TIZIANA ESPOSITO | TECHNOLOGY AND FORMULATION OF HERBAL PRODUCTS

cod. 0712100051

TECHNOLOGY AND FORMULATION OF HERBAL PRODUCTS

	0712100051
	DIPARTIMENTO DI FARMACIA
	EQF6
	HERBAL SCIENCE
	2024/2025

PERCORSO COMUNE

	OBBLIGATORIO
	YEAR OF COURSE 3
	YEAR OF DIDACTIC SYSTEM 2020
	FULL ACADEMIC YEAR

TEACHING UNITS

	SSD	CFU	HOURS	ACTIVITY	TYPE OF ACTIVITY
1	TECNOLOGIA DEI PRODOTTI ERBORISTICI MODULO DI TECNOLOGIA E FORMULAZIONE DEI PRODOTTI ERBORISTICI
	CHIM/09	6	48	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS
2	FORMULAZIONE E LEGISLAZIONE DEI PRODOTTI COSMETICI MODULO DI TECNOLOGIA E FORMULAZIONE DEI PRODOTTI ERBORISTICI
	CHIM/09	3	24	LESSONS	COMPULSORY SUBJECTS, CHARACTERISTIC OF THE CLASS

PROFESSORS

	PASQUALE DEL GAUDIO1 T Curriculum
	TIZIANA ESPOSITO2 Curriculum

	Objectives
	THE COURSE IS AIMED AT THE ACQUISITION OF KNOWHOW AND METHODOLOGIES FOR THE CORRECT PREPARATION OF HEALTHY PRODUCTS BASED ON PLANTS OR HERBAL PRODUCTS, WITH PARTICULAR ATTENTION TO THE DIFFERENT PHASES, SUCH AS THE PREPARATION OF THE VEGETABLE MATERIAL, THE PRODUCTION OF THE DOSAGE FORM, CONTROL AND LABELING OF THE FINISHED PRODUCT, EACH ACCORDING TO THE PROVISIONS OF THE CURRENT REGULATIONS. THE COURSE ALSO PROVIDES THE ACQUISITION OF KNOWHOW ON THE REGULATORY ASPECTS CONCERNING THE PRODUCTION AND MARKETING OF COSMETIC PRODUCTS, AS WELL AS THE ACQUISITION OF CHEMICAL AND TECHNOLOGICAL KNOWLEDGE ABOUT COSMETIC RAW MATERIALS, THE DIFFERENT TYPES OF FORMULATION AND THE FINISHED COSMETIC PRODUCTS. BY APPLYING THE SKILLS ACQUIRED, THE STUDENT MUST BE ABLE TO PREPARE AN HERBAL PREPARATION, LABELING IT CORRECTLY, PROVIDING INFORMATION SUCH AS THE STABILITY TIME OF THE FORMULATION ITSELF AND THE RULES FOR HANDLING BY THIRD PARTIES. THE STUDENT SHOULD ALSO BE ABLE TO APPLY THE KNOWLEDGE ACQUIRED TO CHOOSE AND RECOMMEND A COSMETIC PRODUCT, BASED ON THE TYPE OF FORMULATUION AND THE INGREDIENTS CONTAINED INTO IT

THE COURSE IS AIMED AT THE ACQUISITION OF KNOWHOW AND METHODOLOGIES FOR THE CORRECT PREPARATION OF HEALTHY PRODUCTS BASED ON PLANTS OR HERBAL PRODUCTS, WITH PARTICULAR ATTENTION TO THE DIFFERENT PHASES, SUCH AS THE PREPARATION OF THE VEGETABLE MATERIAL, THE PRODUCTION OF THE DOSAGE FORM, CONTROL AND LABELING OF THE FINISHED PRODUCT, EACH ACCORDING TO THE PROVISIONS OF THE CURRENT REGULATIONS.
THE COURSE ALSO PROVIDES THE ACQUISITION OF KNOWHOW ON THE REGULATORY ASPECTS CONCERNING THE PRODUCTION AND MARKETING OF COSMETIC PRODUCTS, AS WELL AS THE ACQUISITION OF CHEMICAL AND TECHNOLOGICAL KNOWLEDGE ABOUT COSMETIC RAW MATERIALS, THE DIFFERENT TYPES OF FORMULATION AND THE FINISHED COSMETIC PRODUCTS.

BY APPLYING THE SKILLS ACQUIRED, THE STUDENT MUST BE ABLE TO PREPARE AN HERBAL PREPARATION, LABELING IT CORRECTLY, PROVIDING INFORMATION SUCH AS THE STABILITY TIME OF THE FORMULATION ITSELF AND THE RULES FOR HANDLING BY THIRD PARTIES.
THE STUDENT SHOULD ALSO BE ABLE TO APPLY THE KNOWLEDGE ACQUIRED TO CHOOSE AND RECOMMEND A COSMETIC PRODUCT, BASED ON THE TYPE OF FORMULATUION AND THE INGREDIENTS CONTAINED INTO IT

	Prerequisites
	STUDENTS MUST HAVE PASSED ALL THE EXAMS OF THE 1ST YEAR OF THE COURSE, AS REQUIRED BY THE EDUCATIONAL REGULATIONS.

	Contents
	THE "TECHNOLOGY AND FORMULATION OF HERBAL PRODUCTS" COURSE IS DIVIDED INTO TWO INTEGRATED PARTS. SPECIFICALLY, A FIRST PART "TECHNOLOGY OF HERBAL PRODUCTS" PROVIDES THE FOLLOWING CONTENTS: 1. PRODUCTS OF VEGETABLE ORIGIN WITH HEALTHY ACTIVITIES (4 HOURS OF FACULTY) - CLASSIFICATION; CURRENT REGULATION; STANDARDS OF GOOD PREPARATION (NBP_OFFICIAL PHARMACOPOEIA) AND STANDARDS OF GOOD MANUFACTURING (NBF). - HERBAL PREPARATIONS (GROUNDED OR PULVERIZED VEGETABLE DRUGS, TINCTURES, EXTRACTS, ESSENTIAL OILS, PRESSED JUICES, TREATED EXUDATES) AND FORMULATION DEVELOPMENT. 2. BIOPHARMACEUTICAL ASPECTS OF DOSAGE FORMS DESIGN (4 HOURS OF LESSONS) 3. SOLID DOSAGE FORMS (12 HOURS OF LESSONS + 4 HOURS LABORATORY EXERCISES) - PREPARATION OF POWDERS AND UNIT OPERATIONS (GRINDING, MIXING, GRANULATION, DRYING, COMPRESSION); FORMULATION AND PREPARATION OF: POWDERS, GRANULES, TABLETS, COATED TABLETS (DRESSES AND FILM TABLETS), CANDIES, CHEWABLE TABLETS AND CAPSULES. 4. LIQUID DOSAGE FORMS (8 HOURS OF LESSONS + 4 HOURS LABORATORY EXERCISES) - UNIT OPERATIONS (DISSOLUTION AND FILTRATION); FORMULATION AND PREPARATION OF: SOLUTIONS (WATER, ALCOHOLIC, OIL, GLYCERIC SOLUTIONS), SYRUPS, ELIXIRS, DISPERSE SYSTEMS (SUSPENSIONS AND COLLOIDAL DISPERSIONS, FLOCCULATED AND DEFLOCCULATED SUSPENSION) AND EMULSIONS. 5. SEMI-SOLID DOSAGE FORMS FOR SKIN APPLICATION; RHEOLOGY, OINTMENTS, PASTES, CREAMS, GEGELS (2 HOURS OF LECTURE-CLASS + 2 HOURS OF LABORATORY EXERCISES) 6. PRESSURIZED PREPARATIONS AND SUPPOSITORS (2 HOURS OF LESSONS) 7. THE STABILITY (CHEMICAL, PHYSICAL AND MICROBIOLOGICAL) OF THE DIFFERENT DOSAGE FORMS (2 HOURS OF LESSONS) 8. PACKAGING OF THE DOSAGE FORMS (2 HOURS OF LESSONS) 9. THE "QUALITY" OF HERBAL PRODUCTS (2 HOURS OF FACULTY) A SECOND PART OF "FORMULATION AND LEGISLATION OF COSMETIC PRODUCTS" PROVIDES THE FOLLOWING CONTENTS: 1. EC REGULATION N. 1223/2009 ON COSMETIC PRODUCTS: STRUCTURE AND CONTENT OF THE ARTICULATION AND OF THE ANNEXES, GLOSSARY OF COSMETIC INGREDIENTS (6 HOURS OF LECTURED TEACHING) 2. SKIN: STRUCTURE AND MAIN FUNCTIONS. FACTORS THAT INFLUENCE SKIN PERMEATION (2 HOURS OF LESSONS) 3. CHEMICAL AND FUNCTIONAL CLASSIFICATION OF COSMETIC INGREDIENTS: LIPIDS, ANTIOXIDANTS AND SEQUESTRANTS, PRESERVATIVES, COLORANTS, RHEOLOGICAL MODIFIERS, SURFACTANTS, EMULSIFIERS, UV FILTERS (8 HOURS OF LESSONS) 4. COSMETIC FORMS AND PREPARATION TECHNIQUES: SOLUTIONS (AQUEOUS, ALCOHOLIC, HYDROALCOHOLIC, GLYCERIC, HYDROGLYCERIC, OILY), GELS, TENSIOLITES, EMULSIONS (5 HOURS OF LESSONS + 3 HOURS OF PRACTICES)

Contents

THE "TECHNOLOGY AND FORMULATION OF HERBAL PRODUCTS" COURSE IS DIVIDED INTO TWO INTEGRATED PARTS.

SPECIFICALLY, A FIRST PART "TECHNOLOGY OF HERBAL PRODUCTS" PROVIDES THE FOLLOWING CONTENTS:
1. PRODUCTS OF VEGETABLE ORIGIN WITH HEALTHY ACTIVITIES (4 HOURS OF FACULTY)
- CLASSIFICATION; CURRENT REGULATION; STANDARDS OF GOOD PREPARATION (NBP_OFFICIAL PHARMACOPOEIA) AND STANDARDS OF GOOD MANUFACTURING (NBF).
- HERBAL PREPARATIONS (GROUNDED OR PULVERIZED VEGETABLE DRUGS, TINCTURES, EXTRACTS, ESSENTIAL OILS, PRESSED JUICES, TREATED EXUDATES) AND FORMULATION DEVELOPMENT.
2. BIOPHARMACEUTICAL ASPECTS OF DOSAGE FORMS DESIGN (4 HOURS OF LESSONS)
3. SOLID DOSAGE FORMS (12 HOURS OF LESSONS + 4 HOURS LABORATORY EXERCISES)
- PREPARATION OF POWDERS AND UNIT OPERATIONS (GRINDING, MIXING, GRANULATION, DRYING, COMPRESSION); FORMULATION AND PREPARATION OF: POWDERS, GRANULES, TABLETS, COATED TABLETS (DRESSES AND FILM TABLETS), CANDIES, CHEWABLE TABLETS AND CAPSULES.
4. LIQUID DOSAGE FORMS (8 HOURS OF LESSONS + 4 HOURS LABORATORY EXERCISES)
- UNIT OPERATIONS (DISSOLUTION AND FILTRATION); FORMULATION AND PREPARATION OF: SOLUTIONS (WATER, ALCOHOLIC, OIL, GLYCERIC SOLUTIONS), SYRUPS, ELIXIRS, DISPERSE SYSTEMS (SUSPENSIONS AND COLLOIDAL DISPERSIONS, FLOCCULATED AND DEFLOCCULATED SUSPENSION) AND EMULSIONS.
5. SEMI-SOLID DOSAGE FORMS FOR SKIN APPLICATION; RHEOLOGY, OINTMENTS, PASTES, CREAMS, GEGELS (2 HOURS OF LECTURE-CLASS + 2 HOURS OF LABORATORY EXERCISES)
6. PRESSURIZED PREPARATIONS AND SUPPOSITORS (2 HOURS OF LESSONS)
7. THE STABILITY (CHEMICAL, PHYSICAL AND MICROBIOLOGICAL) OF THE DIFFERENT DOSAGE FORMS (2 HOURS OF LESSONS)
8. PACKAGING OF THE DOSAGE FORMS (2 HOURS OF LESSONS)
9. THE "QUALITY" OF HERBAL PRODUCTS (2 HOURS OF FACULTY)

A SECOND PART OF "FORMULATION AND LEGISLATION OF COSMETIC PRODUCTS" PROVIDES THE FOLLOWING CONTENTS:
1. EC REGULATION N. 1223/2009 ON COSMETIC PRODUCTS: STRUCTURE AND CONTENT OF THE ARTICULATION AND OF THE ANNEXES, GLOSSARY OF COSMETIC INGREDIENTS (6 HOURS OF LECTURED TEACHING)
2. SKIN: STRUCTURE AND MAIN FUNCTIONS. FACTORS THAT INFLUENCE SKIN PERMEATION (2 HOURS OF LESSONS)
3. CHEMICAL AND FUNCTIONAL CLASSIFICATION OF COSMETIC INGREDIENTS: LIPIDS, ANTIOXIDANTS AND SEQUESTRANTS, PRESERVATIVES, COLORANTS, RHEOLOGICAL MODIFIERS, SURFACTANTS, EMULSIFIERS, UV FILTERS (8 HOURS OF LESSONS)
4. COSMETIC FORMS AND PREPARATION TECHNIQUES: SOLUTIONS (AQUEOUS, ALCOHOLIC, HYDROALCOHOLIC, GLYCERIC, HYDROGLYCERIC, OILY), GELS, TENSIOLITES, EMULSIONS (5 HOURS OF LESSONS + 3 HOURS OF PRACTICES)

	Teaching Methods
	THE FIRST MODULE OF 6 CFU (48 HOURS) PROVIDES LESSONS (38 HOURS) OF THE ABOVE DESCRIPTION OF THE TOPICS, LABORATORY EXERCISES (10 HOURS) ON THE TOPICS MENTIONED, INTERACTION WITH THE TEACHER AND/OR WITH SCHOLARS AND EXPERTS OF THE SECTOR. THE SECOND MODULE OF 3 CFU (24 HOURS) INCLUDES LESSONS (21 HOURS) AND PRACTICAL EXERCISES IN SMALL GROUPS (3 HOURS).

	Verification of learning
	THE ACHIEVEMENT OF THE EDUCATIONAL OBJECTIVES WILL BE VERIFIED THROUGH A PRACTICAL TEST, A WRITTEN TEST AND AN ORAL TEST, THE OVERALL EVALUATION OF WHICH WILL BE EXPRESSED IN THIRTY. TO ACCESS THE ORAL, YOU MUST PASS THE LABORATORY TEST AND THE WRITTEN TEST. THE FINAL MARK OF THIS MODULE MUST BE PROPERLY MEDIATED WITH THAT OF THE SECOND MODULE PROVIDED FOR THIS COURSE. FOR THE FIRST MODULE THE PRACTICAL AND THE WRITTEN TEST, TO BE CARRIED OUT AT THE END OF THE COURSE, WILL BE AIMED AT ASSESSING THE KNOWLEDGE AND OPERATIONAL SKILLS ACQUIRED. THE LAB TEST WILL BE FOCUSED MAINLY ON THE APPLICATION OF NBP FOR THE PREPARATION OF A HERBAL PRODUCT (METHOD OF PREPARATION, CONTROLS BY FU, COMPILATION OF THE PROCESSING SHEET, LABELING ETC.); THE WRITTEN TEST WILL CONTAIN ABOUT 20 QUESTIONS (TRUE OR FALSE; COMPLETION; CORRESPONDENCE; MULTIPLE CHOICE TO ONE OR MORE SOLUTIONS; CLOSED STIMULUS - OPEN ANSWER) ON THE MAIN TOPICS OF THE COURSE (MAXIMUM DURATION: 90 MINUTES). THE ORAL EXAMINATION WILL BE INTENDED TO DEEPEN THE LEVEL OF THEORETICAL KNOWLEDGE, THE AUTONOMY OF ANALYSIS AND JUDGMENT, AS WELL AS THE STUDENT'S EXHIBITION CAPABILITIES. THE EVALUATION LEVEL OF THE TEST WILL TAKE ACCOUNT OF THE MASTERY OF THE CONTENTS, APPROPRIATENESS OF THE DEFINITIONS AND THEORETICAL REFERENCES, CLARITY OF THE ARGUMENT, DOMAIN OF THE SPECIALIST LANGUAGE (MAXIMUM DURATION: 20 MINUTES). FOR THE SECOND MODULE - WRITTEN EXAM, DURATION 70 MINUTES, CONSISTING IN 4 OPEN ANSWER QUESTIONS (EACH SCORE RANGES FROM 0 TO 4) AND 14 CLOSED ANSWER QUESTIONS (EACH SCORE RANGES FROM 0 TO 1). THE FINAL EVALUATION WILL BE OBTAINED AS THE AVERAGE OF THE PARTIAL EVALUATIONS. THE MINIMUM ASSESSMENT LEVEL (18/30) WILL BE ASSIGNED IF THE STUDENT DEMONSTRATES TO HAVE A FRAGMENTARY KNOWLEDGE OF THEORETICAL CONTENTS AND A LIMITED ABILITY TO USE THEM IN THE STUDY CONTEXT. THE MAXIMUM LEVEL (30/30) WILL BE ASSIGNED IF THE STUDENT DEMONSTRATES TO HAVE A COMPLETE AND IN-DEPTH KNOWLEDGE OF THE METHODOLOGIES AND TOOLS AND A CONSIDERABLE ABILITY TO USE THEM IN THE STUDY CONTEXT. PRAISE WILL BE GIVEN ONLY TO STUDENTS WITH A SIGNIFICANT KNOWLEDGE OF THE METHODOLOGIES AND WITH A HIGH ABILITY TO RE-WORK THE ACQUIRED CONCEPTS.

Verification of learning

THE ACHIEVEMENT OF THE EDUCATIONAL OBJECTIVES WILL BE VERIFIED THROUGH A PRACTICAL TEST, A WRITTEN TEST AND AN ORAL TEST, THE OVERALL EVALUATION OF WHICH WILL BE EXPRESSED IN THIRTY. TO ACCESS THE ORAL, YOU MUST PASS THE LABORATORY TEST AND THE WRITTEN TEST. THE FINAL MARK OF THIS MODULE MUST BE PROPERLY MEDIATED WITH THAT OF THE SECOND MODULE PROVIDED FOR THIS COURSE.

FOR THE FIRST MODULE
THE PRACTICAL AND THE WRITTEN TEST, TO BE CARRIED OUT AT THE END OF THE COURSE, WILL BE AIMED AT ASSESSING THE KNOWLEDGE AND OPERATIONAL SKILLS ACQUIRED. THE LAB TEST WILL BE FOCUSED MAINLY ON THE APPLICATION OF NBP FOR THE PREPARATION OF A HERBAL PRODUCT (METHOD OF PREPARATION, CONTROLS BY FU, COMPILATION OF THE PROCESSING SHEET, LABELING ETC.); THE WRITTEN TEST WILL CONTAIN ABOUT 20 QUESTIONS (TRUE OR FALSE; COMPLETION; CORRESPONDENCE; MULTIPLE CHOICE TO ONE OR MORE SOLUTIONS; CLOSED STIMULUS - OPEN ANSWER) ON THE MAIN TOPICS OF THE COURSE (MAXIMUM DURATION: 90 MINUTES).
THE ORAL EXAMINATION WILL BE INTENDED TO DEEPEN THE LEVEL OF THEORETICAL KNOWLEDGE, THE AUTONOMY OF ANALYSIS AND JUDGMENT, AS WELL AS THE STUDENT'S EXHIBITION CAPABILITIES. THE EVALUATION LEVEL OF THE TEST WILL TAKE ACCOUNT OF THE MASTERY OF THE CONTENTS, APPROPRIATENESS OF THE DEFINITIONS AND THEORETICAL REFERENCES, CLARITY OF THE ARGUMENT, DOMAIN OF THE SPECIALIST LANGUAGE (MAXIMUM DURATION: 20 MINUTES).

FOR THE SECOND MODULE
- WRITTEN EXAM, DURATION 70 MINUTES, CONSISTING
IN 4 OPEN ANSWER QUESTIONS (EACH SCORE RANGES FROM 0 TO 4) AND 14 CLOSED ANSWER QUESTIONS (EACH SCORE RANGES FROM 0 TO 1).

THE FINAL EVALUATION WILL BE OBTAINED AS THE AVERAGE OF THE PARTIAL EVALUATIONS.

THE MINIMUM ASSESSMENT LEVEL (18/30) WILL BE ASSIGNED IF THE STUDENT DEMONSTRATES TO HAVE A FRAGMENTARY KNOWLEDGE OF THEORETICAL CONTENTS AND A LIMITED ABILITY TO USE THEM IN THE STUDY CONTEXT.
THE MAXIMUM LEVEL (30/30) WILL BE ASSIGNED IF THE STUDENT DEMONSTRATES TO HAVE A COMPLETE AND IN-DEPTH KNOWLEDGE OF THE METHODOLOGIES AND TOOLS AND A CONSIDERABLE ABILITY TO USE THEM IN THE STUDY CONTEXT.
PRAISE WILL BE GIVEN ONLY TO STUDENTS WITH A SIGNIFICANT KNOWLEDGE OF THE METHODOLOGIES AND WITH A HIGH ABILITY TO RE-WORK THE ACQUIRED CONCEPTS.

	Texts
	GIOVANNI D’AGOSTINIS, ELIO MIGNINI. MANUALE DEL COSMETOLOGO. EDITORE: TECNICHE NUOVE. COLLANA: TECNICA FARMACEUTICA E COSMETICA. FRANCO BETTIOL, MASSIMILIANO CECCHI. MANUALE DELLE PREPARAZIONI COSMETICHE E DERMATOLOGICHE. EDITORE: TECNICHE NUOVE COLLANA: TECNICA FARMACEUTICA E COSMETICA. AMOROSA M., PRINCIPI DI TECNICA FARMACEUTICA (ED. 6 - GIUGNO 2021) ISBN-13 978-8829931606 EDITORE PICCIN-NUOVA LIBRARIA

Texts

GIOVANNI D’AGOSTINIS, ELIO MIGNINI. MANUALE DEL COSMETOLOGO. EDITORE: TECNICHE NUOVE. COLLANA: TECNICA FARMACEUTICA E COSMETICA.
FRANCO BETTIOL, MASSIMILIANO CECCHI. MANUALE DELLE PREPARAZIONI COSMETICHE E DERMATOLOGICHE. EDITORE: TECNICHE NUOVE COLLANA: TECNICA FARMACEUTICA E COSMETICA.
AMOROSA M., PRINCIPI DI TECNICA FARMACEUTICA (ED. 6 - GIUGNO 2021) ISBN-13 978-8829931606 EDITORE PICCIN-NUOVA LIBRARIA

Lessons Timetable

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TIZIANA ESPOSITO | TECHNOLOGY AND FORMULATION OF HERBAL PRODUCTS