Eduardo Maria SOMMELLA | ADVANCED METHODOLOGY IN MEDICINAL CHEMISTRY
Eduardo Maria SOMMELLA ADVANCED METHODOLOGY IN MEDICINAL CHEMISTRY
cod. 0760200039
ADVANCED METHODOLOGY IN MEDICINAL CHEMISTRY
| 0760200039 | |
| DIPARTIMENTO DI FARMACIA | |
| EQF7 | |
| PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY | |
| 2020/2021 |
| YEAR OF DIDACTIC SYSTEM 2016 | |
| PRIMO SEMESTRE |
| SSD | CFU | HOURS | ACTIVITY | |
|---|---|---|---|---|
| CHIM/08 | 5 | 40 | LESSONS |
| Objectives | |
|---|---|
| THE COURSE AIM TO PROVIDE THE KNOWLEDGE REGARDING INNOVATIVE METHODOLOGIES EMPLOYED IN MEDICINAL CHEMISTRY FOR DRUG-DISCOVERY BY COMPUTATIONAL, ANALYTICAL-PHARMACEUTICAL AND BIOINFORMATICS METHODS, THUS ALLOWING THE BASE CONCEPTS THAT LED TO THE DEVELOPMENT OF NOVEL RESEARCH SCOPES SUCH AS COMPUTATIONAL CHEMISTRY AND OMIC SCIENCES. IN LINE WITH THE OBJECTIVES OF THE COURSE, THE TEACHING HAS THE TARGET TO IMPROVE THE KNOWLEDGE LEVELS ON DRUG DISCOVERY AND OMIC SCIENCES AND ACQUIRE CRITICAL APPROACH OF THE STUDENT FOR THE RESOLUTION OF MEDICINAL CHEMISTRY PROBLEMS BY NEW METHODOLOGIES |
| Prerequisites | |
|---|---|
| THE FOLLOWING OBJECTIVES ARE MANDATORY: PHISICAL METHODS IN ORGANIC CHEMISTRY INTRODUCTIVE MEDICINAL CHEMISTRY ORGANIC CHEMISTRY II |
| Contents | |
|---|---|
| THE COURSE IS ONE MODULE -TRIDIMENSIONAL MOLECULAR MODEL CONCEPT (3D) PHYSICO-CHEMICAL CHARACTERISTICHS ASSOCIATED TO A MOLECULE (6H) -COMPUTATIONAL METHODS FOR CONFORMATIONAL ANALYSIS AND FOR THE CALCULATION OF MOLECULAR ENERGY (6H) -LIGAND-BASED AND TARGET BASED DRUG DESIGN -DEVELOPMENT OF A PHARMACORE MODEL, STRUCTURE ACTIVITY RELATIONSHIP (6H) -DE NOVO LIGAND DESIGN, BIOINFORMATICS PRINCIPLES, BIOBANKS, HOMOLOGY MODELING, MOLECULAR DOCKING AND SCORING, VIRTUAL SCREENING. (3H) HIGH PERFORMANCE LIQUID AFFINITY CHROMATOGRAPHY, ENZYME AND PROTEIN IMMOBILIZATION AND AFFINITY BIND SCREENING TO TARGET PROTEINS (3H) -OMIC SCIENCES AND MEDICINAL CHEMISTRY, METABOLOMICS AND PHARMACOMETABOLOMICS, TARGETED AND UNTARGETD APPROACHES, (6H) LIPIDOMICS TARGETED AND UNTARGETED -PROTEOMICS AND LIGAND-PROTEIN INTERACTION, BOTTOM-UP AND TOP-DOWN METHODS, LIMITED PROTEOLYSIS (LIP) (3H) -MALDI IMAGING AND SPATIAL DISTRIBUTION ANALYSIS OF A DRUG (2H) |
| Teaching Methods | |
|---|---|
| THE TEACHING IS BASED ON FRONTAL LESSONS OF A SUM OF 40 HOURS (5 CFU) TO BE EXECUTED IN CLASSROOM |
| Verification of learning | |
|---|---|
| A SELF-ASSESSEMENT TEST WILL BE HELD AT HALF COURSE AND DISCUSSED WITH THE TEACHER. AT THE END OF THE COURSE A SHORT PPT PRESENTATION BASED ON AN ARGUMENT CHOSEN IN ACCORDANCE WITH THE TEACHER WILL BE DISCUSSED A PRE-EXAM WILL BE HELD THE FINAL EVALUATION CONSIST IN ORAL EXAM OF ROUGHLY 30 MINUTES LENGHT FOCUSED ON COURSE ARGUMENT WITH PARTICULAR ATTENTION TO LANGUAGE AND CRITICAL SENSE |
| Texts | |
|---|---|
| COURSE SLIDES WILL BE SUFFICIENT FOR PASSING THE EXAM. PRINCIPLES AND APPLICATIONS (AUTHOR: A. R. LEACH) PHARMACEUTICAL ANALYSIS: A TEXTBOOK FOR PHARMACY STUDENTS AND PHARMACEUTICAL CHEMISTS (AUTHOR: D. WATSON) METABOLOMICS: FROM FUNDAMENTALS TO CLINICAL APPLICATIONS EDITORS: SUSSULINI, |
| More Information | |
|---|---|
| FREQUENCE IS NOT OBLIGATORY BUT STRONGLY SUGGESTED. FOR FURTHER INFORMATION PLEASE CONTACT THE TEACHER |
BETA VERSION Data source ESSE3 [Ultima Sincronizzazione: 2022-05-23]
