strisciuglio T., De Biase C., Luciano R., Piccolo R., Pierri A., Di Gioia G., Prevete N., Trimarco B., Piscione F., Iaccarino G. β2-adrenergic receptor stimulation improves endothelial progenitor cells mediated ischemic neoangiogenesis. Circ Res. 2013 Mar 29;112(7):1026-34.
  62. Wei Z, Hurtt R, Ciccarelli M, Koch WJ, Doria C. Growth inhibition of human hepatocellular carcinoma cells by overexpression of G protein-coupled receptor kinase 2. J Cell Physiol. 2011 Aug 8. 227(6):2371-2377
  63. Katz MG, Fargnoli AS, Swain JD, Tomasulo CE, Ciccarelli M, Huang ZM, Rabinowitz JE, Bridges CR. AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve. J Thorac Cardiovasc Surg. 2011 Dec 3. 143(3): 720-723
  64. Cipolletta E, Ciccarelli M, Izzo R, Finelli R, Trimarco B, Iaccarino G. A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients. Transl Med UNISA. 2012 Jan 18;2:10-9. Print 2012 Jan
  65. Ciccarelli M, Cipolletta E, Iaccarino G. GRK2 at the control shaft of cellular metabolism. Curr Pharm Des. 2012;18(2):121-7.
  66. Ciccarelli M, Chuprun KJ, Rengo G, Gao E, Wei Z, Gold G, Gumpert A, Chen M, Otis N, Dorn II GW, Trimarco B, Iaccarino G & Koch WJ. GRK2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance following Myocardial Ischemia. Circulation. 2011 May; 123(18):1953-62.
  67. Santulli G, Campanile A, Spinelli L, Panzillo EA, Ciccarelli M, Trimarco B, Iaccarino G. G Protein-Coupled Receptor Kinase 2 in Patients With Acute Myocardial Infarction. Am J Cardiol. 2011 Feb. 107(8):1125-1130
  68. Ciccarelli M, Sorriento D, Zhou RH, Eckhart AD, Koch WJ, Trimarco B, Iaccarino G. Impaired neoangiogenesis in β2 Adrenergic Receptor gene deficient mice is restored by adenoviral mediated gene transfer of the human b2 adrenergic receptor. Br J Pharmacology. 2011 Feb;162(3):712-21.
  69. Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G. In vivo properties of the proangiogenic peptide QK. J Transl Med. 2009 Jun 8.Vol 7 Art 41.
  70. Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G. The G-protein-coupled receptor kinase 5 inhibits NfkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. ProcNatlAcadSci U S A. 2008 Nov 18;105(46):17818-23. Epub 2008 Nov 13.
  71. Izzo R, Cipolletta E, Ciccarelli M, Campanile A, Santulli G, Palumbo G, Vasta A, Formisano S, Trimarco B, Iaccarino G. Enhanced GRK2 Expression and Desensitization of beta AR Vasodilatation in Hypertensive Patients. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 1 (3): 215-220 DEC 2008.
  72. Leosco D, Rengo G, Iaccarino G, Golino L, Marchese M, Fortunato F, Zincarelli C, Sanzari E, Ciccarelli M,Galasso G, Altobelli GG, Conti V, Matrone G, Cimini V, Ferrara N, Filippelli A, Koch WJ, Rengo F. Exercise promotes angiogenesis and improves adrenergic signaling in the post ischemic failing rat heart. Cardiovasc Res. 2008 May 1;78(2):385-94. Epub 2007 Dec 18.
  73. Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervèro P, Altobelli GG, Cimini V, Pastore L, Piscione F, Trimarco B, Iaccarino G. Endothelialalpha(1)-adrenoceptorsregulate neo-angiogenesis. Br J Pharmacol. 2008 Mar;153(5):936-46. Epub 2007 Dec 17.
  74. Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervero P, Pastore L, Astone D, Trimarco B, Iaccarino G. Endothelial beta(2) adrenergicsignaling to AKT: Role of G(i) and SRC. Cellular Signalling, 19 (9): 1949-1955 SEP 2007.
  75. Leosco D, Rengo G, Iaccarino G, Sanzari E, Golino L, De Lisa G, Zincarelli C, Fortunato F, Ciccarelli M, Cimini V, Altobelli GG, Piscione F, Galasso G, Trimarco B, Koch W, Rengo F. Prior exercise improves age-dependent vascular endothelial growth factor down regulation and angiogenesisresponses to hind-limb ischemia in oldrats. Journal of Gerontology Series A- Biological Sciences and Medical Sciences, 62 (5): 471-480 MAY 2007.
  76. Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B. Ischemicneoangiogenesisenhanced by beta 2-adrenergic receptor overexpression - A novel role for the endothelial adrenergic system. Circ Res, 97 (11): 1182-1189 NOV 25 2005.
  77. Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B. AKT participates in endothelialdysfunction in hypertension. Circulation, 109 (21): 2587-2593 JUN 1 2004.
  78. Iaccarino G, Cipolletta E, Fiorillo A, Annecchiarico M, Ciccarelli M, Cimini V, Koch WJ, Trimarco, B. beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension. Circulation, 106 (3): 349-355 JUL 16 2002.

Books, Monographs, Chapters:

  1. Ciccarelli, D.Sorriento, E.Coscioni, G. Iaccarino, G. Santulli. Endocrinology of the Heart in Health and Disease. CHAPTER 11: Adrenergic Receptors. Academic Press 2017. https://doi.org/10.1016/C2014-0-04170-6
  2. Ciccarelli M, Sorriento D, Iaccarino G The Cardiovascular Adrenergic System: The Adrenergic System in Vascular Endothelial Cells (Chapter 3) 2015. ISBN: 978-3-319-13679-0 (Print) 978-3-319-13680-6 (Online)
  3. Ciccarelli M, Chuprun K, Koch WJ. G Protein-Coupled Receptors: Structure, Signaling, and Physiology “Beta adrenergic receptors in cardiovascular and respiratory disease” CAMBRIDGE UNIVERSITY PRESS, 2010.
  4. M. Ciccarelli, A. Paudice, A. Elia, A. Bonanno, G. Iaccarino, B. Trimarco. Storia naturale dell’infarto rivascolarizzato: di quanto si allunga la vita? Conoscere e curare e il cuore. Atti XX simposio del centro per la lotta contro l’infarto 2003. pp117-126
  5. Iaccarino G, Annechiarico M, Ciccarelli M, Bonanno A, Trimarco V, Guerrera L, Elia A, Trimarco B. The evolution of Chronic Heart Faliure: The Endothelial Border. ADVANCES IN REHABILITATION. Maugeri Foundation Books. 2002 Vol 13 99-103